Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of clozapine, but not haloperidol

European Journal of Pharmacology

Volumn 519, Issue 1-2, 2005, Pages 114-117

  Hashimoto, Kenji ^a   Fujita, Yuko ^a   Shimizu, Eiji ^a   Iyo, Masaomi ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Clozapine; Cognition; Haloperidol; NMDA receptor; Phencyclidine; Schizophrenia

Indexed keywords

CLOZAPINE; HALOPERIDOL; PHENCYCLIDINE; NEUROLEPTIC AGENT; PSYCHEDELIC AGENT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; EXPLORATORY BEHAVIOR; MALE; MEMORY CONSOLIDATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECOGNITION; ANALYSIS OF VARIANCE; ANIMAL; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG EFFECT; INSTITUTE FOR CANCER RESEARCH MOUSE; TIME;

ANALYSIS OF VARIANCE; ANIMALS; ANTIPSYCHOTIC AGENTS; BEHAVIOR, ANIMAL; CLOZAPINE; COGNITION DISORDERS; EXPLORATORY BEHAVIOR; HALLUCINOGENS; HALOPERIDOL; MALE; MICE; MICE, INBRED ICR; PHENCYCLIDINE; TIME FACTORS;

EID: 27744572308     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.07.002     Document Type: Article

References (17)

1. J.T. Coyle The glutamatergic dysfunction hypothesis for schizophrenia Harv. Rev. Psychiatry 3 1996 241 253
2. R. Freedman Schizophrenia N. Engl. J. Med. 349 2003 1738 1749
3. M.F. Green, K.H. Nuechterlein, J.M. Gold, D.M. Barch, J. Cohen, S. Essock, W.S. Fenton, F. Frese, T.E. Goldberg, R.K. Heaton, R.S. Keefe, R.S. Kern, H. Kraemer, E. Stover, D.R. Weinberger, S. Zalcman, and S.R. Marder Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria Biol. Psychiatry 56 2004 301 307
4. K. Hashimoto, T. Fukushima, E. Shimizu, N. Komatsu, H. Watanabe, N. Shinoda, M. Nakazato, C. Kumakiri, S. Okada, H. Hasegawa, K. Imai, and M. Iyo Decreased serum levels of d-serine in patients with schizophrenia: evidence in support of the N-methyl-d-aspartate receptor hypofunction hypothesis of schizophrenia Arch. Gen. Psychiatry 60 2003 572 576
5. K. Hashimoto, K. Okamura, E. Shimizu, and M. Iyo Glutamate hypothesis of schizophrenia and approach for possible therapeutic drugs Curr. Med. Chem.-CNS Agents 4 2004 147 154
6. K. Hashimoto, E. Shimizu, and M. Iyo Dysfunction of glia-neuron communication in pathophysiology of schizophrenia Curr. Psychiatry Rev. 1 2005 151 163
7. D.C. Javitt, and S.R. Zukin Recent advances in the phencyclidine model of schizophrenia Am. J. Psychiatry 148 1991 1301 1308
8. J.D. Jentsch, and R.H. Roth The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia Neuropsychopharmacology 20 1999 201 225
9. J.H. Krystal, D.C. D'Souza, I.L. Petrakis, A. Belger, R.M. Berman, D.S. Charney, W. Abi-Saab, and S. Madonick NMDA agonists and antagonists as probes of glutamatergic dysfunction and pharmacotherapies in neuropsychiatric disorders Harv. Rev. Psychiatry 7 1999 125 143
10. S. Mandillo, A. Rinaldi, A. Oliverio, and A. Mele Repeated administration of phencyclidine, amphetamine and MK-801 selectively impairs spatial learning in mice: a possible model of psychotomimetic drug-induced cognitive deficits Behav. Pharmacol. 14 2003 533 544
11. J.W. Olney, and N.B. Farber Glutamate receptor dysfunction and schizophrenia Arch. Gen. Psychiatry 52 1995 998 1007
12. S.G. Potkin, K. Fleming, Y. Jin, and B. Gulasekaram Clozapine enhances neurocognition and clinical symptomatology more than standard neuroleptics J. Clin. Psychopharmacol. 21 2001 479 483
13. F. Sams-Dodd Effects of continuous d-amphetamine and phencyclidine administration on social behaviour, stereotyped behaviour, and locomotor activity in rats Neuropsychopharmacology 19 1998 18 25
14. Y.P. Tang, E. Shimizu, G.R. Dube, C. Rampon, G.A. Kerchner, M. Zhuo, G. Liu, and J.Z. Tsien Genetic enhancement of learning and memory in mice Nature 401 1999 63 69
15. Y.P. Tang, H. Wang, R. Feng, M. Kyin, and J.Z. Tsien Differential effects of enrichment on learning and memory function in NR2B transgenic mice Neuropharmacology 41 2001 779 790
16. K.K. Zakzanis Neuropsychological correlates of positive vs. negative schizophrenic symptomatology Schizophr. Res. 29 1998 227 233
17. L. Zuckerman, M. Rehavi, R. Nachman, and I. Weiner Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia Neuropsychopharmacology 28 2003 1778 1789