Both cell-surface and secreted CSF-1 expressed by tumor cells metastatic to bone can contribute to osteoclast activation

Experimental Cell Research

Volumn 315, Issue 14, 2009, Pages 2442-2452

  Yagiz, Kader ^a   Rittling, Susan R ^a,b  

^a FORSYTH INSTITUTE   (United States)

^b HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

Bone metastasis; M CSF; Osteoclast; Syngeneic

Indexed keywords

CELL SURFACE PROTEIN; COLONY STIMULATING FACTOR 1; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BONE DESTRUCTION; BONE METASTASIS; CELL ACTIVATION; CELL PROTECTION; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HYPOTHESIS; IN VITRO STUDY; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; TUMOR CELL LINE;

MUS;

EID: 67649236132     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2009.05.002     Document Type: Article

References (57)

1. Martin T.J., and Moseley J.M. Mechanisms in the skeletal complications of breast cancer. Endocr. Relat. Cancer 7 (2000) 271-284
2. Teitelbaum S.L. Osteoclasts: what do they do and how do they do it?. Am. J. Pathol. 170 (2007) 427-435
3. Teitelbaum S.L., and Ross F.P. Genetic regulation of osteoclast development and function. Nat. Rev. Genet. 4 (2003) 638-649
4. Kong Y.Y., Yoshida H., Sarosi I., Tan H.L., Timms E., Capparelli C., Morony S., Oliveira-dos-Santos A.J., Van G., Itie A., Khoo W., Wakeham A., Dunstan C.R., Lacey D.L., Mak T.W., Boyle W.J., and Penninger J.M. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397 (1999) 315-323
5. Yoshida H., Hayashi S., Kunisada T., Ogawa M., Nishikawa S., Okamura H., Sudo T., Shultz L.D., and Nishikawa S. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345 (1990) 442-444
6. Yin J.J., Selander K., Chirgwin J.M., Dallas M., Grubbs B.G., Wieser R., Massague J., Mundy G.R., and Guise T.A. TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J. Clin. Invest. 103 (1999) 197-206
7. Guise T.A., Yin J.J., Taylor S.D., Kumagai Y., Dallas M., Boyce B.F., Yoneda T., and Mundy G.R. Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis. J. Clin. Invest. 98 (1996) 1544-1549
8. Chirgwin J.M., and Guise T.A. Molecular mechanisms of tumor-bone interactions in osteolytic metastases. Crit. Rev. Eukaryot. Gene Expr. 10 (2000) 159-178
9. Natasha T., Kuhn M., Kelly O., and Rittling S.R. Override of the osteoclast defect in osteopontin-deficient mice by metastatic tumor growth in the bone. Am. J. Pathol. 168 (2006) 551-561
10. Guise T.A. Parathyroid hormone-related protein and bone metastases. Cancer 80 (1997) 1572-1580
11. Yoneda T., and Hiraga T. Crosstalk between cancer cells and bone microenvironment in bone metastasis. Biochem. Biophys. Res. Commun. 328 (2005) 679-687
12. Canon J.R., Roudier M., Bryant R., Morony S., Stolina M., Kostenuik P.J., and Dougall W.C. Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis. Clin. Exp. Metastasis 25 (2008) 119-129
13. Biskobing D.M., Fan X., and Rubin J. Characterization of MCSF-induced proliferation and subsequent osteoclast formation in murine marrow culture. J. Bone Miner. Res. 10 (1995) 1025-1032
14. Kacinski B.M., Scata K.A., Carter D., Yee L.D., Sapi E., King B.L., Chambers S.K., Jones M.A., Pirro M.H., and Stanley E.R. FMS (CSF-1 receptor) and CSF-1 transcripts and protein are expressed by human breast carcinomas in vivo and in vitro. Oncogene 6 (1991) 941-952
15. Kacinski B.M. CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract. Mol. Reprod. Dev. 46 (1997) 71-74
16. Scholl S.M., Lidereau R., la R.A.d., Nir C.C.L., Mosseri V., Nogues C., Pouillart P., and Stanley F.R. Circulating levels of the macrophage colony stimulating factor CSF-1 in primary and metastatic breast cancer patients. A pilot study. Breast Cancer Res. Treat. 39 (1996) 275-283
17. Lawicki S., Szmitkowski M., and Wojtukiewicz M. The pretreatment plasma level and diagnostic utility of M-CSF in benign breast tumor and breast cancer patients. Clin. Chim. Acta 371 (2006) 112-116
18. Mancino A.T., Klimberg V.S., Yamamoto M., Manolagas S.C., and Abe E. Breast cancer increases osteoclastogenesis by secreting M-CSF and upregulating RANKL in stromal cells. J. Surg. Res. 100 (2001) 18-24
19. Chellaiah M.A., and Hruska K.A. The integrin alpha(v)beta(3) and CD44 regulate the actions of osteopontin on osteoclast motility. Calcif. Tissue Int. 72 (2003) 197-205
20. Zhao S., Zhang Y.K., Harris S., Ahuja S.S., and Bonewald L.F. MLOY4 osteocyte-like cells support osteoclast formation and activation. J. Bone Miner. Res. 17 (2002) 2068-2079
21. Rittling S.R., and Denhardt D.T. p53 mutations in spontaneously immortalized 3T12 but not 3T3 mouse embryo cells. Oncogene 7 (1992) 935-942
22. Christensen B., Kazanecki C.C., Petersen T.E., Rittling S.R., Denhardt D.T., and Sorensen E.S. Cell type-specific post-translational modifications of mouse osteopontin are associated with different adhesive properties. J. Biol. Chem. 282 (2007) 19463-19472
23. Rittling S.R., and Feng F. Detection of mouse osteopontin by western blotting. Biochem. Biophys. Res. Comm. 250 (1998) 287-292
24. Rubin J., Fan X., Thornton D., Bryant R., and Biskobing D. Regulation of murine osteoblast macrophage colony-stimulating factor production by 1,25(OH)2D3. Calcif. Tissue Int. 59 (1996) 291-296
25. Yates B., Zetterberg C., Rajeev V., Reiss M., and Rittling S.R. Promoter-independent regulation of vimentin expression in mammary epithelial cells by val(12)ras and TGFbeta. Exp. Cell Res 313 (2007) 3718-3728
26. Yao G.Q., Sun B., Hammond E.E., Spencer E.N., Horowitz M.C., Insogna K.L., and Weir E.C. The cell-surface form of colony-stimulating factor-1 is regulated by osteotropic agents and supports formation of multinucleated osteoclast-like cells. J. Biol. Chem. 273 (1998) 4119-4128
27. Anway M.D., Wright W.W., Zirkin B.R., Korah N., Mort J.S., and Hermo L. Expression and localization of cathepsin K in adult rat sertoli cells. Biol. Reprod. 70 (2004) 562-569
28. Gallet M., Mentaverri R., Sevenet N., Brazier M., and Kamel S. Ability of breast cancer cell lines to stimulate bone resorbing activity of mature osteoclasts correlates with an anti-apoptotic effect mediated by macrophage colony stimulating factor. Apoptosis 11 (2006) 1909-1921
29. Chen Y., and Rittling S.R. Novel murine mammary epithelial cell lines that form osteolytic bone metastases: effect of strain background on tumor homing. Clin. Exp. Metastasis 20 (2003) 111-120
30. Hohensinner P.J., Kaun C., Rychli K., Niessner A., Pfaffenberger S., Rega G., de M.R., Maurer G., Ullrich R., Huber K., and Wojta J. Macrophage colony stimulating factor expression in human cardiac cells is upregulated by tumor necrosis factor-alpha via an NF-kappaB dependent mechanism. J. Thromb. Haemost. 5 (2007) 2520-2528
31. Price L.K., Choi H.U., Rosenberg L., and Stanley E.R. The predominant form of secreted colony stimulating factor-1 is a proteoglycan. J. Biol. Chem. 267 (1992) 2190-2199
32. Pixley F.J., and Stanley E.R. CSF-1 regulation of the wandering macrophage: complexity in action. Trends Cell Biol. 14 (2004) 628-638
33. Douglass T.G., Driggers L., Zhang J.G., Hoa N., Delgado C., Williams C.C., Dan Q., Sanchez R., Jeffes E.W.B., Wepsic H.T., Myers M.P., Koths K., and Jadus M.R. Macrophage colony stimulating factor: not just for macrophages anymore! A gateway into complex biologies. International Immunopharmacology 8 (2008) 1354-1376
34. Dai X.M., Zong X.H., Sylvestre V., and Stanley E.R. Incomplete restoration of colony-stimulating factor 1 (CSF-1) function in CSF-1-deficient Csf1op/Csf1op mice by transgenic expression of cell surface CSF-1. Blood 103 (2004) 1114-1123
35. Ladner M.B., Martin G.A., Noble J.A., Wittman V.P., Warren M.K., McGrogan M., and Stanley E.R. cDNA cloning and expression of murine macrophage colony-stimulating factor from L929 cells. Proc. Natl. Acad. Sci. U. S. A 85 (1988) 6706-6710
36. Ryan G.R., Dai X.M., Dominguez M.G., Tong W., Chuan F., Chisholm O., Russell R.G., Pollard J.W., and Stanley E.R. Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1(op)/Csf1(op)) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis. Blood 98 (2001) 74-84
37. Yao G.Q., Sun B.H., Weir E.C., and Insogna K.L. A role for cell-surface CSF-1 in osteoblast-mediated osteoclastogenesis. Calcif. Tissue Int. 70 (2002) 339-346
38. Kuhn M., Shah S., Natasha T., and Rittling S.R. A mouse model of breast cancer metastasis to the choroid of the eye. Clin. Exp. Metastasis 22 (2005) 685-690
39. Fingleton B. Molecular targets in metastasis: lessons from genomic approaches. Cancer Genomics Proteomics 4 (2007) 211-221
40. Pollard J.W. Tumour-educated macrophages promote tumour progression and metastasis. Nat. Rev. Cancer 4 (2004) 71-78
41. Gallet M., Sevenet N., Dupont C., Brazier M., and Kamel S. Breast cancer cell line MDA-MB 231 exerts a potent and direct anti-apoptotic effect on mature osteoclasts. Biochem. Biophys. Res. Commun. 319 (2004) 690-696
42. Schwaninger R., Rentsch C.A., Wetterwald A., der H.G.v., Bezooijen R.L.v., der P.G.v., Lowik C.W., Ackermann K., Pyerin W., Hamdy F.C., Thalmann G.N., and Cecchini M.G. Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases. Am. J. Pathol. 170 (2007) 160-175
43. Yao G.Q., Wu J.J., Sun B.H., Troiano N., Mitnick M.A., and Insogna K. The cell surface form of colony-stimulating factor-1 is biologically active in bone in vivo. Endocrinology 144 (2003) 3677-3682
44. Ohshiba T., Miyaura C., Inada M., and Ito A. Role of RANKL-induced osteoclast formation and MMP-dependent matrix degradation in bone destruction by breast cancer metastasis. Br. J. Cancer 88 (2003) 1318-1326
45. Clohisy D.R., Ogilvie C.M., and Ramnaraine M.L. Tumor osteolysis in osteopetrotic mice. J. Orthop. Res. 13 (1995) 892-897
46. Ishijima M., Tsuji K., Rittling S.R., Yamashita T., Kurosawa H., Denhardt D.T., Nifuji A., and Noda M. Resistance to unloading-induced three-dimensional bone loss in osteopontin-deficient mice. J. Bone Miner. Res. 17 (2002) 661-667
47. Yoshitake H., Rittling S.R., Denhardt D.T., and Noda M. Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption [published erratum appears in Proc Natl Acad Sci U S A 1999 Sep 14;96(19):10944]. Proc. Natl. Acad. Sci. U. S. A 96 (1999) 8156-8160
48. Faccio R., Takeshita S., Zallone A., Ross F.P., and Teitelbaum S.L. c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiation. J. Clin. Invest. 111 (2003) 749-758
49. Bakewell S.J., Nestor P., Prasad S., Tomasson M.H., Dowland N., Mehrotra M., Scarborough R., Kanter J., Abe K., Phillips D., and Weilbaecher K.N. Platelet and osteoclast beta3 integrins are critical for bone metastasis. Proc. Natl. Acad. Sci. U. S. A 100 (2003) 14205-14210
50. Trebec D.P., Chandra D., Gramoun A., Li K., Heersche J.N., and Manolson M.F. Increased expression of activating factors in large osteoclasts could explain their excessive activity in osteolytic diseases. J. Cell Biochem. 101 (2007) 205-220
51. Lees R.L., Sabharwal V.K., and Heersche J.N. Resorptive state and cell size influence intracellular pH regulation in rabbit osteoclasts cultured on collagen-hydroxyapatite films. Bone 28 (2001) 187-194
52. Lees R.L., and Heersche J.N. Macrophage colony stimulating factor increases bone resorption in dispersed osteoclast cultures by increasing osteoclast size. J. Bone Miner. Res. 14 (1999) 937-945
53. Janssens K., ten D.P., Janssens S., and Van H.W. Transforming growth factor-beta1 to the bone. Endocr. Rev. 26 (2005) 743-774
54. Quinn J.M.W., and Gillespie M.T. Modulation of osteoclast formation. Biochem. Biophys. Res. Comm 328 (2005) 739-745
55. Kozlow W., and Guise T.A. Breast cancer metastasis to bone: mechanisms of osteolysis and implications for therapy. J. Mammary Gland Biol. Neoplasia. 10 (2005) 169-180
56. Hughes D.E., Dai A., Tiffee J.C., Li H.H., Mundy G.R., and Boyce B.F. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-[beta]. Nat. Med. 2 (1996) 1132-1136
57. Lari R., Fleetwood A.J., Kitchener P.D., Cook A.D., Pavasovic D., Hertzog P.J., and Hamilton J.A. Macrophage lineage phenotypes and osteoclastogenesis - complexity in the control by GM-CSF and TGF-beta. Bone 40 (2007) 323-336