Prevention of Brefeldin A-induced resistance to teniposide by the proteasome inhibitor MG-132: Involvement of NF-κB activation in drug resistance

Cancer Research

Volumn 58, Issue 14, 1998, Pages 3059-3065

  Lin, Z Ping ^a   Boiler, Yoonkyung C ^a   Amer, Suad M ^a   Russell, Rosalind L ^a   Pacelli, Karen A ^a   Patierno, Steven R ^a   Kennedy, Katherine A ^a  

^a GEORGE WASHINGTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BREFELDIN A; CASTANOSPERMINE; DOXORUBICIN; ETOPOSIDE; MESSENGER RNA; PROTEASOME; PROTEASOME INHIBITOR; TENIPOSIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER RESISTANCE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; SOLID TUMOR;

EID: 0032527915     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Vaupel, P., Kallinowski, F., and Okunieff, P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res., 49: 6449-6465, 1989.
2. Shen, J., Hughes, C., Chao, C., Cai, J., Bartels, C., Gessner, T., and Subjeck, J. Coinduction of glucose-regulated proteins and doxorubicin resistance in Chinese hamster cells. Proc. Natl. Acad. Sci. USA, 84: 3278-3282, 1987.
3. Hughes, C. S., Shen, J. W., and Subjeck, J. R. Resistance to etoposide induced by three glucose-regulated stresses in Chinese hamster ovary cells. Cancer Res., 49: 4452-4454, 1989.
4. Vichi, P. J., and Tritton, T. R. Protection from Adriamycin cytotoxicity in L1210 cells by brefeldin A. Cancer Res., 53: 5237-5243, 1993.
5. Lee, A. S. Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells. Trends Biochem. Sci., 12: 20-23, 1987.
6. Kozutsumi, Y., Segal, M., Normington, K., Gething, M-J., and Sambrook, J. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature (Lond.), 332: 462-464, 1988.
7. Bole, D. G., Hendershot, L. M., and Kearney, J. F. Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas. J. Cell Biol., 102: 1558-1566, 1986.
8. Gething, M-J., McCammon, K., and Sambrook, J., Expression of wild-type and mutant forms of influenza hemagglutinin: the role of folding in intracellular transport. Cell, 46: 939-950, 1986.
9. Li, L-J., Li, X., Ferrario, A., Rucker, N., Liu, E. S., Wong, S., Gomer, C. J., and Lee, A. S. Establishment of a Chinese hamster ovary cell line that expresses grp78 antisense transcripts and suppresses A23187 induction of both GRP78 and GRP94. J. Cell. Physiol., 153: 575-582, 1992.
10. Koong, A. C., Chen, E. Y., Lee, A. S., Brown, J. M., and Giaccia, A. J., Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction. Int. J. Radiat. Oncol., 28: 661-666, 1994.
11. Sugawara, S., Nowicki, M., Xie, S., Song, H-J., and Dennert, G. Effects of stress on Iysability of tumor targets by cytotoxic T cells and tumor necrosis factor. J. Immunol., 145: 1991-1998, 1990.
12. +-deficient V79 cell lines and its relation to resistance to the topoisomerase II inhibitor etoposide. Cancer Res., 54: 4405-4411, 1994.
13. Chatterjee, S., Cheng, M-F., Berger, R, B., Berger, S. J., and Berger, N. A. Effect of inhibitors of poly(ADP-ribose) polymerase on the induction of GRF78 and subsequent development of resistance to etoposide. Cancer Res., 55: 868-873, 1995.
14. Pahl, H. L., and Baeuerle, P. A. A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-κB. EMBO J., 14: 2580-2588, 1995.
15. 2+ and reactive oxygen intermediates as messengers. FEBS Lett., 392: 129-136, 1996.
16. Schreck, R., Rieber, P., and Baeuerle, P. A. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-κB transcription factor and HIV-1. EMBO J., 10: 2247-2258, 1991.
17. Baeuerle, P. A., and Baltimore, D. A 65 kDa subunit of active NF-κB is required for inhibition of NF-κB by IκB. Gene Dev., 3: 1689-1698, 1989.
18. Ghosh, S., Gifford, A. M., Riviere, L. R., Tempst, P., Nolan, G. P., and Baltimore, D., Cloning of the p50 DNA binding subunit of NF-κB: homology to rel and dorsal. Cell, 62: 1019-1029, 1990.
19. Urban, M. B., Schreck, R., and Baeuerle, P. A. NF-κB contacts DNA by a heterodimer of the p50 and p65 subunits. EMBO J., 10: 1817-1825, 1991.
20. Baeuerle, P. A., and Baltimore, D., IκB, a specific inhibitor of the NF-κB transcription factor. Science (Washington DC), 242: 540-546, 1988.
21. Ghosh, S., and Baltimore, D., Activation in vitro of NF-κB by phosphorylation of its inhibitor IκB. Nature (Lond.), 344: 678-682, 1990.
22. Traenckner, E. B-M., Pahl, H. L., Henkel, T., Schmidt, K. N., Wilk, S., and Baeuerle, P. A., Phosphorylation of human IκB-α on serines 32 and 36 controls IκB-α proteolysis and NF-κB activation in response to diverse stimuli. EMBO J., 14: 2876-2883, 1995.
23. Henkel, T., Machleidt, T., Alkalay, I., Kronke, M., Ben-Neriah, Y., and Baeuerle, P. A. Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB. Nature (Lond.), 565: 182-185, 1993.
24. Palombella, V. J., Rando, O. J., Goldberg, A. L., and Maniatis, T., The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell, 78: 773-785, 1994.
25. Lenardo, M. J., and Baltimore, D. NF-κB, a pleiotropic mediator of inducible and tissue-specific gene control. Cell, 58: 227-229, 1989.
26. Wang, C-Y., Mayo, M. W., and Baldwin, A. S. TNF- and cancer therapy-induced apoptosis. Potentiation by inhibition of NF-κB. Science (Washington DC), 274: 784-787, 1996.
27. Van Antwerp, D. J., Martin, S. J., Kafri, T., Green, D. R., and Verma, I. M., Suppression of TNF-α-induced apoptosis by NF-κB. Science (Washington DC), 274: 787-789, 1996.
28. Liu, Z-G., Hsu, H., Goeddel, D. V., and Karin, M. Dissection of TNF receptor 1 effector functions. JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell, 87: 565-576, 1996.
29. Liu, E. S., Ou, J-H., and Lee, A. S., Brefeldin A as a regulator of grp78 gene expression in mammalian cells. J. Biol. Chem., 267: 7128-7133, 1992.
30. - stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis. J. Cell. Physiol., 152: 545-552, 1992.
31. Pahl, H. L., and Baeuerle, P. A., Endoplasmic reticulum-induced signal transduction and gene expression. Trends Cell Biol., 7: 50-55, 1997.
32. Pahl, H. L., and Baeuerle, P. A., The ER-overload response. Activation of NF-κB. Trends Biochem. Sci., 22: 63-67, 1997.
33. Trevenin, C., Kim, S-J., Rieckmann, P., Fujiki, H., Norcross, M. A., Sporn, M. B., Fauci, A. S., and Kehrl, J. H. Induction of nuclear factor-κB and the human immunodeficiency virus long terminal repeat by okadaic acid, a specific inhibitor of phosphatase 1 and 2A. New Biol., 2: 793-800, 1990.
34. Cao, X., Zhou, Y., and Lee, A. S. Requirement of tyrosine- and serine/threonine kinases in the transcriptional activation of the mammalian grp78/BiP promoter by thapsigargin. J. Biol. Chem., 270: 494-502, 1995.
35. Watowich, S. S., and Morimoto, R. I. Complex regulation of heat shock- and glucose-responsive genes in human cells. Mol. Cell. Biol., 8: 393-405, 1988.
36. Chomczynski, P., and Sacchi, N., Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
37. Feinberg, A., and Vogelstein, B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem., 132: 6-13, 1983.
38. Stein, B., Rahmsdorf, H. J., Steffen, A., Litfin, M., and Herrlich, P. UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein. Mol. Cell. Biol., 9: 5169-5181, 1989.
39. + T lymphocytes. Science (Washington DC), 256: 1452-1456, 1992.
40. Traenckner, E. B-M., Wilk, S., and Baeuerle, P. A. A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κKB. EMBO J., 13: 5433-5441, 1994.
41. Adams, J., and Stein, R., Novel inhibitors of the proteasome and their therapeutic use in inflammation. Ann. Rep. Med. Chem., 31: 279-288, 1996.
42. Misumi, Y., Misumi, Y., Miki, K., Takatsuki, A., Tamura, G., and Ikehara, Y. Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes. J. Biol. Chem., 261: 11398-11403, 1986.
43. Lippincott-Schwartz, J., Yuan, L. C., Bonifacino, J. S., and Klausner, R. D. Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell, 56: 801-813, 1989.
44. Cohen, P., Holmes, C. F. B., and Tsukitani, Y., Okadaic acid. A new probe for the study of cellular regulation. Trends Biochem. Sci., 15: 98-102, 1994.
45. Chiao, P. J., Miyamoto, S., and Verma, I. M. Autoregulation of IκB activity. Proc. Natl. Acad. Sci. USA, 91. 28-32, 1994.
46. Suzuki, Y. J., Mizuno, M., and Packer, L. Signal transduction for nuclear factor-κB activation. J. Immunol., 153: 5008-5015, 1994.
47. Long, B. H., Musial, S. T., and Brattain, M. G. Comparison of cytotoxicity and DNA breakage activity of congeners of podophyllotoxin including VP-16-213 and VM-26: a quantitative structure-activity relationship. Biochemistry, 23: 1183-1188, 1984.
48. Rose, K. M. DNA topoisomerases as targets for chemotherapy. FASEB J., 2: 2474-2478, 1988.
49. Liu, L. F., DNA topoisomerase II poisons as antitumor drugs. Annu. Rev. Biochem., 58: 351-375, 1989.
50. Kaufmann, S. H. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res., 49: 5870-5878, 1989.
51. Roy, C., Brown, D. L., Little, J. E., Valentine, B. K., Walker, P. R., Sikorska, M., Leblanc, J., and Chaly, N., The topoisomerase II inhibitor teniposide (VM-26) induces apoptosis in unstimulated mature murine lymphocytes. Exp. Cell Res., 200: 416-424, 1992.
52. Mizumoto, K., Rothman, R. J., and Farber, J. L. Programmed cell death (apoptosis) of mouse fibroblasts is induced by topoisomerase II inhibitor etoposide. Mol. Pharmacol., 46: 890-895, 1994.
53. Kamesaki, S., Kamesaki, H., Jorgensen, T. J., Tanizawa, A., Pommier, Y., and Cossman, J. bcl-2 protein inhibits etoposide-induced apoptosis through its effects on events subsequent to topoisomerase II-induced DNA strand breaks and their repair. Cancer Res., 53: 4251-4256, 1993.
54. Van Tellingen, O., Boogerd, W., Nooijen, W. J., and Beijnen, J. H. The vascular compartment hampers accurate determination of teniposide penetration into brain tumor tissue. Cancer Chemother. Pharmacol., 40: 330-334, 1997.