Synthesis, DNA binding, and cytotoxic evaluation of new analogs of diallyldisulfide, an active principle of garlic

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 15, 2008, Pages 7302-7310

  Rai, Santosh Kumar ^a   Sharma, Meenakshi ^b   Tiwari, Manisha ^a  

^a UNIVERSITY OF DELHI   (India)

^b UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Circular dichroism; Diallyldisulfide; Differential scanning calorimetry; Drug DNA interaction

Indexed keywords

ALLICIN; AMINOACRIDINE; ATORVASTATIN; BIS[3 (2' BROMOPHENYL)PROP 2 ENE]DISULFIDE; BIS[3 (2' CHLOROPHENYL)PROP 2 ENE]DISULFIDE; BIS[3 (2,4' DIBROMOPHENYL)PROP 2 ENE]DISULFIDE; BIS[3 (2,4' DICHLOROPHENYL)PROP 2 NE]DISULFIDE; BIS[3 (4' FLUOROPHENYL)PROP 2 ENE]DISULFIDE; BIS[3 (4' NITROPHENYL)PROP 2 ENE]DISULFIDE; BIS[3 [(4' TRIFLUOROMETHYL)PHENYL]PROP 2 ENE]DISULFIDE; DAUNORUBICIN; DISULFIDE; DOUBLE STRANDED DNA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; NOGALAMYCIN; SIMVASTATIN; UNCLASSIFIED DRUG;

ABSORPTION SPECTROSCOPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CARDIOVASCULAR DISEASE; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG BINDING; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENTHALPY; GARLIC; GC RICH SEQUENCE; HYPERCHOLESTEROLEMIA; IN VITRO STUDY; LIVER CELL CULTURE; MALE; MASS SPECTROMETRY; MOLECULAR INTERACTION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; THERMODYNAMICS;

ALLYL COMPOUNDS; ANIMALS; ANTILIPEMIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELLS, CULTURED; CIRCULAR DICHROISM; DNA; GARLIC; HEPATOCYTES; HYPERCHOLESTEROLEMIA; MALE; NUCLEIC ACID DENATURATION; RATS; RATS, WISTAR; SULFIDES;

ALLIUM SATIVUM;

EID: 48449094891     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.06.029     Document Type: Article

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