메뉴 건너뛰기




Volumn 1279, Issue , 2009, Pages 189-196

Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent subchronic administration of donepezil: Role of sigma-1 receptors

Author keywords

Cognition; NMDA receptor; Phencyclidine; Schizophrenia; Sigma 1 receptor

Indexed keywords

2 [4 METHOXY 3 (2 PHENYLETHOXY)PHENYL] N,N DIPROPYLETHYLAMINE; DONEPEZIL; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENCYCLIDINE; PHYSOSTIGMINE; SIGMA 1 OPIATE RECEPTOR;

EID: 67649398772     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.05.004     Document Type: Article
Times cited : (65)

References (62)
  • 2
    • 39749154052 scopus 로고    scopus 로고
    • Differential regulation of the NMDA receptor by acute and sub-chronic phencyclidine administration in the developing rat
    • Anastasio N.C., and Johnson K.M. Differential regulation of the NMDA receptor by acute and sub-chronic phencyclidine administration in the developing rat. J. Neurochem. 104 (2008) 1210-1218
    • (2008) J. Neurochem. , vol.104 , pp. 1210-1218
    • Anastasio, N.C.1    Johnson, K.M.2
  • 3
    • 17144365477 scopus 로고    scopus 로고
    • The role of sigma receptors in depression
    • Bermack J.E., and Debonnel G. The role of sigma receptors in depression. J. Pharmacol. Sci. 97 (2005) 317-336
    • (2005) J. Pharmacol. Sci. , vol.97 , pp. 317-336
    • Bermack, J.E.1    Debonnel, G.2
  • 5
    • 0037209930 scopus 로고    scopus 로고
    • An open-labeled trial of adjunctive donepezil for cognitive impairments in patients with schizophrenia
    • Buchanan R.W., Summerfelt A., Tek C., and Gold J. An open-labeled trial of adjunctive donepezil for cognitive impairments in patients with schizophrenia. Schizophr. Res. 59 (2003) 29-33
    • (2003) Schizophr. Res. , vol.59 , pp. 29-33
    • Buchanan, R.W.1    Summerfelt, A.2    Tek, C.3    Gold, J.4
  • 6
    • 67649406776 scopus 로고    scopus 로고
    • Effect of donepezil added to atypical antipsychotics on cognition in patients with schizophrenia: an open-label trial
    • Chung Y.G., Lee C.R., Park T.W., Yang K.H., and Kim K.W. Effect of donepezil added to atypical antipsychotics on cognition in patients with schizophrenia: an open-label trial. World J. Biol. Psychiatry 10 (2009) 156-162
    • (2009) World J. Biol. Psychiatry , vol.10 , pp. 156-162
    • Chung, Y.G.1    Lee, C.R.2    Park, T.W.3    Yang, K.H.4    Kim, K.W.5
  • 7
    • 0030044715 scopus 로고    scopus 로고
    • The glutamatergic dysfunction hypothesis for schizophrenia
    • Coyle J.T. The glutamatergic dysfunction hypothesis for schizophrenia. Harv. Rev. Psychiatry 3 (1996) 241-253
    • (1996) Harv. Rev. Psychiatry , vol.3 , pp. 241-253
    • Coyle, J.T.1
  • 8
    • 3142737856 scopus 로고    scopus 로고
    • The NMDA receptor glycine modulatory site: a therapeutic target for improving cognition and reducing negative symptoms in schizophrenia
    • Coyle J.T., and Tsai G. The NMDA receptor glycine modulatory site: a therapeutic target for improving cognition and reducing negative symptoms in schizophrenia. Psychopharmacology (Berl) 174 (2004) 32-38
    • (2004) Psychopharmacology (Berl) , vol.174 , pp. 32-38
    • Coyle, J.T.1    Tsai, G.2
  • 10
    • 33846815311 scopus 로고    scopus 로고
    • Effects of donepezil adjunctive treatment to ziprasidone on cognitive deficits in schizophrenia: a double-blind, placebo-controlled study
    • Fagerlund B., Soholm B., Fink-Jensen A., Lublin H., and Glenthoj B.Y. Effects of donepezil adjunctive treatment to ziprasidone on cognitive deficits in schizophrenia: a double-blind, placebo-controlled study. Clin. Neuropharmacol. 30 (2007) 3-12
    • (2007) Clin. Neuropharmacol. , vol.30 , pp. 3-12
    • Fagerlund, B.1    Soholm, B.2    Fink-Jensen, A.3    Lublin, H.4    Glenthoj, B.Y.5
  • 11
    • 0142244688 scopus 로고    scopus 로고
    • Schizophrenia
    • Freedman R. Schizophrenia. N. Engl. J. Med. 349 (2003) 1738-1749
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1738-1749
    • Freedman, R.1
  • 13
    • 3142746642 scopus 로고    scopus 로고
    • Cholinergic targets for cognitive enhancement in schizophrenia: focus on cholinesterase inhibitors and muscarinic agonists
    • Friedman J.I. Cholinergic targets for cognitive enhancement in schizophrenia: focus on cholinesterase inhibitors and muscarinic agonists. Psychopharmacology (Berl) 174 (2004) 45-53
    • (2004) Psychopharmacology (Berl) , vol.174 , pp. 45-53
    • Friedman, J.I.1
  • 16
    • 3843108019 scopus 로고    scopus 로고
    • Sigma receptors: biology and therapeutic potential
    • Guitart X., Codony X., and Monroy X. Sigma receptors: biology and therapeutic potential. Psychopharmacology (Berl) 174 (2004) 301-319
    • (2004) Psychopharmacology (Berl) , vol.174 , pp. 301-319
    • Guitart, X.1    Codony, X.2    Monroy, X.3
  • 17
    • 67649390249 scopus 로고    scopus 로고
    • Hashimoto, K., in press. Sigma-1 receptors and selective serotonin reuptake inhibitors: clinical implications of their relationship. CNS Agents Med. Chem.
    • Hashimoto, K., in press. Sigma-1 receptors and selective serotonin reuptake inhibitors: clinical implications of their relationship. CNS Agents Med. Chem.
  • 18
    • 0005847382 scopus 로고
    • Imaging sigma receptors and cerebral responses to sigma drugs
    • Itzhak Y. (Ed), Academic. Press, New York
    • Hashimoto K., and London E.D. Imaging sigma receptors and cerebral responses to sigma drugs. In: Itzhak Y. (Ed). Sigma Receptors (1994), Academic. Press, New York 225-242
    • (1994) Sigma Receptors , pp. 225-242
    • Hashimoto, K.1    London, E.D.2
  • 19
    • 0028797501 scopus 로고
    • Interactions of erythro-ifenprodil, threo-ifenprodil, erythro-iodoifenprodil, and eliprodil with subtypes of sigma receptors
    • Hashimoto K., and London E.D. Interactions of erythro-ifenprodil, threo-ifenprodil, erythro-iodoifenprodil, and eliprodil with subtypes of sigma receptors. Eur. J. Pharmacol. 273 (1995) 307-310
    • (1995) Eur. J. Pharmacol. , vol.273 , pp. 307-310
    • Hashimoto, K.1    London, E.D.2
  • 20
    • 33749852123 scopus 로고    scopus 로고
    • Sigma receptor ligands: possible application as therapeutic drugs and as radiopharmaceuticals
    • Hashimoto K., and Ishiwata K. Sigma receptor ligands: possible application as therapeutic drugs and as radiopharmaceuticals. Curr. Pharm. Des. 12 (2006) 3857-3876
    • (2006) Curr. Pharm. Des. , vol.12 , pp. 3857-3876
    • Hashimoto, K.1    Ishiwata, K.2
  • 22
    • 2442614201 scopus 로고    scopus 로고
    • Glutamate hypothesis of schizophrenia and approach for possible therapeutic drugs
    • Hashimoto K., Okamura N., Shimizu E., and Iyo M. Glutamate hypothesis of schizophrenia and approach for possible therapeutic drugs. Curr. Med. Chem-CNS.Agents 4 (2004) 147-154
    • (2004) Curr. Med. Chem-CNS.Agents , vol.4 , pp. 147-154
    • Hashimoto, K.1    Okamura, N.2    Shimizu, E.3    Iyo, M.4
  • 23
    • 27744572308 scopus 로고    scopus 로고
    • Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of clozapine, but not haloperidol
    • Hashimoto K., Fujita Y., Shimizu E., and Iyo M. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of clozapine, but not haloperidol. Eur. J. Pharmacol. 519 (2005) 114-117
    • (2005) Eur. J. Pharmacol. , vol.519 , pp. 114-117
    • Hashimoto, K.1    Fujita, Y.2    Shimizu, E.3    Iyo, M.4
  • 24
    • 21244442890 scopus 로고    scopus 로고
    • Dysfunction of glia-neuron communication in pathophysiology of schizophrenia
    • Hashimoto K., Shimizu E., and Iyo M. Dysfunction of glia-neuron communication in pathophysiology of schizophrenia. Curr. Psychiatry Rev. 1 (2005) 151-163
    • (2005) Curr. Psychiatry Rev. , vol.1 , pp. 151-163
    • Hashimoto, K.1    Shimizu, E.2    Iyo, M.3
  • 25
    • 33847044420 scopus 로고    scopus 로고
    • Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of fluvoxamine: role of sigma-1 receptors
    • Hashimoto K., Fujita Y., and Iyo M. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of fluvoxamine: role of sigma-1 receptors. Neuropsychopharmacology 32 (2007) 514-521
    • (2007) Neuropsychopharmacology , vol.32 , pp. 514-521
    • Hashimoto, K.1    Fujita, Y.2    Iyo, M.3
  • 26
    • 36849055179 scopus 로고    scopus 로고
    • Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective α7 nicotinic receptor agonist SSR180711
    • Hashimoto K., Ishima T., Fujita Y., Matsuo M., Kobashi T., Takahagi M., Tsukada H., and Iyo M. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the novel selective α7 nicotinic receptor agonist SSR180711. Biol. Psychiatry 63 (2008) 92-97
    • (2008) Biol. Psychiatry , vol.63 , pp. 92-97
    • Hashimoto, K.1    Ishima, T.2    Fujita, Y.3    Matsuo, M.4    Kobashi, T.5    Takahagi, M.6    Tsukada, H.7    Iyo, M.8
  • 27
    • 1942485807 scopus 로고    scopus 로고
    • Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders
    • Hayashi T., and Su T.P. Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders. CNS Drugs 18 (2004) 269-284
    • (2004) CNS Drugs , vol.18 , pp. 269-284
    • Hayashi, T.1    Su, T.P.2
  • 28
    • 35549006797 scopus 로고    scopus 로고
    • 2+ signaling and cell survival
    • 2+ signaling and cell survival. Cell 131 (2007) 596-610
    • (2007) Cell , vol.131 , pp. 596-610
    • Hayashi, T.1    Su, T.P.2
  • 35
    • 0025952455 scopus 로고
    • Recent advances in the phencyclidine model of schizophrenia
    • Javitt D.C., and Zukin S.R. Recent advances in the phencyclidine model of schizophrenia. Am. J. Psychiatry 148 (1991) 1301-1308
    • (1991) Am. J. Psychiatry , vol.148 , pp. 1301-1308
    • Javitt, D.C.1    Zukin, S.R.2
  • 36
    • 0842286593 scopus 로고    scopus 로고
    • Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-d-aspartate receptor/glycine-site agonists
    • Javitt D.C., Balla A., Burch S., Suckow R., Xie S., and Sershen H. Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-d-aspartate receptor/glycine-site agonists. Neuropsychopharmacology 29 (2004) 300-307
    • (2004) Neuropsychopharmacology , vol.29 , pp. 300-307
    • Javitt, D.C.1    Balla, A.2    Burch, S.3    Suckow, R.4    Xie, S.5    Sershen, H.6
  • 37
    • 0032903301 scopus 로고    scopus 로고
    • The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia
    • Jentsch J.D., and Roth R.H. The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 20 (1999) 201-225
    • (1999) Neuropsychopharmacology , vol.20 , pp. 201-225
    • Jentsch, J.D.1    Roth, R.H.2
  • 38
    • 0033593489 scopus 로고    scopus 로고
    • TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons
    • Kato K., Hayako H., Ishihara Y., Marui S., Iwane M., and Miyamoto M. TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons. Neurosci. Lett. 260 (1999) 5-8
    • (1999) Neurosci. Lett. , vol.260 , pp. 5-8
    • Kato, K.1    Hayako, H.2    Ishihara, Y.3    Marui, S.4    Iwane, M.5    Miyamoto, M.6
  • 39
    • 42049123448 scopus 로고    scopus 로고
    • Efficacy and safety of donepezil in patients with schizophrenia or schizoaffective disorder: significant placebo/practice effects in a 12-week, randomized, double-blind, placebo-controlled trial
    • Keefe R.S., Malhotra A.K., Meltzer H.Y., Kane J.M., Buchanan R.W., Murthy A., Sovel M., Li C., and Goldman R. Efficacy and safety of donepezil in patients with schizophrenia or schizoaffective disorder: significant placebo/practice effects in a 12-week, randomized, double-blind, placebo-controlled trial. Neuropsychopharmacology 33 (2008) 1217-1228
    • (2008) Neuropsychopharmacology , vol.33 , pp. 1217-1228
    • Keefe, R.S.1    Malhotra, A.K.2    Meltzer, H.Y.3    Kane, J.M.4    Buchanan, R.W.5    Murthy, A.6    Sovel, M.7    Li, C.8    Goldman, R.9
  • 41
    • 13444271819 scopus 로고    scopus 로고
    • Neurocognitive impairment across the lifespan in schizophrenia: an update
    • Kurtz M.M. Neurocognitive impairment across the lifespan in schizophrenia: an update. Schizophr. Res. 74 (2005) 15-26
    • (2005) Schizophr. Res. , vol.74 , pp. 15-26
    • Kurtz, M.M.1
  • 42
    • 0035216181 scopus 로고    scopus 로고
    • Donepezil in schizophrenia-is it helpful? An experimental design case study
    • MacEwan G.W., Ehmann T.S., Khanbhai I., and Wrixon C. Donepezil in schizophrenia-is it helpful? An experimental design case study. Acta Psychiatr. Scand. 104 (2001) 469-472
    • (2001) Acta Psychiatr. Scand. , vol.104 , pp. 469-472
    • MacEwan, G.W.1    Ehmann, T.S.2    Khanbhai, I.3    Wrixon, C.4
  • 43
    • 1442299144 scopus 로고    scopus 로고
    • Repeated administration of phencyclidine, amphetamine and MK-801 selectively impairs spatial learning in mice: a possible model of psychotomimetic drug-induced cognitive deficits
    • Mandillo S., Rinaldi A., Oliverio A., and Mele A. Repeated administration of phencyclidine, amphetamine and MK-801 selectively impairs spatial learning in mice: a possible model of psychotomimetic drug-induced cognitive deficits. Behav. Pharmacol. 14 (2003) 533-544
    • (2003) Behav. Pharmacol. , vol.14 , pp. 533-544
    • Mandillo, S.1    Rinaldi, A.2    Oliverio, A.3    Mele, A.4
  • 44
    • 0035170334 scopus 로고    scopus 로고
    • Dysregulation of cellular calcium homeostasis in Alzheimer's disease: bad genes and bad habits
    • Mattson M.P., and Chan S.L. Dysregulation of cellular calcium homeostasis in Alzheimer's disease: bad genes and bad habits. J. Mol. Neurosci. 17 (2001) 205-224
    • (2001) J. Mol. Neurosci. , vol.17 , pp. 205-224
    • Mattson, M.P.1    Chan, S.L.2
  • 45
    • 0035660075 scopus 로고    scopus 로고
    • The interaction between neuroactive steroids and the sigma-1 receptor function: behavioral consequences and therapeutic opportunities
    • Maurice T., Urani A., Phan V.L., and Romieu P. The interaction between neuroactive steroids and the sigma-1 receptor function: behavioral consequences and therapeutic opportunities. Brain Res. Rev. 37 (2001) 116-132
    • (2001) Brain Res. Rev. , vol.37 , pp. 116-132
    • Maurice, T.1    Urani, A.2    Phan, V.L.3    Romieu, P.4
  • 46
    • 33645885043 scopus 로고    scopus 로고
    • Interaction with sigma-1 protein, but not N-methyl-d-aspartate receptor, is involved in the pharmacological activity of donepezil
    • Maurice T., Meunier J., Feng B., Ieni J., and Monaghan D.T. Interaction with sigma-1 protein, but not N-methyl-d-aspartate receptor, is involved in the pharmacological activity of donepezil. J. Pharmacol. Exp. Ther. 317 (2006) 606-614
    • (2006) J. Pharmacol. Exp. Ther. , vol.317 , pp. 606-614
    • Maurice, T.1    Meunier, J.2    Feng, B.3    Ieni, J.4    Monaghan, D.T.5
  • 47
    • 33646757887 scopus 로고    scopus 로고
    • Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas
    • Meunier J., Ieni J., and Maurice T. Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. J. Pharmacol. Exp. Ther. 317 (2006) 1307-1319
    • (2006) J. Pharmacol. Exp. Ther. , vol.317 , pp. 1307-1319
    • Meunier, J.1    Ieni, J.2    Maurice, T.3
  • 48
    • 33845651380 scopus 로고    scopus 로고
    • The anti-amnesic and neuroprotective effects of donepezil against amyloid-β25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor
    • Meunier J., Ieni J., and Maurice T. The anti-amnesic and neuroprotective effects of donepezil against amyloid-β25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor. Br. J. Pharmacol. 149 (2006) 998-1012
    • (2006) Br. J. Pharmacol. , vol.149 , pp. 998-1012
    • Meunier, J.1    Ieni, J.2    Maurice, T.3
  • 49
    • 33244462381 scopus 로고    scopus 로고
    • The sigma-1 protein as a target for the non-genomic effects of neuro(active)steroids: molecular, physiological, and behavioral aspects
    • Monnet F.P., and Maurice T. The sigma-1 protein as a target for the non-genomic effects of neuro(active)steroids: molecular, physiological, and behavioral aspects. J. Pharmacol. Sci. 100 (2006) 93-118
    • (2006) J. Pharmacol. Sci. , vol.100 , pp. 93-118
    • Monnet, F.P.1    Maurice, T.2
  • 50
    • 0034610743 scopus 로고    scopus 로고
    • Caspase-12 mediated ebdoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
    • Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., and Yuan J. Caspase-12 mediated ebdoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403 (2000) 98-103
    • (2000) Nature , vol.403 , pp. 98-103
    • Nakagawa, T.1    Zhu, H.2    Morishima, N.3    Li, E.4    Xu, J.5    Yankner, B.A.6    Yuan, J.7
  • 51
    • 0030594575 scopus 로고    scopus 로고
    • Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain
    • Narita N., Hashimoto K., Tomitaka S., and Minabe Y. Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain. Eur. J. Pharmacol. 307 (1996) 117-119
    • (1996) Eur. J. Pharmacol. , vol.307 , pp. 117-119
    • Narita, N.1    Hashimoto, K.2    Tomitaka, S.3    Minabe, Y.4
  • 52
    • 0030017401 scopus 로고    scopus 로고
    • NE-100: a novel sigma receptor antagonist
    • Okuyama S., and Nakazato A. NE-100: a novel sigma receptor antagonist. CNS Drug Rev. 2 (1996) 226-237
    • (1996) CNS Drug Rev. , vol.2 , pp. 226-237
    • Okuyama, S.1    Nakazato, A.2
  • 53
    • 0028850552 scopus 로고
    • Glutamate receptor dysfunction and schizophrenia
    • Olney J.W., and Farber N.B. Glutamate receptor dysfunction and schizophrenia. Arch. Gen. Psychiatry 52 (1995) 998-1007
    • (1995) Arch. Gen. Psychiatry , vol.52 , pp. 998-1007
    • Olney, J.W.1    Farber, N.B.2
  • 55
    • 34249317238 scopus 로고    scopus 로고
    • Double-blind donepezil-placebo crossover augmentation study of atypical antipsychotics in chronic, stable schizophrenia: a pilot study
    • Risch S.C., Horner M.D., McGurk S., Palecko S., Markowitz J.S., Nahas Z., and DeVane C.L. Double-blind donepezil-placebo crossover augmentation study of atypical antipsychotics in chronic, stable schizophrenia: a pilot study. Schizophr. Res. 93 (2007) 131-135
    • (2007) Schizophr. Res. , vol.93 , pp. 131-135
    • Risch, S.C.1    Horner, M.D.2    McGurk, S.3    Palecko, S.4    Markowitz, J.S.5    Nahas, Z.6    DeVane, C.L.7
  • 57
    • 0031045754 scopus 로고    scopus 로고
    • Reduction of the scopolamine-induced impairment of passive-avoidance performance by sigma receptor agonist in mice
    • Senda T., Matsuno K., Kobayashi T., and Mita S. Reduction of the scopolamine-induced impairment of passive-avoidance performance by sigma receptor agonist in mice. Physiol. Behav. 61 (1997) 257-264
    • (1997) Physiol. Behav. , vol.61 , pp. 257-264
    • Senda, T.1    Matsuno, K.2    Kobayashi, T.3    Mita, S.4
  • 58
    • 0026631524 scopus 로고
    • Alterations in phencyclidine and sigma binding sites in schizophrenic brains. Effects of disease process and neuroleptic medication
    • Shibuya H., Mori H., and Toru M. Alterations in phencyclidine and sigma binding sites in schizophrenic brains. Effects of disease process and neuroleptic medication. Neurochem. Res. 17 (1992) 983-990
    • (1992) Neurochem. Res. , vol.17 , pp. 983-990
    • Shibuya, H.1    Mori, H.2    Toru, M.3
  • 59
    • 0025720980 scopus 로고
    • Alterations in phencyclidine and sigma binding sites in schizophrenic brains. Effects of disease process and neuroleptic medication
    • Simpson M.D., Slater P., Royston M.C., and Deakin J.F. Alterations in phencyclidine and sigma binding sites in schizophrenic brains. Effects of disease process and neuroleptic medication. Schizophr. Res. 6 (1991) 41-48
    • (1991) Schizophr. Res. , vol.6 , pp. 41-48
    • Simpson, M.D.1    Slater, P.2    Royston, M.C.3    Deakin, J.F.4
  • 60
    • 0141426716 scopus 로고    scopus 로고
    • Understanding the molecular mechanism of sigma-1 receptors: towards a hypothesis that sigma-1 receptors are intracellular amplifiers for signal transduction
    • Su T.P., and Hayashi T. Understanding the molecular mechanism of sigma-1 receptors: towards a hypothesis that sigma-1 receptors are intracellular amplifiers for signal transduction. Curr. Med. Chem. 10 (2003) 2073-2080
    • (2003) Curr. Med. Chem. , vol.10 , pp. 2073-2080
    • Su, T.P.1    Hayashi, T.2
  • 61
    • 17544402307 scopus 로고    scopus 로고
    • A double-blind, placebo controlled, cross-over trial of adjunctive donepezil for cognitive impairment in schizophrenia
    • Tugal O., Yazici K.M., Anil Yagcioglu A.E., and Gogus A. A double-blind, placebo controlled, cross-over trial of adjunctive donepezil for cognitive impairment in schizophrenia. Int. J. Neuropsychopharmacol. 7 (2004) 117-123
    • (2004) Int. J. Neuropsychopharmacol. , vol.7 , pp. 117-123
    • Tugal, O.1    Yazici, K.M.2    Anil Yagcioglu, A.E.3    Gogus, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.