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Volumn 380, Issue 7-8, 1999, Pages 825-839

Molecular farming of recombinant antibodies in plants

Author keywords

Biotechnology; Molecular farming; Pharmaceuticals; Plant derived antibodies; Protein production; Transgenic plants

Indexed keywords

BLOOD SUBSTITUTE; CARO RX; RECOMBINANT ANTIBODY; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

EID: 0032848431     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.1999.102     Document Type: Review
Times cited : (69)

References (134)
  • 1
    • 0001610054 scopus 로고
    • High efficiency transformation of cultured tobacco cells
    • An, G. (1985). High efficiency transformation of cultured tobacco cells. Plant Physiol. 79, 568-570.
    • (1985) Plant Physiol. , vol.79 , pp. 568-570
    • An, G.1
  • 2
    • 0026261919 scopus 로고
    • Large-scale (20 I) culture of surface-immobilized Catharanthus roseus cells
    • Archambault, J. (1991). Large-scale (20 I) culture of surface-immobilized Catharanthus roseus cells. Enzyme Microb. Technol. 13 (11), 882-892.
    • (1991) Enzyme Microb. Technol. , vol.13 , Issue.11 , pp. 882-892
    • Archambault, J.1
  • 3
    • 0029394902 scopus 로고
    • Expression of a single-chain Fv antibody against abscisic acid creates a wilty phenotype in transgenic tobacco
    • Artsaenko, O., Peisker, M., zur Nieden, U., Fiedler, U., Weiler, E. W., Müntz, K., and Conrad, U. (1995). Expression of a single-chain Fv antibody against abscisic acid creates a wilty phenotype in transgenic tobacco. The Plant J. 8, 745-750.
    • (1995) The Plant J. , vol.8 , pp. 745-750
    • Artsaenko, O.1    Peisker, M.2    Zur Nieden, U.3    Fiedler, U.4    Weiler, E.W.5    Müntz, K.6    Conrad, U.7
  • 5
    • 0025625217 scopus 로고
    • Regulatory agency concerns in the manufacturing and testing of monoclonal antibodies for therapeutic use
    • Baker, D., and Harkonen, W. (1990). Regulatory agency concerns in the manufacturing and testing of monoclonal antibodies for therapeutic use. Targeted Diagn. Ther. 3, 75-98.
    • (1990) Targeted Diagn. Ther. , vol.3 , pp. 75-98
    • Baker, D.1    Harkonen, W.2
  • 6
    • 0028222738 scopus 로고
    • Novel strategies for engineering virus resistance in plants
    • Baulcombe, D. (1994). Novel strategies for engineering virus resistance in plants. Curr. Opin. Bio/Technology 5, 117-124.
    • (1994) Curr. Opin. Bio/Technology , vol.5 , pp. 117-124
    • Baulcombe, D.1
  • 7
    • 0029832960 scopus 로고    scopus 로고
    • Expression in tobacco of a functional monoclonal antibody specific to stylet secretions of the root-knot nematode
    • Baum, T.J., Hiatt, A., Parrott, W.A., Pratt, L.H., and Hussey, R.S. (1996). Expression in tobacco of a functional monoclonal antibody specific to stylet secretions of the root-knot nematode. MPMI 9, 382-387.
    • (1996) MPMI , vol.9 , pp. 382-387
    • Baum, T.J.1    Hiatt, A.2    Parrott, W.A.3    Pratt, L.H.4    Hussey, R.S.5
  • 8
    • 0026167075 scopus 로고
    • Large-scale plant cell culture: Methods, applications and products
    • Bisaria, V., and Panda, A. (1991). Large-scale plant cell culture: methods, applications and products. Current Opinion in Biotechnology 2, 370-374.
    • (1991) Current Opinion in Biotechnology , vol.2 , pp. 370-374
    • Bisaria, V.1    Panda, A.2
  • 9
    • 0030775030 scopus 로고    scopus 로고
    • Plant cell suspension culture in a bench-scale fermenter with a newly designed membrane stirrerfor bubble-free aeration
    • Böhme, C., Schröder, M.B., Jung-Heiliger, H., and Lehmann, J. (1997). Plant cell suspension culture in a bench-scale fermenter with a newly designed membrane stirrerfor bubble-free aeration. Applied Microbiology and Biotechnology 48, 149-154.
    • (1997) Applied Microbiology and Biotechnology , vol.48 , pp. 149-154
    • Böhme, C.1    Schröder, M.B.2    Jung-Heiliger, H.3    Lehmann, J.4
  • 10
    • 0031799615 scopus 로고    scopus 로고
    • Biological therapy of ovarian cancer: Current directions
    • Bookman, M.A. (1998). Biological therapy of ovarian cancer: current directions. Semin. Oncol. 25(3), 381-396.
    • (1998) Semin. Oncol. , vol.25 , Issue.3 , pp. 381-396
    • Bookman, M.A.1
  • 11
    • 0028236409 scopus 로고
    • Infectious transcripts and cDNA clones of RNA viruses
    • Boyer, J.C., and Haenni, A.L. (1994). Infectious transcripts and cDNA clones of RNA viruses. Virology 198, 415-426.
    • (1994) Virology , vol.198 , pp. 415-426
    • Boyer, J.C.1    Haenni, A.L.2
  • 13
    • 0039547497 scopus 로고
    • Determination of the pore size of cell walls of living plant cells
    • Carpita, N., Sabularse, D., Montezinos, D., and Delmer, D.P. (1979). Determination of the pore size of cell walls of living plant cells. Science 205, 1144-1147.
    • (1979) Science , vol.205 , pp. 1144-1147
    • Carpita, N.1    Sabularse, D.2    Montezinos, D.3    Delmer, D.P.4
  • 14
    • 0031916168 scopus 로고    scopus 로고
    • Antibody-mediated protection against intracellular pathogens
    • Casadevall, A. (1998). Antibody-mediated protection against intracellular pathogens. Trends Microbiol. 6(3), 102-107.
    • (1998) Trends Microbiol. , vol.6 , Issue.3 , pp. 102-107
    • Casadevall, A.1
  • 15
    • 0014674467 scopus 로고
    • Tropomyosin, crystal structure, polymorphism and molecular interactions
    • Caspar, D.L., Cohen, C., and Longley, W. (1969). Tropomyosin, crystal structure, polymorphism and molecular interactions. J. Mol. Biol. 41, 87.
    • (1969) J. Mol. Biol. , vol.41 , pp. 87
    • Caspar, D.L.1    Cohen, C.2    Longley, W.3
  • 16
    • 0030966078 scopus 로고    scopus 로고
    • Antibodies, killer toxins and antifungal immunoprotection: A lesson from nature?
    • Cassone, A., Conti, S., Bernardis, F., and Polonelli, L. (1997). Antibodies, killer toxins and antifungal immunoprotection: a lesson from nature? Immunology Today 18, 164-169.
    • (1997) Immunology Today , vol.18 , pp. 164-169
    • Cassone, A.1    Conti, S.2    Bernardis, F.3    Polonelli, L.4
  • 17
    • 0028180895 scopus 로고
    • Expression of alpha-amylases, carbohydrate metabolism, and autophagy in cultured rice cells is coordinately regulated by sugar nutrient
    • Chen, M.H., Liu, L.F., Chen, Y.R., Wu, H.K., and Yu, S.M. (1994). Expression of alpha-amylases, carbohydrate metabolism, and autophagy in cultured rice cells is coordinately regulated by sugar nutrient. Plant J. 6, 625-636.
    • (1994) Plant J. , vol.6 , pp. 625-636
    • Chen, M.H.1    Liu, L.F.2    Chen, Y.R.3    Wu, H.K.4    Yu, S.M.5
  • 18
  • 19
    • 0002138820 scopus 로고
    • Strategies for variety-independent genetic transformation of important cereals, legumes and woody species utilizing particle bombardment
    • Christou, P. (1995). Strategies for variety-independent genetic transformation of important cereals, legumes and woody species utilizing particle bombardment. Euphytica 85(1-3), 13-27.
    • (1995) Euphytica , vol.85 , Issue.1-3 , pp. 13-27
    • Christou, P.1
  • 20
    • 0030440711 scopus 로고    scopus 로고
    • Transformation technology
    • Christou, P. (1996). Transformation technology. Trends Plant Sci. 1, 423-431.
    • (1996) Trends Plant Sci. , vol.1 , pp. 423-431
    • Christou, P.1
  • 21
    • 0032168897 scopus 로고    scopus 로고
    • Compartment-specific accumulation of recombinant immunoglobulins in plant cells: An essential tool for antibody production and immunomodulation of physiological functions and pathogen activity
    • Conrad, U., and Fiedler, U. (1998). Compartment-specific accumulation of recombinant immunoglobulins in plant cells: an essential tool for antibody production and immunomodulation of physiological functions and pathogen activity. Plant Mol. Biol. 38, 101-109.
    • (1998) Plant Mol. Biol. , vol.38 , pp. 101-109
    • Conrad, U.1    Fiedler, U.2
  • 22
    • 0031814173 scopus 로고    scopus 로고
    • High level and stable accumulation of single chain Fv antibodies in plant storage organs
    • Conrad, U., Fiedler, U., Artsaenko, O., and Phillips, J. (1998). High level and stable accumulation of single chain Fv antibodies in plant storage organs. J. Plant Physiol. 152, 708-711.
    • (1998) J. Plant Physiol. , vol.152 , pp. 708-711
    • Conrad, U.1    Fiedler, U.2    Artsaenko, O.3    Phillips, J.4
  • 23
    • 0028821555 scopus 로고
    • Changes in protein methylation associated with the elicitation response in cell cultures of alfalfa (Medicago sativa L.)
    • Daniell, T., and Edwards, R. (1995). Changes in protein methylation associated with the elicitation response in cell cultures of alfalfa (Medicago sativa L.). FEBS Lett 360, 57-61.
    • (1995) FEBS Lett , vol.360 , pp. 57-61
    • Daniell, T.1    Edwards, R.2
  • 27
    • 0030925538 scopus 로고    scopus 로고
    • Induction of micronuclei with ochratoxin a in ovine seminal vescle cell cultures
    • Degen, G., Gerber, M., Obrecht-Pflumio, S., and Dirheimer, G. (1997). Induction of micronuclei with ochratoxin A in ovine seminal vescle cell cultures. Arch. Toxicol. 71, 365-371.
    • (1997) Arch. Toxicol. , vol.71 , pp. 365-371
    • Degen, G.1    Gerber, M.2    Obrecht-Pflumio, S.3    Dirheimer, G.4
  • 28
    • 0029934404 scopus 로고    scopus 로고
    • Elicitor-induced generation of active oxygen in suspension cultures of Arabidopsis thaliana
    • Desikan, R., Hancock, J.T., Neill, S.J., Coffey, M.J., and Jones, O.T. (1996). Elicitor-induced generation of active oxygen in suspension cultures of Arabidopsis thaliana. Biochem. Soc. Trans. 24, 199S.
    • (1996) Biochem. Soc. Trans. , vol.24
    • Desikan, R.1    Hancock, J.T.2    Neill, S.J.3    Coffey, M.J.4    Jones, O.T.5
  • 30
    • 0000376019 scopus 로고
    • Design of reactors for plant cells and organs
    • Doran, P. (1993). Design of reactors for plant cells and organs. Advances in biochemical engineering 48, 115-168.
    • (1993) Advances in Biochemical Engineering , vol.48 , pp. 115-168
    • Doran, P.1
  • 31
    • 0032795393 scopus 로고    scopus 로고
    • Affinity-purification of a TMV-specific recombinant full-size antibody from a transgenic tobacco suspension culture
    • in press
    • Drossard, J., Liao, Y.-C., and Fischer, R. (1999). Affinity-purification of a TMV-specific recombinant full-size antibody from a transgenic tobacco suspension culture. J. Immunol. Meth., in press.
    • (1999) J. Immunol. Meth.
    • Drossard, J.1    Liao, Y.-C.2    Fischer, R.3
  • 32
    • 0003492872 scopus 로고
    • Crystallization of Nucleic Acids and Proteins, A Practical Approach
    • D. Rickwood and B.D. Hames, eds., (Oxford, UK: Oxford University Press)
    • Ducruix, A., and Giegé, R. (1992). Crystallization of Nucleic Acids and Proteins, A Practical Approach. The Practical Approach Series, D. Rickwood and B.D. Hames, eds., (Oxford, UK: Oxford University Press).
    • (1992) The Practical Approach Series
    • Ducruix, A.1    Giegé, R.2
  • 33
    • 0025477259 scopus 로고
    • Synthesis and selfassembly of a functional monoclonal antibody in transgenic Nicotiana tabacum
    • Düring, K., Hippe, S., Kreuzaler, F., and Schell, J. (1990). Synthesis and selfassembly of a functional monoclonal antibody in transgenic Nicotiana tabacum. Plant Mol. Biol. 15, 281-293.
    • (1990) Plant Mol. Biol. , vol.15 , pp. 281-293
    • Düring, K.1    Hippe, S.2    Kreuzaler, F.3    Schell, J.4
  • 34
    • 0030272085 scopus 로고    scopus 로고
    • Recombinant protein production in transgenic animals
    • Echelard, Y. (1996). Recombinant protein production in transgenic animals. Curr. Opin. Biotechnol. 7, 536-540.
    • (1996) Curr. Opin. Biotechnol. , vol.7 , pp. 536-540
    • Echelard, Y.1
  • 35
    • 0030477901 scopus 로고    scopus 로고
    • Expression of single-chain antibody fragments (scFv) specific for beet necrotic yellow vein virus coat protein or 25kDa protein in Escherichia coli and Nicotiana benthamiana
    • Fecker, L.F., Kaufmann, A., Commandeur, U., Commandeur, J., Koenig, R., and Burgermeister, W. (1996). Expression of single-chain antibody fragments (scFv) specific for beet necrotic yellow vein virus coat protein or 25kDa protein in Escherichia coli and Nicotiana benthamiana. Plant Mol. Biol. 32, 979-986.
    • (1996) Plant Mol. Biol. , vol.32 , pp. 979-986
    • Fecker, L.F.1    Kaufmann, A.2    Commandeur, U.3    Commandeur, J.4    Koenig, R.5    Burgermeister, W.6
  • 36
    • 0030758331 scopus 로고    scopus 로고
    • Nicotiana benthamiana plants expressing beet necrotic yellow vein virus (BNYVV) coat protein-specific scFv are partially protected against the establishment of the virus in the early stages of infection and its pathogenic effects in the late stages of infection
    • Fecker, L.F., Koenig, R., and Obermeier, C. (1997). Nicotiana benthamiana plants expressing beet necrotic yellow vein virus (BNYVV) coat protein-specific scFv are partially protected against the establishment of the virus in the early stages of infection and its pathogenic effects in the late stages of infection. Arch. Virol 142, 1857-1863.
    • (1997) Arch. Virol , vol.142 , pp. 1857-1863
    • Fecker, L.F.1    Koenig, R.2    Obermeier, C.3
  • 37
    • 0022372143 scopus 로고
    • Momnoclonal antibodies to T-2 toxin in vitro neutralization of protein synthesis inhibition and protection of rats against lethal toxemia
    • Feuerstein, G., Powell, J., Knower, A., and Hunter, K. (1985). Momnoclonal antibodies to T-2 toxin In vitro neutralization of protein synthesis inhibition and protection of rats against lethal toxemia. J. Clinical Investigation 76, 2134-2138.
    • (1985) J. Clinical Investigation , vol.76 , pp. 2134-2138
    • Feuerstein, G.1    Powell, J.2    Knower, A.3    Hunter, K.4
  • 38
    • 0028889621 scopus 로고
    • High-level production and long-term storage of engineered antibodies in transgenic tobacco seeds
    • Fiedler, U., and Conrad, U. (1995). High-level production and long-term storage of engineered antibodies in transgenic tobacco seeds. Bio/Technology 13, 1090-1093.
    • (1995) Bio/Technology , vol.13 , pp. 1090-1093
    • Fiedler, U.1    Conrad, U.2
  • 39
    • 0030731752 scopus 로고    scopus 로고
    • Optimisation of scFv antibody production in transgenic plants
    • Fiedler, U., Philips, J., Artsaenko, O., and Conrad, U. (1997). Optimisation of scFv antibody production in transgenic plants. Immunotechnology 3, 205-216.
    • (1997) Immunotechnology , vol.3 , pp. 205-216
    • Fiedler, U.1    Philips, J.2    Artsaenko, O.3    Conrad, U.4
  • 40
    • 0027688050 scopus 로고
    • Secretion of a functional single-chain Fv protein in transgenic tobacco plants and cell suspension cultures
    • Firek, S., Draper, J., Owen, M.R.L., Gandecha, A., Cockburn, B., and Whitelam, G.C. (1993). Secretion of a functional single-chain Fv protein in transgenic tobacco plants and cell suspension cultures. Plant Mol. Biol. 23, 861-870.
    • (1993) Plant Mol. Biol. , vol.23 , pp. 861-870
    • Firek, S.1    Draper, J.2    Owen, M.R.L.3    Gandecha, A.4    Cockburn, B.5    Whitelam, G.C.6
  • 44
    • 0033564752 scopus 로고    scopus 로고
    • Expression and characterization of bispecific single chain Fv fragments produced in transgenic plants
    • Fischer, R., Schumann, D., Zimmermann, S., Drossard, J., Sack, M., and Schillberg, S. (1999b). Expression and characterization of bispecific single chain Fv fragments produced in transgenic plants. Eur. J. Biochemistry, 262, 810-816.
    • (1999) Eur. J. Biochemistry , vol.262 , pp. 810-816
    • Fischer, R.1    Schumann, D.2    Zimmermann, S.3    Drossard, J.4    Sack, M.5    Schillberg, S.6
  • 46
    • 0032034804 scopus 로고    scopus 로고
    • Controlling gene expression in transgenics
    • Gallie, D. (1998). Controlling gene expression in transgenics. Curr. Opin. Plant Biol. 1, 166-172.
    • (1998) Curr. Opin. Plant Biol. , vol.1 , pp. 166-172
    • Gallie, D.1
  • 47
    • 0030853154 scopus 로고    scopus 로고
    • Costimulation of T-cell proliferation by a chimeric B7-antibody fusion protein
    • Gerstmayer, B., Hoffmann, M., Altenschmidt, U., and Wels, W. (1997). Costimulation of T-cell proliferation by a chimeric B7-antibody fusion protein. Cancer Immunol Immunother. 45, 156-158.
    • (1997) Cancer Immunol Immunother. , vol.45 , pp. 156-158
    • Gerstmayer, B.1    Hoffmann, M.2    Altenschmidt, U.3    Wels, W.4
  • 48
    • 0000120725 scopus 로고
    • Crystallogenesis of biological macromolecules: Facts and perspectives
    • Giegé, R., Lorber, B., and Théobald-Dietrich, A. (1994). Crystallogenesis of biological macromolecules: facts and perspectives. Acta. Cryst. D50, 339-350.
    • (1994) Acta. Cryst. , vol.D50 , pp. 339-350
    • Giegé, R.1    Lorber, B.2    Théobald-Dietrich, A.3
  • 49
    • 0029187060 scopus 로고
    • Production of polyclonal and monoclonal antibodies against hyphae from arbuscular mycorrhizal fungi
    • Goebel, C., Hahn, A., and Hock, B. (1995). Production of polyclonal and monoclonal antibodies against hyphae from arbuscular mycorrhizal fungi. Critical Reviews in Biotechnology 15, 293-304.
    • (1995) Critical Reviews in Biotechnology , vol.15 , pp. 293-304
    • Goebel, C.1    Hahn, A.2    Hock, B.3
  • 50
    • 0025715923 scopus 로고
    • Antibodies produced in plants
    • Hiatt, A. (1990). Antibodies produced in plants. Nature 344, 469-470.
    • (1990) Nature , vol.344 , pp. 469-470
    • Hiatt, A.1
  • 51
    • 0025910258 scopus 로고
    • Production of monoclonal antibody in plants
    • Hiatt, A.C. (1991). Production of monoclonal antibody in plants. Transplant Proc 23 (3 Suppl 3), 147-151.
    • (1991) Transplant Proc , vol.23 , Issue.3 SUPPL. 3 , pp. 147-151
    • Hiatt, A.C.1
  • 52
    • 0027484798 scopus 로고
    • Characterization and applications of antibodies produced in plants
    • Hiatt, A., and Ma, J.K. (1993). Characterization and applications of antibodies produced in plants. Int. Rev. Immunol. 10, 139-152.
    • (1993) Int. Rev. Immunol. , vol.10 , pp. 139-152
    • Hiatt, A.1    Ma, J.K.2
  • 53
    • 0024959945 scopus 로고
    • Production of antibodies in transgenic plants
    • Hiatt, A., Cafferkey, R., and Bowdish, K. (1989). Production of antibodies in transgenic plants. Nature 342, 76-78.
    • (1989) Nature , vol.342 , pp. 76-78
    • Hiatt, A.1    Cafferkey, R.2    Bowdish, K.3
  • 54
    • 0026473876 scopus 로고
    • Assembly of antibodies and mutagenized variants in transgenic plants and plant cell cultures
    • Hiatt, A., Tang, Y., Weiser, W., and Hein, M.B. (1992). Assembly of antibodies and mutagenized variants in transgenic plants and plant cell cultures. Genet. Eng. 14, 49-64.
    • (1992) Genet. Eng. , vol.14 , pp. 49-64
    • Hiatt, A.1    Tang, Y.2    Weiser, W.3    Hein, M.B.4
  • 55
    • 0025325736 scopus 로고
    • Growth and hyoscyamine production of 'hairy root' cultures of Datura stramonium in a modified stirred tank reactor
    • Hilton, M.G., and Rhodes, M.J. (1990). Growth and hyoscyamine production of 'hairy root' cultures of Datura stramonium in a modified stirred tank reactor. Appl. Microbiol. Biotechnol. 33(2), 132-138.
    • (1990) Appl. Microbiol. Biotechnol. , vol.33 , Issue.2 , pp. 132-138
    • Hilton, M.G.1    Rhodes, M.J.2
  • 56
    • 0000833916 scopus 로고
    • Growth and Nicotinate Biotransformation in Batch Cultured and Airlift Fermenter Grown Soybean Cell Suspension Cultures
    • Hoehl, U., Upmeier, B., and Barz, W. (1988). Growth and Nicotinate Biotransformation in Batch Cultured and Airlift Fermenter Grown Soybean Cell Suspension Cultures. Applied Microbiology and Biotechnology 28, 319-323.
    • (1988) Applied Microbiology and Biotechnology , vol.28 , pp. 319-323
    • Hoehl, U.1    Upmeier, B.2    Barz, W.3
  • 57
    • 0025453365 scopus 로고
    • Production of a foreign protein product with genetically modified plant cells
    • Hogue, R.S., Lee, J.M., and An, G. (1990). Production of a foreign protein product with genetically modified plant cells. Enzyme Microb. Technol. 12, 533-538.
    • (1990) Enzyme Microb. Technol. , vol.12 , pp. 533-538
    • Hogue, R.S.1    Lee, J.M.2    An, G.3
  • 58
    • 0025700254 scopus 로고
    • Cultivation of plant cells in a stirred tank reactor
    • Hooker, B.S., Lee, J.M., and An, G. (1990). Cultivation of plant cells in a stirred tank reactor. Biotechnology and Bioengineering 35, 296-304.
    • (1990) Biotechnology and Bioengineering , vol.35 , pp. 296-304
    • Hooker, B.S.1    Lee, J.M.2    An, G.3
  • 59
    • 37049182668 scopus 로고
    • A simple and general method for transferring genes into plants
    • Horsch, R.B., Fry, J.E., Hoffman, N.L., Rogers, S.G., and Fraley, R.T. (1985). A simple and general method for transferring genes into plants. Science 227, 1229-1231.
    • (1985) Science , vol.227 , pp. 1229-1231
    • Horsch, R.B.1    Fry, J.E.2    Hoffman, N.L.3    Rogers, S.G.4    Fraley, R.T.5
  • 61
    • 0028519072 scopus 로고
    • Jasmonate-inducible expression of a potato cathepsin D inhibitor-GUS gene fusion in tobacco cells
    • Ishikawa, A., Yoshihara, T., and Nakamura, K. (1994). Jasmonate-inducible expression of a potato cathepsin D inhibitor-GUS gene fusion in tobacco cells. Plant Mol. Biol. 26, 403-414.
    • (1994) Plant Mol. Biol. , vol.26 , pp. 403-414
    • Ishikawa, A.1    Yoshihara, T.2    Nakamura, K.3
  • 62
    • 0030793945 scopus 로고    scopus 로고
    • Presentation of heterologous peptides on plant viruses- Genetics, structure and function
    • Johnson, J., Lin, T., and Lomonossoff, G. (1997). Presentation of heterologous peptides on plant viruses- genetics, structure and function. Annu. Rev. Phytopathol. 35, 67-86.
    • (1997) Annu. Rev. Phytopathol. , vol.35 , pp. 67-86
    • Johnson, J.1    Lin, T.2    Lomonossoff, G.3
  • 63
    • 0000146626 scopus 로고    scopus 로고
    • An Agrobacterium-mediated transient gene expression system for intact leaves
    • Kapila, J., De Rycke, R., van Montagu, M., and Angenon, G. (1996). An Agrobacterium-mediated transient gene expression system for intact leaves. Plant Sci. 122, 101-108.
    • (1996) Plant Sci. , vol.122 , pp. 101-108
    • Kapila, J.1    De Rycke, R.2    Van Montagu, M.3    Angenon, G.4
  • 64
    • 0033524365 scopus 로고    scopus 로고
    • The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate
    • Ketchum, R.E.B., Gibson, D.M., Croteau, R.B., and Shuler, L. (1999). The kinetics of taxoid accumulation in cell suspension cultures of Taxus following elicitation with methyl jasmonate. Biotechnology and Bioengineering 62, 91-105.
    • (1999) Biotechnology and Bioengineering , vol.62 , pp. 91-105
    • Ketchum, R.E.B.1    Gibson, D.M.2    Croteau, R.B.3    Shuler, L.4
  • 65
    • 0031576708 scopus 로고    scopus 로고
    • Plant cell suspension cultures: Some engineering considerations
    • Kieran, P.M., MacLoughlin, P.F., and Malone, D.M. (1997). Plant cell suspension cultures: some engineering considerations. J. Biotechnol. 59, 39-52.
    • (1997) J. Biotechnol. , vol.59 , pp. 39-52
    • Kieran, P.M.1    MacLoughlin, P.F.2    Malone, D.M.3
  • 66
    • 0016756272 scopus 로고
    • Continuous cultures of fused cells secreting antibody of predefined specificity
    • Kohler, G., and Milstein, C. (1975). Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256, 495-497.
    • (1975) Nature , vol.256 , pp. 495-497
    • Kohler, G.1    Milstein, C.2
  • 67
    • 0001200134 scopus 로고
    • The promoter of TL-DNA gene 5 controls the tissue-specific expression of chimaeric genes carried by a novel type of Agrobacterium binary vector
    • Koncz, C., and Schell, J. (1986). The promoter of TL-DNA gene 5 controls the tissue-specific expression of chimaeric genes carried by a novel type of Agrobacterium binary vector. Mol. Gen. Genet. 204, 383-396.
    • (1986) Mol. Gen. Genet. , vol.204 , pp. 383-396
    • Koncz, C.1    Schell, J.2
  • 68
    • 0031555505 scopus 로고    scopus 로고
    • Production of recombinant proteins in transgenic plants: Practical Considerations
    • Kusnadi, A.R., Nikolov, Z.L., and Howard, J.A. (1997). Production of recombinant proteins in transgenic plants: Practical Considerations. Biotechnology and Bioengineering 56, 473-484.
    • (1997) Biotechnology and Bioengineering , vol.56 , pp. 473-484
    • Kusnadi, A.R.1    Nikolov, Z.L.2    Howard, J.A.3
  • 70
    • 0001931742 scopus 로고
    • Transient gene expression in electroporated protoplasts and intact cells of sugar beet
    • Lindsey, K., and Jones, M.G.K. (1987). Transient gene expression in electroporated protoplasts and intact cells of sugar beet. Plant Molecular Biology 10(1), 43-52.
    • (1987) Plant Molecular Biology , vol.10 , Issue.1 , pp. 43-52
    • Lindsey, K.1    Jones, M.G.K.2
  • 71
    • 0031903637 scopus 로고    scopus 로고
    • Expression and characterisation of single-chain antibody fragments produced in transgenic plants against the organic herbicides atrazine and paraquat
    • Longstaff, M., Newell, C.A., Boonstra, B., Strachan, G., Learmonth, D., Harris, W.J., Porter, A.J., and Hamilton, W.D. (1998). Expression and characterisation of single-chain antibody fragments produced in transgenic plants against the organic herbicides atrazine and paraquat. Biochimica Et Biophysica Acta 1381, 147-160.
    • (1998) Biochimica et Biophysica Acta , vol.1381 , pp. 147-160
    • Longstaff, M.1    Newell, C.A.2    Boonstra, B.3    Strachan, G.4    Learmonth, D.5    Harris, W.J.6    Porter, A.J.7    Hamilton, W.D.8
  • 72
    • 0029411968 scopus 로고
    • Immunotherapeutic potential of antibodies produced in plants
    • Ma, J., and Hein, M. (1995a). Immunotherapeutic potential of antibodies produced in plants. Trends Biotechnol. 13, 522-527.
    • (1995) Trends Biotechnol. , vol.13 , pp. 522-527
    • Ma, J.1    Hein, M.2
  • 73
    • 0029379799 scopus 로고
    • Plant antibodies for Immunotherapy
    • Ma, J., and Hein, M. (1995b). Plant antibodies for Immunotherapy. Plant Physiol. 109, 341-346.
    • (1995) Plant Physiol. , vol.109 , pp. 341-346
    • Ma, J.1    Hein, M.2
  • 74
    • 0028031827 scopus 로고
    • Assembly of monoclonal antibodies with IgG1 and IgA heavy chain domains in transgenic tobacco plants
    • Ma, J.K.C., Lehner, T., Stabila, P., Fux, C.I., and Hiatt, A. (1994). Assembly of monoclonal antibodies with IgG1 and IgA heavy chain domains in transgenic tobacco plants. Eur. J. Immunol. 24, 131-138.
    • (1994) Eur. J. Immunol. , vol.24 , pp. 131-138
    • Ma, J.K.C.1    Lehner, T.2    Stabila, P.3    Fux, C.I.4    Hiatt, A.5
  • 76
    • 0031835622 scopus 로고    scopus 로고
    • Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans
    • Ma, J.K., Hikmat, B.Y., Wycoff, K., Vine, N.D., Chargelegue, D., Yu, L., Hein, M.B., and Lehner, T. (1998). Characterization of a recombinant plant monoclonal secretory antibody and preventive immunotherapy in humans. Nat. Med. 4, 601-606.
    • (1998) Nat. Med. , vol.4 , pp. 601-606
    • Ma, J.K.1    Hikmat, B.Y.2    Wycoff, K.3    Vine, N.D.4    Chargelegue, D.5    Yu, L.6    Hein, M.B.7    Lehner, T.8
  • 77
    • 0032103849 scopus 로고    scopus 로고
    • Secretion of biologically active human interleukin-2 and interleukin-4 from genetically modified tobacco cells in suspension culture
    • Magnuson, N.S., Linzmaier, P.M., Reeves, R., An, G., HayGlass, K., and Lee, J.M. (1998). Secretion of biologically active human interleukin-2 and interleukin-4 from genetically modified tobacco cells in suspension culture. Protein Expr. Purif. 13, 45-52.
    • (1998) Protein Expr. Purif. , vol.13 , pp. 45-52
    • Magnuson, N.S.1    Linzmaier, P.M.2    Reeves, R.3    An, G.4    Hayglass, K.5    Lee, J.M.6
  • 78
    • 0018375692 scopus 로고
    • Prevention of fungal infection of plants by specific inhibition of cutinase
    • Maiti, I., and Kolattukudy, P. (1979). Prevention of fungal infection of plants by specific inhibition of cutinase. Science 205, 507-508.
    • (1979) Science , vol.205 , pp. 507-508
    • Maiti, I.1    Kolattukudy, P.2
  • 79
    • 0029294009 scopus 로고
    • Intracellular antibodies (intrabodies) as research reagents and therapeutic molecules for gene therapy
    • Marasco, W.A. (1995). Intracellular antibodies (intrabodies) as research reagents and therapeutic molecules for gene therapy. Immunotechnology 1, 1-19.
    • (1995) Immunotechnology , vol.1 , pp. 1-19
    • Marasco, W.A.1
  • 80
    • 0026534731 scopus 로고
    • Validating the preparation of clinical monoclonal antibodies
    • Mariani, M., and Tarditi, L. (1992). Validating the preparation of clinical monoclonal antibodies. Biotechnology 10, 394-396.
    • (1992) Biotechnology , vol.10 , pp. 394-396
    • Mariani, M.1    Tarditi, L.2
  • 81
    • 0029150867 scopus 로고
    • Transgenic plants as vaccine production systems
    • Mason, H.S., and Arntzen, C.J. (1995). Transgenic plants as vaccine production systems. Trends. Biotechnol. 13, 388-392.
    • (1995) Trends. Biotechnol. , vol.13 , pp. 388-392
    • Mason, H.S.1    Arntzen, C.J.2
  • 82
    • 0031257710 scopus 로고    scopus 로고
    • Purification of an elicitor-induced glucan synthase (callose synthase) from suspension cultures of French bean (Phaseolus vulgaris L.): Purification and immunolocation of a probable M(r)-65,000 subunit of the enzyme
    • McCormack, B.A., Gregory, A.C., Kerry, M.E., Smith, C., and Bolwell, G.P. (1997). Purification of an elicitor-induced glucan synthase (callose synthase) from suspension cultures of French bean (Phaseolus vulgaris L.): purification and immunolocation of a probable M(r)-65,000 subunit of the enzyme. Planta 203, 196-203.
    • (1997) Planta , vol.203 , pp. 196-203
    • McCormack, B.A.1    Gregory, A.C.2    Kerry, M.E.3    Smith, C.4    Bolwell, G.P.5
  • 86
    • 0031081649 scopus 로고    scopus 로고
    • Plants as bioreactors for pharmaceutical: Regulatory considerations
    • Miele, L. (1997). Plants as bioreactors for pharmaceutical: regulatory considerations. Tibech. 15, 45-50.
    • (1997) Tibech. , vol.15 , pp. 45-50
    • Miele, L.1
  • 87
    • 0030060485 scopus 로고    scopus 로고
    • Methyl jasmonate induced production of taxol in suspension cultures of Taxus cuspidata: Ethylene interaction and induction models
    • Mirjalili, N., and Linden, J.C. (1996). Methyl jasmonate induced production of taxol in suspension cultures of Taxus cuspidata: ethylene interaction and induction models. Biotechnol Prog 12, 110-118.
    • (1996) Biotechnol Prog , vol.12 , pp. 110-118
    • Mirjalili, N.1    Linden, J.C.2
  • 88
    • 0031454517 scopus 로고    scopus 로고
    • Subcellular targeting and purification of recombinant proteins in plant production systems. Biotechnol
    • Moloney, M.M., and Holbrook, L.A. (1997). Subcellular targeting and purification of recombinant proteins in plant production systems. Biotechnol. Genet. Eng. Rev. 14, 321-336.
    • (1997) Genet. Eng. Rev. , vol.14 , pp. 321-336
    • Moloney, M.M.1    Holbrook, L.A.2
  • 89
    • 0031308296 scopus 로고    scopus 로고
    • FDA perspective on specifications for biotechnology products - From IND to PLA
    • Murano, G. (1997). FDA perspective on specifications for biotechnology products - from IND to PLA. Dev. Biol. Stand. 91, 3-13.
    • (1997) Dev. Biol. Stand. , vol.91 , pp. 3-13
    • Murano, G.1
  • 90
    • 0031853473 scopus 로고    scopus 로고
    • Production and characterization of monoclonal antibodies to cell wall components of the flax rust fungus
    • Murdoch, L., Kobayashi, I., and Hardham, A. (1998). Production and characterization of monoclonal antibodies to cell wall components of the flax rust fungus. European J. Plant Pathology 104, 331-346.
    • (1998) European J. Plant Pathology , vol.104 , pp. 331-346
    • Murdoch, L.1    Kobayashi, I.2    Hardham, A.3
  • 91
    • 0026568783 scopus 로고
    • Tobacco BY-2 cell line as the "HeLa" cell in the cell biology of higher plants
    • Nagata, T., Nemoto, Y., and Seiichiro, H. (1992). Tobacco BY-2 cell line as the "HeLa" cell in the cell biology of higher plants. International Review of Cytology 132, 1-30.
    • (1992) International Review of Cytology , vol.132 , pp. 1-30
    • Nagata, T.1    Nemoto, Y.2    Seiichiro, H.3
  • 92
    • 0025183234 scopus 로고
    • Extrachromosomal homologous recombination and gene targeting in plant cells after Agrobacterium mediated transformation
    • Offringa, R., de Groot, M.J.A., Haagsman, H.J., Does, M.P., van den Elzen, P.J.M., and Hooykaas, P.J.J. (1990). Extrachromosomal homologous recombination and gene targeting in plant cells after Agrobacterium mediated transformation. EMBO J. 9, 3077-3084.
    • (1990) EMBO J. , vol.9 , pp. 3077-3084
    • Offringa, R.1    De Groot, M.J.A.2    Haagsman, H.J.3    Does, M.P.4    Van Den Elzen, P.J.M.5    Hooykaas, P.J.J.6
  • 93
    • 14744306329 scopus 로고
    • Synthesis of a functional anti-phytochrome single-chain Fv protein in transgenic tobacco
    • Owen, M., Gandecha, A., Cockburn, B., and Whitelam, G. (1992). Synthesis of a functional anti-phytochrome single-chain Fv protein in transgenic tobacco. Bio/Technology 10, 790-794.
    • (1992) Bio/Technology , vol.10 , pp. 790-794
    • Owen, M.1    Gandecha, A.2    Cockburn, B.3    Whitelam, G.4
  • 94
    • 0000343239 scopus 로고
    • Monoclonal antibodies which show restricted binding to four Colletotrichum species: C. Iindemuthianum, C. malvarum, C. orbiculare and C. trifolii
    • Pain, N., O'Connell, R., Bailey, J., and Green, J. (1992). Monoclonal antibodies which show restricted binding to four Colletotrichum species: C. Iindemuthianum, C. malvarum, C. orbiculare and C. trifolii. Physiological and Molecular Plant Pathology 41, 111-126.
    • (1992) Physiological and Molecular Plant Pathology , vol.41 , pp. 111-126
    • Pain, N.1    O'Connell, R.2    Bailey, J.3    Green, J.4
  • 95
    • 0028982069 scopus 로고
    • Fusarium ear blight (scab) in small grain cereals - A review
    • Parry, D., Jenkinson, P., and Mcleod, L. (1995). Fusarium ear blight (scab) in small grain cereals - a review. Plant Pathology 44, 207-238.
    • (1995) Plant Pathology , vol.44 , pp. 207-238
    • Parry, D.1    Jenkinson, P.2    Mcleod, L.3
  • 96
    • 0030787077 scopus 로고    scopus 로고
    • Seed-specific immunomodulation of abscisic acid activity induces a developmental switch
    • Phillips, J., Artsaenko, O., Fiedler, U., Horstmann, C., Mock, H.P., Müntz, K., and Conrad, U. (1997). Seed-specific immunomodulation of abscisic acid activity induces a developmental switch. EMBO 16, 4489-4496.
    • (1997) EMBO , vol.16 , pp. 4489-4496
    • Phillips, J.1    Artsaenko, O.2    Fiedler, U.3    Horstmann, C.4    Mock, H.P.5    Müntz, K.6    Conrad, U.7
  • 97
    • 0030158570 scopus 로고    scopus 로고
    • Use of viral replicons for the expression of genes in plants
    • Porta, C., and Lomonossoff, G.P. (1996). Use of viral replicons for the expression of genes in plants. Mol. Biotech. 5, 209-221.
    • (1996) Mol. Biotech. , vol.5 , pp. 209-221
    • Porta, C.1    Lomonossoff, G.P.2
  • 98
    • 0001567469 scopus 로고
    • Annu. Rev. Plant Physiol
    • Potrykus, I. (1991). Annu. Rev. Plant Physiol. Plant Mol. Biol. 42, 205-225.
    • (1991) Plant Mol. Biol. , vol.42 , pp. 205-225
    • Potrykus, I.1
  • 99
    • 0027135679 scopus 로고
    • Molecular differentiation in the extrahaustorial membrane of pea powdery mildew haustoria at early and late stages of development
    • Robert, A., Mackie, A., Hathaway, V., Callow, J., and Green, J. (1993). Molecular differentiation in the extrahaustorial membrane of pea powdery mildew haustoria at early and late stages of development. Physiological and Molecular Plant Pathology 43, 147-160.
    • (1993) Physiological and Molecular Plant Pathology , vol.43 , pp. 147-160
    • Robert, A.1    Mackie, A.2    Hathaway, V.3    Callow, J.4    Green, J.5
  • 101
    • 0030025294 scopus 로고    scopus 로고
    • Culturing conditions affecting the production of anthocyanin in suspended cell cultures of strawberry
    • Sato, K., Nakayama, M., and Shigeta, J. (1996). Culturing conditions affecting the production of anthocyanin in suspended cell cultures of strawberry. Plant Science 113, 91-98.
    • (1996) Plant Science , vol.113 , pp. 91-98
    • Sato, K.1    Nakayama, M.2    Shigeta, J.3
  • 102
    • 0024429732 scopus 로고
    • Production of soluble recombinant proteins in bacteria
    • Schein, C.H. (1989). Production of soluble recombinant proteins in bacteria. Biotechnology 7, 1141-1149.
    • (1989) Biotechnology , vol.7 , pp. 1141-1149
    • Schein, C.H.1
  • 103
    • 0033178118 scopus 로고    scopus 로고
    • Apoplastic and cytosolic expression of full-size antibodies and antibody fragments in Nicotiana tabacum
    • in press
    • Schillberg, S., Zimmermann, S., Voss, A., and Fischer, R. (1999). Apoplastic and cytosolic expression of full-size antibodies and antibody fragments in Nicotiana tabacum. Transgenic Research, in press.
    • (1999) Transgenic Research
    • Schillberg, S.1    Zimmermann, S.2    Voss, A.3    Fischer, R.4
  • 105
    • 0029983963 scopus 로고    scopus 로고
    • Plant virus gene vectors for transient expression of foreign proteins in plants
    • Scholthof, H., Scholthof, K., and Jackson, A. (1996). Plant virus gene vectors for transient expression of foreign proteins in plants. Annu. Rev. Phytopathol. 34, 299-323.
    • (1996) Annu. Rev. Phytopathol. , vol.34 , pp. 299-323
    • Scholthof, H.1    Scholthof, K.2    Jackson, A.3
  • 107
    • 0026848670 scopus 로고
    • Large-scale plant cell culture: Methods, applications and products
    • Scragg, A.H. (1992). Large-scale plant cell culture: methods, applications and products. Current Opinion in Biotechnology 3, 105-109.
    • (1992) Current Opinion in Biotechnology , vol.3 , pp. 105-109
    • Scragg, A.H.1
  • 108
    • 0031013444 scopus 로고    scopus 로고
    • Taxol (Paclitaxel) production using free and immobilized cells of taxus cuspidata
    • Seki, M., Ohzora, C., Takeda, M., and Furusaki, S. (1997). Taxol (Paclitaxel) production using free and immobilized cells of taxus cuspidata. Biotechnology and Bioengineering 53, 214-219.
    • (1997) Biotechnology and Bioengineering , vol.53 , pp. 214-219
    • Seki, M.1    Ohzora, C.2    Takeda, M.3    Furusaki, S.4
  • 109
    • 0028968966 scopus 로고
    • Vectors based on maize streak virus can replaicate to high copy numbers in maize plants
    • Shen, W.H., and Hohn, B. (1995). Vectors based on maize streak virus can replaicate to high copy numbers in maize plants. J. Gen. Virol. 76, 965-969.
    • (1995) J. Gen. Virol. , vol.76 , pp. 965-969
    • Shen, W.H.1    Hohn, B.2
  • 112
    • 0027312336 scopus 로고
    • Bacterial expression of immunoglobulin fragments
    • Skerra, A. (1993). Bacterial expression of immunoglobulin fragments. Curr. Opin. Biotech. 5, 256-262.
    • (1993) Curr. Opin. Biotech. , vol.5 , pp. 256-262
    • Skerra, A.1
  • 114
    • 0027742234 scopus 로고
    • Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack
    • Tavladoraki, P., Benvenuto, E., Trinca, S., De Martinis, D., Cattaneo, A., and Galeffi, P. (1993). Transgenic plants expressing a functional single-chain Fv antibody are specifically protected from virus attack. Nature 366, 469-472.
    • (1993) Nature , vol.366 , pp. 469-472
    • Tavladoraki, P.1    Benvenuto, E.2    Trinca, S.3    De Martinis, D.4    Cattaneo, A.5    Galeffi, P.6
  • 119
    • 0031732939 scopus 로고    scopus 로고
    • Expression and assembly of a full-length monoclonal antibody in plants using a plant virus vector
    • Verch, T., Yusibov, V., and Koprowski, H. (1998). Expression and assembly of a full-length monoclonal antibody in plants using a plant virus vector. J. Immunological Methods 220, 69-75.
    • (1998) J. Immunological Methods , vol.220 , pp. 69-75
    • Verch, T.1    Yusibov, V.2    Koprowski, H.3
  • 121
  • 122
    • 0030841224 scopus 로고    scopus 로고
    • Pectase lyase of Colletotrichum gloeospoprioides attacking avocado fruits: cDNA cloning and involvment in pathogenicity
    • Wattad, C., Kobiler, D., Dinoor, A., and Prusky, D. (1997). Pectase lyase of Colletotrichum gloeospoprioides attacking avocado fruits: cDNA cloning and involvment in pathogenicity. Physiological and Molecular Plant Pathology 50, 197-212.
    • (1997) Physiological and Molecular Plant Pathology , vol.50 , pp. 197-212
    • Wattad, C.1    Kobiler, D.2    Dinoor, A.3    Prusky, D.4
  • 123
    • 51249165768 scopus 로고
    • Bioprocessing technology for plant cell suspension cultures
    • Wen, W.S. (1995). Bioprocessing technology for plant cell suspension cultures. Applied Biochemistry and Biotechnology 50, 189-216.
    • (1995) Applied Biochemistry and Biotechnology , vol.50 , pp. 189-216
    • Wen, W.S.1
  • 124
    • 0030207039 scopus 로고    scopus 로고
    • Antibody expression in transgenic plants
    • Whitelam, G., and Garry, W. (1996). Antibody expression in transgenic plants. Trends in Plant Science 1, 268-271.
    • (1996) Trends in Plant Science , vol.1 , pp. 268-271
    • Whitelam, G.1    Garry, W.2
  • 127
    • 0030207039 scopus 로고    scopus 로고
    • Antibody expression in transgenic plants
    • Whitelam, G.C., and Garry, W. (1996). Antibody expression in transgenic plants. Trends in Plant Science 1, 268-271.
    • (1996) Trends in Plant Science , vol.1 , pp. 268-271
    • Whitelam, G.C.1    Garry, W.2
  • 129
    • 0027416841 scopus 로고
    • Strategies to protect crop plants against viruses: Pathogen-derived resistance blossoms
    • Wilson, T.M.A. (1993). Strategies to protect crop plants against viruses: pathogen-derived resistance blossoms. Proc. Natl. Acad. Sci. USA 90, 3134-3141.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3134-3141
    • Wilson, T.M.A.1
  • 131
    • 0030009423 scopus 로고    scopus 로고
    • Effect of sucrose, exogenous product concentration, and other culture conditions on growth and steroidal alkaloid production by Solanum aviculare hairy roots
    • Yu, S., Kwok, K.H., and Doran, P.M. (1996). Effect of sucrose, exogenous product concentration, and other culture conditions on growth and steroidal alkaloid production by Solanum aviculare hairy roots. Enzyme and Microbial Technology 18, 238-243.
    • (1996) Enzyme and Microbial Technology , vol.18 , pp. 238-243
    • Yu, S.1    Kwok, K.H.2    Doran, P.M.3
  • 132
    • 0029737648 scopus 로고    scopus 로고
    • Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures
    • Yukimune, Y., Tabata, H., Higashi, Y., and Hara, Y. (1996). Methyl jasmonate-induced overproduction of paclitaxel and baccatin III in Taxus cell suspension cultures. Nat. Biotechnol. 14, 1129-1132.
    • (1996) Nat. Biotechnol. , vol.14 , pp. 1129-1132
    • Yukimune, Y.1    Tabata, H.2    Higashi, Y.3    Hara, Y.4
  • 134
    • 0031678633 scopus 로고    scopus 로고
    • Intracellular expression of TMV-specific single-chain Fv fragments leads to improved virus resistance in Nicotiana tabacum
    • Zimmermann, S., Schillberg, S., Liao, Y.C., and Fischer, R. (1998). Intracellular expression of TMV-specific single-chain Fv fragments leads to improved virus resistance in Nicotiana tabacum. Molecular Breeding 4, 369-379.
    • (1998) Molecular Breeding , vol.4 , pp. 369-379
    • Zimmermann, S.1    Schillberg, S.2    Liao, Y.C.3    Fischer, R.4


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