Differential gene expression in response to transforming growth factor-β1 by fetal and postnatal dermal fibroblasts

Wound Repair and Regeneration

Volumn 15, Issue 6, 2007, Pages 897-906

  Rolfe, Kerstin J ^a   Irvine, Laurie M ^b   Grobbelaar, Addie O ^a   Linge, Claire ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

^b WATFORD GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ARTICLE; CONTROLLED STUDY; DERMIS; DOWN REGULATION; FEMALE; FETUS; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFANT; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SKIN FIBROBLAST; SKIN FIBROSIS; SKIN SCAR; TISSUE REGENERATION; UPREGULATION; WOUND HEALING;

BLOTTING, WESTERN; CELL DIFFERENTIATION; CELLS, CULTURED; CICATRIX; COLLAGEN TYPE I; DERMIS; FEMALE; FETUS; FIBROBLASTS; GENE EXPRESSION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; REGENERATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA; WOUND HEALING;

EID: 36249031854     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2007.00314.x     Document Type: Article

References (57)

1. Leksa V, Godar S, Schiller HB, Fuertbauer E, Muhannad A, Slezakova K, Horejsi V, Steinlein P, Weidle UH, Binder BR, Stockinger H. TGF-beta induced apoptosis in endothelial cells mediated by M6P/IGFII-R and mini plasminogen. J Cell Sci 2005 118 : 4577 86.
2. Derynck R, Akhurst RJ, Balmain A. TGF-β signaling in tumor suppression and cancer progression. Nat Genet 2001 29 : 117 29.
3. Massagué J, Balin SW, Lo RS. TGF-β signalling in growth control, cancer, and heritable disorders. Cell 2000 103 : 211 5.
4. Whitman M. Smads and early developmental signalling by TGF β superfamily. Genes Dev 1998 12 : 2445 62.
5. Blobe GC, Schiemann WP, Lodish HF. Role of transforming growth factor β in human disease. N Engl J Med 2000 342 : 1350 8.
6. Varga R, Jimenez SA. Transforming growth factor beta causes a persistent increase in steady-state amounts for type I and type III collagen and fibronectin mRNAs in normal dermal human fibroblasts. Biochem J 1987 297 : 597 604.
7. Overall CM, Wrana JL, Sodek J. Independent regulation of collagenase, 72 kDa pro gelatinase, and metalloproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta. J Biol Chem 1989 264 : 1860 9.
8. Piek E, Heldin CH, Ten Dijke P. Specificity, diversity, and regulation in TGF-beta superfamily signaling. FASEB J 1999 13 : 2105 24.
9. Kagami S, Border WA, Miller DE, Noble NA. Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-beta expression in rat glomerular mesangial cells. J Clin Invest 1994 93 : 2431 7.
10. Bissell DM, Roulot D, George J. Transforming growth factor beta and the liver. Hepatology 2001 34 : 859 67.
11. Rube CE, Uthe D, Schmid KW, Richter KD, Wessel J, Schuck A, Willich N, Rube C. Dose-dependent induction of transforming growth factor beta (TGF-β) in the lung tissue of fibrosis-prone mice after thoracic irradiation. Int J Radiat Oncol Biol Phys 2000 47 : 1033 42.
12. Ghahary A, Shen YJ, Scott PG, Gong Y, Tredget EE. Enhanced expression of mRNA for transforming growth factor - β, type I and type III procollagen in human post burn hypertrophic scar tissues. J Clin Lab Med 1993 122 : 465 73.
13. Sporn MB, Roberts AB. Transforming growth factor beta: recent progress and new challenges. J Cell Biol 1992 119 : 1017 21.
14. Rowlatt U. Intrauterine wound healing in a 20 week human fetus. Virchows Arch A Pathol Anat Histol 1979 381 : 353 61.
15. Martin P, Dickson MC, Millan FA, Akhurst RJ. Rapid induction and clearance of TGFβ1 is an early response to wounding in the mouse embryo. Dev Genet 1993 14 : 225 38.
16. Cowin AJ, Holmes TM, Brosnan P, Fergurson MWJ. Expression of TGF-beta and its receptors in murine fetal and adult dermal wounds. Eur J Dermatol 2001 11 : 424 31.
17. Rolfe KJ, Richardson J, Vigor C, Irvine L, Grobbelaar AO, Linge C. A role for TGF-β1- induced cellular responses during wound healing of the non-scarring early human fetus. J Invest Dermatol 2007 [Epub ahead of print PMID: 17687390].
18. Verrecchia F, Chu M-L, Mauviel A. Identification of a novel TGF-β/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem 2001 276 : 17058 62.
19. Chambers RC, Leoni P, Kaminski N, Laurent GJ, Heller RA. Global expression profiling of fibroblast responses to transforming growth factor-β1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching. Am J Pathol 2003 162 : 533 46.
20. Duncan MR, Frazier KS, Abramson S, Williams S, Klapper H, Huang X, Grotendorst GR. Connective tissue growth factor mediates transforming growth factor β-induced collagen synthesis: down regulation by cAMP. FASEB J 1999 13 : 1774 86.
21. Van Obberghen-Schilling E, Roche NS, Flanders KC, Sporn MB, Roberts AB. Transforming growth factor β1 positively regulates its own expression in normal and transformed cells. J Biol Chem 1988 263 : 7741 6.
22. Yue J, Mulder KM. Requirement of Ras/MAPK pathway activation by transforming growth factor β for transforming growth factor β1 production in a Smad-dependent pathway. J Biol Chem 2000 275 : 30765 73.
23. Liu G, Ding W, Neiman J, Mulder KM. Requirement of Smad3 and CREB-1 in mediating transforming growth factor-β (TGFβ) induction of TGF β3 secretion. J Biol Chem 2006 281 : 29479 90.
24. Chen W, Fu X, Ge S, Sun T, Zhou G, Jiang D, Sheng Z. Ontogeny of expression of transforming growth factor beta and its receptors and their possible relationship with scarless healing in human fetal skin. Wound Repair Regen 2005 13 : 68 75.
25. Soo C, Beanes SR, Hu F-Y, Zhand X, Dang C, Chang G, Wang Y, Nishimura I, Freymiller E, Longaker MT, Lorenz HP, Ting K. Ontogenetic transition in fetal wound transforming growth factor-β regulation correlates with collagen organization. Am J Pathol 2003 163 : 2459 76.
26. Renzoni EA, Abraham DJ, Howat S, Shi-Wen X, Sestini P, Bou-Gharios G, Wells AU, Veeraraghavan S, Nicholson AG, Denton CP, Leask A, Pearson JD, Black CM, Welsh KI, du Bois RM. Gene expression profiling reveals novel TGF β targets in adult lung fibroblasts. Respir Res 2004 5 : 24.
27. ©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 2002 30 : e36.
28. Inman GJ, Nicolás FJ, Hill CS. Nucleocytoplasmic shuttling of Smads 2,3, and 4 permits sensing of TGF-β receptor activity. Mol Cell 2002 10 : 283 94.
29. Nicolás FJ, Hill CS. Attenuation of the TGF-β-Smad signaling pathway in pancreatic tumor cells confers resistance to TGF-β-induced growth arrest. Oncogene 2003 22 : 3698 711.
30. Niederreither K, D'Souza RN, Crombrugghe B. Minimal DNA sequences that control the cell lineage specific expression of the pro-alpha 2(I) collagen promoter in transgenic mice. J Cell Biol 1992 119 : 1361 70.
31. Broekelmann TJ, Limper AH, Colby TV, McDonald JA. Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis. Proc Natl Acad Sci USA 1991 88 : 6612 46.
32. Ignotz RA, Endo T, Limper Massagué J. Regulation of fibronectin and type I collagen mRNA levels by TGF-β. J Biol Chem 1987 262 : 6443 6.
33. Whitby DJ, Fergurson MWJ. The extracellular matrix of lip wounds in fetal, neonatal and adult mice. Development 1991 112 : 651.
34. Vogel KG, Trotter JA. The effect of proteoglycans on the morphology of collagen fibrils formed in vitro. Coll Relat Res 1987 7 : 105 14.
35. Olutoye OO, Cohen IK. Fetal wound healing: an overview. Wound Repair Regen 1996 4 : 66.
36. Muslow JJ, Watson RW, Fitzpatrick JM, O'Connell PR. Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK 1/2 mitogen activated protein kinase cell signaling. Ann Surg 2005 134 : 168 72.
37. Evans RA, Tian YC, Steadman R, Phillips AO. TGF-β1-mediated fibroblast-myofibroblast terminal differentiation-the role of Smad proteins. Exp Cell Res 2003 282 : 90 100.
38. Allen JT, Knight RA, Bloor CA, Spiteri MA. Enhanced insulin like growth factor binding protein-related protein 2 (connective tissue growth factor) expression in patients with idiopathic pulmonary fibrosis and pulmonary sarcoidosis. Am J Repir Cell Moll Biol 1999 21 : 693 700.
39. Igarashi A, Nashiro K, Kikuchi K, Sato S, Ihn H, Fujimoto M, Grotendorst GR, Takehara K. Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloids and other fibrotic skin disorders. J Invest Dermatol 1996 106 : 729 33.
40. Igarashi A, Okochi H, Bradham DM, Grotendorst GR. Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol Biol Cell 1993 4 : 637 45.
41. Grotendorst GR, Okochi H, Hayashi N. A novel transforming growth factor-β response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ 1996 7 : 469 80.
42. Grotendorst GR. Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 1997 8 : 171 9.
43. Abraham DJ, Shiwen X, Black CM, Sa S, Xu Y, Leask A. Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by TGF-β in normal and scleroderma fibroblasts. J Biol Chem 2000 275 : 15220 5.
44. Holmes A, Abraham DJ, Sa S, Shiwen X, Black CM, Leask A. CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J Biol Chem 2001 276 : 10594 601.
45. Leask A, Sa S, Holmes A, Shiwen X, Black CM, Abraham DJ. The control of ccn2 (ctgf) gene expression in normal and scleroderma fibroblasts. Mol Pathol 2001 154 : 180 3.
46. Chen Y, Blom IE, Sa S, Goldschmeding R, Abraham DJ, Leask A. CTGF expression in mesangial cells: involvement of SMADs, MAP kinase, and PKC. Kidney Int 2002 62 : 1149 59.
47. 2-terminal kinase mediates expression of connective tissue growth factor induced by Transforming growth factor-β1 in human lung fibroblasts. Am J Respir Cell Mol Biol 2003 28 : 754 61.
48. Colwell AS, Krummel TM, Longaker MT, Lorenz HP. Fetal and adult fibroblasts have similar TGF-beta mediated, Smad-dependent signaling pathways. Plast Reconst Surg 2006 117 : 2277 83.
49. Mori T, Kawara S, Shinozaki M, Hayashi N, Kakinuma T, Igarashi A, Takigawa M, Nakanishi T, Takehara K. Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: a mouse fibrosis model. J Cell Physiol 1999 181 : 153 9.
50. Kim SJ, Angel P, Lafyatis R, Hattori K, Kim KY, Sporn MB, Karin M, Roberts AB. Auto induction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol Cell Biol 1990 10 : 1492 7.
51. Shah M, Foreman DM, Fergurson MWJ. Neutralisation of TGFβ1 and TGFβ2 or exogenous addition of TGFβ3 to cutaneous rat wounds reduces scarring. J Cell Sci 1995 108 : 985 1002.
52. Eitzman DT, McCoy RD, Zheng X, Fay WP, Shen T, Ginsburg D, Simon RH. Bleomycin induced pulmonary fibrosis in transgenic mice that either lack or over express the murine plasminogen activator inhibitor-1 gene. J Clin Invest 1996 97 : 232 7.
53. Tuan T-L, Zhu JY, Sun B, Nichter LS, Nimni ME, Lang WE. Elevated levels of plasminogen activator inhibitor-1 may account for the altered fibrinolysis by keloid fibroblasts. J Invest Dermatol 1996 106 : 1007 11.
54. Huang EY, Wu H, Island ER, Chong SS, Warburton D, Anderson KD, Tuan TL. Differential expression of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 in early and late gestational mouse skin and skin wounds. Wound Repair Regen 2002 21 : 634 44.
55. Reunanen N, Foschi M, Han J, Kähäri VM. Activation of extracellular signal-regulated kinase 1/2 inhibits type I collagen expression by human skin fibroblasts. J Biol Chem 2000 275 : 34634 9.
56. Hayashida T, daCaestecker M, Schnaper HW. Cross-talk between ERK MAP kinase and Smad-signaling pathways enhances TGF-β dependent responses in human mesangial cells. FASEB J 2003 17 : 1576 8.
57. Qi W, Twigg S, Chen X, Polhill TS, Poronnik P, Gilbert RE, Pollock CA. Integrated actions of transforming growth factor-β1 and connective tissue growth factor in renal fibrosis. Am J Physiol Renal Phsyiol 2005 288 : F800 9.