Extracts of Lindera obtusiloba induce antifibrotic effects in hepatic stellate cells via suppression of a TGF-β-mediated profibrotic gene expression pattern

Journal of Nutritional Biochemistry

Volumn 20, Issue 8, 2009, Pages 597-606

  Ruehl, Martin ^a   Erben, Ulrike ^a   Kim, Kiyoung ^b   Freise, Christian ^a   Dagdelen, Tarkan ^a   Eisele, Silke ^a,e   Trowitzsch Kienast, Wolfram ^c   Zeitz, Martin ^a   Jia, Jidong ^d   Stickel, Felix ^e   Somasundaram, Rajan ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Wonkwang University   (South Korea)

^c UNIVERSITY OF APPLIED SCIENCES   (Germany)

^d CAPITAL MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF BERN   (Switzerland)

Author keywords

Hepatic stellate cells; L. obtusiloba; Liver fibrosis; Oxidative stress; Plant extracts

Indexed keywords

GELATINASE A; LINDERA OBTUSILOBA EXTRACT; PLANT EXTRACT; STROMELYSIN; TERT BUTYL HYDROPEROXIDE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; AUTOCRINE EFFECT; CELL STRAIN HEPG2; CHRONIC LIVER DISEASE; CIRCULATION; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; DRUG EFFECT; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; KOREA; LINDERA OBTUSILOBA; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; NONHUMAN; ORIENTAL MEDICINE; OXIDATIVE STRESS; PLANT; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RAT; STELLATE CELL; VIRUS HEPATITIS;

ACTINS; ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; COLLAGEN TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; HEPATIC STELLATE CELLS; HEPATOCYTES; HUMANS; LINDERA; LIVER CIRRHOSIS; MATRIX METALLOPROTEINASE 13; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 3; OXIDATIVE STRESS; PLANT BARK; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRANSFORMING GROWTH FACTOR BETA; WOOD;

LINDERA OBTUSILOBA; RATTUS;

EID: 67649819538     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2008.06.003     Document Type: Article

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