Brain nicotinic receptors: Structure and regulation, role in learning and reinforcement

Brain Research Reviews

Volumn 26, Issue 2-3, 1998, Pages 198-216

  Changeux, Jean Pierre ^a   Bertrand, Daniel ^a,b   Corringer, Pierre Jean ^a   Dehaene, Stanislas ^a,c   Edelstein, Stuart ^a,d   Léna, Clément ^a   Le Novère, Nicolas ^a   Marubio, Lisa ^a   Picciotto, Marina ^a,e   Zoli, Michele ^a,f  

^a INSTITUT PASTEUR   (France)

^b Dept of Physiology   (Switzerland)

^c SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^d UNIVERSITY OF GENEVA   (Switzerland)

^e YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Learning; Nicotinic receptor; Reinforcement; Structure

Indexed keywords

NICOTINIC RECEPTOR;

CONFERENCE PAPER; HUMAN; LEARNING; NEUROTRANSMISSION; PRIORITY JOURNAL; PROTEIN STRUCTURE; REINFORCEMENT; REWARD; STRUCTURE ACTIVITY RELATION; TASK PERFORMANCE;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; BRAIN; COGNITION; EVOLUTION, MOLECULAR; HUMANS; LEARNING; MODELS, NEUROLOGICAL; MUTAGENESIS, SITE-DIRECTED; NERVE NET; NEURONS; RECEPTORS, NICOTINIC; REINFORCEMENT (PSYCHOLOGY);

EID: 18844464648     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0173(97)00040-4     Document Type: Conference Paper

References (169)

1. Albuquerque E.X., Pereira E., Alkondon M., Schrattenholz A., Maelicke A. Minireview: Nicotinic acetylcholine receptors on hippocampal neurons: Distribution on the neuronal surface and modulation of receptor activity. J. Recept. Signal Transduct Res. 17:1997;243-266.
2. Agnati L.F., Zoli M., Strömberg I., Fuxe K. Intercellular communication in the brain: wiring versus volume transmission. Neuroscience. 69:1995;711-726.
3. Altman J., Everitt B.J., Glautier S., Markun A., Nutt D., Oretti R., Philipps G.D., Robbins T.W. The biological, social and clinical bases of drug addiction: commentary and debate. Psychopharmacology. 125:1996;285-345.
4. Amador M., Dani J. Mechanisms for modulation of nicotinic acetylcholine receptors that can influence synaptic transmission. J. Neurosci. 15:1995;4525-4532.
5. P. Andersen, O. Hvalby, B. Paulsen, T. Hökfelt (Eds.), Memory concepts Basic and Clinical aspects, Excerpta Medica, Amsterdam, 1993.
6. Barford D., Johnson L.N. The allosteric transition of glycogen phosphorylase. Nature. 340:1989;609-616.
7. Bertrand D., Changeux J.P. Nicotinic receptor: an allosteric protein specialized for intercellular communication. Seminars Neurosci. 7:1995;75-90.
8. Bertrand D., Ballivet M., Rungger D. Activation and blocking of neuronal nicotinic acetylcholine receptor reconstituted in Xenopus oocytes. Proc. Natl. Acad. Sci. USA. 87:1990;1993-1997.
9. Bertrand D., Galzi J.L., Devillers-Thiéry A., Bertrand S., Changeux J.P. Stratification of the channel domain in neurotransmitter receptors. Current Opinion in Cell Biol. 5:1993;688-693.
10. Bertrand D., Galzi J.L., Devillers-Thiéry A., Bertrand S., Changeux J.P. Mutations at two distinct sites within the channel domain M2 alter calcium permeability of neuronal alpha7 nicotinic receptor. Proc. Nat. Acad. Sci. USA. 90:1993;6971-6975.
11. Bertrand D., Devillers-Thiéry A., Revah F., Galzi J.L., Hussy N., Mulle C., Bertrand S., Ballivet M., Changeux J.P. Unconventional pharmacology of a neuronal nicotinic receptor mutated in the channel domain. Proc. Natl. Acad. Sci. USA. 89:1992;1261-1265.
12. S. Bertrand, A. Devillers-Thiéry, E. Palma, B. Buisson, S. Edelstein, P.J. Corringer, J.P. Changeux, D. Bertrand, Paradoxical allosteric effects of competitive inhibitors on neuronal alpha 7 nicotinic receptor mutants, NeuroReport (1997) in press.
13. Bertrand D., Valera S., Bertrand S., Ballivet M., Rungger D. Steroids inhibit nicotinic acetylcholine receptors. NeuroReport. 2:1991;277-280.
14. Bessis A., Champtiaux N., Chatelin L., Changeux J.P. The neuron-restrictive silencer element (NRSE): a dual enhancer/silencer crucial for patterned expression of a nicotinic receptor gene in the brain. Proc. Natl. Acad. Sci. USA. 94:1997;5906-5911.
15. Boulter J., Evans K., Goldman D., Martin G., Treco D., Heinemann S., Patrick J. Isolation of a cDNA clone coding for a possible neural nicotinic acetylcholine receptor alpha-subunit. Nature. 319:1986;368-374.
16. 3H carbamylcholine to Torpedo postsynaptic membranes: slow conformational transitions of the cholinergic receptor Biochemistry. 19:1980;5344-5358.
17. Changeux J.P. The feedback control mechanism of biosynthetic L-threonine deaminase by L-isoleucine. Cold Spring Harbor. Symp., Quant. Biol. 26:1961;313-318.
18. Changeux J.P. Sur les propriétés allostériques de la L-thréonine deaminase de biosynthèse VI. Discussion générale. Bull Soc. Chim. Biol. 47:1965;281-300.
19. Changeux J.P. Responses of acetylcholinesterase from Torpedo marmorata to salts and curarizing drugs. Mol. Pharmacol. 2:1966;369-392.
20. J.P. Changeux, Remarks on the symmetry and cooperative properties of biological membranes, Nobel Symposium: Symmetry and functions in Biological Systems at the Macromolecular level, Wiley, New York, 1969, pp. 235-256.
21. J.P. Changeux, L'Homme Neuronal, Fayard, Paris (1983); English translation: Neuronal man, Princeton University Press (1985 and 1997).
22. J.P. Changeux, Functional architecture and dynamics of the nicotinic acetylcholine receptor: an allosteric ligand-gated ion channel, Fidia Research Foundation Neuroscience Award Lectures, Vol. 4, 1990, pp. 21-168.
23. J.P. Changeux, A critical view of neuronal models of learning and memory. Memory concepts. Basic and clinical aspects. Novo Nordisk Foundation, Copenhagen, Danemark, Elsevier, Amsterdam, 1993, pp. 413-433.
24. J.P. Changeux, Neurotransmitter receptors in the changing brain: allosteric transitions, gene expression and pathology at the molecular level, Nobel Symposium: Individual Development over the Lifespan: Biological and Psychosocial Perspectives, Cambridge University Press, 1996, pp. 107-138.
25. J.P. Changeux, T. Heidmann, Allosteric receptors and molecular models of learning. In: Synaptic Function. Wiley, New York, 1987, pp. 549-604.
26. Changeux J.P., Devillers-Thiéry A., Chemouilli P. Acetylcholine receptor: an allosteric protein. Science. 225:1984;1335-1345.
27. Changeux J.P., Kasai M., Lee C.Y. The use of a snake venom toxin to characterize the cholinergic receptor protein. Proc. Natl. Acad. Sci. USA. 67:1970;1241-1247.
28. Changeux J.P., Thiéry J.P., Tung Y., Kittel C. On the cooperativity of biological membranes. Proc. Nat. Acad. Sci. USA. 57:1967;335-341.
29. J.P. Changeux, A. Bessis, J.P. Bourgeois, P.J. Corringer, A. Devillers-Thiéry, J.L. Eiselé, M. Kerszberg, C. Léna, N. Le Novère, M. Picciotto, M. Zoli, Nicotinic Receptors and Brain Plasticity. Function and Dysfunction in the nervous system. Cold Spring Harb. Symp. Quant. Biol. Volume 61, Cold Spring Harb. Laboratory Press, 1996, pp. 343-362.
30. P.S. Churchland, T. Sejnowski, The computational brain. MIT Press, Cambridge Mass., 1992.
31. Clarke P.B.S. Nicotinic receptors in mammalian brain: localization and relation to cholinergic function. Prog. Brain Res. 98:1993;77-83.
32. 125I]-alpha-bungarotoxin. J. Neurosci. 5:1985;1307-1315.
33. D. Colquhoun, H.P. Rang, The relation between clasical and cooperative models for drug action in drug receptors, Macmillan, London, 1973.
34. Colquhoun D., Sakmann B. Fast-events in single-channel currents activated by acetylcholine and its analogues at the frog muscle endplate. J. Physiol. 369:1985;501-557.
35. Connolly J.G., Gibb A.J., Colquhoun D. Heterogeneity of neuronal nicotinic acetylcholine receptors in thin slices of rat medial habenula. J. Physiol. 484:1995;87-105.
36. W.G. Conroy, D.K. Berg, Neurons can maintain multiple classes of nicotinic acetylcholine receptors distinguished by different subunit compositions, J. Biol. Chem. (1995) 4424-4431.
37. Conroy W.G., Vernallis A.B., Berg D.K. The alpha 5 product assembles with multiple acetylcholine receptor subunits to form distinctive receptor subtypes in brain. Neuron. 9:1992;679-691.
38. P.J. Corringer, S. Bertrand, S. Bohler, S. Edelstein, J.P. Changeux, D. Bertrand, Identification of critical elements modulating desensitization of neuronal nicotinic receptors (1997) (submitted).
39. Corringer P.J., Galzi J. L, Eiselé J.L., Bertrand S., Changeux J.P., Bertrand D. Identification of a new component of the agonist binding site of the nicotinic alpha 7 homooligomeric receptor. J. Biol. Chem. 270:1995;11749-11752.
40. Dani J., Heinemann S. Molecular and cellular aspects of nicotine abuse. Neuron. 16:1996;905-908.
41. Daubas P., Devillers-Thiéry A., Geoffroy B., Martinez S., Bessis A., Changeux J.P. Differential expression of the neuronal acetylcholine receptor 2 subunit gene during chick brain development as detected by in situ hybridization and cDNA amplification. Neuron. 5:1990;49-60.
42. Dehaene S., Changeux J.P. A simple model of prefrontal cortex function in delayed-response tasks. J. Cogn. Neurosci. 1:1989;244-261.
43. Dehaene S., Changeux J.P. The Wisconsin card sorting test: theoretical analysis and simulation of a reasoning task in a model neuronal network. Cereb. Cortex. 1:1991;62-79.
44. Dehaene S., Changeux J.P., Nadal J.P. Neural networks that learn temporal sequences by selection. Proc. Natl. Acad. Sci. U.S.A. 84:1987;2727-2731.
45. S. Dehaene, J.P. Changeux, A hierarchical neuronal network for planning behavior, Proc. Natl. Acad. Sci. U.S.A. (1997) in press.
46. Del Castillo J., Katz B. A study of curare action with an electrical micro-method. Proc. R. Soc. Lond. (Biol.). 146:1957;339-356.
47. Deneris E.S., Boulter J., Swanson L.W., Patrick J., Heinemann S. Beta 3: a new member of nicotinic acetylcholine receptor gene family is expressed in brain. J. Biol. Chem. 264:1989;6268-6272.
48. Dennis M., Giraudat J., Kotzyba-Hibert F., Goeldner M., Hirth C., Chang J.Y., Lazure C., Chrétien M., Changeux J.P. Amino acids of theTorpedo marmorata acetylcholine receptor subunit labeled by a photoaffinity ligand for the acetylcholine binding site. Biochemistry. 27:1988;2346-2357.
49. Devillers-Thiéry A., Galzi J.L., Bertrand S., Changeux J.P., Bertrand D. Stratified organization of the nicotinic acetylcholine receptor channel. NeuroReport. 3:1992;1001-1004.
50. Dineley-Miller K., Patrick J. Gene transcripts for the nicotinic acetylcholine receptor subunit beta4 are distributed in multiple areas of the rat central nervous system. Mol. Brain Res. 16:1992;339-344.
51. J.E. Dowling, Information processing by local circuits: The vertebrate retina as a model system. In: F.O. Schmitt, F.G. Worden (Eds.), The Neurosciences: Fourth Study Program, MIT Press, Cambridge, Mass, 1979, pp. 163-181.
52. G. Edelman, Neural Darwinism, Basic Books, New York, 1987.
53. G. Edelman, G. Tononi, Selection and development: the brain as a complex system, Behavioral, Neurobiological and Psychosocial perspectives, Cambridge University Press, 1996, pp. 107-138.
54. Edelstein S.J. An allosteric mechanism for the acetylcholine receptor. Biochem. Biophys. Res. Commun. 48:1972;1160-1165.
55. Edelstein S., Changeux J.P. Allosteric proteins after 30 years: the binding and state functions of the neuronal alpha 7 nicotinic acetylcholine receptor. Experientia. 52:1996;1083-1090.
56. S. Edelstein, J.P. Changeux, Allosteric transitions of the acetylcholine receptor. Linkage Thermodynamics of Macromolecular Interactions, Advances in Protein Chemistry (1997) (in press).
57. S. Edelstein, O. Schaad, J.P. Changeux, Myasthenic nicotinic receptor mutant interpreted in terms of the allosteric model, C.R. Acad. Sci. Paris (1997) in press.
58. Edelstein S., Schaad O., Henry E., Bertrand D., Changeux J.P. A kinetic mechanism for nicotinic acetylcholine receptors based on multiple allosteric transitions. Biol. Cybern. 75:1996;361-379.
59. Eiselé J.L., Bertrand S., Galzi J.L., Devillers-Thiéry A., Changeux J.P., Bertrand D. Chimaeric nicotinic-serotonergic receptor combines distinct ligand binding and channel specificities. Nature. 366:1993;479-483.
60. Forster I., Bertrand D. Inward rectification of neuronal nicotinic acetylcholine receptors investigated by using the homomeric α7 receptor. Proc. R. Soc. Lond. 260:1995;139-148.
61. J.M. Fuster, The prefrontal cortex: Anatomy, physiology, and neuropsychology of the frontal lobe, Raven Press, New York, 1989.
62. Galzi J.L., Changeux J.P. Neuronal nicotinic receptors: molecular organization and regulations. Neuropharmacology. 34:1995;563-582.
63. Galzi J.L., Edelstein S.J., Changeux J.P. The multiple phenotypes of allosteric receptor mutants. Proc. Natl. Acad. Sci. USA. 93:1996;1853-1858.
64. Galzi J.L., Bertrand S., Corringer P.J., Changeux J.P., Bertrand D. Identification of calcium binding sites that regulate potentiation of a neuronal nicotinic acetylcholine receptor. EMBO J. 15:1996;5824-5832.
65. Galzi J.L., Bertrand D., Devillers-Thiéry A., Revah F., Bertrand S., Changeux J.P. Functional significance of aromatic amino acids from three peptide loops of the alpha 7 neuronal nicotinic receptor site investigated by site-directed mutagenesis. FEBS Lett. 294:1991;198-202.
66. Galzi J.L., Devillers-Thiery A., Hussy N., Bertrand S., Changeux J.P., Bertrand D. Mutations in the ion channel domain of a neuronal nicotinic receptor convert ion selectivity from cationic to anionic. Nature. 359:1992;500-505.
67. Galzi J.L., Revah F., Bouet F., Ménez A., Goeldner M., Hirth C., Changeux J.P. Allosteric transitions of the acetylcholine receptor probed at the amino acid level with a photolabile cholinergic ligand. Proc. Natl. Acad. Sci. USA. 88:1991;5051-5055.
68. 3H]-chlorpromazine. Proc. Natl. Acad. Sci. USA. 83:1986;2719-2723.
69. 3H] chlorpromazine labels homologous residues in the beta and delta chains. Biochemistry. 26:1987;2410-2418.
70. Goldman-Rakic P.S. Cellular basis of working memory. Neuron. 14:1995;477-485.
71. Granon S., Poucet B., Thinus-Blanc C., Changeux J.P., Vidal C. Nicotinic and muscarinic receptors in the rat prefrontal cortex: differential roles in working memory, response selection, and effortful processing. Psychopharmacology. 119:1995;139-144.
72. Grillner S., Wallen P., Brodin L. Neuronal network generating locomotor behavior in lamprey: circuitry, transmitters, membrane properties and simulation. Ann. Rev. Neurosc. 14:1991;169-199.
73. Heidmann T., Changeux J.P. Fast kinetic studies on the interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from T. marmorata. Eur. J. Biochem. 94:1979;255-279.
74. Heidmann T., Changeux J.P. Fast kinetic studies on the allosteric interactions between acetylcholine receptor and local anesthetic binding sites. Eur. J. Biochem. 94:1979;281-296.
75. Heidmann T., Changeux J.P Interaction of a fluorescent agonist with the membrane-bound acetylcholine receptor from Torpedo marmorata in the millisecond time range: resolution of an 'intermediate' conformational transition and evidence for positive cooperative effects. Biochem. Biophys. Res. Commun. 97:1980;889-896.
76. Heidmann T., Changeux J.P. Un modèle moléculaire de régulation d'efficacité d'un synapse chimique au niveau postsynaptique. C. R. Acad. Sci. Paris 3. 295:1982;665-670.
77. Hill J.A., Zoli M., Bourgeois J.P., Changeux J.P. Immunocytochemical localization of a neuronal nicotinic receptor: the beta2 subunit. J. Neurosci. 13:1993;1551-1568.
78. B. Hille, Ionic channel of excitable membranes. M.A. Sunderland (Ed.), Sinauer, 1984.
79. Hökfelt T. Neuropeptides in perspective: the last ten years. Neuron. 7:1991;867-879.
80. Hucho F., Oberthür W., Lottspeich F. The ion channel of the nicotinic acetylcholine receptor is formed by the homologous helices M2 of the receptor subunits. FEBS Lett. 205:1986;137-142.
81. Huganir R.L., Greengard P. Regulation of neurotransmitter receptor desensibilization by protein phosphorylation. Neuron. 5:1990;555-567.
82. Ifune C.K., Steinbach J.H. Inward rectification of acetylcholine-elicited currents in rat phacochromocytoma cells. J. Physiol. Lond. 457:1992;143-165.
83. Imoto K., Busch C., Sackmann B., Mishina M., Konno T., Nakai J., Bujo H., Mori Y., Fukuda K., Numa S. Rings of negatively charged amino acids determine the acetylchoine receptor channel conductance. Nature. 335:1988;645-648.
84. Imperato A., Mulas A., Di Chiara G. Nicotine preferentially stimulates dopamine release in the limbic system of freely moving rats. Eur. J. Pharmacol. 132:1986;337-338.
85. Iwata S., Kamata K., Yoshida S., Minowa T., Ohta T. T and R states in the crystals of bacterial L-lactate dehydrogenase reveal the mechanism of an allosteric control. Nature Structural Biology. 1:1994;176-184.
86. Jackson M.B. Spontaneous openings of the acetylcholine receptor channel. Proc. Natl. Acad. Sci. USA. 81:1984;3901-3904.
87. Jackson M.B. Kinetics of unliganded acetylcholine receptor channel. Proc. Natl. Acad. Sci. USA. 81:1986;3901-3904.
88. Jackson M.B., Imoto K., Mishina M., Konno T., Numa S., Sakmann B. Spontaneous and agonist-induced openings of an acetylcholine receptor channel composed of bovine muscle alpha-, beta- and delta-subunits. Pflügers Arch. Eur. J. Physiol. 417:1990;129-135.
89. Kao P.N., Dwork A.J., Kaldany R.R.J., Silver M. L, Widemann J., Stein J., Karlin A. Identification of the alpha-subunit half-cystine specifically labeled by an affinity reagent for acetylcholine receptor binding site. J. Biol. Chem. 259:1984;11662-11665.
90. Karlin A. On the application of 'a plausible model' of allosteric proteins to the receptor for acetylcholine. J. Theoret. Biol. 16:1967;306-320.
91. Karlin A. Structure of nicotinic acetylcholine receptors. Curr. Op. Neurobiol. 3:1993;299-309.
92. Karlin A., Akabas M. Toward a structural basis for the function of the nicotinic acetylcholine receptors and their cousins. Neuron. 15:1996;1231-1244.
93. Kerszberg M., Changeux J.P. A model for reading morphogenetic gradients: autocatalysis and competition at the gene level. Proc. Natl. Acad. Sci. USA. 91:1994;5823-5827.
94. Koshland D., Nemethy G., Filmer D. Comparison of experimental binding data and theoretical models in proteins containing subunits. Biochemistry. 5:1966;365-385.
95. Léna C., Changeux J.P. Allosteric modulations of the nicotinic acetylcholine receptor. Trends Neurosci. 16:1993;181-186.
96. Léna C., Changeux J.P. Role of calcium ions in nicotinic facilitation of GABA release in mouse thalamus. J. Neurosci. 17:1997;576-585.
97. Léna C., Changeux J.P., Mulle C. Evidence for 'Preterminal' nicotinic receptors on GABAergic axons in the rat interpeduncular nucleus. J. Neurosci. 13:1993;2680-2688.
98. Le Novère N., Changeux J.P. Molecular evolution of the nicotinic acetylcholine receptor: an example of multigene family in excitable cells. J. Mol. Evol. 40:1995;155-172.
99. Le Novère N., Zoli M., Changeux J.P. Neuronal nicotinic receptor alpha-6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain. J. Neurosci. 8:1996;2428-2439.
100. Leonard R.J., Labarca C.G., Charnet P., Davidson N., Lester H.A. Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor. Science. 242:1988;1578-1581.
101. Levin E.D. Nicotinic systems and cognitive function. Psychopharmacology. 108:1992;417-431.
102. Li X.M., Zoli M., Finnman U.B., Le Novère N., Changeux J.P., Fuxe K. A single (-) nicotine injection causes change with a time delay in the affinity of striatal D2 receptors for antagonist, but not for agonist, nor in the D2 receptor mRNA levels in the rat substantia nigra. Brain Res. 679:1995;157-167.
103. A.R. Luria, Higher cortical functions in man, Basic Books, New York, 1966.
104. MacGehee D.S., Role L. Presynaptic ionotropic receptors. Cur. Op. Neurobiol. 6:1996;342-349.
105. McGehee D.S., Heath M., Gelber S., Devay P., Role L.W. Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science. 269:1995;1692-1697.
106. McMahon L.L., Yoon K.W., Chiappinelli V.A. Nicotinic receptor activation facilitates GABAergic neurotransmission in the avian lateral spiriform nucleus. Neuroscience. 59:1994;689-698.
107. McMahon L.L., Yoon K.W., Chiappinelli V.A. Electrophysiological evidence for presynaptic nicotinic receptors in the avian ventral lateral geniculate nucleus. J. Neurophysiol. 71:1994;826-829.
108. R. Maldonado, A. Salardi, O. Valverde, T.A. Samad, B. Roques, E. Borrelli, Absence of opiate rewarding effects in mice lacking dopamine D2 receptors, Nature (in press).
109. Marks M.J., Pauly J.R., Gross S.D., Deneris E.S., Hermans-Borgmeyer I., Heinemann S.F., Collins A.C. Nicotine binding and nicotinic receptor subunit RNA after chronic treatment. J. Neurosci. 12:1992;2765-2784.
110. Mathie A., Colquhoun D., Cull-Candy S.G. Rectification of currents activated by nicotinic acetylcholine receptors in rat sympathetic ganglion cells. J. Physiol. Lond. 427:1990;625-655.
111. Merlo Pich E., Pagliusi S.R., Tessari M., Talabot-Ayer D., Hooft van Huijsduijnen R., Chiamulera C. Common neural substrates for the addictive properties of nicotine and cocaine. Science. 275:1997;83-86.
112. Marks M.J., Pauly J.R., Gross S.D., Deneris E.S., Hermans-Borgmeyer I., Heinemann S.F., Collins A.C. Nicotine binding and nicotinic receptor subunit RNA after chronic treatment. J. Neurosci. 12:1992;2765-2784.
113. Monod J., Changeux J.P., Jacob F. Allosteric proteins and cellular control systems. J. Mol. Biol. 6:1963;306.
114. Monod J., Wyman J., Changeux J.P. On the nature of allosteric transitions: a plausible model. J. Mol. Biol. 12:1965;88-118.
115. Montague P.R., Dayan P., Sejnowski T.J. A framework for mesencephalic dopamine systems based on predictive Hebbian learning. J. Neurosci. 16:1996;1936-1947.
116. Morris R.G.M., Schenk F., Tweedie F., Jarrard L.E. Ibotenate lesions of hippocampus and/or subiculum: dissociating components of allocentric spatial learning. Eur. J. Neurosci. 2:1990;1016-1028.
117. H. Muirhead, M.F. Perutz, Structure of hemoglobin. A three dimensional Fourier synthesis of reduced human hemoglobin at 5.5 Å resolution, Nature (1963) 633-638.
118. Mulle C., Changeux J.P. A novel type of nicotinic receptor in the rat central nervous system characterized by patch-clamp techniques. J. Neurosci. 10:1990;169-175.
119. Mulle C., Léna C., Changeux J.P. Potentiation of nicotinic receptor response by external calcium in rat central neurons. Neuron. 8:1992;937-945.
120. Mulle C., Choquet D., Korn H., Changeux J.P. Calcium influx through nicotinic receptor in rat central neurons: Its relevance to cellular regulation. Neuron. 8:1992;135-143.
121. Mulle C., Vidal C., Benoit P., Changeux J.P. Existence of different subtypes of nicotinic acetylcholine receptors in the rat habenulo interpeduncular system. J. Neurosci. 11:1991;2588-2597.
122. D. Nachmansohn, Chemical and molecular basis of nerve activity, Academic Press, New York, 1959, p. 235.
123. Nakazawa K. ATP-activated current and its interaction with acetylcholine-activated current in rat sympathetic neurons. J. Neurosci. 14:1994;740-750.
124. Neubig R.R., Cohen J.B. Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization. Biochemistry. 21:1982;3460-3467.
125. 3H -acetylcholine binding sites in the frontal cortex of Alzheimer brains Neurosci. Lett. 72:1986;307-318.
126. Numa S. A molecular view of neurotransmitter receptors and ionic channels. Harvey Lecture Ser. 83:1989;121-165.
127. Numa S., Noda M., Takahashi H., Tanabe T., Toyosato M., Furutani Y., Kikyotani S. Molecular structure of the nicotinic acetylcholine receptor. Cold Spring Harb. Symp. Quant. Biol. 48:1983;57-69.
128. Ortells M., Lunt G. Evolutionary history of the ligand-gated ion channel superfamily of receptors. Trends Neurosci. 18:1995;121-127.
129. Oswald R.E., Changeux J.P. Crosslinking of alpha-bungarotoxin to the acetylcholine receptor fromTorpedo marmorata by ultraviolet light irradiation. FEBS Lett. 139:1982;225-229.
130. Y. Paas, The macro- and microarchitectures of the ligand-binding domain of glutamate receptors, Trends Neurosci. (1997) in press.
131. Pedersen S.E., Cohen J.B. D-tubocurarine binding sites are located at the alpha-gamma and alpha-delta subunit interfaces of the nicotinic acetylcholine receptor. Proc. Natl. Acad. Sci. USA. 87:1990;2785-2789.
132. Pereira E.F., Alkondon M., Tano T., Castro N.G., Froes F.M., Rozental R., Aronstam R.S., Schrattenholz A., Maelicke A., Albuquerque E.X. A novel agonist binding site on nicotinic acetylcholine receptors. J. Recept. Res. 13:1993;413-436.
133. Perutz M.F. Mechanisms of cooperativity and allosteric regulation in proteins. Quart. Rev. Biophys. 22:1989;139-236.
134. M. Picciotto, M. Zoli, V. Zachariou, J.P. Changeux, Contribution of nicotinic acetylcholine receptors containing the β2-subunit to the behavioural effects of nicotine, Biochem. Soc. Trans. 25 (1997) in press.
135. M. Picciotto, M. Zoli, R. Rimondini, C. Léna, L. Marubio, E. Merlo Pich, K. Fuxe, J.P. Changeux, β-2 subunit containing acetylcholine receptors are involved in the reinforcing properties of nicotine, Nature (1997) in press.
136. Picciotto M., Zoli M., Léna C., Bessis A., Lallemand Y., Le Novère N., Vincent P., Merlo Pich E., Brûlet P., Changeux J.P. Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature. 374:1995;65-67.
137. Pontieri F.E., Tanda G., Orzi F., Di Chiara G. Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs. Nature. 382:1996;255-257.
138. Ramirez-Latorre J., Yu C.R., Qu X., Perin F., Karlin A., Role L. Functional contributions of alpha 5 subunit to neuronal acetylcholine receptor channels. Nature. 380:1996;347-351.
139. Révah F., Bertrand D., Galzi J.L., Devillers-Thiéry A., Mulle C., Hussy N., Bertrand S., Ballivet M., Changeux J.P. Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor. Nature. 353:1991;846-849.
140. Role L.W. Diversity in primary structure and function of neuronal nicotinic acetylcholine receptor channels. Current Opinion in Neurobiol. 2:1992;254-262.
141. Role L.W., Berg D.K. Nicotinic receptors in the development and modulation of CNS synapses. Neuron. 16:1996;1077-1085.
142. Sands S.B., Costa A.C.S., Patrick J.W. Barium permeability of neuronal nicotinic receptor alpha 7 expressed in Xenopus oocytes. Biophys. J. 65:1993;2614-2621.
143. Schirmer T., Evans P.R. Structural basis of the allosteric behavior of phosphofructokinase. Nature. 343:1990;140-145.
144. Schoffield P.R., Lynch J.W., Rajendra S., Pierce K.D., Handford C.A., Barry P.H. Molecular and genetic insights into ligand binding and signal transduction at the inhibitory glycine receptor. Cold Spring Harbor Symp. Quant. Biol. 61:1997;333-342.
145. Schulz W., Dayan P., Montague R. A neural substrate of prediction and reward. Science. 275:1997;1593-1599.
146. T. Shallice, From neuropsychology to mental structure, Cambridge University Press, 1988.
147. Séguéla P., Wadiche J., Dineley-Miller K., Dani J.A., Patrick J.W. Molecular cloning, functional properties and distribution of rat brain alpha7: A nicotinic cation channel highly permeable to calcium. J. Neurosci. 13:1993;596-604.
148. Sine S.M., Kreienkamp H.J., Bren N., Maeda R., Taylor P. Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of determinants of alpha-conotoxin M1 selectivity. Neuron. 15:1995;205-211.
149. Stafford G., Oswald R.E., Weiland G. The beta subunit of neuronal nicotinic acetylcholine receptors is a determinant of the affinity for substance P inhibition. Mol. Pharmacol. 45:1994;758-762.
150. Steinlein O.K., Magnusson A., Stoodt J., Bertrand S., Weiland S., Berkovic S.F., Nakken K.O., Propping P., Bertrand D. An insertion mutation of the CHRNA4 gene in a familial autosomal dominant nocturnal frontal lobe epilepsy. Human Mol. Gen. 6:1997;943-947.
151. Steinlein O., Mulley J., Propping P., Wallace R., Philipps H., Sutherland G., Scheffer I., Berkovic S. A missense mutation in the neuronal nicotinic acetylcholine receptor alpha 4 subunit is associated with autosomal dominant nocturnal frontal lobe epilepsy. Nature Genet. 11:1995;201-203.
152. Umbriaco D., Watkins K.C., Descarries L., Cozzari C., Hartman B.K. Ultrastructural and morphometric features of the acetylcholine innervation in adult rat parietal cortex: an electron microscopic study in serial sections. J. Comp. Neurol. 348:1994;351-373.
153. Unwin N. Acetylcholine receptor channel imaged in the open state. Nature. 373:1995;37-43.
154. Valera S., Ballivet M., Bertrand D. Progesterone modulates a neuronal nicotinic acetylcholine receptor. Proc. Nat. Acad. Sci. USA. 89:1992;9949-9953.
155. Vernallis A.B., Conroy W.G., Berg D.K. Neurons assemble acetylcholine receptors with as many as three kinds of subunits and can segregate subunits among receptor subtypes. Neuron. 10:1993;451-464.
156. Vernino S., Amador M., Luetje C.W., Patrick J., Dani J.A. Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors. Neuron. 8:1992;127-134.
157. Vidal C., Changeux J.P. Pharmacological profile of nicotinic acetylcholine receptors in the rat prefrontal cortex: an electrophysiological study in slice preparation. Neuroscience. 29:1989;261-270.
158. Vidal C., Changeux J.P. Nicotinic and muscarinic modulations of excitatory synaptic transmission in the rat prefrontal cortex in vitro. Neuroscience. 56:1993;23-32.
159. 5) in the rat central nervous system. Brain Res. 526:1990;45-53.
160. Wada E., Wada K., Boulter J., Deneris E., Heinemann S., Patrick J., Swanson L.W. Distribution of alpha2, alpha3, alpha4, and beta2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridization histochemical study in the rat. J. Comp. Neurol. 284:1989;314-335.
161. Wang F., Gerzanich V., Wells G.B., Anand R., Peng X., Keyser K., Lindstrom J. Assembly of human neuronal nicotinic receptor alpha 5 subunits with alpha 3, beta 2 and beta 4 subunits. J. Biol. Chem. 271:1996;17656-17665.
162. Warpman U., Nordberg A. Epibatidine and ABT 418 reveal selective losses of alpha4 beta 2 nicotinic receptors in Alzheimer brains. NeuroReport. 6:1995;2419-2423.
163. 14C]dopamine in rat brain striatum and hypothalamus slices. Neuropharmacology. 13:1974;1025-1032.
164. Wigstrom H., Gustafsson B. On long-lasting potentiation in the hippocampus: a proposed mechanism for its dependence on coincident pre- and postsynaptic activity. Acta Physiol. Scan. 123:1985;519-522.
165. Winkler J., Suhr S.T., Gage F.H., Thai L.J., Fisher L.J. Essential role of neocortical acetylcholine in spatial memory. Nature. 375:1995;484-487.
166. Wonnacott S. Presynaptic nicotinic ACh receptors. Trends Neurosci. 20:1997;92-98.
167. Zoli M., Agnati L.F., Hedlund P., Li X.M., Ferré S., Fuxe K. Receptor-receptor interactions as an integrative mechanism in nerve cells. Mol. Neurob. 7:1993;293-334.
168. Zoli M., Le Novère N., Hill J., Changeux J.P. Developmental regulation of nicotinic receptor subunit mRNAs in the rat central and peripheral nervous system. J. Neurosci. 15:1995;1912-1939.
169. M. Zoli, M. Picciotto, R. Ferrari, J.P. Changeux, A spatial learning deficit in aged mice lacking high-affinity nicotinic receptors, Soc. Neurosci. Abstr. vol. 23 (1997).