Disruption of intermolecular disulfide bonds in PDGF-BB dimers by N-acetyl-L-cysteine does not prevent PDGF signaling in cultured hepatic stellate cells

Biochemical and Biophysical Research Communications

Volumn 338, Issue 4, 2005, Pages 1711-1718

  Borkham Kamphorst, Erawan ^a   Meurer, Steffen K ^a   Gressner, Axel M ^a   Weiskirchen, Ralf ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Hepatic stellate cell; PDGF; ROS; Signaling; TGF

Indexed keywords

ACETYLCYSTEINE; ANTIFIBROTIC AGENT; COLLAGEN; DIMER; DISULFIDE; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; COLLAGEN SYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISULFIDE BOND; DRUG EFFECT; DRUG MEGADOSE; LIVER CELL CULTURE; LIVER FIBROSIS; LIVER INJURY; LIVER MITOCHONDRION; LIVER TOXICITY; MALE; MOLECULAR INTERACTION; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR BINDING; STELLATE CELL;

ACETYLCYSTEINE; ANIMALS; DISULFIDES; LIVER; MALE; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA;

EID: 27844522733     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.10.139     Document Type: Article

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