Modeling nicotinic neuromodulation from global functional and network levels to nAChR based mechanisms

Acta Pharmacologica Sinica

Volumn 30, Issue 6, 2009, Pages 681-693

  Graupner, Michael ^a   Gutkin, Boris ^a  

^a ECOLE NORMALE SUPÉRIEURE   (France)

Author keywords

Computational model; Mean field model; NAChR kinetics; Nicotine

Indexed keywords

ACETYLCHOLINE; DOPAMINE; LIGAND; NICOTINE; NICOTINIC RECEPTOR;

BIOLOGICAL MODEL; COMPUTER MODEL; DOPAMINERGIC TRANSMISSION; DRUG ACTIVITY; KINETICS; MEMORY; NERVE CELL NETWORK; NEUROMODULATION; POPULATION DYNAMICS; PROTEIN ANALYSIS; PROTEIN INTERACTION; RECALL; REVIEW; SIGNAL PROCESSING; TOBACCO DEPENDENCE; VENTRAL TEGMENTUM;

EID: 67549132873     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.87     Document Type: Review

References (74)

1. Fellous JM, Linster C. Computational models of neuromodulation. Neural Comput 1998; 10: 771-805.
2. Dayan P, Abbot LF. Teoretical neuroscience-computational and mathematical modeling of neural systems. Cambridge (MA): MIT Press; 2001.
3. Koch C, Segev I, editors. Methods in neuronal modeling: from ions to networks. 2nd edition. Cambridge (MA): MIT Press; 1998.
4. Katz PS. Beyond neurotransmission: Neuromodulation and its importance for information processing. Oxford: Oxford University Press; 1999.
5. Sutton RS, Barto AG. Reinforcement learning: an introduction. IEEE Trans Neural Netw 1998; 9: 1054.
6. Mitchell TM. Machine Learning. McGraw Hill; 1997.
7. Hasselmo ME. Te role of acetylcholine in learning and memory. Curr Opin Neurobiol 2006; 16: 710-5.
8. Yu AJ, Dayan P. Acetylcholine in cortical inference. Neural Netw 2002; 15: 719-30.
9. Yu AJ, Dayan P. Uncertainty, neuromodulation, and attention. Neuron 2005; 46: 681-92.
10. Durstewitz D, Seamans JK. Beyond bistability: biophysics and temporal dynamics of working memory. Neuroscience 2006;139: 119-33.
11. Durstewitz D, Seamans JK. Te computational role of dopamine D1 receptors in working memory. Neural Netw 2002;15: 561-72.
12. Phillips JM, McAlonan K, Robb WG, Brown VJ. Cholinergic neuro transmission influences covert orientation of visuospatial atten tion in the rat. Psychopharmacology (Berl) 2000; 150: 112-6.
13. Hasselmo ME. Expecting the unexpected: modeling of neuro-modu lation. Neuron 2005; 46: 526-8.
14. Montague PR, Dayan P, Sejnowski TJ. A framework for mesence-phalic dopamine systems based on predictive Hebbian learning. J Neurosci 1996; 16: 1936-47.
15. Compte A, Wang XJ. Tuning curve shif by atention modulation in cortical neurons: a computational study of its mechanisms. Cereb Cortex 2006;16:761-78.
16. Hasselmo ME, Anderson BP, Bower JM. Cholinergic modulation of cortical associative memory function. J Neurophysiol 1992; 67: 1230-46.
17. Deco G, Rolls ET. Attention, short-term memory, and action selection: a unifying theory. Prog Neurobiol 2005; 76: 236-56.
18. Gil Z, Connors BW, Amitai Y. Diferential regulation of neocortical synapses by neuromodulators and activity. Neuron 1997; 19: 679-86.
19. Linster C, Cleland TA. Cholinergic modulation of sensory representations in the olfactory bulb. Neural Netw 2002;15: 709- 17.
20. Linster C, Hasselmo ME. Neuromodulation and the functional dynamics of piriform cortex. Chem Senses 2001; 26: 585-94.
21. Hasselmo ME, McGaughy J. High acetylcholine levels set circuit dynamics for atention and encoding and low acetylcholine levels set dynamics for consolidation. Prog Brain Res 2004; 145: 207- 31.
22. Hertz J, Krogh A, Palmer RG. Introduction to the theory of neural computation. Redwood City (CA): Addison Wesley; 1991.
23. Hasselmo. Neuromodulation: acetylcholine and memory consolidation. Trends Cogn Sci 1999; 3: 351-9.
24. Patil MM, Hasselmo ME. Modulation of inhibitory synaptic potentials in the piriform cortex. J Neurophysiol 1999; 81: 2103- 18.
25. Myers CS, Taylor RC, Moolchan ET, Heishman SJ. Dose-related enhancement of mood and cognition in smokers administered nicotine nasal spray. Neuropsychopharmacology 2008; 33: 588- 98.
26. Gutkin BS, Dehaene S, Changeux JP. A neurocomputational hypothesis for nicotine addiction. Proc Natl Acad Sci USA 2006; 103: 1106-11.
27. Corrigall WA, Coen KM. Nicotine maintains robust self-administration in rats on a limited-access schedule. Psycho pharma cology (Berl) 1989; 99: 473-8.
28. David V, Besson M, Changeux JP, Granon S, Cazala P. Reinforcing efects of nicotine microinjections into the ventral tegmental area of mice: dependence on cholinergic nicotinic and dopaminergic D1 receptors. Neuropharmacology 2006; 50: 1030-40.
29. Piccioto MR, Zoli M, Rimondini R, Lena C, Marubio LM, Pich EM, et al. Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. Nature 1998; 391: 173-7.
30. Champtiaux N, Gotti C, Cordero-Erausquin M, David DJ, Przybylski C, Lena C, et al. Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J Neurosci 2003; 23: 7820-9.
31. Changeux JP, Bertrand D, Corringer PJ, Dehaene S, Edelstein S, Léna C, et al. Brain nicotinic receptors: structure and regulation, role in learning and reinforcement. Brain Res Brain Res Rev 1998; 26: 198-216.
32. Dani JA, Heinemann S. Molecular and cellular aspects of nicotine abuse. Neuron 1996;16: 905-8.
33. Usher M, McClelland JL. Te time course of perceptual choice: the leaky, competing accumulator model. Psychol Rev 2001; 108: 550-92.
34. Cho RY, Nystrom LE, Brown ET, Jones AD, Braver TS, Holmes PJ, et al. Mechanisms underlying dependencies of performance on stimulus history in a two-alternative forced-choice task. Cogn Afect Behav Neurosci 2002; 2: 283-99.
35. Beiser DG, Hua SE, Houk JC. Network models of the basal ganglia. Curr Opin Neurobiol 1997; 7: 185-90.
36. Dehaene S, Changeux JP. Reward-dependent learning in neuronal networks for planning and decision making. Prog Brain Res 2000; 126: 217-29.
37. DiChiara G. Drug addiction as a dopamine-dependent associative learning disorder. Eur J Pharmacol 1999; 375: 13-30.
38. Rahman S, Zhang J, Engleman EA, Corrigall WA. Neuroadaptive changes in the mesoaccumbens dopamine system after chronic nicotine self-administration: a microdialysis study. Neuroscience 2004; 129: 415-24.
39. Granon S, Faure P, Changeux JP. Executive and social behaviors under nicotinic receptor regulation. Proc Natl Acad Sci USA 2002; 100: 9596-601.
40. Karlin A. Emerging structure of the nicotinic acetylcholine receptors. Nat Rev Neurosci 2002; 3: 102-14.
41. Edelstein SJ, Schaad O, Henry E, Bertrand D, Changeux JP. A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions. Biol Cybern 1996; 75: 361-79.
42. Fenster CP, Rains MF, Noerager B, Quick MW, Lester RA. Infuence of subunit composition on desensitization of neuronal acetyl choline receptors at low concentrations of nicotine. J Neurosci 1997; 17: 5747-59.
43. Monond J, Wyman J, Changeux JP. On the nature of allosteric transitions: a plausible model. J Mol Biol 1965;12: 88-118.
44. Castillo JD, Katz B. Interaction at end-plate receptors between different choline derivatives. Proc R Soc Lond B Biol Sci 1957; 146: 369-81.
45. Katz B, Thesleff S. A study of the desensitization produced by acetylcholine at the motor end-plate. J Physiol 1957;138: 63-80.
46. Colquhoun D, Sakmann B. Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate. J Physiol 1985; 369: 501-57.
47. Franke C, Parnas H, Hovav G, Dudel J. A molecular scheme for the reaction between acetylcholine and nicotinic channels. Biophys J 1993; 64: 339-56.
48. Heidmann T, Changeux JP. Interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedo marmorata in the millisecond time range: resolution of an "intermediate" conformational transition and evidence for positive cooperative effects. Biochem Biophys Res Commun 1980; 97: 889-96.
49. Neubig RR, Cohen JB. Permeability control by cholinergic receptors in Torpedo postsynaptic membranes: agonist dose-response relations measured at second and millisecond times. Biochemistry 1980; 19: 2770-9.
50. Auerbach A, Akk G. Desensitization of mouse nicotinic acetyl-choline receptor channels. A two-gate mechanism. J Gen Physiol 1998; 112: 181-97.
51. Prince RJ, Sine SM. Acetylcholine and epibatidine binding to muscle acetylcholine receptors distinguish between concerted and uncoupled models. J Biol Chem 1999;274:19623-9.
52. Reitstetter R, Lukas RJ, Gruener R. Dependence of nicotinic acetylcholine receptor recovery from desensitization on the duration of agonist exposure. J Pharmacol Exp Ter 1999; 289: 656- 60.
53. Kalivas PW, Churchill L, Klitenick MA. GABA and enkephalin projection from the nucleus accumbens and ventral pallidum to the ventral tegmental area. Neuroscience 1993; 57:1047-60.
54. Christie MJ, Bridge S, James LB, Beart PM. Excitotoxin lesions suggest an aspartatergic projection from rat medial prefrontal cortex to ventral tegmental area. Brain Res 1985; 333: 169-72.
55. Cornwall J, Cooper JD, Phillipson OT. Afferent and efferent connections of the laterodorsal tegmental nucleus in the rat. Brain Res Bull 1990; 25: 271-84.
56. Oakman SA, Faris PL, Kerr PE, Cozzari C, Hartman BK. Distri-bu tion of pontomesencephalic cholinergic neurons projecting to substantia nigra differs significantly from those projecting to ventral tegmental area. J Neurosci 1995;15: 5859-69.
57. Johnson SW, North R. Two types of neurone in the rat ventral tegmental area and their synaptic inputs. J Physiol 1992; 450: 455-68.
58. Mansvelder HD, Rover MD, McGehee DS, Brussaard AB. Cho-linergic modulation of dopaminergic reward areas: upstream and downstream targets of nicotine addiction. Eur J Pharmacol 2003; 480: 117-23.
59. Mansvelder HD, McGehee DS. Long-term potentiation of excitatory inputs to brain reward areas by nicotine. Neuron 2000; 27: 349-57.
60. Goti C, Moreti M, Gaimarri A, Zanardi A, Clementi F, Zoli M. Heterogeneity and complexity of native brain nicotinic receptors. Biochem Pharmacol 2007;74: 1102-11.
61. Klink R, de Kerchove d'Exaerde A, Zoli M, Changeux J P. Molecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci 2001; 21: 1452-63.
62. Corrigall WA, Coen KM, Adamson KL. Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area. Brain Res 1994;653: 278-84.
63. Dani JA, Ji D, Zhou FM. Synaptic plasticity and nicotine addiction. Neuron 2001; 31: 349-52.
64. Henningfeld JE, Stapleton JM, Benowitz NL, Grayson RF, London ED. Higher levels of nicotine in arterial than in venous blood afer cigarete smoking. Drug Alcohol Depend 1993; 33: 23-9.
65. Pidoplichko VI, DeBiasi M, Williams JT, Dani JA. Nicotine activates and desensitizes midbrain dopamine neurons. Nature 1997; 390: 401-4.
66. Wilson HR, Cowan JD. Excitatory and inhibitory interactions in localized populations of model neurons. Biophys J 1972; 12: 1-24.
67. Hansel D, Sompolinsky H. Modeling Feature Selectivity in Local Cortical Circuits. In Methods in Neuronal Modeling: From Synapse to Networks. Koch C, Segev I, editors. Cambridge (MA): MIT Press; 1998.
68. Peng X, Katz M, Gerzanich V, Anand R, Lindstrom J. Human alpha7 acetylcholine receptor: cloning of the alpha7 subunit from the SH-SY5Y cell line and determination of pharmacological properties of native receptors and functional alpha7 homomers expressed in Xenopus oocytes. Mol Pharmacol 1994;45: 546-54.
69. Gerzanich V, Peng X, Wang F, Wells G, Anand R, Fletcher S, et al. Comparative pharmacology of epibatidine: a potent agonist for neuronal nicotinic acetylcholine receptors. Mol Pharmacol 1995; 48: 774-82.
70. Buisson B, Bertrand D. Chronic exposure to nicotine upregulates the human (alpha)4(beta)2 nicotinic acetylcholine receptor function. J Neurosci 2001; 21:1819-29.
71. Eaton JB, Peng JH, Schroeder KM, George AA, Fryer JD, Krishnan C, et al. Characterization of human (alpha)4(beta)2- nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells. Mol Pharmacol 2003; 64: 1283-94.
72. Papke RL. Estimation of both the potency and efcacy of alpha7 nAChR agonists from single-concentration responses. Life Sci 2006; 78: 2812-9.
73. Schultz W. Predictive reward signal of dopamine neurons. J Neurophysiol 1998; 80: 1-27.
74. Matsumoto M, Hikosaka O. Lateral habenula as a source of negative reward signals in dopamine neurons. Nature 2007; 447: 1111-5.