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Volumn 10, Issue 7, 2009, Pages 753-760

Immunological synapse formation inhibits, via NF-κB and FOXO1, the apoptosis of dendritic cells

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CD40 ANTIGEN; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN AKT1; PROTEIN KINASE B; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

EID: 67649214476     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1750     Document Type: Article
Times cited : (68)

References (50)
  • 1
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau, J. & Steinman, R.M. Dendritic cells and the control of immunity. Nature 392, 245-252 (1998).
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 2
    • 0742305006 scopus 로고    scopus 로고
    • Imaging immune cell interactions and functions: SMAC and the immunological synapse
    • Kupfer, A. & Kupfer, H. Imaging immune cell interactions and functions: SMAC and the immunological synapse. Semin. Immunol. 15, 295-300 (2003).
    • (2003) Semin. Immunol , vol.15 , pp. 295-300
    • Kupfer, A.1    Kupfer, H.2
  • 4
    • 0037036114 scopus 로고    scopus 로고
    • Dynamic imaging of T-cell-dendritic cell interactions in lymph nodes
    • Stoll, S., Delon, J., Brotz, T.M. & Germain, R.M. Dynamic imaging of T-cell-dendritic cell interactions in lymph nodes. Science 296 1873-1876 (2002).
    • (2002) Science , vol.296 , pp. 1873-1876
    • Stoll, S.1    Delon, J.2    Brotz, T.M.3    Germain, R.M.4
  • 5
    • 0036862529 scopus 로고    scopus 로고
    • Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue
    • Delon, J., Stoll, S. & Germain, R.M. Imaging of T-cell interactions with antigen presenting cells in culture and in intact lymphoid tissue. Immunol. Rev. 189, 51-63 (2002).
    • (2002) Immunol. Rev , vol.189 , pp. 51-63
    • Delon, J.1    Stoll, S.2    Germain, R.M.3
  • 6
    • 0041695164 scopus 로고    scopus 로고
    • Continuous T-cell receptor signaling required for synapse maintenance and full effector potential
    • Huppa, J.B., Gleimer, M., Sumen, C. & Davis, M.M. Continuous T-cell receptor signaling required for synapse maintenance and full effector potential. Nat. Immunol. 4, 749-755 (2003).
    • (2003) Nat. Immunol , vol.4 , pp. 749-755
    • Huppa, J.B.1    Gleimer, M.2    Sumen, C.3    Davis, M.M.4
  • 7
    • 0347717903 scopus 로고    scopus 로고
    • T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases
    • Mempel, T.R., Henrickson, S.E. & von Andrian, U.H. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427, 154-159 (2004).
    • (2004) Nature , vol.427 , pp. 154-159
    • Mempel, T.R.1    Henrickson, S.E.2    von Andrian, U.H.3
  • 8
    • 0347364690 scopus 로고    scopus 로고
    • Dendritic cell maturation controls adhesion, synapse formation, and duration of the duration of the interactions with naive T lymphocytes
    • Benvenuti, F. et al. Dendritic cell maturation controls adhesion, synapse formation, and duration of the duration of the interactions with naive T lymphocytes. J. Immunol. 172, 292-301 (2004).
    • (2004) J. Immunol , vol.172 , pp. 292-301
    • Benvenuti, F.1
  • 9
    • 4644317252 scopus 로고    scopus 로고
    • Immunological synapse formation licences CD40-CD40L accumulation at T-APC contact sites
    • Boisvert, J., Edmondson, S. & Krummel, M.F. Immunological synapse formation licences CD40-CD40L accumulation at T-APC contact sites. J. Immunol. 173, 3647-3652 (2004).
    • (2004) J. Immunol , vol.173 , pp. 3647-3652
    • Boisvert, J.1    Edmondson, S.2    Krummel, M.F.3
  • 10
    • 0034005120 scopus 로고    scopus 로고
    • Cytoskeletal polarization and redistribution of cell surface molecules during T cell antigen recognition
    • Van der Merwe, P.A., Davis, S.J., Shaw, A.S. & Dustin, M.L. Cytoskeletal polarization and redistribution of cell surface molecules during T cell antigen recognition. Semin. Immunol. 12, 5-21 (2000).
    • (2000) Semin. Immunol , vol.12 , pp. 5-21
    • Van der Merwe, P.A.1    Davis, S.J.2    Shaw, A.S.3    Dustin, M.L.4
  • 11
    • 0035182368 scopus 로고    scopus 로고
    • Identification of self through twodimensional chemistry and synapses
    • Dustin, M.L., Bromley, S.K., Davis, M.M. & Zhu, C. Identification of self through twodimensional chemistry and synapses. Annu. Rev. Cell Dev. Biol. 17, 133-157 (2001).
    • (2001) Annu. Rev. Cell Dev. Biol , vol.17 , pp. 133-157
    • Dustin, M.L.1    Bromley, S.K.2    Davis, M.M.3    Zhu, C.4
  • 12
    • 0036604984 scopus 로고    scopus 로고
    • Formation and function of the immunological synapse
    • Van der Merwe, P.A. Formation and function of the immunological synapse. Curr. Opin. Immunol. 1, 293-298 (2002).
    • (2002) Curr. Opin. Immunol , vol.1 , pp. 293-298
    • Van der Merwe, P.A.1
  • 13
    • 2342566929 scopus 로고    scopus 로고
    • What is the importance of the immunological synapse?
    • Davis, D.M. & Dustin, M.L. What is the importance of the immunological synapse? Trends Immunol. 25, 323-327 (2004).
    • (2004) Trends Immunol , vol.25 , pp. 323-327
    • Davis, D.M.1    Dustin, M.L.2
  • 14
    • 0033538574 scopus 로고    scopus 로고
    • The immunological synapse: A molecular machine controlling T cell activation
    • Grakoui, A. et al. The immunological synapse: A molecular machine controlling T cell activation. Science 285, 221-227 (1999).
    • (1999) Science , vol.285 , pp. 221-227
    • Grakoui, A.1
  • 15
    • 0242497659 scopus 로고    scopus 로고
    • The immunological synapse balances T cell receptor signaling and degradation
    • Lee, K.-H. et al. The immunological synapse balances T cell receptor signaling and degradation. Science 302, 1218-1222 (2003).
    • (2003) Science , vol.302 , pp. 1218-1222
    • Lee, K.-H.1
  • 16
    • 0035901568 scopus 로고    scopus 로고
    • The immunological synapse: Required for T-cell receptor signaling or directing T-cell effector function?
    • Davis, S.J. & Van der Merwe, P.A. The immunological synapse: Required for T-cell receptor signaling or directing T-cell effector function? Curr. Biol. 11, R289-R291 (2001).
    • (2001) Curr. Biol , vol.11
    • Davis, S.J.1    Van der Merwe, P.A.2
  • 17
    • 4944266186 scopus 로고    scopus 로고
    • A role for the immunological synapse in lineage commitment of CD4 lymphocytes
    • Maldonado, R.A., Irvine, D.J., Schreiber, R. & Glimcher, L.H. A role for the immunological synapse in lineage commitment of CD4 lymphocytes. Nature 431, 527-532 (2004).
    • (2004) Nature , vol.431 , pp. 527-532
    • Maldonado, R.A.1    Irvine, D.J.2    Schreiber, R.3    Glimcher, L.H.4
  • 18
    • 0346244099 scopus 로고    scopus 로고
    • T-cell-antigen recognition and the immunological synapse
    • Huppa, J.B. & Davis, M.M. T-cell-antigen recognition and the immunological synapse. Nat. Rev. Immunol. 3, 973-983 (2003).
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 973-983
    • Huppa, J.B.1    Davis, M.M.2
  • 19
    • 0035253596 scopus 로고    scopus 로고
    • The dendritic cell cytoskeleton is critical for the formation of the immunological synapse
    • Al-Alwan, M.M., Rowden, G., Lee, T.D.G. & West, K.A. The dendritic cell cytoskeleton is critical for the formation of the immunological synapse. J. Immunol. 166, 1452-1456 (2001).
    • (2001) J. Immunol , vol.166 , pp. 1452-1456
    • Al-Alwan, M.M.1    Rowden, G.2    Lee, T.D.G.3    West, K.A.4
  • 22
    • 1342321750 scopus 로고    scopus 로고
    • Downward, J. PI 3-kinase, Akt and cell survival. Semin. Cell Dev. Biol. 15, 177-182 (2004).
    • Downward, J. PI 3-kinase, Akt and cell survival. Semin. Cell Dev. Biol. 15, 177-182 (2004).
  • 23
    • 2942679279 scopus 로고    scopus 로고
    • Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells
    • Hou, W.S. & Van Parijs, L.A. Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells. Nat. Immunol. 5, 583-589 (2004).
    • (2004) Nat. Immunol , vol.5 , pp. 583-589
    • Hou, W.S.1    Van Parijs, L.A.2
  • 24
    • 0036009115 scopus 로고    scopus 로고
    • Karin, M. & Lin, A. NF-kB at the crossroads of life and death. Nat. Immunol. 3, 221-227 (2002).
    • Karin, M. & Lin, A. NF-kB at the crossroads of life and death. Nat. Immunol. 3, 221-227 (2002).
  • 25
    • 0036629251 scopus 로고    scopus 로고
    • Cell cycle and death control: Long lived forkheads
    • Burgering, B.M.T. & Kops, G.J.P.L. Cell cycle and death control: Long lived forkheads. Trends Biochem. Sci. 27, 352-360 (2002).
    • (2002) Trends Biochem. Sci , vol.27 , pp. 352-360
    • Burgering, B.M.T.1    Kops, G.J.P.L.2
  • 26
    • 0042591476 scopus 로고    scopus 로고
    • FOXO transcription factors as regulators of immune homeostasis: Molecules to die for?
    • Birkenkamp, K.U. & Coffer, P.J. FOXO transcription factors as regulators of immune homeostasis: Molecules to die for? J. Immunol. 171 1623-1629 (2003).
    • (2003) J. Immunol , vol.171 , pp. 1623-1629
    • Birkenkamp, K.U.1    Coffer, P.J.2
  • 27
    • 0034327828 scopus 로고    scopus 로고
    • Anatomical origin of dendritic cells determine their life span in peripheral lymph nodes
    • Ruedl, C., Koebel, P., Bachmann, M., Hess, M. & Karjalainen, K. Anatomical origin of dendritic cells determine their life span in peripheral lymph nodes. J. Immunol. 165, 4910-4916 (2000).
    • (2000) J. Immunol , vol.165 , pp. 4910-4916
    • Ruedl, C.1    Koebel, P.2    Bachmann, M.3    Hess, M.4    Karjalainen, K.5
  • 28
    • 0042884327 scopus 로고    scopus 로고
    • Genetic tagging shows increased frequency and longevity of antigen-presenting, skin derived dendritic cells in vivo
    • Garg, S. et al. Genetic tagging shows increased frequency and longevity of antigen-presenting, skin derived dendritic cells in vivo. Nat. Immunol. 4, 907-912 (2003).
    • (2003) Nat. Immunol , vol.4 , pp. 907-912
    • Garg, S.1
  • 29
    • 0031884839 scopus 로고    scopus 로고
    • The duration of antigen stimulation determines the fate of naïve and effector cells
    • Iezzi, G., Karjalainen, K. & Lanzavecchia, A. The duration of antigen stimulation determines the fate of naïve and effector cells. Immunity 8, 89-95 (1998).
    • (1998) Immunity , vol.8 , pp. 89-95
    • Iezzi, G.1    Karjalainen, K.2    Lanzavecchia, A.3
  • 30
    • 35348978611 scopus 로고    scopus 로고
    • Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation
    • Celli, S., Lemaître, F. & Bousso, P. Real-time manipulation of T cell-dendritic cell interactions in vivo reveals the importance of prolonged contacts for CD4+ T cell activation. Immunity 27, 625-634 (2007).
    • (2007) Immunity , vol.27 , pp. 625-634
    • Celli, S.1    Lemaître, F.2    Bousso, P.3
  • 31
    • 3242790985 scopus 로고    scopus 로고
    • Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells
    • Sanchez-Sanchez, N. et al. Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells. Blood 104, 619-625 (2004).
    • (2004) Blood , vol.104 , pp. 619-625
    • Sanchez-Sanchez, N.1
  • 32
    • 48749084864 scopus 로고    scopus 로고
    • A synapsis basis for paracrine interleukin-2 signaling during homotypic T cell interaction
    • Sabatos, C.A. et al. A synapsis basis for paracrine interleukin-2 signaling during homotypic T cell interaction. Immunity 29, 238-248 (2008).
    • (2008) Immunity , vol.29 , pp. 238-248
    • Sabatos, C.A.1
  • 33
    • 0242526431 scopus 로고    scopus 로고
    • Interactions of fluorochrome-labeled caspases inhibitors with apoptotic cells: A caution in data interpretation
    • Pozarowski, P. et al. Interactions of fluorochrome-labeled caspases inhibitors with apoptotic cells: A caution in data interpretation. Cytometry A 55, 50-60 (2003).
    • (2003) Cytometry A , vol.55 , pp. 50-60
    • Pozarowski, P.1
  • 34
    • 4444335279 scopus 로고    scopus 로고
    • Multiparametric evaluation of apoptosis: Effects of standard cytotoxic agents and cyanoguanidine CHS 828
    • Lovborg, H., Nygren, P. & Larsson, R. Multiparametric evaluation of apoptosis: Effects of standard cytotoxic agents and cyanoguanidine CHS 828. Mol. Cancer Ther. 3, 521-526 (2004).
    • (2004) Mol. Cancer Ther , vol.3 , pp. 521-526
    • Lovborg, H.1    Nygren, P.2    Larsson, R.3
  • 35
    • 0032547744 scopus 로고    scopus 로고
    • 3H]inositol-labeled phosphoinositide pools
    • 3H]inositol-labeled phosphoinositide pools. J. Cell Biol. 143, 501-510 (1998).
    • (1998) J. Cell Biol , vol.143 , pp. 501-510
    • Várnai, P.1    Balla, T.2
  • 36
    • 0036853106 scopus 로고    scopus 로고
    • Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse
    • Costello, P.S., Gallagher, P.J. & Cantrell, D.A. Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse. Nat. Immunol. 3, 1082-1089 (2002).
    • (2002) Nat. Immunol , vol.3 , pp. 1082-1089
    • Costello, P.S.1    Gallagher, P.J.2    Cantrell, D.A.3
  • 37
    • 0037111201 scopus 로고    scopus 로고
    • G protein-coupled chemokine receptors induce both survival and apoptotic signaling pathways
    • Vlahakis, S.R. et al. G protein-coupled chemokine receptors induce both survival and apoptotic signaling pathways. J. Immunol. 169 5546-5554 (2002).
    • (2002) J. Immunol , vol.169 , pp. 5546-5554
    • Vlahakis, S.R.1
  • 38
    • 0034595687 scopus 로고    scopus 로고
    • Dynamics of NF κB and IκBα studied with green fluorescent protein (GFP) fusion proteins. Investigation of GFP-p65 binding to DNA by fluorescence resonance energy transfer
    • Schmid, J.A. et al. Dynamics of NF κB and IκBα studied with green fluorescent protein (GFP) fusion proteins. Investigation of GFP-p65 binding to DNA by fluorescence resonance energy transfer. J. Biol. Chem. 275, 17035-17042 (2000).
    • (2000) J. Biol. Chem , vol.275 , pp. 17035-17042
    • Schmid, J.A.1
  • 39
    • 0038771214 scopus 로고    scopus 로고
    • Modulation of NF-κB activity by exchange of dimers
    • Saccani, S., Pantano, S. & Natoli, G. Modulation of NF-κB activity by exchange of dimers. Mol. Cell 11, 1563-1574 (2003).
    • (2003) Mol. Cell , vol.11 , pp. 1563-1574
    • Saccani, S.1    Pantano, S.2    Natoli, G.3
  • 40
    • 0037204948 scopus 로고    scopus 로고
    • TNF-R1 signaling: A beautiful pathway
    • Chen, G. & Goeddel, D.V. TNF-R1 signaling: A beautiful pathway. Science 296, 1634-1635 (2002).
    • (2002) Science , vol.296 , pp. 1634-1635
    • Chen, G.1    Goeddel, D.V.2
  • 41
    • 0037160050 scopus 로고    scopus 로고
    • Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding
    • Zhang, X. et al. Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding. J. Biol. Chem. 277, 45276-45284 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 45276-45284
    • Zhang, X.1
  • 42
    • 0024380087 scopus 로고
    • Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells
    • Schreiber, E., Matthias, P., Muller, M.M. & Schaffner, W. Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells. Nucleic Acids Res. 17, 6419 (1989).
    • (1989) Nucleic Acids Res , vol.17 , pp. 6419
    • Schreiber, E.1    Matthias, P.2    Muller, M.M.3    Schaffner, W.4
  • 43
    • 0035104229 scopus 로고    scopus 로고
    • Inhibition of glucocorticoid-mediated, caspase-independent dendritic cell death by CD40 activation
    • Kim, K.D., Choe, Y.K., Choe, I.S. & Lim, J.S. Inhibition of glucocorticoid-mediated, caspase-independent dendritic cell death by CD40 activation. J. Leukoc. Biol. 69, 426-434 (2001).
    • (2001) J. Leukoc. Biol , vol.69 , pp. 426-434
    • Kim, K.D.1    Choe, Y.K.2    Choe, I.S.3    Lim, J.S.4
  • 44
    • 0035079904 scopus 로고    scopus 로고
    • Dendritic cell longevity and T-cell persistence is controlled by CD154-CD40 interactions
    • Miga, A.J. et al. Dendritic cell longevity and T-cell persistence is controlled by CD154-CD40 interactions. Eur. J. Immunol. 31 959-965 (2001).
    • (2001) Eur. J. Immunol , vol.31 , pp. 959-965
    • Miga, A.J.1
  • 45
    • 14644431885 scopus 로고    scopus 로고
    • Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo
    • Hanks, B.A. et al. Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo. Nat. Med. 11, 130-137 (2005).
    • (2005) Nat. Med , vol.11 , pp. 130-137
    • Hanks, B.A.1
  • 46
    • 0034769286 scopus 로고    scopus 로고
    • Functional antigen-independent synapses formed between T cells and dendritic cells
    • Revy, P., Sospedra, M., Barbour, B. & Trautmann, A. Functional antigen-independent synapses formed between T cells and dendritic cells. Nat. Immunol. 2, 925-931 (2001).
    • (2001) Nat. Immunol , vol.2 , pp. 925-931
    • Revy, P.1    Sospedra, M.2    Barbour, B.3    Trautmann, A.4
  • 47
    • 0034769254 scopus 로고    scopus 로고
    • Dendritic cells signal T cells in the absence of exogenous antigen
    • Kondo, T. et al. Dendritic cells signal T cells in the absence of exogenous antigen. Nat. Immunol. 2, 932-938 (2001).
    • (2001) Nat. Immunol , vol.2 , pp. 932-938
    • Kondo, T.1
  • 48
    • 0035798698 scopus 로고    scopus 로고
    • Rho and ROCK modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1
    • Rodriguez-Fernandez, J.L. et al. Rho and ROCK modulate the tyrosine kinase PYK2 in T-cells through regulation of the activity of the integrin LFA-1. J. Biol. Chem. 276, 40518-40527 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 40518-40527
    • Rodriguez-Fernandez, J.L.1
  • 49
    • 0031897801 scopus 로고    scopus 로고
    • Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements
    • Barnden, M.J., Allison, J., Heath, W.R. & Carbone, F.R. Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements. Immunol. Cell Biol. 76, 34-40 (1998).
    • (1998) Immunol. Cell Biol , vol.76 , pp. 34-40
    • Barnden, M.J.1    Allison, J.2    Heath, W.R.3    Carbone, F.R.4
  • 50
    • 9144222974 scopus 로고    scopus 로고
    • The neuronal protein Kidins220 localizes in a raft compartment at the leading edge of motile immature dendritic cells
    • Riol-Blanco, L. et al. The neuronal protein Kidins220 localizes in a raft compartment at the leading edge of motile immature dendritic cells. Eur. J. Immunol. 34, 108-118 (2004).
    • (2004) Eur. J. Immunol , vol.34 , pp. 108-118
    • Riol-Blanco, L.1


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