Development of novel ibuprofen-loaded solid dispersion with improved bioavailability using aqueous solution

Archives of Pharmacal Research

Volumn 32, Issue 5, 2009, Pages 767-772

  Park, Young Joon ^b   Kwon, Ram ^a   Quan, Qi Zhe ^c   Oh, Dong Hoon ^a   Kim, Jong Oh ^a   Hwang, Ma Ro ^a   Koo, Yoon Bon ^b   Woo, Jong Soo ^a   Yong, Chul Soon ^b   Choi, Han Gon ^a  

^a Yeungnam University   (South Korea)

^b Samil Pharmaceutical Co Ltd   (South Korea)

^c BEIJING UNION UNIVERSITY   (China)

Author keywords

Ibuprofen; Pharmacokinetics; Solid dispersion; Solubility

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; IBUPROFEN; POLOXAMER; WATER; DRUG CARRIER; DRUG DERIVATIVE; METHYLCELLULOSE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DISPERSION; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG SOLUBILITY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; RAT; ANIMAL; BIOAVAILABILITY; BLOOD; CHEMISTRY; COMPARATIVE STUDY; DRUG DOSAGE FORM; ORAL DRUG ADMINISTRATION; POWDER; SOLUBILITY; SPRAGUE DAWLEY RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DOSAGE FORMS; DRUG CARRIERS; IBUPROFEN; MALE; METHYLCELLULOSE; POLOXAMER; POWDERS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; WATER;

EID: 67649371135     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-009-1516-3     Document Type: Article

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