Inhibitory effects of eicosapentaenoic acid on chronic cerebral vasospasm after subarachnoid hemorrhage: Possible involvement of a sphingosylphosphorylcholine-Rho-kinase pathway

Cerebrovascular Diseases

Volumn 26, Issue 1, 2008, Pages 30-37

  Shirao, Satoshi ^a   Fujisawa, Hirosuke ^a   Kudo, Akira ^b   Kurokawa, Tetsu ^a   Yoneda, Hiroshi ^a   Kunitsugu, Ichiro ^a   Ogasawara, Kuniaki ^b   Soma, Masaaki ^c   Kobayashi, Sei ^a   Ogawa, Akira ^b   Suzuki, Michiyasu ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b IWATE MEDICAL UNIVERSITY   (Japan)

^c MOCHIDA PHARMACEUTICAL CO   (Japan)

Author keywords

Eicosapentaenoic acid; Rho kinase; Sphingosylphosphorylcholine; Subarachnoid hemorrhage; Vasospasm

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CALCIUM ION; ICOSAPENTAENOIC ACID; PROTEIN TYROSINE KINASE; RHO KINASE; RHO KINASE INHIBITOR; SPHINGOSYLPHOSPHORYLCHOLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASILAR ARTERY; BRAIN VASOSPASM; CALCIUM SIGNALING; CISTERNA MAGNA; CONTROLLED STUDY; DOG; DRUG CEREBROSPINAL FLUID LEVEL; DRUG MECHANISM; ENZYME INACTIVATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTILITY; SUBARACHNOID HEMORRHAGE; VASCULAR SMOOTH MUSCLE; VASOCONSTRICTION;

ANIMALS; BASILAR ARTERY; BENZOPYRANS; CEREBRAL ANGIOGRAPHY; CISTERNA MAGNA; DISEASE MODELS, ANIMAL; DOGS; EICOSAPENTAENOIC ACID; FEMALE; INJECTIONS; MALE; PHOSPHORYLCHOLINE; PROTEIN KINASE INHIBITORS; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; SPHINGOSINE; SUBARACHNOID HEMORRHAGE; TIME FACTORS; VASOCONSTRICTION; VASODILATOR AGENTS; VASOSPASM, INTRACRANIAL;

EID: 46449093290     PISSN: 10159770     EISSN: None     Source Type: Journal    
DOI: 10.1159/000135650     Document Type: Article

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