Epigallocatechin gallate preserves endothelial function by reducing the endogenous nitric oxide synthase inhibitor level

Canadian Journal of Physiology and Pharmacology

Volumn 84, Issue 2, 2006, Pages 163-171

  Tang, Wei Jun ^a   Hu, Chang Ping ^a   Chen, Mei Fang ^b   Deng, Pan Yue ^a   Li, Yuan Jian ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Asymmetric dimethylarginine; Dimethylarginine dimethylaminohydrolase; Endothelial cells; Epigallocatechin gallate; Low density lipoprotein; Tumor necrosis factor

Indexed keywords

ACETYLCHOLINE; EPIGALLOCATECHIN GALLATE; LACTATE DEHYDROGENASE; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; N(G),N(G) DIMETHYLARGININE; NITRATE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; TUMOR NECROSIS FACTOR ALPHA;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; PRIORITY JOURNAL; SMOOTH MUSCLE TONE;

ANIMALS; ARGININE; CATECHIN; CELLS, CULTURED; CHOLESTEROL, LDL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; HUMANS; MALE; NITRIC OXIDE SYNTHASE; RATS; RATS, SPRAGUE-DAWLEY; VASODILATION;

EID: 33745133405     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y05-156     Document Type: Article

References (42)

1. Berliner, J.A., and Heinecke, J.W. 1996. The role of oxidized lipoproteins in atherosclerosis. Free Radic. Biol. Med. 20: 707-727. doi: 10.1016/0891-5849(95)02173-6. PMID: 8721615.
2. Böger, R.H., Bode-Böger, S.M., Szuba, A., Tsao, P.S., Chan, J.R., Tangphao, O., Blaschke, T.F., and Cooke, J.P. 1998. Asymmetric dimethylarginine: a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation, 98: 1842-1847. PMID: 9799202.
3. Böger, R.H., Bode-Böger, S.M., Sydow, K., Heistad, D.D., and Lentz, S.R. 2000a. Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia. Arterioscler. Thromb. Vasc. Biol. 20: 1557-1564. PMID: 10845872.
4. Böger, R.H., Sydow, K., Borlak, J., Thum, T., Lenzen, H., Schubert, B., Tsikas, D., and Bode-Böger, S.M. 2000e. LDL cholesterol upregulates synthesis of asymmetrical dimethylarginine in human endothelial cells: involvement of S-adenosylmethionine-dependent methyltransferases. Circ. Res. 87: 99-105. PMID: 10903992.
5. Bode-Boger, S.M., Boger, R.H., Kienke, S., Junker, W., and Frölich, J.C. 1996. Elevated L-arginine/dimethylarginie ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits. Biochem. Biophys. Res. Commun. 219: 598-603. PMID: 8605033.
6. Calara, F., Dimayuga, P., Niemann, A., Thyberg, J., Diczfalusy, U., Witztum, J.L., et al. 1998. An animal model to study local oxidation of LDL and its biological effects in the arterial wall. Arterioscler. Thromb. Vasc. Biol. 18: 884-893. PMID: 9633927.
7. G-dimethylarginine in human plasma by high-performance liquid chromatography. J. Chromatogr. B Biomed. Sci. Appl. 692: 467-471. doi: 10.1016/S0378-4347(96)00531-2. PMID: 9188838.
8. Choi, Y.J., Kang, J.S., Park, J.H., Lee, Y.J., Choi, J.S., and Kang, Y.H. 2003. Polyphenolic flavonoids differ in their antiapoptotic efficacy in hydrogen peroxide-treated human vascular endothelial cells. J. Nutr. 133: 985-991. PMID: 12672908.
9. Cooke, J.P. 2000. Does ADMA cause endothelial dysfunction? Arterioscler. Thromb. Vasc. Biol. 20: 2032-2037. PMID: 10978245.
10. Deng, S., Deng, P.Y., Jiang, J.L., Ye, F., Yu, J., Yang, T.L., Deng, H.D., and Li, Y.J. 2004. Aspirin protected against endothelial damage induced by LDL: role of endogenous NO synthase inhibitors in rats. Acta Pharmacol. Sin. 25: 1633-1639. PMID: 15569408.
11. Feng, Q., Lu, X., Jones, D.L., Shen, J., and Arnold, J.M. 2001. Increased inducible nitric oxide synthase expression contributes to myocardial dysfunction and higher mortality after myocardial infarction in mice. Circulation, 104: 700-704. PMID: 11489778.
12. Fujiki, H. 1999. Two stages of cancer prevention with green tea. J. Cancer Res. Clin. Oncol. 125: 589-597. doi: 10.1007/S004320050321. PMID: 10541965.
13. Havel, R.J., Eder, H.A., and Bragdon, J.H. 1955. The distribution and chemical composition of ultra-centrifugally separated lipoproteins in human serum. J. Clin. Invest. 34: 1345-1353. PMID: 13252080.
14. Hashimoto, T., Suganuma, M., Fujiki, H., Yamada, M., Kohno, T., and Asakawa, Y. 2003. Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum). Phytomedicine, 10: 309-317. doi: 10.1078/094471103322004802. PMID: 12809361.
15. Higdon, J.V., and Frei, B. 2003. Tea catechins and polyphenols: health effects, metabolism, and antioxidant functions. Crit. Rev. Food Sci. Nutr, 43: 89-143. doi: 10.1080/10408690390826464. PMID: 12587987.
16. Huang, Y., Zhang, A., Lau, C.W., and Chen, Z.Y. 1998. Vasorelaxant effects of purified green tea epicatechin derivatives in rat mesenteric artery. Life Sci. 63: 275-283. doi: 10.1016/S0024-3205(98)00273-2. PMID: 9698036.
17. Huang, Y., Chan, N.W., Lau, C.W., Yao, X.Q., Chan, F.L., and Chen, Z.Y. 1999. Involvement of endothelium/nitric oxide in vasorelaxation induced by purified green tea (-)epicatechin. Biochim. Biophys. Acta, 1427: 322-328. PMID: 10216249.
18. Imai, K., and Nakachi, K. 1995. Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases. BMJ, 310: 693-696. PMID: 7711535.
19. Ito, A., Tsao, P.S., Adimoolam, S., Kimoto, M., Ogawa, T., and Cooke, J.P. 1999. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation, 99: 3092-3095. PMID: 10377069.
20. Jiang, D.J., Jiang, J.L., Tan, G.S., Huang, Z.Z., Deng, H.W., and Li, Y.J. 2003. Demethylbellidifolin inhibits adhesion of monocytes to endothelial cells via reduction of tumor necrosis factor alpha and endogenous nitric oxide synthase inhibitor level. Planta Med. 69: 1150-1152. PMID: 14750034.
21. Jiang, D.J., Jiang, J.L., Zhu, H.Q., Tan, G.S., Liu, S.Q., Xu, K.P., and Li, Y.J. 2004a. Demethylbellidifolin preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level. J. Ethnopharmacol. 93: 295-306. doi: 10.1016/j. jep.2004.03.055. PMID: 15234768.
22. Jiang, J.L., Jiang, D.J., Tang, Y.H., Li, N.S., Deng, H.W., and Li, Y.J. 2004e. Effect of simvastatin on endothelium-dependent vasorelaxation and endogenous nitric oxide synthase inhibitor. Acta Pharmacol. Sin. 25: 893-901. PMID: 15210062.
23. Jiang, J.L., Li, N.S., Li, Y.J., and Deng, H.W. 2002. Probucol preserves endothelial function by reduction of the endogenous nitric oxide synthase inhibitor level. Br. J. Pharmacol. 135: 1175-1182. doi: 10.1038/sj.bjp.0704563. PMID: 11877324.
24. Kimoto, M., Whitley, G.S., Tsuji, H., and Ogawa, T. 1995. Detection of NG,NG-dimethylarginine dimethylaminohydrolase in human tissues using a monoclonal antibody. J. Biochem. (Tokyo), 117: 237-238. PMID: 7608105.
25. Kono, S., Shinchi, K., Wakabayashi, K., Honjo, S., Todoroki, L, Sakurai, Y., et al. 1996. Relation of green tea consumption to serum lipids and lipoproteins in Japanese men. J. Epidemiol. 6: 128-133. PMID: 8952216.
26. Kurowska, E.M. 2002. Nitric oxide therapies in vascular diseases. Curr. Pharm. Des. 8: 155-166. doi: 10.2174/1381612023396429. PMID: 11812265.
27. Leiper, J., and Vallance, P. 1999. Biological significance of endogenous methylarginines that inhibit nitric oxide synthases. Cardiovasc. Res. 43: 542-548. doi: 10.1016/S0008-6363(99)00162-5. PMID: 10690326.
28. Libby, P. 2002. Inflammation in atherosclerosis. Nature, 420: 868-874. doi: 10.1038/nature01323. PMID: 12490960.
29. Lin, K.Y., Ito, A., Asagami, T., Tsao, P.S., Adimoolam, S., Kimoto, M., et al. 2002. Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Circulation, 106: 987-992. doi: 10.1161/01.CIR.0000027109.14149.67. PMID: 12186805.
30. Lorenz, M., Wessler, S., Follmann, E., Michaelis, W., Dusterhoft, T., Baumann, G., Stangl, K., and Stangl, V. 2004. A constituent of green tea, epigallocatechin-3-gallate, activates endothelial nitric oxide synthase by a phosphatidylinositol-3-OH-kinase-, cAMP-dependent protein kinase-, and Akt-dependent pathway and leads to endothelial-dependent vasorelaxation. J. Biol. Chem. 279: 6190-6195. PMID: 14645258.
31. Ludwig, A., Lorenz, M., Grimbo, N., Steinle, F., Meiners, S., Bartsch, C., et al. 2004. The tea flavonoid epigallocatechin-3-gallate reduces cytokine-induced VCAM-1 expression and monocyte adhesion to endothelial cells. Biochem. Biophys. Res. Commun. 316: 659-665. doi: 10.1016/j.bbrc.2004.02.099. PMID: 15033450.
32. Ohkawa, H., Ohishi, N., and Yagi, K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95: 351-358. doi: 10.1016/0003-2697(79)90738-3. PMID: 36810.
33. Ramadass, P., Meerarani, P., Toborek, M., Robertson, L.W., and Hennig, B. 2003. Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells. Toxicol. Sci. 76: 212-219. doi: 10.1093/toxsci/kfg227. PMID: 12970578.
34. Saran, R., Novak, I.E., Desai, A., Abdulhayoglu, E., Warren, J.S., Bustami, R., et al. 2003. Impact of vitamin E on plasma asymmetric dimethylarginine (ADMA) in chronic kidney disease (CKD): a pilot study. Nephrol. Dial. Transplant. 18: 2415-2420. PMID: 14551376.
35. Steinberg, D. 1997. Low density lipoprotein oxidation and its pathobiological significance. J. Biol. Chem. 272: 20963-20966. doi: 10.1074/jbc.272.34.20963. PMID: 9261091.
36. Stuhlinger, M.C., Tsao, P.S., Her, J.H., Kimoto, M., Balint, R.F., and Cooke, J.P. 2001. Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Circulation, 104: 2569-2575. PMID: 11714652.
37. Teppo, A.M., and Maury, C.P. 1987. Radioimmunoassay of tumor necrosis factor in serum. Clin. Chem. 33: 2024-2027. PMID: 3677374.
38. Tsubono, Y., and Tsugane, S. 1997. Green tea intake in relation to serum lipid levels in middle-aged Japanese men and women. Ann. Epidemiol. 7: 280-284. doi: 10.1016/S1047-2797(97)00005-7. PMID: 9177111.
39. Xiong, Y., Li, Y.J., Yu, X.J., Liu, G.Z., and Li, N.S. 1996. Endogenous inhibitors of nitric oxide synthesis and lipid peroxidation in hyperlipidemic rabbits. Zhongguo Yao Li Xue Bao 17: 149-152. PMID: 9772666.
40. Yang, T.L., Chen, M.F., Luo, B.L., Yu, J., Jiang, J.L., and Li, Y.J. 2004. Effect of fenofibrate on LDL-induced endothelial dysfunction in rats. Naunyn Schmiedebergs Arch. Pharmacol. 370: 79-83. PMID: 15316718.
41. Yoshida, H., Ishikawa, T., Hosoai, H., Suzukawa, M., Ayaori, M., Hisada, T., et al. 1999. Inhibitory effect of tea flavonoids on the ability of cells to oxidize low density lipoprotein. Biochem. Pharmacol. 58: 1695-1703. doi: 10.1016/S0006-2952(99)00256-7. PMID: 10571243.
42. Yu, X.J., Li, Y.J., and Xiong, Y. 1994. Increase of an endogenous inhibitor of nitric oxide synthesis in serum of high cholesterol fed rabbits. Life Sci. 54: 753-758. doi: 10.1016/0024-3205(94) 00443-9. PMID: 8121238.