Nifedipine inhibits activation of transcription factor NF-κB

Life Sciences

Volumn 67, Issue 21, 2000, Pages 2655-2661

  Matsumori, Akira ^a   Nunokawa, Youichi ^b   Sasayama, Shigetake ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SUNTORY LTD   (Japan)

Author keywords

Calcium channel blockers; Cytokine; Immunosuppression; NF B; Nifedipine

Indexed keywords

AMLODIPINE; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; DILTIAZEM; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; NIFEDIPINE; PHORBOL 13 ACETATE 12 MYRISTATE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; VERAPAMIL;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA BINDING; DRUG EFFECT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOSUPPRESSIVE TREATMENT; MOUSE; NONHUMAN; TRANSCRIPTION INITIATION; VASCULAR SMOOTH MUSCLE;

ANIMALIA;

EID: 0034644766     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(00)00849-3     Document Type: Article

References (30)

1. Effects of calcium and its antagonists on the canine mesenteric circulation
2. ++ antagonist-induced vasodilation. Intracellular actions
3. Mechanism of action of calcium-channel-blocking agents
4. Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialyzed heart cells
5. The interference of T cell activation by calcium channel blocking agents
6. Potent and specific inhibition of IL-8, IL-1α- and IL-1β-induced in vitro human lymphocyte migration by calcium channel antagonists
7. 45Ca uptake and histamine release in rat mast cells induced by various stimulating agents
8. Inhibition of macrophage activation by calcium channel blockers and calmodulin antagonists
9. The suppression of macrophage secretion by calcium blockers and adenosine
10. Calcium channel blockers suppress the contact hypersensitivity reaction (CHR) by inhibiting antigen transport and presentation by epidermal Langerhans cells in mice
11. Manidipine regulates the transcription of cytokine genes
12. Ca(2+)-channel blockers modulate the expression of interleukin-6 and interleukin-8 genes in human vascular smooth muscle cells
13. Calcium channel blockers activate the interleukin-6 gene via the transcription factors NF-IL6 and NF-κB in primary human vascular smooth muscle cells
14. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
15. Multiple nuclear factors interact with the immunoglobulin enhancer sequences
16. NF-κB and rel proteins in innate immunity
17. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-κB
18. Cross-coupling of the NF-κB p65 and Fos/Jun transcription factors produces potentiated biological function
19. Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
20. Inhibition of NF-κB by sodium salicylate and aspirin
21. Inhibition of the DNA-binding activity of NF-κB by gold compounds in vitro
22. Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8
23. Transcriptional modulation of human IL-6 gene expression by verapamil
24. Ca(2+)-channel blockers modulate expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and low density lipoprotein receptor genes stimulated by platelet-derived growth factor
25. Function and activation of NF-κB in the immune system
26. The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation
27. Signal transduction through NF-κB
28. Effect of nifedipine on renal transplant rejection
29. Excellent outcome with a calcium channel blocker-supplemented immunosuppressive regimen in cadaveric renal transplantation. A potential strategy to avoid antibody induction protocols
30. The NF-kB and I-κB proteins: New discoveries and insights