Nitrite exerts potent negative inotropy in the isolated heart via eNOS-independent nitric oxide generation and cGMP-PKG pathway activation

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1787, Issue 7, 2009, Pages 818-827

  Pellegrino, Daniela ^a   Shiva, Sruti ^b,c,d   Angelone, Tommaso ^a   Gladwin, Mark T ^b,c,d   Tota, Bruno ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c CLINICAL CENTER   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

cGMP; Heart; Langendorff rat heart; Nitric oxide; Nitrite; NOS; PKG

Indexed keywords

CYCLIC GMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRITE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; HEART CONTRACTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CONTRACTILITY; HEART PERFORMANCE; INOTROPISM; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; VASODILATATION;

ANIMALS; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; HEART; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; MYOCYTES, CARDIAC; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; PERFUSION; RATS; RATS, WISTAR;

RATTUS;

EID: 67649249942     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbabio.2009.02.007     Document Type: Article

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