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Volumn 8, Issue 2, 2007, Pages 150-158

Valopicitabine dihydrochloride: A specific polymerase inhibitor of hepatitis C virus

Author keywords

[No Author keywords available]

Indexed keywords

PEGINTERFERON; PEGINTERFERON ALPHA2B; RIBAVIRIN; VALOPICITABINE;

EID: 33947309390     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (42)

References (58)
  • 1
    • 33947313438 scopus 로고    scopus 로고
    • 478931 Idenix Research. Idenix Pharmaceuticals Inc COMPANY WORLD WIDE WEB SITE 2003 February 17
    • 478931 Idenix Research. Idenix Pharmaceuticals Inc COMPANY WORLD WIDE WEB SITE 2003 February 17
  • 2
    • 33947321828 scopus 로고    scopus 로고
    • 485185 NM-283 shows promise. Idenix Pharmaceuticals Inc PRESS RELEASE 2003 April 09
    • 485185 NM-283 shows promise. Idenix Pharmaceuticals Inc PRESS RELEASE 2003 April 09
  • 3
    • 33947306376 scopus 로고    scopus 로고
    • 508920 Sirna Therapeutics, Setting the plan in motion. Sirna Therapeutics Inc ANNUAL REPORT 2003 May 29
    • 508920 Sirna Therapeutics - Setting the plan in motion. Sirna Therapeutics Inc ANNUAL REPORT 2003 May 29
  • 4
    • 0037179698 scopus 로고    scopus 로고
    • 511549 Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Goncales FL Jr, Haussinger D, Diago M, Carosi G, Dhumeaux D, Craxi A et al N ENGL J MED 2002 347 13 975-982
    • 511549 Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Goncales FL Jr, Haussinger D, Diago M, Carosi G, Dhumeaux D, Craxi A et al N ENGL J MED 2002 347 13 975-982
  • 5
    • 33947319597 scopus 로고    scopus 로고
    • 513647 Future Antivirals, SMi Conference, Latest developments in HIV, Hepatitis, Herpes, Influenza, RSV and SARS, London, UK Harrison R IDDB MEETING REPORT 2003 November 12-13
    • 513647 Future Antivirals - SMi Conference, Latest developments in HIV, Hepatitis, Herpes, Influenza, RSV and SARS, London, UK Harrison R IDDB MEETING REPORT 2003 November 12-13
  • 6
    • 33947321667 scopus 로고    scopus 로고
    • 514125 NM 283 has potent antiviral activity against genotype 1 chronic hepatitis C virus (HCV-1) infection in the chimpanzee. Standring DN, Lanford R, Wright T, Chung RT, Bichko V, Cretton-Scott E, Pan-Zhou X, Bergelson S, Qu L, Tausek M, Bridges E et al J HEPATOL 2003 2 Abs 3
    • 514125 NM 283 has potent antiviral activity against genotype 1 chronic hepatitis C virus (HCV-1) infection in the chimpanzee. Standring DN, Lanford R, Wright T, Chung RT, Bichko V, Cretton-Scott E, Pan-Zhou X, Bergelson S, Qu L, Tausek M, Bridges E et al J HEPATOL 2003 2 Abs 3
  • 7
    • 33947323844 scopus 로고    scopus 로고
    • 538687 A phase I/II dose escalation trial assessing tolerance, pharmacokinetics, and antiviral activity of NM283, a novel antiviral treatment for hepatitis C. Godofsky E, Afdhal NH, Rustgi V, Shick L, Duncan L, Zhou XJ, Chao G, Fang C, Fielman B, Myers M, Brown N GASTROENTEROLOGY 2004 126 4 Suppl 2 Abs 1020 •• This abstract reports the first clinical data for valopicitabine dihydrochloride. In this phase I/II dose-escalation trial, patients were treated with valopicitabine dihydrochloride ranging from 50 to 400 mg/day. Dose-related decreases in serum HCV RNA were observed
    • 538687 A phase I/II dose escalation trial assessing tolerance, pharmacokinetics, and antiviral activity of NM283, a novel antiviral treatment for hepatitis C. Godofsky E, Afdhal NH, Rustgi V, Shick L, Duncan L, Zhou XJ, Chao G, Fang C, Fielman B, Myers M, Brown N GASTROENTEROLOGY 2004 126 4 Suppl 2 Abs 1020 •• This abstract reports the first clinical data for valopicitabine dihydrochloride. In this phase I/II dose-escalation trial, patients were treated with valopicitabine dihydrochloride ranging from 50 to 400 mg/day. Dose-related decreases in serum HCV RNA were observed.
  • 8
    • 33947318903 scopus 로고    scopus 로고
    • 539033 Idenix Pharmaceuticals Inc announces first human clinical trial data for NM283 for the treatment of hepatitis C. Idenix Pharmaceuticals Inc PRESS RELEASE 2004 May 18
    • 539033 Idenix Pharmaceuticals Inc announces first human clinical trial data for NM283 for the treatment of hepatitis C. Idenix Pharmaceuticals Inc PRESS RELEASE 2004 May 18
  • 9
    • 33947309177 scopus 로고    scopus 로고
    • 563621 First clinical results for a novel antiviral treatment for hepatitis C: A phase I/II dose escalation trial assessing tolerance, pharmacokinetics, and antiviral activity of NM283. Godofsky E, Afdhal N, Rustgi V, Shick L, Duncan L, Zhou XJ, Chao G, Fang C, Fielman B, Myers M, Brown NA J HEPATOL 2004 40 Suppl 1 35 •• In this phase I/II clinical trial, escalating doses of valopicitabine dihydrochloride (50 to 400 mg/day) were well tolerated with no serious adverse events, DLTs or pattern of laboratory abnormalities
    • 563621 First clinical results for a novel antiviral treatment for hepatitis C: A phase I/II dose escalation trial assessing tolerance, pharmacokinetics, and antiviral activity of NM283. Godofsky E, Afdhal N, Rustgi V, Shick L, Duncan L, Zhou XJ, Chao G, Fang C, Fielman B, Myers M, Brown NA J HEPATOL 2004 40 Suppl 1 35 •• In this phase I/II clinical trial, escalating doses of valopicitabine dihydrochloride (50 to 400 mg/day) were well tolerated with no serious adverse events, DLTs or pattern of laboratory abnormalities.
  • 10
    • 33947326670 scopus 로고    scopus 로고
    • 567853 Idenix's NM-283 reduces HCV viral load in combination with PEGylated interferon. Idenix Pharmaceuticals Inc PRESS RELEASE 2004 November 01
    • 567853 Idenix's NM-283 reduces HCV viral load in combination with PEGylated interferon. Idenix Pharmaceuticals Inc PRESS RELEASE 2004 November 01
  • 11
    • 33947314745 scopus 로고    scopus 로고
    • 568262 Idenix Pharmaceuticals announces third quarter and nine month financial results. Idenix Pharmaceuticals Inc PRESS RELEASE 2004 November 02
    • 568262 Idenix Pharmaceuticals announces third quarter and nine month financial results. Idenix Pharmaceuticals Inc PRESS RELEASE 2004 November 02
  • 12
    • 33947324286 scopus 로고    scopus 로고
    • 570841 Japan Tobacco Inc clinical development. Japan Tobacco Inc COMPANY WORLD WIDE WEB SITE 2003 September 16
    • 570841 Japan Tobacco Inc clinical development. Japan Tobacco Inc COMPANY WORLD WIDE WEB SITE 2003 September 16
  • 13
    • 33947325446 scopus 로고    scopus 로고
    • 578943 Isis tightens belt for 2005. Isis Pharmaceuticals Inc PRESS RELEASE 2005 10 January
    • 578943 Isis tightens belt for 2005. Isis Pharmaceuticals Inc PRESS RELEASE 2005 10 January
  • 14
    • 33947314419 scopus 로고    scopus 로고
    • 579005 Idenix reports positive phase IIa results for HCV drug. Idenix Pharmaceuticals Inc PRESS RELEASE 2005 January 10
    • 579005 Idenix reports positive phase IIa results for HCV drug. Idenix Pharmaceuticals Inc PRESS RELEASE 2005 January 10
  • 15
    • 33947303940 scopus 로고    scopus 로고
    • 595098 Idenix's HCV therapy reduces serum virus levels in phase IIa study. Idenix Pharmaceuticals Inc PRESS RELEASE 2005 April 14
    • 595098 Idenix's HCV therapy reduces serum virus levels in phase IIa study. Idenix Pharmaceuticals Inc PRESS RELEASE 2005 April 14
  • 16
    • 33947321390 scopus 로고    scopus 로고
    • 623777 Japan Tobacco Inc. Clinical development. Japan Tobacco Inc COMPANY WORLD WIDE WEB SITE 2005 August 01
    • 623777 Japan Tobacco Inc. Clinical development. Japan Tobacco Inc COMPANY WORLD WIDE WEB SITE 2005 August 01
  • 17
    • 33947312087 scopus 로고    scopus 로고
    • 634092 Valopicitabine (NM283) combined with pegylated interferon demonstrated significantly greater suppression of hepatitis C virus (HCV) replication in treatment-refractory patients compared to retreatment with ribavirin plus pegylated interferon. Idenix Pharmaceuticals Inc PRESS RELEASE 2005 November 11
    • 634092 Valopicitabine (NM283) combined with pegylated interferon demonstrated significantly greater suppression of hepatitis C virus (HCV) replication in treatment-refractory patients compared to retreatment with ribavirin plus pegylated interferon. Idenix Pharmaceuticals Inc PRESS RELEASE 2005 November 11
  • 18
    • 33947319086 scopus 로고    scopus 로고
    • 634310 Schering-Plough's HCV protease inhibitor safe and effective in phase I trials. Schering-Plough Corp PRESS RELEASE 2005 14 November
    • 634310 Schering-Plough's HCV protease inhibitor safe and effective in phase I trials. Schering-Plough Corp PRESS RELEASE 2005 14 November
  • 19
    • 33947305374 scopus 로고    scopus 로고
    • 640132 American Association for the Study of Liver Diseases (AASLD, 56th Annual Meeting Part I, San Francisco, CA, USA, 11-15 November 2005. Phend C IDDB MEETING REPORT 2005 November 11-15
    • 640132 American Association for the Study of Liver Diseases (AASLD) - 56th Annual Meeting (Part I), San Francisco, CA, USA, 11-15 November 2005. Phend C IDDB MEETING REPORT 2005 November 11-15
  • 20
    • 33947306526 scopus 로고    scopus 로고
    • 640570 Idenix's valopicitabine suppresses HCV replication in phase IIb study. Idenix Pharmaceuticals Inc PRESS RELEASE 2005 December 14
    • 640570 Idenix's valopicitabine suppresses HCV replication in phase IIb study. Idenix Pharmaceuticals Inc PRESS RELEASE 2005 December 14
  • 21
    • 33947309351 scopus 로고    scopus 로고
    • 644094 Idenix Pharmaceuticals reports positive 4-week data from a phase IIb clinical trial evaluating valopicitabine (NM283) combined with pegylated interferon in treatment-naive hepatitis C patients. Idenix Pharmaceuticals Inc PRESS RELEASE 2006 January 09
    • 644094 Idenix Pharmaceuticals reports positive 4-week data from a phase IIb clinical trial evaluating valopicitabine (NM283) combined with pegylated interferon in treatment-naive hepatitis C patients. Idenix Pharmaceuticals Inc PRESS RELEASE 2006 January 09
  • 22
    • 33947315715 scopus 로고    scopus 로고
    • 645327 Vertex Pharmaceuticals Inc JP MORGAN ANNUAL HEALTHCARE CONFERENCE 2006 24 9-12 Suppl
    • 645327 Vertex Pharmaceuticals Inc JP MORGAN ANNUAL HEALTHCARE CONFERENCE 2006 24 9-12 Suppl
  • 23
    • 33947310008 scopus 로고    scopus 로고
    • 652504 Roche Holding AG, product pipeline. Roche Holding AG COMPANY WORLD WIDE WEB SITE 2005 31 December
    • 652504 Roche Holding AG - product pipeline. Roche Holding AG COMPANY WORLD WIDE WEB SITE 2005 31 December
  • 24
    • 33947326200 scopus 로고    scopus 로고
    • 657654 Idenix reduces phase II HCV drug dose due to GI side effects. Idenix Pharmaceuticals Inc PRESS RELEASE 2006 March 23
    • 657654 Idenix reduces phase II HCV drug dose due to GI side effects. Idenix Pharmaceuticals Inc PRESS RELEASE 2006 March 23
  • 25
    • 33947316351 scopus 로고    scopus 로고
    • 658432 Idenix announces licensing of valopicitabine (NM283) by Novartis. Idenix Pharmaceuticals Inc PRESS RELEASE 2006 March 29
    • 658432 Idenix announces licensing of valopicitabine (NM283) by Novartis. Idenix Pharmaceuticals Inc PRESS RELEASE 2006 March 29
  • 26
    • 33947313113 scopus 로고    scopus 로고
    • 662618 Schering-Plough expands phase II SCH-503034 HCV trial. Schering-Plough Corp PRESS RELEASE 2006 20 April
    • 662618 Schering-Plough expands phase II SCH-503034 HCV trial. Schering-Plough Corp PRESS RELEASE 2006 20 April
  • 27
    • 33947303445 scopus 로고    scopus 로고
    • 664719 Favorable antiviral activity and improved tolerability demonstrated by valopicitabine 200 mg/day in combination with pegylated interferon in an ongoing phase IIb trial in treatment-naive genotype 1 patients. Idenix Pharmaceuticals Inc PRESS RELEASE 2006 April 29
    • 664719 Favorable antiviral activity and improved tolerability demonstrated by valopicitabine 200 mg/day in combination with pegylated interferon in an ongoing phase IIb trial in treatment-naive genotype 1 patients. Idenix Pharmaceuticals Inc PRESS RELEASE 2006 April 29
  • 28
    • 33947311450 scopus 로고    scopus 로고
    • 667980 Investor relations: SG Cowen Presentation, Idenix Pharmaceuticals: Building a leading antiviral franchise. Idenix Pharmaceuticals Inc COMPANY PRESENTATION 2006 March 06
    • 667980 Investor relations: SG Cowen Presentation - Idenix Pharmaceuticals: Building a leading antiviral franchise. Idenix Pharmaceuticals Inc COMPANY PRESENTATION 2006 March 06
  • 29
    • 0032475822 scopus 로고    scopus 로고
    • 673701 Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon alfa therapy. Neumann AU, Lam NP, Dahari H, Gretch DR, Wiley TE, Layden TJ, Perelson AS SCIENCE 1998 282 5386 103-107
    • 673701 Hepatitis C viral dynamics in vivo and the antiviral efficacy of interferon alfa therapy. Neumann AU, Lam NP, Dahari H, Gretch DR, Wiley TE, Layden TJ, Perelson AS SCIENCE 1998 282 5386 103-107
  • 30
    • 33947305188 scopus 로고    scopus 로고
    • 720923 NCT00367887: A study evaluating the safety and clinical activity of HCV-796 in treatment-naive and non-responder subjects. Wyeth INTERNET SITE 2006 September 21
    • 720923 NCT00367887: A study evaluating the safety and clinical activity of HCV-796 in treatment-naive and non-responder subjects. Wyeth INTERNET SITE 2006 September 21 www.clinicaltrials.gov
  • 31
    • 33947303941 scopus 로고    scopus 로고
    • 731316 Roche's R-1626 enters phase II and gets Fast Track status for HCV. Roche Holding AG PRESS RELEASE 2006 October 16
    • 731316 Roche's R-1626 enters phase II and gets Fast Track status for HCV. Roche Holding AG PRESS RELEASE 2006 October 16
  • 32
    • 26644455085 scopus 로고    scopus 로고
    • 733379 NM 283, an efficient prodrug of the potent anti-HCV agent 2′-C-methylcytidine. Pierra C, Benzaria S, Amador A, Moussa A, Mathieu S, Storer R, Gosselin G NUCLEOSIDES NUCLEOTIDES NUCLEIC ACIDS 2005 24 5-7 767-770
    • 733379 NM 283, an efficient prodrug of the potent anti-HCV agent 2′-C-methylcytidine. Pierra C, Benzaria S, Amador A, Moussa A, Mathieu S, Storer R, Gosselin G NUCLEOSIDES NUCLEOTIDES NUCLEIC ACIDS 2005 24 5-7 767-770
  • 33
    • 33947312413 scopus 로고    scopus 로고
    • 733380 Pharmacokinetics and pharmacodynamics of valopicitabine (NM283, a new nucleoside HCV polymerase inhibitor: Results from a phase I/II dose-escalation trial in patients with HCV-1 infection. Zhou XJ, Afdhal N, Godofsky E, Dienstag J, Rustgi V, Schick L, McInery D, Fielman BA, Brown NA J HEPATOL 2005 42 Suppl 2 229 • In this phase I/II clinical trial, orally administered valopicitabine dihydrochloride (50 to 800 mg/day) was well absorbed, drug levels were proportional to the dose and there was no significant drug accumulation
    • 733380 Pharmacokinetics and pharmacodynamics of valopicitabine (NM283), a new nucleoside HCV polymerase inhibitor: Results from a phase I/II dose-escalation trial in patients with HCV-1 infection. Zhou XJ, Afdhal N, Godofsky E, Dienstag J, Rustgi V, Schick L, McInery D, Fielman BA, Brown NA J HEPATOL 2005 42 Suppl 2 229 • In this phase I/II clinical trial, orally administered valopicitabine dihydrochloride (50 to 800 mg/day) was well absorbed, drug levels were proportional to the dose and there was no significant drug accumulation.
  • 34
    • 33749518268 scopus 로고    scopus 로고
    • 733390 Ribavirin antagonizes the in vitro anti-hepatitis C virus activity of 2′-C-methylcytidine, the active component of valopicitabine. Coelmont L, Paeshuyse J, Windisch MP, De Clercq E, Bartenschlager R, Neyts J ANTIMICROB AGENTS CHEMOTHER 2006 50 10 3444-3446 •• This interesting study shows the interaction between ribavirin and valopicitabine dihydrochloride in antagonizing HCV replication in vitro. Data demonstrate that at pharmacological concentrations ribavirin was able to antagonize the antiviral effect of valopicitabine dihydrochloride
    • 733390 Ribavirin antagonizes the in vitro anti-hepatitis C virus activity of 2′-C-methylcytidine, the active component of valopicitabine. Coelmont L, Paeshuyse J, Windisch MP, De Clercq E, Bartenschlager R, Neyts J ANTIMICROB AGENTS CHEMOTHER 2006 50 10 3444-3446 •• This interesting study shows the interaction between ribavirin and valopicitabine dihydrochloride in antagonizing HCV replication in vitro. Data demonstrate that at pharmacological concentrations ribavirin was able to antagonize the antiviral effect of valopicitabine dihydrochloride.
  • 35
    • 33947321227 scopus 로고    scopus 로고
    • 733391 Valopicitabine (NM283) plus peg-interferon for chronic hepatitis C in treatment naive and nonresponder patients: Interim phase IIb results. Sherman KE, Lawitz E, O'Brien CB J CLIN VIROL 2006 36 Suppl 2 S24
    • 733391 Valopicitabine (NM283) plus peg-interferon for chronic hepatitis C in treatment naive and nonresponder patients: Interim phase IIb results. Sherman KE, Lawitz E, O'Brien CB J CLIN VIROL 2006 36 Suppl 2 S24
  • 36
    • 33947307104 scopus 로고    scopus 로고
    • 733401 A nucleoside inhibitor of hepatitis C virus replication efficiently inhibits the replication of flaviviruses in vitro. Leyssen P, De Lamballerie X, De Clercq E, Neyts J ANTIVIR RES 2006 70 1 A80
    • 733401 A nucleoside inhibitor of hepatitis C virus replication efficiently inhibits the replication of flaviviruses in vitro. Leyssen P, De Lamballerie X, De Clercq E, Neyts J ANTIVIR RES 2006 70 1 A80
  • 37
    • 33947327805 scopus 로고    scopus 로고
    • 733402 Valopicitabine (NM283, alone or with peg-interferon, compared to peg-interferon/ribavirin (pegIFN/RBV) re-treatment in hepatitis C patients with prior non-response to pegIFN/RBV: Week 24 results. Afdhal N, O'Brien C, Godofsky E, Rodriguez-Torres M, Pappas SC, Pockros P, Lawitz E, Bzowej N, Rustgi V, Sulkowski M, Sherman K J HEPATOL 2006 44 Suppl 2 S19 •• This phase IIb clinical trial compared the antiviral efficacy of valopicitabine dihydrochloride plus PEG-IFN with PEG-IFN plus ribavirin in a group of HCV-positive treatment-refractory patients. After 24 weeks of treatment, a significantly higher decrease in mean circulating HCV RNA was observed in patients treated with valopicitabine
    • 733402 Valopicitabine (NM283), alone or with peg-interferon, compared to peg-interferon/ribavirin (pegIFN/RBV) re-treatment in hepatitis C patients with prior non-response to pegIFN/RBV: Week 24 results. Afdhal N, O'Brien C, Godofsky E, Rodriguez-Torres M, Pappas SC, Pockros P, Lawitz E, Bzowej N, Rustgi V, Sulkowski M, Sherman K J HEPATOL 2006 44 Suppl 2 S19 •• This phase IIb clinical trial compared the antiviral efficacy of valopicitabine dihydrochloride plus PEG-IFN with PEG-IFN plus ribavirin in a group of HCV-positive treatment-refractory patients. After 24 weeks of treatment, a significantly higher decrease in mean circulating HCV RNA was observed in patients treated with valopicitabine
  • 38
    • 33947319772 scopus 로고    scopus 로고
    • 733404 Long-term study of NM283 (valopicitabine) resistance using bovine viral diarrhea virus. Bichko V, LaColla M, Tausek MM, Lallos L, Gillum G, Qu L, Sommadossi JP, Standring DN J HEPATOL 2006 44 Suppl 2 S152 •• This abstract describes the emergence of a BVDV mutation (equivalent to a S282T mutation in HCV polymerase) during prolonged treatment with valopicitabine dihydrochloride
    • 733404 Long-term study of NM283 (valopicitabine) resistance using bovine viral diarrhea virus. Bichko V, LaColla M, Tausek MM, Lallos L, Gillum G, Qu L, Sommadossi JP, Standring DN J HEPATOL 2006 44 Suppl 2 S152 •• This abstract describes the emergence of a BVDV mutation (equivalent to a S282T mutation in HCV polymerase) during prolonged treatment with valopicitabine dihydrochloride.
  • 39
    • 33947314746 scopus 로고    scopus 로고
    • 733408 Safety and pharmacokinetics of NM107 following intravenous infusion of escalating doses in healthy volunteers: Determination of absolute oral bioavailability of valopicitabine NM283, Zhou XJ, Knox S, Fielman B, Chao G, Brown N J HEPATOL 2006 44 Suppl 2 S231-S232
    • 733408 Safety and pharmacokinetics of NM107 following intravenous infusion of escalating doses in healthy volunteers: Determination of absolute oral bioavailability of valopicitabine (NM283). Zhou XJ, Knox S, Fielman B, Chao G, Brown N J HEPATOL 2006 44 Suppl 2 S231-S232
  • 40
    • 33947318745 scopus 로고    scopus 로고
    • 733410 Absence of effect of pegylated interferon α-2b on the pharmacokinetics of valopicitabine (NM283) in patients with chronic hepatitis C. Zhou XJ, Fielman B, Chao G, Knox S, Brown N J HEPATOL 2006 44 Suppl 2 S232 A624
    • 733410 Absence of effect of pegylated interferon α-2b on the pharmacokinetics of valopicitabine (NM283) in patients with chronic hepatitis C. Zhou XJ, Fielman B, Chao G, Knox S, Brown N J HEPATOL 2006 44 Suppl 2 S232 A624
  • 41
    • 33947303623 scopus 로고    scopus 로고
    • 733411 Early clearance of HCV RNA with valopicitabine (NM283) plus PEG-interferon in treatment-naive patients with HCV-1 infection: First results from a phase IIb trial. Dicterich A, Lawitz E, Nguyen T Younes Z, Santoro J, Gitlin N, McEniry D, Chasen R, Goff J, Knox S, Kleber K et al J HEPATOL 2006 44 Suppl 2 S271 A736
    • 733411 Early clearance of HCV RNA with valopicitabine (NM283) plus PEG-interferon in treatment-naive patients with HCV-1 infection: First results from a phase IIb trial. Dicterich A, Lawitz E, Nguyen T Younes Z, Santoro J, Gitlin N, McEniry D, Chasen R, Goff J, Knox S, Kleber K et al J HEPATOL 2006 44 Suppl 2 S271 A736
  • 42
    • 33947313114 scopus 로고    scopus 로고
    • 733413 Pharmacokinetics and pharmacodynamics of valopicitabine NM283, a new nucleoside HCV polymerase inhibitor: Results from a phase I/II dose-escalation trial in patients with HCV-1 infection. Zhou XJ, Afdhal N, Godofsky E, Dienstag J, Rustgi V, Schick L, Duncan L, Constance BF Chao G, Brown NA GASTROENTEROLOGY 2005 128 4 Suppl 2 A700
    • 733413 Pharmacokinetics and pharmacodynamics of valopicitabine (NM283), a new nucleoside HCV polymerase inhibitor: Results from a phase I/II dose-escalation trial in patients with HCV-1 infection. Zhou XJ, Afdhal N, Godofsky E, Dienstag J, Rustgi V, Schick L, Duncan L, Constance BF Chao G, Brown NA GASTROENTEROLOGY 2005 128 4 Suppl 2 A700
  • 43
    • 33947318014 scopus 로고    scopus 로고
    • 733414 Valopicitabine (NM283) alone and in combination with PEG-interferon in patients with genotype 1 chronic hepatitis C: Preliminary results from an ongoing phase II, multicenter study. Rodriguez-Torres M, Lawitz E, Godofsky E, Afdhal N, Chao G, Constance BF, Knox S, Brown NA GASTROENTEROLOGY 2005 128 4 Suppl 2 A695-A696 • This phase II clinical trial investigated the antiviral effect of valopicitabine dihydrochloride monotherapy in comparison with patients treated with valopicitabine dyhidrochloride plus PEG-IFNα2b in HCV-infected patients. A more pronounced HCV viral decline was observed in patients treated with the combination therapy
    • 733414 Valopicitabine (NM283) alone and in combination with PEG-interferon in patients with genotype 1 chronic hepatitis C: Preliminary results from an ongoing phase II, multicenter study. Rodriguez-Torres M, Lawitz E, Godofsky E, Afdhal N, Chao G, Constance BF, Knox S, Brown NA GASTROENTEROLOGY 2005 128 4 Suppl 2 A695-A696 • This phase II clinical trial investigated the antiviral effect of valopicitabine dihydrochloride monotherapy in comparison with patients treated with valopicitabine dyhidrochloride plus PEG-IFNα2b in HCV-infected patients. A more pronounced HCV viral decline was observed in patients treated with the combination therapy.
  • 44
    • 33947317178 scopus 로고    scopus 로고
    • 733416 Characterization of NM283 (valopicitabine) resistance profile using bovine viral diarrhea. Bichko V, Qu L, La Colla M, Tausek M, Bergelson S, Pierra C, Storer R, Gosselin G, Sommadossi JP HEPATOLOGY 2005 42 4 Suppl 1 A543
    • 733416 Characterization of NM283 (valopicitabine) resistance profile using bovine viral diarrhea. Bichko V, Qu L, La Colla M, Tausek M, Bergelson S, Pierra C, Storer R, Gosselin G, Sommadossi JP HEPATOLOGY 2005 42 4 Suppl 1 A543
  • 45
    • 33947317849 scopus 로고    scopus 로고
    • 733417 Randomized trial of valopicitabine (NM283, alone or with peginterferon, vs retreatment with peg-interferon plus ribavirin (PegIFN/RBV) in hepatitis C patients with previous non-response to PegIFN/RBV: First interim results. O'Brien C, Godofsky E, Rodriguez-Torres M, Afdhal N, Pappas SC, Pockros P, Lawitz E, Bzowej N, Rustgi V, Sulkowski M, Sherman K et al HEPATOLOGY 2005 42 4 Suppl 1 A234
    • 733417 Randomized trial of valopicitabine (NM283), alone or with peginterferon, vs retreatment with peg-interferon plus ribavirin (PegIFN/RBV) in hepatitis C patients with previous non-response to PegIFN/RBV: First interim results. O'Brien C, Godofsky E, Rodriguez-Torres M, Afdhal N, Pappas SC, Pockros P, Lawitz E, Bzowej N, Rustgi V, Sulkowski M, Sherman K et al HEPATOLOGY 2005 42 4 Suppl 1 A234
  • 46
    • 33947322459 scopus 로고    scopus 로고
    • 733421 Enhanced antiviral efficacy for valopicitabine (NM283) plus peginterferon in hepatitis C patients with HCV genotype-1 infection: Results of a phase lla multicenter trial. Afdhal N, Rodriguez-Torres M, Lawitz E, Godofsky E, Choa G, Fielman B, Knox S, Brown N J HEPATOL 2005 42 Suppl 2 39-40
    • 733421 Enhanced antiviral efficacy for valopicitabine (NM283) plus peginterferon in hepatitis C patients with HCV genotype-1 infection: Results of a phase lla multicenter trial. Afdhal N, Rodriguez-Torres M, Lawitz E, Godofsky E, Choa G, Fielman B, Knox S, Brown N J HEPATOL 2005 42 Suppl 2 39-40
  • 47
    • 33947317179 scopus 로고    scopus 로고
    • 735359 Novartis and Idenix's valopicitabine plus PEG-INF reduces HCV in phase IIb trial. Idenix Pharmaceuticals Inc PRESS RELEASE 2006 October 27
    • 735359 Novartis and Idenix's valopicitabine plus PEG-INF reduces HCV in phase IIb trial. Idenix Pharmaceuticals Inc PRESS RELEASE 2006 October 27
  • 48
    • 33750465538 scopus 로고    scopus 로고
    • 748199 Synthesis and pharmacokinetics of valopicitabine NM283, an efficient prodrug of the potent anti-HCV agent 2-C- methylcytidine. Pierra C, Amador A, Benzaria S, Cretton-Scott E, D'Amours M, Mao J, Mathieu S, Moussa A, Bridges EG, Standring DN, Sommadossi JP et al J MED CHEM 2006 49 22 6614-6620 •• This study describes the mechanisms adopted for the synthesis of valopicitabine dihydrochloride and shows in detail the main pharmacokinetic characteristics of the drug in animal models
    • 748199 Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2-C- methylcytidine. Pierra C, Amador A, Benzaria S, Cretton-Scott E, D'Amours M, Mao J, Mathieu S, Moussa A, Bridges EG, Standring DN, Sommadossi JP et al J MED CHEM 2006 49 22 6614-6620 •• This study describes the mechanisms adopted for the synthesis of valopicitabine dihydrochloride and shows in detail the main pharmacokinetic characteristics of the drug in animal models.
  • 49
    • 33947322291 scopus 로고    scopus 로고
    • 748850 Final phase I/II trial results for NM283, a new polymerase inhibitor for hepatitis C: Antiviral efficacy and tolerance in patients with HCV-1 infection, including previous interferon failures. Afdhal N, Godofsky E, Dienstag J, Rustgi V, Schick L, McEniry D, Zhou XJ, Chao G, Fang C, Fielman B, Myers M et al HEPATOLOGY 2004 40 4 Suppl 1 Abs 726 LB03
    • 748850 Final phase I/II trial results for NM283, a new polymerase inhibitor for hepatitis C: Antiviral efficacy and tolerance in patients with HCV-1 infection, including previous interferon failures. Afdhal N, Godofsky E, Dienstag J, Rustgi V, Schick L, McEniry D, Zhou XJ, Chao G, Fang C, Fielman B, Myers M et al HEPATOLOGY 2004 40 4 Suppl 1 Abs 726 LB03
  • 50
    • 33947308536 scopus 로고    scopus 로고
    • 751209 Vertex's telaprevir gives high response rate in phase II HCV infection trial. Vertex Pharmaceuticals Inc PRESS RELEASE 2006 13 December
    • 751209 Vertex's telaprevir gives high response rate in phase II HCV infection trial. Vertex Pharmaceuticals Inc PRESS RELEASE 2006 13 December
  • 51
    • 33644980412 scopus 로고    scopus 로고
    • 751267 Management of hepatitis C in liver transplant recipients. Kuo A, Terrault NA AM J TRANSPL 2006 6 3 449-458
    • 751267 Management of hepatitis C in liver transplant recipients. Kuo A, Terrault NA AM J TRANSPL 2006 6 3 449-458
  • 52
    • 25844523297 scopus 로고    scopus 로고
    • 751281 Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Simmonds P, Bukh J, Combet C, Deleage G, Enomoto N, Feinstone S, Halfon P, Inchauspe G, Kuiken C, Maertens G, Mizokami M et al HEPATOLOGY 2005 42 4 962-973
    • 751281 Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes. Simmonds P, Bukh J, Combet C, Deleage G, Enomoto N, Feinstone S, Halfon P, Inchauspe G, Kuiken C, Maertens G, Mizokami M et al HEPATOLOGY 2005 42 4 962-973
  • 53
    • 33745568640 scopus 로고    scopus 로고
    • 751282 Hepatitis C vaccines: Inducing and challenging memory T cells. Shiina M, Rehermann B HEPATOLOGY 2006 43 6 1395-1398
    • 751282 Hepatitis C vaccines: Inducing and challenging memory T cells. Shiina M, Rehermann B HEPATOLOGY 2006 43 6 1395-1398
  • 54
    • 33750093105 scopus 로고    scopus 로고
    • 751298 Antiviral treatment of hepatitis C. Toniutto P, Fabris C, Pirisi M EXPERT OPIN PHARMACOTHER 2006 7 15 2025-2035
    • 751298 Antiviral treatment of hepatitis C. Toniutto P, Fabris C, Pirisi M EXPERT OPIN PHARMACOTHER 2006 7 15 2025-2035
  • 55
    • 0035934568 scopus 로고    scopus 로고
    • 751299 Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial. Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD, Koury K, Ling M LANCET 2001 358 9286 958-965
    • 751299 Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: A randomised trial. Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD, Koury K, Ling M LANCET 2001 358 9286 958-965
  • 56
    • 33947321046 scopus 로고    scopus 로고
    • 751305 National Institutes of Health Consensus Conference Statement: Management of hepatitis C. HEPATOLOGY 2002 36 5 Suppl 1 S3-S20
    • 751305 National Institutes of Health Consensus Conference Statement: Management of hepatitis C. HEPATOLOGY 2002 36 5 Suppl 1 S3-S20
  • 57
    • 33947303446 scopus 로고    scopus 로고
    • 755227 World Health Organization. Global distribution of hepatitis A, B and C, 2001. WEEKLY EPIDEMIOLOGICAL RECORD 2002 77 6 41-48
    • 755227 World Health Organization. Global distribution of hepatitis A, B and C, 2001. WEEKLY EPIDEMIOLOGICAL RECORD 2002 77 6 41-48
  • 58
    • 0042752016 scopus 로고    scopus 로고
    • 755228 Hepatitis C virus (HCV) infection in a community in the Nile Delta: Population description and HCV prevalence. Abdel-Aziz F, Habib M, Mohamed MK, Abdel-Hamid M, Gamil F, Madkour S, Mikhail NN, Thomas D, Fix AD, Strickland GT, Anwar W et al HEPATOLOGY 2000 32 1 111-115
    • 755228 Hepatitis C virus (HCV) infection in a community in the Nile Delta: Population description and HCV prevalence. Abdel-Aziz F, Habib M, Mohamed MK, Abdel-Hamid M, Gamil F, Madkour S, Mikhail NN, Thomas D, Fix AD, Strickland GT, Anwar W et al HEPATOLOGY 2000 32 1 111-115


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.