Induction of fibrogenic mediators by fine and ultrafine titanium dioxide in rat tracheal explants

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 277, Issue 5 21-5, 1999, Pages

  Churg, A ^a   Gilks, B ^a   Dai, J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Air pollution; Particulate matter less than 10 micrometers; Platelet derived growth factor; Platelet derived growth factor receptor; Transforming growth factor ; Transforming growth factor

Indexed keywords

PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROCOLLAGEN; TITANIUM DIOXIDE; TOXIC SUBSTANCE; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; EXPLANT; FIBROGENESIS; FIBROSIS; GENE EXPRESSION; INFLAMMATION; NONHUMAN; ORGAN CULTURE; PARTICLE SIZE; PARTICULATE MATTER; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0032784919     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1999.277.5.l975     Document Type: Article

References (41)

1. Abbey, D. E., P. K. Mills, F. F. Petersen, and W. L. Beeson. Long-term ambient concentrations of total suspended particulates and oxidants as related to incidence of chronic disease in California Seventh-Day Adventists. Environ. Health Perspect. 94: 43-50, 1991.
2. Adamson, I. V. R., H. L. Letourneau, and D. H. Bowden. Comparison of alveolar and interstitial macrophages in fibroblast stimulation after silica and long or short asbestos. Lab. Invest. 64: 339-344, 1991.
3. American Thoracic Society Committee of the Environmental and Occupational Health Assembly. Health effects of outdoor air pollution. Am. J. Respir. Crit. Care Med. 153: 3-50, 1996.
4. Bayram, H., J. L. Devalia, R. J. Sapsford, T. Ohtoshi, Y. Miyabara, M. Sagai, and R. J. Davies. The effect of diesel exhaust particles on cell function and release of inflammatory mediators from human bronchial epithelial cells in vitro. Am. J. Respir. Cell Mol. Biol. 18: 441-448, 1998.
5. Becker, S., J. M. Soukup, M. I. Gilmour, and R. B. Devlin. Stimulation of human and rat alveolar macrophages by urban air particulates: effects on oxidant radical generation and cytokine production. Toxicol. Appl. Pharmacol. 141: 637-648, 1996.
6. Bonner, J. C., A. B. Rice, P. M. Lindroos, P. O. O'Brien, K. L. Dreher, I. Rosas, E. Alfaro-Moreno, and A. R. Osornia-Vargas. Induction of the lung myonbroblast PDGF receptor system by urban ambient particles from Mexico City. Am. J. Respir. Cell Mol. Biol. 19: 672-680, 1998.
7. Carter, J. D., A. Ghio, J. Samet, and R. B. Devlin. Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal dependent. Toxicol. Appl. Pharmacol. 146: 180-188, 1997.
8. Chomczynski, P., and N. Sacchi. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
9. 2 in a tracheal explant system. Am. J. Physiol. 274 (Lung Cell. Mol. Physiol. 18): L81-L86, 1998.
10. 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis. Am. J. Pathol. 150: 981-991, 1997.
11. Dai, J., B. Gilks, K. Price, and A. Churg. Mineral dusts directly induce epithelial and interstitial fibrogenic mediators and matrix components in the airway wall. Am. J. Respir. Crit. Care Med. 158: 1907-1913, 1998.
12. Dockery, D. W., and C. A. Pope. Acute respiratory effects of particulate air pollution. Annu. Rev. Public Health 15: 107-132, 1994.
13. Donaldson, K., X. Y. Li, and W. MacNee. Ultrafine (nanometre) particle mediated lung injury. J. Aerosol Sci. 29: 553-560, 1998.
14. Driscoll, K. E., J. M. Carter, B. W. Howard, D. G. Hassenbein, W. Pepelko, R. B. Baggs, and G. Oberdorster. Pulmonary inflammatory, chemokine, and mutagenic responses in rats after subchronic inhalation of carbon black. Toxicol. Appl. Pharmacol. 136: 372-380, 1996.
15. Driscoll, K. E., D. G. Hassenbein, J. M. Carter, S. L. Kunkel, T. R. Quinlan, and B. T. Mossman. TNFα and increased chemokine expression in rat lung after particle exposure. Toxicol. Lett. 82: 483-489, 1995.
16. Ferin, J., G. Oberdorster, and D. P. Penney. Pulmonary retention of ultrafine and fine particles in rats. Am. J. Respir. Cell Mol. Biol. 6: 535-542, 1992.
17. Ferin, J., G. Oberdorster, S. C. Soderholm, and R. Gelein. Pulmonary tissue access of ultrafine particles. J. Aerosol Med. 4: 57-68, 1991.
18. Finkelstein, J. N., C. Johnson, T. Barrett, and G. Oberdorster. Particle-cell interactions and pulmonary cytokine expression. Environ. Health Perspect. 105, Suppl. 50: 1179-1182, 1997.
19. 10 and ultrafine titanium dioxide: a unifying factor in their toxictiy? Ann. Occup. Hyg. 41, Suppl.: 32-38, 1997.
20. Gore, D. J., and G. Patrick. A quantitative study of the penetration of insoluble particles into the tissues of the conducting airways. Ann. Occup. Hyg. 26, 149-161, 1982.
21. Grant, P. M., J. Tellam, V. L. May, and A. W. Strauss. Isolation and nucleotide sequence of a cDNA clone encoding rat mitochondrial malate dehydrogenase. Nucleic Acids Res. 14: 6053-6066, 1996.
22. Jammes, Y., S. Delpierre, M. J. Delvolgo, C. Humbert, and H. Burnet. Long-term exposure of adults to outdoor air pollution is associated with increased airway obstruction and higher prevalence of bronchial hyperresponsiveness. Arch. Environ. Health 53: 372-377, 1998.
23. Johnston, C. J., J. N. Finkelstein, R. Gelein, R. Baggs, and G. Oberdorster. Characterization of the early pulmonary inflammatory response associated with PTFE fume exposure. Toxicol. Appl. Pharmacol. 140: 154-163, 1996.
24. Lang, D. S., R. A. Jorres, M. Mucke, W. Siegfried, and H. Magnussen. Interactions between human bronchoepithelial cells and lung fibroblasts after ozone exposure in vitro. Toxicol. Lett. 96-97: 13-24, 1998.
25. Lasky, J. A., B. Tonthat, J.-Y. Liu, M. Friedman, and A. R. Brody. Upregulation of the PDGF-alpha receptor precedes asbestos-induced lung fibrosis in rats. Am. J. Respir. Crit. Care Med. 157: 1652-1657, 1998.
26. 10) in vivo and in vitro. Thorax 51: 1216-1222, 1996.
27. Lindross, P. M., P. G. Coin, A. Badgett, D. L. Morgan, and J. C. Bonner. Alveolar macrophages stimulated with titanium dioxide, chrysotile asbestos, and residual oil fly ash upregulate the PDGF receptor-alpha on lung fibroblasts through an IL-1beta-dependent mechanism. Am. J. Respir. Cell Mol. Biol. 16: 283-292, 1997.
28. Liu, J.-Y., G. F. Morris, W. Lei, M. Corti, and A. R. Brody. Up-regulated expression of transforming growth factor-alpha in the bronchiolar-alveolar duct region of asbestos exposed rats. Am. J. Pathol. 149: 205-217, 1996.
29. Liu, J.-Y., G. F. Morris, W.-H. Lei, C. E. Hart, J. A. Lasky, and A. R. Brody. Rapid activation of PDGF-A and -B expression at sites of lung injury in asbestos-exposed rats. Am. J. Respir. Cell Mol. Biol. 17: 129-140, 1997.
30. Mossman, B. T., J. B. Kessler, B. W. Ley, and J. E. Craighead. Interaction of crocidolite asbestos with hamster respiratory mucosa in organ culture. Lab. Invest. 36: 131-139, 1977.
31. Oberdorster, G. Significance of particle parameters in the evaluation of exposure-dose-response relationships of inhaled particles. Inhal. Toxicol. 8, Suppl.: 73-89, 1996.
32. Oberdorster, G., J. Ferin, and B. E. Lehnert. Correlation between particle size, in vivo particle persistence, and lung injury. Environ. Health Perspect. 102, Suppl. 5: 173-179, 1994.
33. Oberdorster, G., R. M. Gelein, J. Ferin, and B. Weiss. Association of particulate air pollution and acute mortality: involvement of ultrafine particles? Inhal. Toxicol. 7: 111-124, 1995.
34. Ohtoshi, T., H. Takizawa, H. Okazaki, S. Kawasaki, N. Takeuchi, K. Ohta, and K. Ito. Diesel exhaust particles stimulate human airway epithelial cells to produce cytokines relevant to airway inflammation in vitro. J. Allergy Clin. Immunol. 101: 778-785, 1998.
35. Quay, J. L., W. Reed, J. Samet, and R. B. Devlin. Air pollution particles induce IL-6 gene expression in human airway epithelial cells via NF-kB activation. Am. J. Respir. Cell Mol. Biol. 19: 98-106, 1998.
36. Seaton, A., W. MacNee, K. Donaldson, and D. Godden. Particulate air pollution and acute health effects. Lancet 345: 176-178, 1995.
37. Stringer, B., and L. Kobzik. Environmental particulate-mediated cytokine production in lung epithelial cells (A549): role of preexisting inflammation and oxidant stress. J. Toxicol. Environ. Health 55: 31-44, 1998.
38. Timblin, C., K. Beruhe, A. Churg, K. Driscoll, T. Gordon, D. Hemenway, E. Walsh, A. B. Cummins, P. Vacek, and B. Mossman. Ambient particulate matter causes activation of the c-jun kinase/stress activated protein kinase cascade and DNA synthesis in lung epithelial cells. Cancer Res. 58: 4543-4547, 1998.
39. Wiggs, B. R., C. Bosken, P. D. Pare, A. James, and J. C. Hogg. A model of airway narrowing in asthma and in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 145: 1251-1258, 1992.
40. Wilson, W. E., and H. H. Suh. Fine particles and coarse particles: concentration relationships relevant to epidemiologic studies. J. Air Waste Manag. Assoc. 47: 1238-1249, 1997.
41. Woodin, M. A., R. Hauser, Y. Liu, R. J. Smith, P. D. Siegel, D. M. Lewis, D. J. Tollerud, and D. C. Christiani. Molecular markers of acute upper airway inflammation in workers exposed to fuel-oil ash. Am. J. Respir. Crit. Care Med. 158: 182-187, 1998.