메뉴 건너뛰기




Volumn 13, Issue 6, 2009, Pages 675-688

Targeting the eicosanoid pathway in non-small-cell lung cancer

Author keywords

Cyclooxygenase 2; Eicosanoids; Non small cell lung cancer; Prostaglandin E2

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 7 [5 (4 BIPHENYLYLMETHOXY) 2 MORPHOLINO 3 OXOCYCLOPENTYL] 4 HEPTENOIC ACID; ANTINEOPLASTIC METAL COMPLEX; CARBOPLATIN; CELECOXIB; CISPLATIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOTOXIC AGENT; DOCETAXEL; ERLOTINIB; GEFITINIB; GEMCITABINE; ICOSANOID; IRINOTECAN; LOW MOLECULAR WEIGHT HEPARIN; ONO AE3 208; PACLITAXEL; PLACEBO; PROSTAGLANDIN E2; ROFECOXIB; ROSIGLITAZONE; TAXANE DERIVATIVE; UNCLASSIFIED DRUG; WARFARIN; ZILEUTON;

EID: 67649607484     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728220902915567     Document Type: Review
Times cited : (13)

References (101)
  • 4
    • 3042665905 scopus 로고    scopus 로고
    • Cyclooxygenase as a target in lung cancer
    • DOI 10.1158/1078-0432.CCR-040014
    • Brown JR, Dubois RN. Cyclooxygenase a target in lung cancer. Clin Cancer Res 2004;10(Suppl.):4266-4269 (Pubitemid 38812460)
    • (2004) Clinical Cancer Research , vol.10 , Issue.12 II
    • Brown, J.R.1    Dubois, R.N.2
  • 6
    • 29244449354 scopus 로고    scopus 로고
    • Prostaglandins and cancer
    • DOI 10.1136/gut.2004.047100
    • Wang D, Dubois RN. Prostaglandins and cancer. Gut 2006;55:115-122 (Pubitemid 41820645)
    • (2006) Gut , vol.55 , Issue.1 , pp. 115-122
    • Wang, D.1    Dubois, R.N.2
  • 7
    • 0037652234 scopus 로고    scopus 로고
    • Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors
    • Ermert L, Dierkes C, Ermert M. Immunohistochemical expression of cyclooxygenase isoenzymes and downstream enzymes in human lung tumors. Clin Cancer Res 2003;9:1604-1610 (Pubitemid 36554582)
    • (2003) Clinical Cancer Research , vol.9 , Issue.5 , pp. 1604-1610
    • Ermert, L.1    Dierkes, C.2    Ermert, M.3
  • 13
    • 24344494462 scopus 로고    scopus 로고
    • Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer
    • Laga AC, Zander DS, Cagle PT. Prognostic significance of cyclooxygenase 2 expression in 259 cases of non-small cell lung cancer. Arch Pathol Lab Med 2005;129:1113-1117 (Pubitemid 41244809)
    • (2005) Archives of Pathology and Laboratory Medicine , vol.129 , Issue.9 , pp. 1113-1117
    • Laga, A.C.1    Zander, D.S.2    Cagle, P.T.3
  • 14
    • 0024517117 scopus 로고
    • Prostaglandin H synthase-dependent mutagenic activation of benzidine in a Salmonella typhimurium Ames tester strain possessing elevated N-acetyltransferase levels
    • Josephy PD, Chiu AL, Eling TE. Prostaglandin H synthase-dependent mutagenic activation of benzidine in a Salmonella typhimurium Ames tester strain possessing elevated N-acetyltransferase levels. Cancer Res 1989;49:853-856 (Pubitemid 19064335)
    • (1989) Cancer Research , vol.49 , Issue.4 , pp. 853-856
    • Josephy, P.D.1    Chiu, A.L.H.2    Eling, T.E.3
  • 16
    • 19944432973 scopus 로고    scopus 로고
    • Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: Evidence for the role of epidermal growth factor receptor and its ligands
    • Moraitis D, Du B, De Lorenzo MS, et al. Levels of cyclooxygenase-2 are increased in the oral mucosa of smokers: evidence for the role of epidermal growth factor receptor and its ligands. Cancer Res 2005;65:664-670
    • (2005) Cancer Res , vol.65 , pp. 664-670
    • Moraitis, D.1    Du, B.2    De Lorenzo, M.S.3
  • 20
    • 0035992439 scopus 로고    scopus 로고
    • Significant growth inhibition of human lung cancer cells both in vitro and in vivo by the combined use of a selective cyclooxygenase 2 inhibitor, JTE-522, and conventional anticancer agents
    • Hida T, Kozaki K-I, Ito H, et al. Significant growth inhibition of human lung cancer cells both in vitro and in vivo by the combined use of a selective cyclooxygenase 2 inhibitor, JTE-522, and conventional anticancer agents. Clin Cancer Res 2002;8:2443-2447
    • (2002) Clin Cancer Res , vol.8 , pp. 2443-2447
    • Hida, T.1    Kozaki, K.-I.2    Ito, H.3
  • 23
    • 64049107388 scopus 로고    scopus 로고
    • A randomized double-blind study of the biological effects of celecoxib as a chemopreventive agent in current and former smokers
    • Kim ES, Hong WK, Lee JJ, et al. A randomized double-blind study of the biological effects of celecoxib as a chemopreventive agent in current and former smokers. J Clin Oncol 2008;26:1501
    • (2008) J Clin Oncol , vol.26 , pp. 1501
    • Kim, E.S.1    Hong, W.K.2    Lee, J.J.3
  • 25
    • 34249673868 scopus 로고    scopus 로고
    • Aspirin and the risk of colorectal cancer in relation to the expression of COX-2
    • DOI 10.1056/NEJMoa067208
    • Chan AT, Ogino S, Fuchs CS. Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med 2007;356:2131-2142 (Pubitemid 47010839)
    • (2007) New England Journal of Medicine , vol.356 , Issue.21 , pp. 2131-2142
    • Chan, A.T.1    Ogino, S.2    Fuchs, C.S.3
  • 27
    • 55749105531 scopus 로고    scopus 로고
    • Cardiovascular events associated with rofecoxib: Final analysis of the APPROVe trial
    • Baron JA, Sandler RS, Bresalier RS, et al. Cardiovascular events associated with rofecoxib: final analysis of the APPROVe trial. Lancet 2008;372:1756-1764
    • (2008) Lancet , vol.372 , pp. 1756-1764
    • Baron, J.A.1    Sandler, R.S.2    Bresalier, R.S.3
  • 28
    • 39749149266 scopus 로고    scopus 로고
    • Eicosanoid modulation in advanced lung cancer: Cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy
    • Cancer and Leukemia Group B Trial 30203
    • Edelman MJ, Watson D, Wang X, et al. Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy. Cancer and Leukemia Group B Trial 30203. J Clin Oncol 2008;26:848-855
    • (2008) J Clin Oncol , vol.26 , pp. 848-855
    • Edelman, M.J.1    Watson, D.2    Wang, X.3
  • 31
    • 0031705797 scopus 로고    scopus 로고
    • Inhibitors of lipoxygenase: A new class of cancer chemopreventive agents
    • DOI 10.1093/carcin/19.8.1393
    • Rioux N, Castonguay A. Inhibitors of lipoxygenase: a new class of cancer chemopreventive agents. Carcinogenesis 1998;19:1393-1400 (Pubitemid 28409837)
    • (1998) Carcinogenesis , vol.19 , Issue.8 , pp. 1393-1400
    • Rioux, N.1    Castonguay, A.2
  • 35
    • 58949100556 scopus 로고    scopus 로고
    • Phase II study of docetaxel and celecoxib, a cyclooxygenase-2 inhibitor, in elderly or poor performance status (PS2) patients with advanced non-small cell lung cancer
    • Gadgeel SM, Wozniak A, Ruckdeschel JC, et al. Phase II study of docetaxel and celecoxib, a cyclooxygenase-2 inhibitor, in elderly or poor performance status (PS2) patients with advanced non-small cell lung cancer. J Thorac Oncol 2008;3:1293-1300
    • (2008) J Thorac Oncol , vol.3 , pp. 1293-1300
    • Gadgeel, S.M.1    Wozniak, A.2    Ruckdeschel, J.C.3
  • 39
    • 18244364810 scopus 로고    scopus 로고
    • Update of a phase I/II trial of carboplatin/ gemcitabine plus escalating doses of celecoxib for first-line treatment of stage IIIB/IV non-small cell lung cancer (NSCLC)
    • Burton JD, Badine E, El-Sayah D, et al. Update of a phase I/II trial of carboplatin/ gemcitabine plus escalating doses of celecoxib for first-line treatment of stage IIIB/IV non-small cell lung cancer (NSCLC). J Clin Oncol 2004;22:7339
    • (2004) J Clin Oncol , vol.22 , pp. 7339
    • Burton, J.D.1    Badine, E.2    El-Sayah, D.3
  • 40
    • 6044278144 scopus 로고    scopus 로고
    • Evaluating the efficiency of targeted designs for randomized clinical trials
    • DOI 10.1158/1078-0432.CCR-04-0496
    • Simon R, Maitournam A. Evaluating the efficiency of targeted designs for randomized clinical trials. Clin Cancer Res 2004;10:6759-6763 (Pubitemid 39383023)
    • (2004) Clinical Cancer Research , vol.10 , Issue.20 , pp. 6759-6763
    • Simon, R.1    Maitournam, A.2
  • 42
    • 0027323229 scopus 로고
    • Pathologic complete response in advanced non-small-cell lung cancer following preoperative chemotherapy: Implications for the design of future non-small-cell lung cancer combined modality trials
    • Pisters KM, Kris MG, Gralla RJ, et al. Pathologic complete response in advanced non-small-cell lung cancer following preoperative chemotherapy: implications for the design of future non-small-cell lung cancer combined modality trials. J Clin Oncol 1993;11:1757-1762 (Pubitemid 23277329)
    • (1993) Journal of Clinical Oncology , vol.11 , Issue.9 , pp. 1757-1762
    • Pisters, K.M.W.1    Kris, M.G.2    Gralla, R.J.3    Zaman, M.B.4    Heelan, R.T.5    Martini, N.6
  • 43
    • 0034685876 scopus 로고    scopus 로고
    • Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 and p38 mitogen- Activated protein kinase pathways
    • DOI 10.1074/jbc.275.20.14838
    • Subbaramaiah K, Hart JC, Norton L, et al. Microtubule-interfering agents stimulate the transcription of cyclooxygenase-2. Evidence for involvement of ERK1/2 and p38 mitogen- activated protein kinase pathways. J Biol Chem 2000;275:14838-14845 (Pubitemid 30337196)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.20 , pp. 14838-14845
    • Subbaramaiah, K.1    Hart, J.C.2    Norton, L.3    Dannenberg, A.J.4
  • 45
    • 67649632725 scopus 로고    scopus 로고
    • Celecoxib combined with fixed dose-rate Gemcitabine (FDR-Gem)/CDDP as induction chemotherapy for stage III non-small cell lung cancer (NSCLC)
    • Milella M, Ceribelli A, Gelibter A, et al. Celecoxib combined with fixed dose-rate Gemcitabine (FDR-Gem)/CDDP as induction chemotherapy for stage III non-small cell lung cancer (NSCLC). J Clin Oncol 2005;23:7324
    • (2005) J Clin Oncol , vol.23 , pp. 7324
    • Milella, M.1    Ceribelli, A.2    Gelibter, A.3
  • 48
    • 0014944305 scopus 로고
    • Inactivation of prostaglandins by the lungs
    • Piper PJ, Vane JR, Wyllie JH. Inactivation of prostaglandins by the lungs. Nature 1970;225:600-604
    • (1970) Nature , vol.225 , pp. 600-604
    • Piper, P.J.1    Vane, J.R.2    Wyllie, J.H.3
  • 49
    • 0016918043 scopus 로고
    • Quantifications of the major urinary metabolite of the e prostaglandins by mass spectrometry: Evaluation of the method's application to clinical studies
    • Seyberth HW, Sweetman BJ, Frolich JC, et al. Quantifications of the major urinary metabolite of the E prostaglandins by mass spectrometry: evaluation of the method's application to clinical studies. Prostaglandins 1976;11:381-397
    • (1976) Prostaglandins , vol.11 , pp. 381-397
    • Seyberth, H.W.1    Sweetman, B.J.2    Frolich, J.C.3
  • 50
    • 5644272862 scopus 로고    scopus 로고
    • Quantification of the major urinary metabolite of PGE(2) by a liquid chromatographic/mass spectrometric assay: Determination of cyclooxygenase- specific PGE(2) synthesis in healthy humans and those with lung cancer
    • Murphey LJ, Williams MK, Sanchez SC, et al. Quantification of the major urinary metabolite of PGE(2) by a liquid chromatographic/mass spectrometric assay: determination of cyclooxygenase-specific PGE(2) synthesis in healthy humans and those with lung cancer. Anal Biochem 2004;334:266-275
    • (2004) Anal Biochem , vol.334 , pp. 266-275
    • Murphey, L.J.1    Williams, M.K.2    Sanchez, S.C.3
  • 52
    • 17044384979 scopus 로고    scopus 로고
    • Docetaxel and cyclooxygenase-2 inhibition with celecoxib for advanced non-small cell lung cancer progressing after platinum-based chemotherapy: A multicenter phase II trial
    • DOI 10.1016/j.lungcan.2004.11.004
    • Nugent FW, Mertens WC, Graziano S, et al. Docetaxel and cyclooxygenase-2 inhibition with celecoxib for advanced non-small cell lung cancer progressing after platinum-based chemotherapy: a multicenter phase II trial. Lung Cancer 2005;48:267-273 (Pubitemid 40501817)
    • (2005) Lung Cancer , vol.48 , Issue.2 , pp. 267-273
    • Nugent, F.W.1    Mertens, W.C.2    Graziano, S.3    Levitan, N.4    Collea, R.5    Gajra, A.6    Marshall, J.7    McCann, J.8
  • 53
    • 61449530281 scopus 로고    scopus 로고
    • Phase II study of celecoxib and docetaxel in non-small cell lung cancer (NSCLC) patients with progression after platinum-based therapy
    • Schneider BJ, Kalemkerian GP, Kraut MJ, et al. Phase II study of celecoxib and docetaxel in non-small cell lung cancer (NSCLC) patients with progression after platinum-based therapy. J Thorac Oncol 2008;3:1454-1459
    • (2008) J Thorac Oncol , vol.3 , pp. 1454-1459
    • Schneider, B.J.1    Kalemkerian, G.P.2    Kraut, M.J.3
  • 57
    • 27144497139 scopus 로고    scopus 로고
    • Targeting COX-2/PG-E2 with a COX-2 inhibitor in combination with chemotherapy for non-small cell lung cancer: Are we ready for phase III?
    • Aisner J. Targeting COX-2/PG-E2 with a COX-2 inhibitor in combination with chemotherapy for non-small cell lung cancer: are we ready for phase III? Cancer J 2005;11:201-203
    • (2005) Cancer J , vol.11 , pp. 201-203
    • Aisner, J.1
  • 59
    • 34249942270 scopus 로고    scopus 로고
    • Failure of apoptosis and activation on NFkappaB by celecoxib and aspirin in lung cancer cell lines
    • Gradilone A, Silvestri I, Scarpa S, et al. Failure of apoptosis and activation on NFkappaB by celecoxib and aspirin in lung cancer cell lines. Oncol Rep 2007;17:823-828
    • (2007) Oncol Rep , vol.17 , pp. 823-828
    • Gradilone, A.1    Silvestri, I.2    Scarpa, S.3
  • 62
    • 33646560295 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of docetaxel, irinotecan, and celecoxib in patients with advanced non-small cell lung cancer
    • DOI 10.1007/s10637-005-3259-4
    • Argiris A, Kut V, Luong L, et al. Phase I and pharmacokinetic study of docetaxel, irinotecan, and celecoxib in patients with advanced non-small cell lung cancer. Invest New Drugs 2006;24:203-212 (Pubitemid 43723897)
    • (2006) Investigational New Drugs , vol.24 , Issue.3 , pp. 203-212
    • Argiris, A.1    Kut, V.2    Luong, L.3    Avram, M.J.4
  • 63
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002;2:442-454
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 64
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
    • DOI 10.1016/j.devcel.2008.05.009, PII S1534580708002098
    • Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 2008;14:818-829 (Pubitemid 351757205)
    • (2008) Developmental Cell , vol.14 , Issue.6 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 66
    • 27144477683 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition
    • DOI 10.1158/0008-5472.CAN-05-1058
    • Thomson S, Buck E, Petti F, et al. Epithelial to mesenchymal transition is a determinant of sensitivity of non-small-cell lung carcinoma cell lines and xenografts to epidermal growth factor receptor inhibition. Cancer Res 2005;65:9455-9462 (Pubitemid 41508014)
    • (2005) Cancer Research , vol.65 , Issue.20 , pp. 9455-9462
    • Thomson, S.1    Buck, E.2    Petti, F.3    Griffin, G.4    Brown, E.5    Ramnarine, N.6    Iwata, K.K.7    Gibson, N.8    Haley, J.D.9
  • 69
    • 0346736504 scopus 로고    scopus 로고
    • Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion
    • DOI 10.1074/jbc.M210707200
    • Dohadwala M, Batra RK, Luo J, et al. Autocrine/paracrine prostaglandin E2 production by non-small cell lung cancer cells regulates matrix metalloproteinase-2 and CD44 in cyclooxygenase-2-dependent invasion. J Biol Chem 2002;277:50828-50833 (Pubitemid 36042248)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.52 , pp. 50828-50833
    • Dohadwala, M.1    Batra, R.K.2    Luo, J.3    Lin, Y.4    Krysan, K.5    Pold, M.6    Sharma, S.7    Dubinett, S.M.8
  • 70
    • 33744925683 scopus 로고    scopus 로고
    • Cyclooxygenase-2-dependent regulation of E-cadherin: Prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer
    • Dohadwala M, Yang SC, Luo J, et al. Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. Cancer Res 2006;66:5338-5345
    • (2006) Cancer Res , vol.66 , pp. 5338-5345
    • Dohadwala, M.1    Yang, S.C.2    Luo, J.3
  • 73
    • 23044454675 scopus 로고    scopus 로고
    • Significant effect of capecitabine on the pharmacokinetics and pharmacodynamics of warfarin in patients with cancer
    • DOI 10.1200/JCO.2005.09.129
    • Camidge R, Reigner B, Cassidy J, et al. Significant effect of capecitabine on the pharmacokinetics and pharmacodynamics of warfarin in patients with cancer. J Clin Oncol 2005;23:4719-4725 (Pubitemid 46224075)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.21 , pp. 4719-4725
    • Camidge, R.1    Reigner, B.2    Cassidy, J.3    Grange, S.4    Abt, M.5    Weidekamm, E.6    Jodrell, D.7
  • 75
    • 34247882824 scopus 로고    scopus 로고
    • Phase II study of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, in patients with platinum refractory non-small cell lung cancer (NSCLC)
    • DOI 10.1097/01.JTO.0000263712.61697.69, PII 0124389420070400000009
    • Gadgeel SM, Ruckdeschel JC, Heath EI, et al. Phase II study of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), and celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, in patients with platinum refractory non-small cell lung cancer (NSCLC). J Thorac Oncol 2007;2:299-305 (Pubitemid 47181712)
    • (2007) Journal of Thoracic Oncology , vol.2 , Issue.4 , pp. 299-305
    • Gadgeel, S.M.1    Ruckdeschel, J.C.2    Heath, E.I.3    Heilbrun, L.K.4    Venkatramanamoorthy, R.5    Wozniak, A.6
  • 76
    • 27544503230 scopus 로고    scopus 로고
    • Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
    • DOI 10.1016/S0140-6736(05)67625-8, PII S0140673605676258
    • Thatcher N, Chang A, Parikh P, et al. Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 2005;366:1527-1537 (Pubitemid 41540110)
    • (2005) Lancet , vol.366 , Issue.9496 , pp. 1527-1537
    • Thatcher, N.1    Chang, A.2    Parikh, P.3    Pereira, J.R.4    Ciuleanu, T.5    Von Pawel, J.6    Thongprasert, S.7    Tan, E.H.8    Pemberton, K.9    Archer, V.10    Carroll, K.11
  • 77
    • 41749124798 scopus 로고    scopus 로고
    • Gefitinib plus celecoxib in chemotherapy-naive patients with stage IIIB/IV non-small cell lung cancer: A phase II study from the Hoosier Oncology Group
    • Agarwala A, Fisher W, Bruetman D, et al. Gefitinib plus celecoxib in chemotherapy-naive patients with stage IIIB/IV non-small cell lung cancer: a phase II study from the Hoosier Oncology Group. J Thorac Oncol 2008;3:374-379
    • (2008) J Thorac Oncol , vol.3 , pp. 374-379
    • Agarwala, A.1    Fisher, W.2    Bruetman, D.3
  • 78
    • 34548212389 scopus 로고    scopus 로고
    • Combination therapy with gefitinib and rofecoxib in patients with platinum-pretreated relapsed non-small-cell lung cancer
    • DOI 10.1200/JCO.2006.09.2791
    • O'Byrne KJ, Danson S, Dunlop D, et al. Combination therapy with gefitinib and rofecoxib in patients with platinum-pretreated relapsed non small-cell lung cancer. J Clin Oncol 2007;25:3266-3273 (Pubitemid 47325611)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.22 , pp. 3266-3273
    • O'Byrne, K.J.1    Danson, S.2    Dunlop, D.3    Botwood, N.4    Taguchi, F.5    Carbone, D.6    Ranson, M.7
  • 79
    • 39749191925 scopus 로고    scopus 로고
    • Epidermal growth factor receptor immunohistochemistry: Comparison of antibodies and cutoff points to predict benefit from gefitinib in a phase 3 placebo-controlled study in advanced nonsmall-cell lung cancer
    • DOI 10.1002/cncr.23282
    • Hirsch FR, Dziadziuszko R, Thatcher N, et al. Epidermal growth factor receptor immunohistochemistry: comparison of antibodies and cutoff points to predict benefit from gefitinib in a phase 3 placebo-controlled study in advanced nonsmall-cell lung cancer. Cancer 2008;112:1114-1121 (Pubitemid 351304597)
    • (2008) Cancer , vol.112 , Issue.5 , pp. 1114-1121
    • Hirsch, F.R.1    Dziadziuszko, R.2    Thatcher, N.3    Mann, H.4    Watkins, C.5    Parums, D.V.6    Speake, G.7    Holloway, B.8    Bunn Jr., P.A.9    Franklin, W.A.10
  • 80
    • 34748817976 scopus 로고    scopus 로고
    • Membrane prostaglandin e synthase-1: A novel therapeutic target
    • DOI 10.1124/pr.59.3.1
    • Samuelsson B, Morgenstern R, Jakobsson P-J. Membrane prostaglandin E synthase-1: A novel therapeutic target. Pharmacol Rev 2007;59:207-224 (Pubitemid 47481434)
    • (2007) Pharmacological Reviews , vol.59 , Issue.3 , pp. 207-224
    • Samuelsson, B.1    Morgenstern, R.2    Jakobsson, P.-J.3
  • 82
    • 56649103898 scopus 로고    scopus 로고
    • Expression and purification of human mPGES-1 in E. coli and identification of inhibitory compounds from a drug-library
    • Kim WI, Choi KA, Do HS, et al. Expression and purification of human mPGES-1 in E. coli and identification of inhibitory compounds from a drug-library. BMB Rep 2008;41:808-813
    • (2008) BMB Rep , vol.41 , pp. 808-813
    • Kim, W.I.1    Choi, K.A.2    Do, H.S.3
  • 83
    • 39449137882 scopus 로고    scopus 로고
    • Human microsomal prostaglandin e synthase-1 (mPGES-1) binding with inhibitors and the quantitative structure-activity correlation
    • DOI 10.1021/ci700315c
    • Abdulhameed MDM, Hamza A, Liu J, et al. Human microsomal prostaglandin E synthase-1 (mPGES-1) binding with inhibitors and the quantitative structure-activity correlation. J Chem Inf Model 2008;48:179-185 (Pubitemid 351271063)
    • (2008) Journal of Chemical Information and Modeling , vol.48 , Issue.1 , pp. 179-185
    • Abdul Hameed, M.D.M.1    Hamza, A.2    Liu, J.3    Huang, X.4    Zhan, C.-G.5
  • 85
    • 48549087414 scopus 로고    scopus 로고
    • 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer
    • Huang G, Eisenberg R, Yan M, et al. 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer. Cancer Res 2008;68:5040-5048
    • (2008) Cancer Res , vol.68 , pp. 5040-5048
    • Huang, G.1    Eisenberg, R.2    Yan, M.3
  • 86
    • 57249089707 scopus 로고    scopus 로고
    • NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer
    • Hughes D, Otani T, Yang P, et al. NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer. Cancer Prev Res 2008;1:241-249
    • (2008) Cancer Prev Res , vol.1 , pp. 241-249
    • Hughes, D.1    Otani, T.2    Yang, P.3
  • 88
    • 13444269594 scopus 로고    scopus 로고
    • +-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer
    • DOI 10.1093/carcin/bgh277
    • Ding Y, Tong M, Liu S, et al. NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer. Carcinogenesis 2005;26:65-72 (Pubitemid 40207700)
    • (2005) Carcinogenesis , vol.26 , Issue.1 , pp. 65-72
    • Ding, Y.1    Tong, M.2    Liu, S.3    Moscow, J.A.4    Tai, H.-H.5
  • 90
    • 44349168815 scopus 로고    scopus 로고
    • 2
    • DOI 10.1038/ng0608-691, PII NG0608691
    • Coggins KG, Coffman TM, Koller BH. The Hippocratic finger points the blame at PGE2. Nat Genet 2008;40:691-692 (Pubitemid 351748881)
    • (2008) Nature Genetics , vol.40 , Issue.6 , pp. 691-692
    • Coggins, K.G.1    Coffman, T.M.2    Koller, B.H.3
  • 91
    • 34347353320 scopus 로고    scopus 로고
    • 2 in non-small-cell lung cancer cells by up-regulating 15-hydroxyprostaglandin dehydrogenase
    • DOI 10.1124/mol.106.033357
    • Hazra S, Batra RK, Tai HH, et al. Pioglitazone and rosiglitazone decrease prostaglandin E2 in non-small-cell lung cancer cells by up-regulating 15-hydroxyprostaglandin dehydrogenase. Mol Pharmacol 2007;71:1715-1720 (Pubitemid 47010924)
    • (2007) Molecular Pharmacology , vol.71 , Issue.6 , pp. 1715-1720
    • Hazra, S.1    Batra, R.K.2    Tai, H.H.3    Sharma, S.4    Cui, X.5    Dubinett, S.M.6
  • 92
    • 61549141756 scopus 로고    scopus 로고
    • Focusing downstream in lung cancer prevention: 15-hydroxyprostaglandin dehydrogenase
    • Dubinett SM, Mao JT, Hazra S. Focusing downstream in lung cancer prevention: 15-hydroxyprostaglandin dehydrogenase. Cancer Prev Res 2008;1:223-225
    • (2008) Cancer Prev Res , vol.1 , pp. 223-225
    • Dubinett, S.M.1    Mao, J.T.2    Hazra, S.3
  • 95
    • 34247160020 scopus 로고    scopus 로고
    • 2 via the phosphatidylinositol 3-kinase and Akt pathway
    • DOI 10.1074/jbc.M610153200
    • Kapoor M, Kojima F, Qian M, et al. Microsomal prostaglandin E synthase-1 deficiency is associated with elevated peroxisome proliferator-activated receptor gamma: regulation by prostaglandin E2 the phosphatidylinositol 3-kinase and Akt pathway. J Biol Chem 2007;282:5356-5366 (Pubitemid 47093760)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.8 , pp. 5356-5366
    • Kapoor, M.1    Kojima, F.2    Qian, M.3    Yang, L.4    Crofford, L.J.5
  • 96
    • 58149178162 scopus 로고    scopus 로고
    • Regression of drug-resistant lung cancer the combination of rosiglitazone and carboplatin
    • Girnun GD, Chen L, Silvaggi J, et al. Regression of drug-resistant lung cancer the combination of rosiglitazone and carboplatin. Clin Cancer Res 2008;14:6478-6486
    • (2008) Clin Cancer Res , vol.14 , pp. 6478-6486
    • Girnun, G.D.1    Chen, L.2    Silvaggi, J.3
  • 98
    • 33645527575 scopus 로고    scopus 로고
    • Prostaglandin e receptor EP4 antagonism inhibits breast cancer metastasis
    • Ma X, Kundu N, Rifat S, et al. Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis. Cancer Res 2006;66:2923-2927
    • (2006) Cancer Res , vol.66 , pp. 2923-2927
    • Ma, X.1    Kundu, N.2    Rifat, S.3
  • 100
    • 39749101912 scopus 로고    scopus 로고
    • Novel strategies for the treatment of lung cancer: Modulation of eicosanoids
    • Backlund MG, Amann JM, Johnson DH. Novel strategies for the treatment of lung cancer: modulation of eicosanoids. J Clin Oncol 2008;26:825-827
    • (2008) J Clin Oncol , vol.26 , pp. 825-827
    • Backlund, M.G.1    Amann, J.M.2    Johnson, D.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.