NF-κB regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-κB site in the ICAM-1 gene

Physiological Genomics

Volumn 38, Issue 1, 2009, Pages 42-53

  Xue, Jiaping ^a   Thippegowda, Prabhakar B ^a   Hu, Guochang ^a   Bachmaier, Kurt ^a   Christman, John W ^a   Malik, Asrar B ^a   Tiruppathi, Chinnaswamy ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Calcineurin; Endothelial cells; Intercellular adhesion molecule 1; Nuclear factor of activated T cells; Nuclear factor B; Protease activated receptor 1; Tumor necrosis factor

Indexed keywords

CALCINEURIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; PROTEINASE ACTIVATED RECEPTOR 1; SMALL INTERFERING RNA; THROMBIN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; PRIMER DNA;

ARTICLE; BINDING SITE; CELL ADHESION; CHROMATIN IMMUNOPRECIPITATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INTRON; NEUTROPHIL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; CELL CULTURE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; METABOLISM; PHYSIOLOGY;

BASE SEQUENCE; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTRONS; NF-KAPPA B; NFATC TRANSCRIPTION FACTORS; RNA, SMALL INTERFERING; THROMBIN;

EID: 67649503016     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00012.2009     Document Type: Article

References (41)

1. Anderson DC, Rothlein R, Marlin SD, Krater SS, Smith CW. Impaired transendothelial migration by neonatal neutrophils: abnormalities of Mac-1 (CD11b/CD18)-dependent adherence reactions. Blood 76: 2613-2621, 1990.
2. Anwar KN, Fazal F, Malik AB, Rahman A. RhoA/Rho-associated kinase pathway selectively regulates thrombin-induced intercellular adhesion molecule-1 expression in endothelial cells via activation of I kappa B kinase beta and phosphorylation of RelA/p65. J Immunol 173: 6965-6972, 2004. (Pubitemid 39541085)
3. Aramburu J, Heitman J, Crabtree GR. Calcineurin: a central controller of signalling in eukaryotes. EMBO Rep 5: 343-348, 2004.
4. Badran BM, Kunstman K, Stanton J, Moschitta M, Zerghe A, Akl H, Burny A, Wolinsky SM, and Willard-Gallo KE. Transcriptional regulation of the human CD3 gamma gene: the TATA-less CD3 gamma promoter functions via an initiator and contiguous Sp-binding elements. J Immunol 174: 6238-6249, 2005. (Pubitemid 40663816)
5. Badran BM, Wolinsky SM, Burny A, Willard-Gallo KE. Identification of three NFAT binding motifs in the 5′-upstream region of the human CD3gamma gene that differentially bind NFATc1, NFATc2, and NF-kappa B p50. J Biol Chem 277: 47136-47148, 2002. (Pubitemid 36159223)
6. 2+ entry via TRPC channels is necessary for thrombin-induced NF-kappaB activation in endothelial cells through AMP-activated protein kinase and protein kinase Cdelta. J Biol Chem 284: 563-574, 2009.
7. Coughlin SR. Protease-activated receptors in vascular biology. Thromb Haemost 86: 298-307, 2001. (Pubitemid 32663960)
8. Coughlin SR. Thrombin signalling and protease-activated receptors. Nature 407: 258-264, 2000.
9. Crabtree GR, Olson EN. NFAT signaling: choreographing the social lives of cells. Cell 109, Suppl: S67-S79, 2002. (Pubitemid 34457853)
10. Diamond MS, Staunton DE, Marlin SD, Springer TA. Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation. Cell 65: 961-971, 1991. (Pubitemid 121001684)
11. 2+ response amplitude and duration. Nature 386: 855-858, 1997.
12. Dolmetsch RE, Xu K, Lewis RS. Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392: 933-936, 1998. (Pubitemid 28232066)
13. Ge B, Li O, Wilder P, Rizzino A, McKeithan TW. NF-κB regulates BCL3 transcription in T lymphocytes through an intronic enhancer. J Immunol 171: 4210-4218, 2003.
14. Hu G, Salem MR, Crystal GJ. Isoflurane and sevoflurane precondition against neutrophil-induced contractile dysfunction in isolated rat hearts. Anesthesiology 100: 489-497, 2004. (Pubitemid 38268864)
15. Hu G, Ye RD, Dinauer MC, Malik AB, Minshall RD. Neutrophil caveolin-1 expression contributes to mechanism of lung inflammation and injury. Am J Physiol Lung Cell Mol Physiol 294: L178-L186, 2008. (Pubitemid 351253354)
16. Kronschnabl M, Stamminger T. Synergistic induction of intercellular adhesion molecule-1 by the human cytomegalovirus transactivators IE2p86 and pp71 is mediated via an Sp1-binding site. J Gen Virol 84: 61-73, 2003. (Pubitemid 36113550)
17. Ledebur HC, Parks TP. Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells. Essential roles of a variant NF-kappa B site and p65 homodimers. J Biol Chem 270: 933-943, 1995.
18. Liu JO. Endogenous protein inhibitors of calcineurin. Biochem Biophys Res Commun 311: 1103-1109, 2003. (Pubitemid 37393433)
19. Liu X, Ye L, Christianson GJ, Yang JQ, Roopenian DC, Zhu X. NF-kappaB signaling regulates functional expression of the MHC class I-related neonatal Fc receptor for IgG via intronic binding sequences. J Immunol 179: 2999-3011, 2007.
20. Miho N, Ishida T, Kuwaba N, Ishida M, Shimote-Abe K, Tabuchi K, Oshima T, Yoshizumi M, Chayama K. Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells. Cardiovasc Res 68: 289-298, 2005. (Pubitemid 41428425)
21. Minami T, Miura M, Aird WC, Kodama T. Thrombin-induced autoinhibitory factor, down syndrome critical region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 expression and inflammation in endothelium. J Biol Chem 281: 20503-20520, 2006. (Pubitemid 44065823)
22. Nilsson LM, Nilsson-Ohman J, Zetterqvist AV, Gomez MF. Nuclear factor of activated T-cells transcription factors in the vasculature: the good guys or the bad guys? Curr Opin Lipidol 19: 483-490, 2008.
23. Paria BC, Malik AB, Kwiatek AM, Rahman A, May MJ, Ghosh S, Tiruppathi C. Tumor necrosis factor-alpha induces nuclear factor-kappaB-dependent TRPC1 expression in endothelial cells. J Biol Chem 278: 37195-37203, 2003. (Pubitemid 37175235)
24. 2+ influx and endothelial permeability. Am J Physiol Lung Cell Mol Physiol 287: L1303-L1313, 2004.
25. Quinlan KL, Naik SM, Cannon G, Armstrong CA, Bunnett NW, Ansel JC, Caughman SW. Substance P activates coincident NF-AT- and NF-kappa B-dependent adhesion molecule gene expression in microvascular endothelial cells through intracellular calcium mobilization. J Immunol 163: 5656-5665, 1999.
26. Rahman A, Anwar KN, True AL, Malik AB. Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion. J Immunol 162: 5466-5476, 1999. (Pubitemid 29307157)
27. Rahman A, True AL, Anwar KN, Ye RD, Voyno-Yasenetskaya TA, Malik AB. Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells. Circ Res 91: 398-405, 2002. (Pubitemid 35034207)
28. Roebuck KA. Oxidant stress regulation of IL-8 and ICAM-1 gene expression: differential activation and binding of the transcription factors AP-1 and NF-kappaB (Review). Int J Mol Med 4: 223-230, 1999.
29. Roebuck KA, Finnegan A. Regulation of intercellular adhesion molecule-1 (CD54) gene expression. J Leukoc Biol 66: 876-888, 1999. (Pubitemid 30010511)
30. Roy J, Audette M, Tremblay MJ. Intercellular adhesion molecule-1 (ICAM-1) gene expression in human T cells is regulated by phosphotyrosyl phosphatase activity. Involvement of NF-kappaB, Ets, and palindromic interferon-gamma- responsive element-binding sites. J Biol Chem 276: 14553-14561, 2001. (Pubitemid 37373324)
31. Rusnak F, Mertz P. Calcineurin: form and function. Physiol Rev 80: 1483-1521, 2000. (Pubitemid 30764162)
32. Schjerven H, Brandtzaeg P, Johansen FE. A novel NF-kappa B/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-alpha-induced transcription of the human polymeric Ig receptor. J Immunol 167: 6412-6420, 2001. (Pubitemid 33081574)
33. Smith CW, Marlin SD, Rothlein R, Toman C, Anderson DC. Cooperative interactions of LFA-1 and Mac-1 with intercellular adhesion molecule-1 in facilitating adherence and transendothelial migration of human neutrophils in vitro. J Clin Invest 83: 2008-2017, 1989. (Pubitemid 19148873)
34. Springer TA. Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76: 301-314, 1994. (Pubitemid 24046692)
35. Staunton DE, Dustin ML, Erickson HP, Springer TA. The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus. Cell 61: 243-254, 1990. (Pubitemid 20149356)
36. Staunton DE, Marlin SD, Stratowa C, Dustin ML, Springer TA. Primary structure of ICAM-1 demonstrates interaction between members of the immunoglobulin and integrin supergene families. Cell 52: 925-933, 1988.
37. 2+ signaling, TRP channels, and endothelial permeability. Microcirculation 13: 693-708, 2006.
38. Tiruppathi C, Shimizu J, Miyawaki-Shimizu K, Vogel SM, Bair AM, Minshall RD, Predescu D, Malik AB. Role of NF-kappaB-dependent caveolin-1 expression in the mechanism of increased endothelial permeability induced by lipopolysaccharide. J Biol Chem 283: 4210-4218, 2008.
39. Van de Stolpe A, Caldenhoven E, Stade BG, Koenderman L, Raaijmakers JA, Johnson JP, van der Saag PT. 12-O-tetradecanoylphorbol-13-acetate- and tumor necrosis factor alpha-mediated induction of intercellular adhesion molecule-1 is inhibited by dexamethasone. Functional analysis of the human intercellular adhesion molecular-1 promoter. J Biol Chem 269: 6185-6192, 1994. (Pubitemid 24978716)
40. Voraberger G, Schafer R, Stratowa C. Cloning of the human gene for intercellular adhesion molecule 1 and analysis of its 5′-regulatory region. Induction by cytokines and phorbol ester. J Immunol 147: 2777-2786, 1991.
41. Wung BS, Ni CW, Wang DL. ICAM-1 induction by TNFalpha and IL-6 is mediated by distinct pathways via Rac in endothelial cells. J Biomed Sci 12: 91-101, 2005. (Pubitemid 40576767)