Unlinking tumor necrosis factor biology from the major histocompatibility complex: Lessons from human genetics and animal models

American Journal of Human Genetics

Volumn 65, Issue 2, 1999, Pages 294-301

  Ruuls, Sigrid R ^a   Sedgwick, Jonathon D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL MODEL; AUTOIMMUNE DISEASE; CHROMOSOME 17; CHROMOSOME 6; GENE LOCATION; GENE LOCUS; GENE TARGETING; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; IMMUNOGENETICS; MAJOR HISTOCOMPATIBILITY COMPLEX; MOLECULAR GENETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALIA;

EID: 0033362022     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302517     Document Type: Article

References (38)

1. Bazzoni F, Beutler B (1996) The tumour necrosis factor ligand and receptor families. N Engl J Med 334:1717-1725
2. Bean AGD, Roach DR, Briscoe H, France MP, Körner H, Sedgwick JD, Britton WJ (1999) Structural deficiencies in granuloma formation in tumor necrosis factor gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection which is not compensated for by lymphotoxin. J Immunol 162:3504-3511
3. Beutler B (1992) Tumor necrosis factors: the molecules and their emerging role in medicine. Raven Press, New York
4. Brinkman BMN, Huizinga TWJ, Kurban SS, Van der Velde EA, Schreuder GMT, Hazes JMW, Breedveld FC, et al. (1997) Tumour necrosis factor alpha gene polymorphisms in rheumatoid arthritis: association with susceptibility to, or severity of, disease? Br J Rheumatol 36:516-521
5. Brinkman BMN, Zuijdgeest D, Kaijzel EL, Breedveld FC, Verweij CI. (1996) Relevance of the tumor necrosis factor alpha - 308 promoter polymorphism in TNF alpha gene regulation. J Inflamm 46:32-41
6. Broide DH, Hoffman H, Sriramarao P (1999) Genes that regulate eosinophilic inflammation. Am J Hum Genet 65: 302-307 (in this issue)
7. Cope AP (1998) Regulation of autoimmunity by proinflammatory cytokines. Curr Opin Immunol 10:669-676
8. Czermak BJ, Sarma V, Bless NM, Schmal H, Friedl HP, Ward PA (1999) In vitro and in vivo dependency of chemokine generation on C5a and TNF-α. J Immunol 162:2321-2325
9. Feldmann M, Charles P, Taylor P, Maini RN (1998) Biological insights from clinical trials with anti-TNF therapy. Springer Semin Immunopathol 20:211-228
10. Frei K, Eugster H-P, Bopst M, Konstantinescu C, Lavi E, Fontana A (1997) Tumor necrosis factor α and lymphotoxin α are not required for induction of acute experimental autoimmune encephalomelitis. J Exp Med 185:2177-2182
11. Fu YX, Chaplin DD (1999) Development and maturation of secondary lymphoid tissue. Ann Rev Immunol 17:399-433
12. Galli-Taliadoros LA, Wood SA, Sedgwick JD, Körner H (1995) Gene knockout technology: a methodological overview for the interested novice. J Immunol Methods 181:1-15
13. Gerlai R (1996) Gene targeting studies of mammalian behaviour: is it the mutation or the background genotype? Trends Neurosci 19:177-181
14. Gruen JR, Weissman SM (1997) Evolving views of the major histocompatibility complex. Blood 90:4252-4265
15. Hodgson H (1999) Prospects of new therapeutic approaches for Crohn's disease. Lancet 353:425-426
16. Jacob CO, Fronek Z, Lewis GD, Koo M, Hansen JA, McDevitt HO (1990) Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus. Proc Natl Acad Sci USA 87: 1233-1237
17. Karpus WJ, Ransohoff RM (1998) Chemokine regulation of experimental autoimmune encephalomyelitis: temporal and spatial expression patterns governing disease pathogenesis. J Immunol 161:2667-2671
18. Kassiotis G, Pasparakis M, Kollias G, Probert I. (1999) TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis. Eur J Immunol 29:774-780
19. Kontoyiannis D, Pasparakis M, Pizarro TT, Cominelli F, Kollias G (1999) Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity 10:387-398
20. Körner H, Cook M, Riminton DS, Lemckert FA, Hock RM, Ledermann B, Köntgen F, et al. (1997a) Distinct roles for lymphotoxin-α and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue. Eur J Immunol 27:2600-2609
21. Körner H, Riminton DS, Strickland D, Lemckert FA, Pollard J, Sedgwick JD (1997b) Critical points of tumor necrosis factor action in central nervous system autoimmune inflammation defined by gene targeting. J Exp Med 186: 1585-1590
22. Liu J, Marino MW, Wong G, Grail D, Dunn A, Bettadapura J, Slavin AJ, et al. ( 1998) TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination. Nat Med 4:78-83
23. Mackay F, Bourdon PR, Griffiths DA, Lawton P, Zafari M, Sizing ID, Miatkowski K, et al. (1997) Cytotoxic activities of recombinant soluble murine lymphotoxin-α and lymphotoxin-αβ complexes. J Immunol 159:3299-3310
24. McDermott MF, Aksentijevich I, Galon J, McDermott EM, Ogunkolade BW, Centola M, Mansfield E, et al. (1999) Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. Cell 97:133-144
25. Ngo VN, Körner H, Gunn MD, Schmidt KN, Riminton DS, Cooper MD, Browning JL, et al. (1999) Lymphotoxin-αβ and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J Exp Med 189:403-412
26. Pasparakis M, Alexopoulou L, Episkopou V, Kollias G (1996) Immune and inflammatory responses in TNF-alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 184:1397-1411
27. Peschon J, Torrance DS, Stocking KL, Glaccum MB, Otten C, Willis CR, Charrier K, et al. (1998) TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation. J Immunol 160:943-952
28. Riminton DS, Körner H, Strickland DH, Lemckert FA, Pollard JD, Sedgwick JD (1998) Challenging cytokine redundancy: inflammatory cell movement and clinical course of experimental autoimmune encephalomyelitis are normal in lymphotoxin-deficient but not TNF-deficient mice. J Exp Med 187:1517-1528
29. Sacca R, Cuff CA, Lesslauer W, Ruddle NH (1998) Differential activities of secreted lymphotoxin-alpha3 and membrane lymphotoxin-alpha 1 beta2 in lymphotoxin-induced inflammation: critical role of TNF receptor 1 signaling. J Immunol 160:485-491
30. Smyth MJ, Kelly JM, Baxter AG, Körner H, Sedgwick JD (1998) An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneum. J Exp Med 188:1611-1619
31. Stuber F, Udalova IA, Book M, Drutskaya LN, Kuprash DV, Turetskaya RL, Schade FU, et al. (1996) - 308 tumor necrosis factor polymorphism is not associated with survival in severe sepsis and is unrelated to lipopolysaccharide inducibility of the human TNF promoter. J Inflamm 46:42-50
32. Suen WE, Bergman CM, Hjelmström P, Ruddle NH (1997) A critical role for lymphotoxin in experimental allergic encephalomyelitis. J Exp Med 186:1233-1240
33. Tessier PA, Naccache PH, Clark-Lewis I, Gladue RP, Neote KS, McColl SR (1997) Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha. J Immunol 159:3595-3602
34. Theofilopoulos AN (1995) The basis of autoimmunity: part II genetic predisposition. Immunol Today 16:150-159
35. Vassalli P (1992) The pathophysiology of tumor necrosis factors. Ann Rev Immunol 10:411-452
36. Wilson AG, Di Giovine FS, Duff GW (1995) Genetics of tumour necrosis factor-alpha in autoimmune, infectious, and neoplastic diseases. J Inflamm 45:1-12
37. Wilson AG, Symons JA, McDowell TL, McDevitt HO, Duff GW (1997) Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation. Proc Natl Acad Sci USA 94:3195-3199
38. Zhang M, Tracey KJ (1998) Tumor necrosis factor. In: Thomson AW (ed) The cytokine handbook. Academic Press, London, pp 517-548