Ultrafine particles (UFP) and health effects. Dangerous. Like no other PM? Review and analysis

Global Nest Journal

Volumn 10, Issue 3, 2008, Pages 439-452

  Politis, M ^a   Pilinis, C ^a   Lekkas, T D ^a  

^a UNIVERSITY OF THE AEGEAN   (Greece)

Author keywords

Air pollution; Cardiovascular system; Central nervous system; Health effects; Nanoparticles; Respiratoty system; Ultrafine particles

Indexed keywords

EID: 67649198236     PISSN: 17907632     EISSN: None     Source Type: Journal    
DOI: 10.30955/gnj.000579     Document Type: Article

References (73)

1. Baggs R. B., Ferin J., Oberdorster G. (1997), Regression of pulmonary lesions produced by inhaled titanium dioxide in rats, Veterinary Pathology, 34(6), 592-597.
2. Baron P. A. and Willeke K. Eds. (2001), Aerosol Measurement: Principles, Techniques and Applications. New York, van Nostrand Reinhold.
3. Beck-Speier I., Dayal N., Karg E., Maier K. L., Roth C., Ziesenis A., Heyder J. (2001), Agglomerates of ultrafine particles of elemental carbon and TiO2 induce generation of lipid mediators in alveolar macrophages, Environmental Health Perspectives, 109, 613-618.
4. Bockhorn H. (2000), Ultrafine particles from combustion sources: approaches to what we want to know, Philosophical Transactions of the Royal Society of London, A 358, 2659-2672.
5. Bodian D., Howe H. A. (1941a), Experimental studies on intraneural spread of poliomyelitis virus. In: Bulletin of the Johns Hopkins Hospital, Bordley, J. I. (ed.), Baltimore: The Johns Hopkins Press, 248-267.
6. Bodian D., Howe H. A. (1941b), The rate of progression of poliomyelitis virus in nerves, Baltimore: The Johns Hopkins Press, 79-85.
7. Boland S., Bonvallot, V., Fournier T., Baeza-Squiban A., Aubier M., Marano F. (2000), Mechanisms of GM-F increase by diesel exhaust particles in human airway epithelial cells, American Journal of Physiology-Lung Cellular and Molecular Physiology, 278(1), L25-L32.
8. Brown D. M., Wilson M. R., MacNee W., Stone V., Donaldson K. (2001), Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines, Toxicology and Applied Pharmacology, 175(3), 191-199.
9. Brown J. S., Zeman K. L., Bennett W. D. (2002), Ultrafine particle deposition and clearance in the healthy and obstructed lung, American Journal of Respiratory and Critical Care Medicine, 166(9), 1240-1247.
10. Brunshidle T. P., Konowalchuk B., Nabeel I., Sullivan J. E. (2003), A Review of the Measurement, Emission, Particles: Characteristics and potential human Health Impacts of Ultrafine Particle, http://enhs. umn. edu/5103/particles/character. html.
11. Cassee F. R., Arts J. H E., Fokkens P. H. B., Spoor S. M., Boere A. J F., Van Bree L., Dormans J. A. M. A. (2002), Pulmonary effects of ultrafine and fine ammonium salts aerosols in healthy and monocrotaline-treated rats following short-term exposure, Inhalation Toxicology, 14(12), 1215-29.
12. CCOHS, Canadian Centre for Occupational Health and Safety. (1999), How do particulates enter the respiratory system?, http://www. ccohs. ca/oshanswers/chemicals/how_do. html.
13. 2 in a tracheal explant system, American Journal of Physiology-Lung Cellular and Molecular Physiology, 18(1), L81-L86.
14. Churg A., Gilks B., & Dai J. (1999). Induction of fibrogenic mediators by fine and ultrafine titanium dioxide in rat tracheal explants, American Journal of Physiology-Lung Cellular and Molecular Physiology, 277(5), L975-L982.
15. DeLorenzo J. (1957), Electron microscopic observations of the olfactory mucosa and olfactory nerve, J Biophys Biochem Cytol, 3, 839-850.
16. Diapouli E., Chaloulakou A., Spyrellis N. (2008), Indoor and outdoor PM concentrations at a residential environment, in the Athens area, Global NEST Journal, 10(2), 201-208.
17. Dick C. A. J., Brown D. M., Donaldson K., Stone V. (2003), The role of free radicals in the toxic and inflammatory effects of four different ultrafine particle types, Inhalation Toxicology, 15(1), 39-52.
18. Dorman D. C., McManus B. E., Parkinson C. U., Manuel C. A., McElveen A. M., Everitt J. I. (2004), Nasal toxicity of manganese sulfate and manganese phosphate in young male rats following subchronic (13-week) inhalation exposure, Inhalation Toxicology, 16, 481-488.
19. Frampton M. W., Voter K. Z., Morrow P. E., Roberts N. J. Jr, Culp D. J., Cox C., Utell M. J. (1992), Sulfuric acid aerosol exposure in humans assessed by bronchoalveolar lavage, American Review of Respiratory Disease, 146, 626-632.
20. Frampton M. W. (2001), Systemic and cardiovascular effects of airway injury and inflammation: Ultrafine particle expolure in humans, Environmental Health Perspective, 109(suppl 4), 529-532.
21. Guo L., Lewis J. O., McLaughlin J. P. (2008). Emissions from Irish domestic fireplaces and their impact on indoor air quality when used as supplementary heating source, Global NEST Journal, 10(2), 209-216.
22. Henriksson J., Tjalve H. (2000), Manganese taken up into the CNS via the olfactory pathway in rats affects astrocytes, Toxicol Sci, 55, 392-398.
23. Hofmann W., Morawska L., Bergmann R. (2001), Environmental tobacco smoke deposition in the human respiratory tract: Differences between experimental and theoretical approaches, Journal of Respiratory Medicine, 14(3), 317-326.
24. 10 concentration in Macau, Global NEST Journal, 10(2), 140-150.
25. Holgate S. T., Sandstrom T., Frew A. J., Stenfors N., Nordenhall C., Sundeep S., Soderberg M. (2002), Health effects of acute exposure to air pollution, Part 1: Healthy and asthmatic subjects exposed to diesel exhaust, Boston: Health Effects Institute.
26. Ibald-Mulli, A., Wichmann, H. E., Kreyling, W, Peters, A. (2002), Epidemiological evidence on health effects of ultrafine particles, Journal of Aerosol Medicine, 15(2), 189-201.
27. Kawasaki S., Takizawa H., Takami K., Desaki M., Okazaki H., Kasama T., Kobayashi K., Yamamoto K., Nakahara K., Tanaka M., Sagai M., Ohtoshi T. (2001), Benzene-extracted components are important for the major activity of diesel exhaust particles-Effect on interleukin-8 gene expression in human bronchial epithelial cells, American Journal of Respiratory Cell and Molecular Biology, 24(4), 419-426.
28. Kim C. S. and Jaques P. A. (2000), Respiratory dose of inhaled ultrafine particles in healthy adults, Philosophical Transactions of the Royal Society of London Series a-Mathematical Physical and Engineering Sciences, 358(1775), 2693-2705.
29. Kim H. J., Liu X. D., Kobayashi T., Kohyama T., Wen F-Q., Romberger D. J., Conner H., Gilmour P. S., Donaldson K., MacNee W., Rennard S. I. (2003), Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contraction, American Journal of Respiratory Cell and Molecular Biology, 28(1), 111-121.
30. 10) concentrations over Greece. Global NEST Journal, 10(2), 132-139.
31. 2. 5) concentrations in urban region of Patras Greece, Global NEST Journal, 10(2), 123-131.
32. Moller W., Hofer T., Ziesenis A., Karg E., Heyder J. (2002), Ultrafine particles cause cytoskeletal dysfunctions in macrophages, Toxicology and Applied Pharmacology, 182(3), 197-207.
33. Morawska L., Bofinger N., Kosic L., Nwankowala A. (1998), Submicron and supermicron particles from diesel vehicle emissions, Environmental Science & Technology, 32(14), 2033-2042.
34. Morawska L., Thomas S., Gilbert D., Greenaway C. and Rijnders E. (1999), A study of the horizontal and vertical profile of submicrometer particulates in relation to a busy road. Atmospheric Environment, 33(8), 1261-1274.
35. Morawska L., Moore M. R., Ristovski Z. D. (2004), Desktop Literature Review and Analysis: Health Impacts of Ultrafine Particles. For the Australian Department of the Environment and Heritage, ISBN 0 642 55055 7, 1-207.
36. Nemmar A., Delaunois A., Nemery B., Dessy-Doize C., Beckers J-F., Sulon J., Gustin P. (1999), Inflammatory effect of intratracheal instillation of ultrafine particles in the rabbit: Role of Cfiber and mast cells, Toxicology and Applied Pharmacology, 160(3), 250-261.
37. Nemmar A., Hoet P. H. M., Vanquickenborne B., Dinsdale D., Thomeer M., Hoylaerts M. F., Vanbilloen H., Mortelmans L., Nemery B. (2002), Passage of inhaled particles into the blood circulation in humans, Circulation, 105, 411-414.
38. NSC, National Safety Council. (1994), Air pollution Fact Sheet (for New Drivers), Environmental Health Center, Washington, DC. USA, www. nsc. org/ehc/mobile/airpollu. htm.
39. Oberdorster G. (1996), Significance of particle parameters in the evaluation of exposure-doseresponse relationships of inhaled particles, Inhalation Toxicology, 8(Suppl), 73-89.
40. Oberdörster G., Finkelstein J. N., Johnston C., Gelein R., Cox C., Baggs R., Elder A. C. P. (2000), HEI research report: Acute pulmonary effects of ultrafine particles in rats and mice, Research Report 96, August Health Effects Institute.
41. Oberdorster G., Utell M. J. (2002), Ultrafine Particles in the Urban Air: To the Respiratory Tract-And Beyond?, Enviromental Health Perspectives, 110(8), 440-441.
42. Oberdorster G., Sharp Z., Atudorei V., Elder A., Gelein R., Kreyling W., Cox C. (2004), Translocation of inhaled ultrafine particles to the brain, Inhalation Toxicology, 16(6/7), 437-445.
43. Oberdorster G., Oberdorster E., Oberdorster J. (2005). Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles, Environ Health Perspect, 113, 823-839.
44. Osier M. and Oberdorster G. (1997), Intratracheal inhalation vs intratracheal instillation: Differences in particle effects, Fundamental and Applied Toxicology, 40(2), 220-227.
45. Osunsanya T., Prescott G., Seaton A. (2001), Acute respiratory effects of particles: mass or number?, Occupational and Environmental Medicine, 58(3), 154-159.
46. Pekkanen, J., Timonen, K. L., Ruuskanen, J., Reponen, A., Mirme, A. (1997), Effects of ultrafine and fine particles in urban air on peak expiratory flow among children with asthmatic symptoms, Environmental Research, 74(1), 24-33.
47. Pekkanen J., Schindler C., Schwartz J. (2001), Confounding and effect modification in the shortterm effects of ambient particles on total mortality: results from 29 European cities within the APHEA2 project, Epidemiology, 12, 521-531.
48. Pekkanen J., Peters A., Hoek G., Tiittanen P., Brunekreef B., de Hartog J., Heinrich J., Ibald-Mulli A., Kreyling W. G., Lanki T., Timonen K L., Vanninen E. (2002), Particulate air pollution and risk of ST-segment depression during repeated submaximal exercise tests among subjects with coronary heart disease. The exposure and risk assessment for fine and ultrafine particles in ambient air (ULTRA) study, Circulation, 106(8), 933-938.
49. Penttinen P., Timonen K. L., Tittanen P., Mirme A., Ruuskanen J., Pekkanen J. (2001), Number concentration and size of particles in urban air: Effects on spirometric lung function in adult asthmatic subjects, Environmental Health Perspectives, 109(4), 319-323.
50. Peters A., Doring A., Wichmann H-E., Koenig W, (1997), Increased plasma viscosity during an air pollution episode: A link to mortality?, Lancet, 349(9065), 1582-1587.
51. Polymeneas P. and Pilinis C., (2008), Athens air quality and importance of biogenic emissions: a case study, Global NEST Journal, 10(2), 151-160.
52. Pope C. A. (2000), Epidemiology of fine particulate air pollution and human health: biologic mechanisms and who's at risk?, Environ Health Persp, 108(Suppl 4), 713-723.
53. Reibman J., Hsu Y. S., Chen L. C., Kumar A., Su W. C., Choy W., Talbot A., Gordon T. (2002), Size fractions of ambient particulate matter induce granulocyte macrophage colony-stimulating factor in human bronchial epithelial cells by mitogen-activated protein kinase pathways, American Journal of Respiratory Cell and Molecular Biology, 27(4), 455-462.
54. Ristovski Z., Morawska L., Thomas S., Hitchins J., Greenaway C. Gilbert, D. (2000), Particle emissions from natural gas engines, Journal of Aerosol Science, 31, 403-413.
55. Salvi S., Holgate, S. (1999), Mechanisms of particulate matter toxicity, Clin Exp Allergy, 29, 1187-1194.
56. Samet J. M., Zeger, S. L., Dominici F., Curriero F., Coursac I., Dockery D. W., Schwartz J., Zanobetti A. (2000), The National Morbidity, Mortality, and Air Pollution Study. Part II: Morbidity and mortality from air pollution in the United States. Health Effects Institute. 94 Part II, 1-82. North Andover MA, Flagship Press.
57. Seinfeld J. H. and Pandis S. N., (2006), Atmospheric Chemistry and Physics: From Air Pollution to Climate Change. New York, NY: Wiley-Interscience, ISBN: 0471720178.
58. Stone V., Brown D. M., Watt N., Ritchie H., Wilson M., Donaldson K. (2000), Ultrafine particlemediated activation of macrophages: intracellular calcium signaling and oxidative stress, Inhalation Toxicology, 12(Suppl. 3), 345-351.
59. Takenaka S., Karg E., Muller W., Roth C., Ziesenis A., Heinzmann U., Scramel P., Heyder J. (2000), A morphologic study on the fate of ultrafine silver particles: Distribution pattern of phagocytized metallic silver in vitro and in vivo, Inhalation Toxicology, 12, 291-299.
60. Takenaka S., Karg E., Roth C., Schulz H., Ziesenis A., Heinzmann U., Schramel P., Heyder J. (2001), Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats, Environmental Health Perspectives, 109, 547-551.
61. Timblin C. R., Shukla A., Berlanger I., Berube K. A., Churg A., Mossman B. T. (2002), Ultrafine airborne particles cause increases in protooncogene expression and proliferation in alveolar epithelial cells, Toxicology and Applied Pharmacology, 179(2), 98-104.
62. Tjalve H, Mejare C, Borg-Neczak K. (1995), Uptake and transport of manganese in primary and secondary olfactory neurons in pike, Pharmacol Toxicol, 77(1), 23-31.
63. Tjalve H., Henriksson J., Tallkvist J., Larsson B. S., Lindquist N. G. (1996), Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats, Pharmacol Toxicol, 79, 347-356.
64. Tjalve H, Henriksson J. (1999), Uptake of metals in the brain via olfactory pathways, Neurotoxicology, 20(2-3), 181-196.
65. US EPA, US Environmental Protection Agency. (1996), Air quality criteria for particulate matter, Research Triangle Park, NC: National Center for Environmental Assessment, RTP Office; reports nos EPA/600/P-95/001aF-cF.
66. Veronesi B., de Haar C., Lseng L., Oortgiesen M. (2002), The surface charge of visible particulate matter predicts biological activation in human bronchial epithelial cells, Toxicology and Applied Pharmacology, 178(3), 144-154.
67. WHO, World Health Organization. (1997), Air Quality Guidelines for Europe 1996: particulate matter. Final edited draft, p. 84.
68. WHO, World Health Organization. (1999a), Health Guidelines for Vegetation Fire Events, Geneva, Switzerland.
69. WHO, World Health Organization. (1999b), Guidelines for Air Quality, Geneva, Switzerland.
70. Wichmann H. E., Spix C., Tuch T., Wölke G., Peters A., Heinrich J., Kreyling W. G., Heyder J. (2000), Daily mortality and fine and ultrafine particles in erfurt, germany, Part I: role of particle number and particle mass, Research report, 98, 5-86.
71. Wilson M. R., Lightbody J. H., Donaldson K., Sales J., Stone V. (2002), Interactions between Ultrafine Particles and Transition Metals in Vivo and in Vitro, Toxicology and Applied Pharmacology, 184(3), 172-179.
72. Yang Y., Li X., Li Y. L., Tan M., Lu W., Zhang G., Li Y. (2008), Platinum concentrations in urban airborne particles from Shanghai, China, Global NEST Journal, 10(2), 169-173.
73. Zimmer A. T., Baron P. A., Biswas P. (2002), The influence of operating parameters on numberweighted aerosol size distribution generated from a gas metal arc welding process, J Aerosol Sci, 33, 519-53.