-
1
-
-
0033791318
-
Cyclooxygenases: Structural, cellular, and molecular biology
-
Smith, W.L., DeWitt, D.L. and Garavito, R.M. (2000) Cyclooxygenases: structural, cellular, and molecular biology. Annu. Rev. Biochem. 69, 145-182.
-
(2000)
Annu. Rev. Biochem
, vol.69
, pp. 145-182
-
-
Smith, W.L.1
DeWitt, D.L.2
Garavito, R.M.3
-
2
-
-
0032701224
-
The cyclooxygenase isoforms: Structural insights into the conversion of arachidonic acid to prostaglandins
-
Garavito, R. M. and Dewitt, D.L. (1999) The cyclooxygenase isoforms: structural insights into the conversion of arachidonic acid to prostaglandins. Biochim. Biochpy. Act. 1441, 278-287.
-
(1999)
Biochim. Biochpy. Act
, vol.1441
, pp. 278-287
-
-
Garavito, R.M.1
Dewitt, D.L.2
-
3
-
-
0034692689
-
-
2 synthase that acts in concert with cyclooxygenase-2. J. Biol. Chem. 275, 32783-32792.
-
2 synthase that acts in concert with cyclooxygenase-2. J. Biol. Chem. 275, 32783-32792.
-
-
-
-
4
-
-
0035830931
-
Cloning, expression, and up-regulation of inducible rat prostaglandin E synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis
-
Mancini, J. A., Blood, K., Guay, J., Gordon, R., Claveau, D., Chan, C. C. and Riendeau, D. (2001) Cloning, expression, and up-regulation of inducible rat prostaglandin E synthase during lipopolysaccharide-induced pyresis and adjuvant-induced arthritis. J. Biol. Chem. 276, 4469-4475.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 4469-4475
-
-
Mancini, J.A.1
Blood, K.2
Guay, J.3
Gordon, R.4
Claveau, D.5
Chan, C.C.6
Riendeau, D.7
-
5
-
-
0035400078
-
Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells
-
Stichtenoth, D.O., Thorén, S., Bian, H., Peters-Golden, M., Jakobsson, P. J. and Crofford, L.J. (2001) Microsomal prostaglandin E synthase is regulated by proinflammatory cytokines and glucocorticoids in primary rheumatoid synovial cells. J. Immunol. 167, 469-574.
-
(2001)
J. Immunol
, vol.167
, pp. 469-574
-
-
Stichtenoth, D.O.1
Thorén, S.2
Bian, H.3
Peters-Golden, M.4
Jakobsson, P.J.5
Crofford, L.J.6
-
6
-
-
0035823609
-
Molecular cloning and induction of bovine prostaglandin E synthase by gonadotropins in ovarian follicles prior to ovulation in vivo
-
Filion, F., Bouchard, N., Goff, A. K., Lussier, J. G. and Sirois, J. (2001) Molecular cloning and induction of bovine prostaglandin E synthase by gonadotropins in ovarian follicles prior to ovulation in vivo. J. Biol. Chem. 276, 34323-34330.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 34323-34330
-
-
Filion, F.1
Bouchard, N.2
Goff, A.K.3
Lussier, J.G.4
Sirois, J.5
-
7
-
-
0038482089
-
Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis
-
Kamei, D., Murakami, M., Nakatani, Y., Ishikawa, Y., Ishii, T. and Kudo, I. (2003) Potential role of microsomal prostaglandin E synthase-1 in tumorigenesis. J. Biol. Chem. 278, 19396-19405.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 19396-19405
-
-
Kamei, D.1
Murakami, M.2
Nakatani, Y.3
Ishikawa, Y.4
Ishii, T.5
Kudo, I.6
-
8
-
-
0034817040
-
Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer
-
Yoshimatsu, K., Altorki, N. K., Golijanin, D., Zhang, F., Jakobsson, P. J., Dannenberg, A. J. and Subbaramaiah, K. (2001) Inducible prostaglandin E synthase is overexpressed in non-small cell lung cancer. Clin. Cancer Res. 7, 2608-2610.
-
(2001)
Clin. Cancer Res
, vol.7
, pp. 2608-2610
-
-
Yoshimatsu, K.1
Altorki, N.K.2
Golijanin, D.3
Zhang, F.4
Jakobsson, P.J.5
Dannenberg, A.J.6
Subbaramaiah, K.7
-
9
-
-
0033594963
-
Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target
-
Jakobsson, P. J., Thorén, S., Morgenstern, R. and Samuelsson, B. (1999) Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc. Natl. Acsd. Aci. U.S.A. 96, 7220-7225.
-
(1999)
Proc. Natl. Acsd. Aci. U.S.A
, vol.96
, pp. 7220-7225
-
-
Jakobsson, P.J.1
Thorén, S.2
Morgenstern, R.3
Samuelsson, B.4
-
10
-
-
0037967579
-
2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase
-
2 release via the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase. FEBS Lett. 547, 75-79.
-
(2003)
FEBS Lett
, vol.547
, pp. 75-79
-
-
Catley, M.C.1
Chivers, J.E.2
Cambridge, L.M.3
Holden, N.4
Slater, D.M.5
Staples, K.J.6
Bergmann, M.W.7
Loser, P.8
Barnes, P.J.9
Newton, R.10
-
11
-
-
0032521038
-
2, cyclooxygenases, and terminal prostanoid synthases in different phases of prostanoid biosynthesis in rat peritoneal macrophages
-
2, cyclooxygenases, and terminal prostanoid synthases in different phases of prostanoid biosynthesis in rat peritoneal macrophages. J. Immunol. 160, 2974-2982.
-
(1998)
J. Immunol
, vol.160
, pp. 2974-2982
-
-
Naraba, H.1
Murakami, M.2
Matsumoto, H.3
Shimbara, S.4
Ueno, A.5
Kudo, I.6
Oh-ishi, S.7
-
13
-
-
0032541676
-
3
-
3. Nature 395, 281-284.
-
(1998)
Nature
, vol.395
, pp. 281-284
-
-
Ushikubi, F.1
Segi, E.2
Sugimoto, Y.3
Murata, T.4
Matsuoka, T.5
Kobayashi, T.6
Hizaki, H.7
Tuboi, K.8
Katsuyama, M.9
Ichikawa, A.10
Tanaka, T.11
Yoshida, N.12
Narumiya, S.13
-
14
-
-
0036316688
-
Prostanoids and pain: Unraveling mechanisms and revealing therapeutic targets
-
Samad, T. A., Sapirstein A. and Woolf, C. J. (2002) Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets. Trends Mol. Med. 8, 390-396.
-
(2002)
Trends Mol. Med
, vol.8
, pp. 390-396
-
-
Samad, T.A.1
Sapirstein, A.2
Woolf, C.J.3
-
16
-
-
0036291419
-
Identification and Characterization of a Novel Type of Membrane-Associated Prostaglandin E Synthase
-
Tanikawa, N., Ohmiya, Y., Ohkubo, H., Hashimoto, K., Kangawa, K., Kojima, M., Ito, S. and Watanabe, K. (2002) Identification and Characterization of a Novel Type of Membrane-Associated Prostaglandin E Synthase. Biochem. Biophys. Res. Comm. 291, 884-889.
-
(2002)
Biochem. Biophys. Res. Comm
, vol.291
, pp. 884-889
-
-
Tanikawa, N.1
Ohmiya, Y.2
Ohkubo, H.3
Hashimoto, K.4
Kangawa, K.5
Kojima, M.6
Ito, S.7
Watanabe, K.8
-
17
-
-
33646415952
-
Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function
-
Cheng, Y., Wang, M., Yu, Y., Lawson, J., Funk, C. D. and Fitzgerald, G. A. (2006) Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. J. Clin. Invest. 116, 1391-1399.
-
(2006)
J. Clin. Invest
, vol.116
, pp. 1391-1399
-
-
Cheng, Y.1
Wang, M.2
Yu, Y.3
Lawson, J.4
Funk, C.D.5
Fitzgerald, G.A.6
-
18
-
-
0043261465
-
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase
-
Trebino, C. E., Stock, J. L., Gibbons, C. P., Naiman, B. M., Wachtmann, T. S., Umland, J. P., Pandher, K., Lapointe, J. M., Saha, S., Roach, M. L., Carter, D., Thomas, N. A., Durtschi, B. A., McNeish, J. D., Hambor, J. E., Jakobsson, P. J., Carty, T. J., Perez, J. R. and Audoly, L. P. (2003) Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. Proc. Natl. Acad. Sci. U. S. A. 100, 9044-9049.
-
(2003)
Proc. Natl. Acad. Sci. U. S. A
, vol.100
, pp. 9044-9049
-
-
Trebino, C.E.1
Stock, J.L.2
Gibbons, C.P.3
Naiman, B.M.4
Wachtmann, T.S.5
Umland, J.P.6
Pandher, K.7
Lapointe, J.M.8
Saha, S.9
Roach, M.L.10
Carter, D.11
Thomas, N.A.12
Durtschi, B.A.13
McNeish, J.D.14
Hambor, J.E.15
Jakobsson, P.J.16
Carty, T.J.17
Perez, J.R.18
Audoly, L.P.19
-
20
-
-
0037087760
-
Inhibition of inducible prostaglandin E(2) synthase by 15-deoxy-Delta(12,14)-prostaglandin J(2) and polyunsaturated fatty acids
-
Quraishi, O., Mancini, J. A. and Riendeau, D. (2002) Inhibition of inducible prostaglandin E(2) synthase by 15-deoxy-Delta(12,14)-prostaglandin J(2) and polyunsaturated fatty acids. Biochem Pharmacol. 63, 1183-1189.
-
(2002)
Biochem Pharmacol
, vol.63
, pp. 1183-1189
-
-
Quraishi, O.1
Mancini, J.A.2
Riendeau, D.3
-
21
-
-
0033755897
-
Coordinate up- and downregulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4
-
Thorén, S. and Jakobsson, P. J. (2000) Coordinate up- and downregulation of glutathione-dependent prostaglandin E synthase and cyclooxygenase-2 in A549 cells. Inhibition by NS-398 and leukotriene C4. Eur. J. Biochem. 267, 6428-6434.
-
(2000)
Eur. J. Biochem
, vol.267
, pp. 6428-6434
-
-
Thorén, S.1
Jakobsson, P.J.2
-
22
-
-
20644467057
-
2 synthase (mPGES-1) derived from MK-886
-
2 synthase (mPGES-1) derived from MK-886. Bioorg. Med. Chem. Lett. 15, 3352-3355.
-
(2005)
Bioorg. Med. Chem. Lett
, vol.15
, pp. 3352-3355
-
-
Riendeau, D.1
Aspiotis, R.2
Ethier, D.3
Gareau, Y.4
Grimm, E.L.5
Guay, J.6
Guiral, S.7
Juteau, H.8
Mancini, J.A.9
Méthot, N.10
Rubin, J.11
Friesen, R.W.12
-
23
-
-
35848954713
-
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors
-
Côté, B., Boulet, L., Brideau, C., Claveau, D., Ethier, D., Frenette, R., Gagnon, M., Giroux, A., Guay, J., Guiral, S., Mancini, J., Martins, E., Massé, F., Méthot, N., Riendeau, D., Rubin, J., Xu, D., Yu, H., Ducharme, Y. and Friesen, R. W. (2007) Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors. Bioorg. Med. Chem. Lett. 17, 6816-6820.
-
(2007)
Bioorg. Med. Chem. Lett
, vol.17
, pp. 6816-6820
-
-
Côté, B.1
Boulet, L.2
Brideau, C.3
Claveau, D.4
Ethier, D.5
Frenette, R.6
Gagnon, M.7
Giroux, A.8
Guay, J.9
Guiral, S.10
Mancini, J.11
Martins, E.12
Massé, F.13
Méthot, N.14
Riendeau, D.15
Rubin, J.16
Xu, D.17
Yu, H.18
Ducharme, Y.19
Friesen, R.W.20
more..
-
24
-
-
33645881701
-
Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis
-
Huang, X., Yan, W., Gao, D., Tong, M., Tai, H. H. and Zhan, C. G. (2006) Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis. Bioorg. Med. Chem. 14, 3553-3562.
-
(2006)
Bioorg. Med. Chem
, vol.14
, pp. 3553-3562
-
-
Huang, X.1
Yan, W.2
Gao, D.3
Tong, M.4
Tai, H.H.5
Zhan, C.G.6
-
25
-
-
0028830109
-
Expression and selective inhibition of the constitutive and inducible forms of human cyclooxygenase
-
Gierse, J. K., Hauser, S. D., Creely, D. P., Koboldt, C., Rangwala, S. H., Isakson, P. C. and Seibert, K. (1995) Expression and selective inhibition of the constitutive and inducible forms of human cyclooxygenase. Biochem J. 305, 479-484.
-
(1995)
Biochem J
, vol.305
, pp. 479-484
-
-
Gierse, J.K.1
Hauser, S.D.2
Creely, D.P.3
Koboldt, C.4
Rangwala, S.H.5
Isakson, P.C.6
Seibert, K.7
-
26
-
-
0036028701
-
Purification and crystallization of N-terminally truncated forms of microsomal cytochrome P450 2C5
-
Wester, M. R., Stout, C. D. and Johnson, E. F. (2002) Purification and crystallization of N-terminally truncated forms of microsomal cytochrome P450 2C5. Methods Enzymol. 357, 73-79.
-
(2002)
Methods Enzymol
, vol.357
, pp. 73-79
-
-
Wester, M.R.1
Stout, C.D.2
Johnson, E.F.3
-
27
-
-
0038266571
-
Human microsomal prostaglandin E synthase-1: Purification, functional characterization, and projection structure determination
-
Thorén, S., Weinander, R., Saha, S., Jegerschöld, C., Pettersson, P. L., Samuelsson, B., Hebert, H., Hamberg, M., Morgenstern, R. and Jakobsson, P. J. (2003) Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination. J. Biol. Chem. 278, 22199-22209.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 22199-22209
-
-
Thorén, S.1
Weinander, R.2
Saha, S.3
Jegerschöld, C.4
Pettersson, P.L.5
Samuelsson, B.6
Hebert, H.7
Hamberg, M.8
Morgenstern, R.9
Jakobsson, P.J.10
-
28
-
-
0036919589
-
Purification and characterization of recombinant microsomal prostaglandin E synthase-1
-
Ouellet, M., Falgueyret, J. P., Ear, P. H., Pen, A., Mancini, J. A., Riendeau, D. and Percival, M. D. (2002) Purification and characterization of recombinant microsomal prostaglandin E synthase-1. Protein Expr. Purif. 26, 489-495.
-
(2002)
Protein Expr. Purif
, vol.26
, pp. 489-495
-
-
Ouellet, M.1
Falgueyret, J.P.2
Ear, P.H.3
Pen, A.4
Mancini, J.A.5
Riendeau, D.6
Percival, M.D.7
-
29
-
-
24944518576
-
An automated multistep high-throughput screening assay for the identification of lead inhibitors of the inducible enzyme mPGES-1
-
Masse, F., Guiral, S., Fortin, L. J., Cauchon, E., Ethier, D., Guay, J. and Brideau, C. (2005) An automated multistep high-throughput screening assay for the identification of lead inhibitors of the inducible enzyme mPGES-1. J. Biomol. Screen. 10, 599-605.
-
(2005)
J. Biomol. Screen
, vol.10
, pp. 599-605
-
-
Masse, F.1
Guiral, S.2
Fortin, L.J.3
Cauchon, E.4
Ethier, D.5
Guay, J.6
Brideau, C.7
-
30
-
-
71849104860
-
Protein measurement with the folin phenol reagent
-
Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951) Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265-275.
-
(1951)
J. Biol. Chem
, vol.193
, pp. 265-275
-
-
Lowry, O.H.1
Rosebrough, N.J.2
Farr, A.L.3
Randall, R.J.4
|