Peperomins as anti-inflammatory agents that inhibit the NF-κB signaling pathway

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 15, 2009, Pages 4084-4087

  Tsutsui, Chieko ^a   Yamada, Yuriko ^a   Ando, Masayoshi ^b   Toyama, Daisuke ^b   Wu, Jian lin ^b   Wang, Liyan ^b   Taketani, Shigeru ^a   Kataoka, Takao ^a  

^a KYOTO INSTITUTE OF TECHNOLOGY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

I B kinase; NF B; Peperomin; Secolignan

Indexed keywords

2,6 DIDEHYDROPEPEROMIN B; ANTIINFLAMMATORY AGENT; BETA ACTIN; CYCLOOXYGENASE 2; I KAPPA B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1; PEPEROMIN A; PEPEROMIN B; PEPEROMIN E; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN DEGRADATION; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS; BENZODIOXOLES; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERLEUKIN-1; MODELS, CHEMICAL; NF-KAPPA B; PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67649959188     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.06.029     Document Type: Article

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