A Ca2+ channel blocker-like effect of dehydrocurdione on rodent intestinal and vascular smooth muscle

European Journal of Pharmacology

Volumn 403, Issue 3, 2000, Pages 235-242

  Irie, Kaoru ^a   Yoshioka, Toshimasa ^a   Nakai, Ai ^b   Ochiai, Kumiko ^b   Nishikori, Tomohiro ^a   Wu, Gui Ron ^a   Shibuya, Hirotaka ^c   Muraki, Takamura ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c FUKUYAMA UNIVERSITY   (Japan)

Author keywords

Ca2+ channel blocker; Herbal drug; Sesquiterpene; Smooth muscle

Indexed keywords

ACETYLCHOLINE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; DEHYDROCURDIONE; FURA 2; HERBACEOUS AGENT; HISTAMINE; NOR ADRENALIN; NORADRENALIN; POTASSIUM; SESQUITERPENE; SUBSTANCE P; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; DUODENUM MOTILITY; GUINEA PIG; ILEUM CONTRACTION; INTESTINE MUSCLE; MALE; MESENTERIC ARTERY; NONHUMAN; PRIORITY JOURNAL; RAT; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CALCIUM; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DUODENUM; GUINEA PIGS; ILEUM; MALE; MESENTERIC ARTERIES; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, WISTAR; SESQUITERPENES;

EID: 0034623176     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00445-3     Document Type: Article

References (14)

1. Hikino H., Konno C., Takemoto T. Structure of dehydrocurdione, a sesquiterpenoid of Curcuma zedoaria. Chem. Pharm. Bull. 20:1972;987-989.
2. Itokawa H., Mihashi S., Watanabe K., Matsumoto H., Hamanaka T. Studies on the constituents of crude drugs having inhibitory activity against contraction of the ileum caused by histamine or barium chloride (1) screening test for the activity of commercially available crude drugs and the related plant materials. Shoyakugaku Zasshi. 37:1983;223-228.
3. Karaki H., Ozaki H., Hori M., Mitui-Saito M., Amano K., Harada K., Miyamoto S., Nakazawa H., Won K.-J., Sato K. Calcium movements, distribution, and functions in smooth muscle. Pharmacol. Rev. 49:1997;157-230.
4. 3 production. Eur. J. Pharmacol. 218:1992;27-33.
5. Maeda H., Sunagane N., Kubota K. Pharmacological effects of the poweder from Curcuma zodoaria Roscoe on the gastrointestinal tract of experimental animals. Yakugaku Zasshi. 104:1984;640-643.
6. Nakanishi T., Gu H., Abe K., Momma K. Developmental changes in the contractile system of the mesenteric small artery of rabbit. Pediatr. Res. 41:1997;65-71.
7. 2+-dependent and independent mechanisms of sustained contraction in vascular smooth muscle of rat aorta. Jpn. J. Pharmacol. 52:1990;509-512.
8. Sato K., Ozaki H., Karaki H. Changes in cytosolic calcium level in vascular smooth muscle strip measured simultaneously with contraction using fluorescent calcium indicator Fura-2. J. Pharmacol. Exp. Ther. 246:1988;294-300.
9. Shibuya H., Yoshihara M., Kitano E., Nadasawa M., Kitagawa I. Qualitative and Quantitative analysis of essential oil constituents in various Zedoariae Rhizoma (Gajutsu) by means of gas liquid chromatography-mass spectrometry. Yakugaku Zasshi. 106:1986;212-216.
10. Somlyo A.P., Somlyo A.V. Signal transduction and regulation in smooth muscle. Nature. 372:1994;231-236.
11. 2+-entry blockade by CAF603, a carotane sesquiterpene isolated from Trichoderma virens. Eur. J. Pharmacol. 335:1997;153-159.
12. Surprenant A. Control of the gastrointestinal tract by enteric neurons. Annu. Rev. Physiol. 56:1994;117-140.
13. Watanabe K., Shibata M., Yano S., Cai Y., Shibuya H., Kitagawa I. Antiulcer activity of extracts and isolated compounds from zedoary (Gajutsu) cultivated in Yakushima (Japan). Yakugaku Zasshi. 106:1986;1137-1142.
14. Yoshioka T., Fujii M., Endo M., Wada K., Tokunaga Y., Shiba N., Hosho H., Shibuya H., Muraki T. Antiinflammatory potency of dehydrocurdione, a zedoary-derived sesquiterpene. Inflammation Res. 47:1998;476-481.