A novel enzyme immunoassay specific for ABCA1 protein quantification in human tissues and cells

Journal of Lipid Research

Volumn 49, Issue 10, 2008, Pages 2259-2267

  Paul, Vijay ^a   Meyer, Heinrich H D ^a   Leidl, Katharina ^a,b   Soumian, Soni ^c   Albrecht, Christiane ^a,d  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

ATP binding cassette transporter A1; Carotid plaques; ELISA

Indexed keywords

ABC TRANSPORTER A1; POLYCLONAL ANTIBODY;

ARTERY; ARTICLE; ATHEROSCLEROTIC PLAQUE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; PLACENTA; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; SENSITIVITY AND SPECIFICITY;

ANTIBODIES; ARTERIES; ATHEROSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; BINDING, COMPETITIVE; CASE-CONTROL STUDIES; CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOBLOTTING; LINEAR MODELS; PLACENTA; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TIME FACTORS;

EID: 67649742830     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.D700040-JLR200     Document Type: Article

References (42)

1. Chauhan, N. B. 2003. Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease. J. Lipid Res. 44: 2019-2029.
2. Oram, J. F. 2002. Molecular basis of cholesterol homeostasis: lessons from Tangier disease and ABCA1. Trends Mol. Med. 8: 168-173.
3. Attie, A. D., J. P. Kastelein, and M. R. Hayden. 2001. Pivotal role of ABCA1 in reverse cholesterol transport influencing HDL levels and susceptibility to atherosclerosis. J. Lipid Res. 42: 1717-1726.
4. Oram, J. F., and J. W. Heinecke. 2005. ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease. Physiol. Rev. 85: 1343-1372.
5. Oram, J. F., and A. M. Vaughan. 2006. ATP-binding cassette cholesterol transporters and cardiovascular disease. Circ. Res. 99: 1031-1043.
6. Bodzioch, M., E. Orso, J. Klucken, T. Langmann, A. Bottcher, W. Diederich,W. Drobnik, S. Barlage, C. Buchler, M. Porsch-Ozcurumez, et al. 1999. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat. Genet. 22: 347-351.
7. Brooks-Wilson, A., M. Marcil, S. M. Clee, L. H. Zhang, K. Roomp, M. van Dam, L. Yu, C. Brewer, J. A. Collins, H. O. Molhuizen, et al. 1999. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat. Genet. 22: 336-345.
8. Albrecht, C., K. Baynes, A. Sardini, S. Schepelmann, E. R. Eden, S. W. Davies, C. F. Higgins, M. D. Feher, J. S. Owen, and A. K. Soutar. 2004. Two novel missense mutations in ABCA1 result in altered trafficking and cause severe autosomal recessive HDL deficiency. Biochim. Biophys. Acta. 1689: 47-57.
9. McNeish, J., R. J. Aiello, D. Guyot, T. Turi, C. Gabel, C. Aldinger, K. L. Hoppe, M. L. Roach, L. J. Royer, J. de Wet, et al. 2000. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. Proc. Natl. Acad. Sci. USA. 97: 4245-4250.
10. Haghpassand, M., P. A. Bourassa, O. L. Francone, and R. J. Aiello. 2001. Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels. J. Clin. Invest. 108: 1315-1320.
11. Van, E. M., I. S. Bos, W. E. Kaminski, E. Orso, G. Rothe, J. Twisk, A. Bottcher, E. S. Van Amersfoort, T. A. Christiansen-Weber, W. P. Fung-Leung, et al. 2002. Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc. Natl. Acad. Sci. USA. 99: 6298-6303.
12. Aiello, R. J., D. Brees, and O. L. Francone. 2003. ABCA1-deficient mice: insights into the role of monocyte lipid efflux in HDL formation and inflammation. Arterioscler. Thromb. Vasc. Biol. 23: 972-980.
13. Singaraja, R. R., V. Bocher, E. R. James, S. M. Clee, L. H. Zhang, B. R. Leavitt, B. Tan, A. Brooks-Wilson, A. Kwok, N. Bissada, et al. 2001. Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1. J. Biol. Chem. 276: 33969-33979.
14. Singaraja, R. R., C. Fievet, G. Castro, E. R. James, N. Hennuyer, S. M. Clee, N. Bissada, J. C. Choy, J. C. Fruchart, B. M. McManus, et al. 2002. Increased ABCA1 activity protects against atherosclerosis. J. Clin. Invest. 110: 35-42.
15. Van, E. M., R. R. Singaraja, D. Ye, R. B. Hildebrand, E. R. James, M. R. Hayden, and T. J. Van Berkel. 2006. Macrophage ATP-binding cassette transporter A1 overexpression inhibits atherosclerotic lesion progression in low-density lipoprotein receptor knockout mice. Arterioscler. Thromb. Vasc. Biol. 26: 929-934.
16. Brunham, L. R., J. K. Kruit, T. D. Pape, J. M. Timmins, A. Q. Reuwer, Z. Vasanji, B. J. Marsh, B. Rodrigues, J. D. Johnson, J. S. Parks, et al. 2007. Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat. Med. 13: 340-347.
17. Langmann, T., J. Klucken, M. Reil, G. Liebisch, M. F. Luciani, G. Chimini, W. E. Kaminski, and G. Schmitz. 1999. Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages. Biochem. Biophys. Res. Commun. 257: 29-33.
18. Kielar, D., W. Dietmaier, T. Langmann, C. Aslanidis, M. Probst, M. Naruszewicz, and G. Schmitz. 2001. Rapid quantification of human ABCA1 mRNA in various cell types and tissues by real-time reverse transcription-PCR. Clin. Chem. 47: 2089-2097.
19. Repa, J. J., and D. J. Mangelsdorf. 2002. The liver X receptor gene team: potential new players in atherosclerosis. Nat. Med. 8: 1243-1248.
20. Thymiakou, E., V. I. Zannis, and D. Kardassis. 2007. Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids. Biochemistry. 46: 11473-11483.
21. Martinez, L. O., B. gerholm-Larsen, N. Wang, W. Chen, and A. R. Tall. 2003. Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I. J. Biol. Chem. 278: 37368-37374.
22. Mukhamedova, N., Y. Fu, M. Bukrinsky, A. T. Remaley, and D. Sviridov. 2007. The role of different regions of ATP-binding cassette transporter A1 in cholesterol efflux. Biochemistry. 46: 9388-9398.
23. Wang, Y., and J. F. Oram. 2007. Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C delta pathway. J. Lipid Res. 48: 1062-1068.
24. Wellington, C. L., E. K. Walker, A. Suarez, A. Kwok, N. Bissada, R. Singaraja, Y. Z. Yang, L. H. Zhang, E. James, J. E. Wilson, et al. 2002. ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation. Lab. Invest. 82: 273-283.
25. Albrecht, C., S. Soumian, J. S. Amey, A. Sardini, C. F. Higgins, A. H. Davies, and R. G. Gibbs. 2004. ABCA1 expression in carotid atherosclerotic plaques. Stroke. 35: 2801-2806.
26. Smith, P. K., R. I. Krohn, G. T. Hermanson, A. K. Mallia, F. H. Gartner, M. D. Provenzano, E. K. Fujimoto, N. M. Goeke, B. J. Olson, and D. C. Klenk. 1985. Measurement of protein using bicinchoninic acid. Anal. Biochem. 150: 76-85.
27. Chinetti, G., S. Lestavel, V. Bocher, A. T. Remaley, B. Neve, I. P. Torra, E. Teissier, A. Minnich, M. Jaye, N. Duverger, et al. 2001. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat. Med. 7: 53-58.
28. Yano, M., T. Matsumura, T. Senokuchi, N. Ishii, Y. Murata, K. Taketa, H. Motoshima, T. Taguchi, K. Sonoda, D. Kukidome, et al. 2007. Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages. Circ. Res. 100: 1442-1451.
29. Tamehiro, N., Y. Shigemoto-Mogami, T. Kakeya, K. Okuhira, K. Suzuki, R. Sato, T. Nagao, and T. Nishimaki-Mogami. 2007. Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status. J. Biol. Chem. 282: 21090-21099.
30. Matsumoto, A., H. Mizukami, S. Mizuno, K. Umegaki, J. Nishikawa, K. Shudo, H. Kagechika, and M. Inoue. 2007. beta-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages. Biochem. Pharmacol. 74: 256-264.
31. Koldamova, R., and I. Lefterov. 2007. Role of LXR and ABCA1 in the pathogenesis of Alzheimer's disease - implications for a new therapeutic approach. Curr. Alzheimer Res. 4: 171-178.
32. Albrecht, C., S. Soumian, N. Tetlow, P. Patel, M. H. Sullivan, L. Lakasing, K. Nicolaides, and C. Williamson. 2007. Placental ABCA1 expression is reduced in primary antiphospholipid syndrome compared to pre-eclampsia and controls. Placenta. 28: 701-708.
33. Bates, S. R., J. Q. Tao, K. J. Yu, Z. Borok, E. D. Crandall, H. L. Collins, and G. H. Rothblat. 2007. Expression and biological activity of ABCA1 in alveolar epithelial cells. Am. J. Respir. Cell Mol. Biol. 38: 283-292.
34. Neufeld, E. B., J. A. Stonik, S. J. Demosky, Jr., C. L. Knapper, C. A. Combs, A. Cooney, M. Comly, N. Dwyer, J. Blanchette-Mackie, A. T. Remaley, et al. 2004. The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease. J. Biol. Chem. 279: 15571-15578.
35. le Maire, M., P. Champeil, and V. J. Moller. 2000. Interaction of membrane proteins and lipids with solubilizing detergents. Biochim. Biophys. Acta. 1508: 86-111.
36. Drobnik, W., H. Borsukova, A. Bottcher, A. Pfeiffer, G. Liebisch, G. J. Schutz, H. Schindler, and G. Schmitz. 2002. Apo AI/ABCA1-dependent and HDL3-mediated lipid efflux from compositionally distinct cholesterol based microdomains. Traffic. 3: 268-278.
37. Soumian, S., C. Albrecht, A. H. Davies, and R. G. Gibbs. 2005. ABCA1 and atherosclerosis. Vasc. Med. 10: 109-119.
38. Favari, E., F. Zimetti, A. E. Bortnick, M. P. Adorni, I. Zanotti, M. Canavesi, and F. Bernini. 2005. Impaired ATP-binding cassette transporter A1-mediated sterol efflux from oxidized LDL-loaded macrophages. FEBS Lett. 579: 6537-6542.
39. Geeraert, B., K. D. De, P. C. Davey, F. Crombe, N. Benhabiles, and P. Holvoet. 2007. Oxidized LDL-induced expression of ABCA1 in blood monocytes precedes coronary atherosclerosis and is associated with plaque complexity in hypercholesterolemic pigs. J. Thromb. Haemost. 5: 2529-2536.
40. Tabas, I. 1997. Phospholipid metabolism in cholesterol-loaded macrophages. Curr. Opin. Lipidol. 8: 263-267.
41. Feng, B., and I. Tabas. 2002. ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity. J. Biol. Chem. 277: 43271-43280.
42. Felton, C. V., D. Crook, M. J. Davies, and M. F. Oliver. 1997. Relation of plaque lipid composition and morphology to the stability of human aortic plaques. Arterioscler. Thromb. Vasc. Biol. 17: 1337-1345.