Disease-associated Substitutions in the Filamin B Actin Binding Domain Confer Enhanced Actin Binding Affinity in the Absence of Major Structural Disturbance: Insights from the Crystal Structures of Filamin B Actin Binding Domains

Journal of Molecular Biology

Volumn 390, Issue 5, 2009, Pages 1030-1047

  Sawyer, Gregory M ^a   Clark, Alice R ^a   Robertson, Stephen P ^b   Sutherland Smith, Andrew J ^a  

^a MASSEY UNIVERSITY   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

actin binding; atelosteogenesis; cytoskeleton; filamin; skeletal dysplasia

Indexed keywords

ACTIN BINDING PROTEIN; AMINO ACID; ARGININE; FILAMIN; FILAMIN B; METHIONINE; MUTANT PROTEIN; TRYPTOPHAN; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BONE DYSPLASIA; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISEASE ASSOCIATION; DISSOCIATION CONSTANT; FLUOROMETRY; HUMAN; MELTING POINT; MISSENSE MUTATION; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEDIMENTATION; WILD TYPE; X RAY CRYSTALLOGRAPHY;

EID: 67649846288     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.06.009     Document Type: Article

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