Chunghyuldan attenuates brain microglial inflammatory response

Canadian Journal of Physiology and Pharmacology

Volumn 87, Issue 6, 2009, Pages 448-454

  Nam, Kyong Nyon ^a   Jung, Hoon Ji ^a   Kim, Mi Hyun ^a   Kang, Chulhun ^a   Jung, Woo Sang ^b   Cho, Ki Ho ^b   Lee, Eunjoo H ^a  

^a Kyung Hee University   (South Korea)

^b Kyung Hee University College of Medicine   (South Korea)

Author keywords

Brain inflammation; Chunghyuldan; Microglia; Mitogen activated protein kinase; Nitric oxide; PGE2; TNF

Indexed keywords

CHUNGHYULDAN; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATTENUATION; BRAIN CELL; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; IN VITRO STUDY; INFLAMMATION; MEDICINAL PLANT; MICROGLIA; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; CYCLOOXYGENASE 2; DOWN-REGULATION; DRUGS, CHINESE HERBAL; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MICROGLIA; NEUROPROTECTIVE AGENTS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 67449164825     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/Y09-028     Document Type: Article

References (30)

1. Bhat, N.R., Zhang, P., Lee, J.C., and Hogan, E.L. 1998. Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J. Neurosci. 18: 1633-1641. PMID:9464988. (Pubitemid 28103071)
2. Cho, K.H., Kim, Y.S., Bae, H.S., Moon, S.K., Jung, W.S., Park, E.K., and Kim, D.H. 2004. Inhibitory effect of Chunghyuldan in prostaglandin E2 and nitric oxide biosynthesis of lipopolysaccharide-induced RAW 264.7 cells. Biol. Pharm. Bull. 27: 1810-1813. doi:10.1248/bpb.27.1810. PMID:15516728.
3. Cho, K.H., Kang, H.S., Jung, W.S., Park, S.U., and Moon, S.K. 2005. Efficacy and safety of chunghyul-dan (qingwie-dan) in patients with hypercholesterolemia. Am. J. Chin. Med. 33: 241-248. doi:10.1142/ S0192415X05002898. PMID:15974483.
4. Cho, K.H., Noh, K.H., Jung, W.S., Park, S.U., Moon, S.K., Park, J.M., et al. 2008. A preliminary study on the inhibitory effect of Chunghyul-dan on stroke recurrence in patients with small vessel disease. Neurol. Res. 30: 655-658. doi:10.1179/174313208X305382. PMID:18498682.
5. Dheen, S.T., Kaur, C., and Ling, E.A. 2007. Microglial activation and its implications in the brain diseases. Curr. Med. Chem. 14: 1189-1197. doi:10.2174/092986707780597961. PMID:17504139.
6. Glezer, I., Simard, A.R., and Rivest, S. 2007. Neuroprotective role of the innate immune system by microglia. Neuroscience, 147: 867-883. doi:10.1016/j.neuroscience.2007.02.055. PMID:17459594.
7. Han, I.O., Kim, K.W., Ryu, J.H., and Kim, W.K. 2002. p38 mitogen-activated protein kinase mediates lipopolysaccharide, not interferon-γ, -induced inducible nitric oxide synthase expression in mouse BV2 microglial cells. Neurosci. Lett. 325: 9-12. doi:10.1016/S0304-3940(02) 00218-5. PMID:12023055.
8. Jeohn, G.H., Cooper, C.L., Jang, K.J., Liu, B., Lee, D.S., Kim, H.C., and Hong, J.S. 2002. Gö6976 inhibits LPS-induced microglial TNFα release by suppressing p38 MAP kinase activation. Neuroscience, 114: 689-697. doi:10.1016/S0306-4522(02)00356-1. PMID:12220570. (Pubitemid 35247655)
9. Jones, B.W., Heldwein, K.A., Means, T.K., Saukkonen, J.J., and Fenton, M.J. 2001. Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages. Ann. Rheum. Dis. 60(Suppl 3): 6-12. doi:10.1136/ard.60.1.6.
10. Jung, B., Kim, M.O., Yun, S.J., and Lee, E.H. 2003. Down-regulation of the expression of rat inhibitor-of-apoptosis protein-1 and -3 during transforming growth factor-beta1-mediated apoptosis in rat brain microglia. Neuroreport, 14: 857-860. doi:10.1097/00001756-200305060-00016. PMID:12858047. (Pubitemid 36667926)
11. Jung, K.K., Lee, H.S., Cho, J.Y., Shin, W.C., Rhee, M.H., Kim, T.G., et al. 2006. Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia. Life Sci. 79: 2022-2031. doi:10.1016/j.lfs.2006.06.048. PMID:16934299. (Pubitemid 44528586)
12. Kim, Y.S., Jung, E.A., Shin, J.E., Chang, J.C., Yang, H.K., Kim, N.J., et al. 2002. Daio-Orengedokuto inhibits HMG-CoA reductase and pancreatic lipase. Biol. Pharm. Bull. 25: 1442-1445. doi:10.1248/bpb.25.1442. PMID:12419956.
13. Koistinaho, M., and Koistinaho, J. 2002. Role of p38 and p44/42 mitogen-activated protein kinases in microglia. Glia, 40: 175-183. doi:10.1002/glia.10151. PMID:12379905. (Pubitemid 35337375)
14. Lee, H., Kim, Y.O., Kim, H., Kim, S.Y., Noh, H.S., Kang, S.S., et al. 2003. Flavonoid wogonin from medicinal herb is neuroprotective by inhibiting inflammatory activation of microglia. FASEB J. 17: 1943-1944. PMID:12897065.
15. Lee, J.Y., Jhun, B.S., Oh, Y.T., Lee, J.H., Choe, W., Haik, H.H., et al. 2006. Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NF-kappaB activation in murine BV2 microglial cells. Neurosci. Lett. 396: 1-6. doi:10.1016/j.neulet.2005.11.004. PMID:16324785.
16. Lee, K.H., Yun, S.J., Nam, K.N., Gho, Y.S., and Lee, E.H. 2007. Activation of microglial cells by ceruloplasmin. Brain Res. 1171: 1-8. doi:10.1016/j.brainres.2007.07.053. PMID:17727827. (Pubitemid 47404539)
17. Li, R., Huang, Y.G., Fang, D., and Le, W.D. 2004. (-)-Epigallocatechin gallate inhibits lipopolysaccharide-induced microglial activation and protects against inflammation-mediated dopaminergic neuronal injury. J. Neurosci. Res. 78: 723-731. doi:10.1002/jnr.20315. PMID:15478178.
18. Li, F.Q., Wang, T., Pei, Z., Liu, B., and Hong, J.S. 2005. Inhibition of microglial activation by the herbal flavonoid baicalein attenuates inflammation-mediated degeneration of dopaminergic neurons. J. Neural Transm. 112: 331-347. doi:10.1007/s00702-004-0213-0. PMID:15503194. (Pubitemid 40868048)
19. McCarthy, K.D., and de Vellis, J. 1980. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85: 890-902. doi:10.1083/jcb.85.3.890. PMID:6248568. (Pubitemid 10007455)
20. McCarty, M.F. 2006. Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders. Med. Hypotheses, 67: 251-269. doi:10.1016/j.mehy.2006.01.013. PMID:16513287.
21. Meda, L., Cassatella, M.A., Szendrei, G.I., Otvos, L., Jr., Baron, P., Villalba, M., et al. 1995. Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature, 374: 647-650. doi:10.1038/374647a0. PMID:7715705.
22. Nam, K.N., Son, M.S., Park, J.H., and Lee, E.H. 2008. Shikonins attenuate microglial inflammatory responses by inhibition of ERK, Akt, and NF-kB: neuroprotective implications. Neuropharmacology, 55: 819-825. doi:10.1016/j.neuropharm.2008.06.065. PMID:18657551.
23. Park, S.U., Jung, W.S., Moon, S.K., Ko, C.N., Cho, K.H., Kim, Y.S., and Bae, H.S. 2006. Chunghyul-dan (Qingxie-dan) improves arterial stiffness in patients with increased baPWV. Am. J. Chin. Med. 34: 553-563. doi:10.1142/S0192415X06004090. PMID:16883627.
24. Park, Y.K., Chung, Y.S., Kim, Y.S., Kwon, O.Y., and Joh, T.H. 2007. Inhibition of gene expression and production of iNOS and TNF-alpha in LPS-stimulated microglia by methanol extract of Phellodendri cortex. Int. Immunopharmacol. 7: 955-962. doi:10.1016/j.intimp.2006.03.018. PMID:17499198.
25. Pfaffl, M.W., Horgan, G.W., and Dempfle, L. 2002. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res. 30: e36. doi:10.1093/nar/30.9.e36. PMID:11972351.
26. Wee, S.S., Shin, Y.W., Bae, E.A., and Kim, D.H. 2005. Effect of chunghyuldan in chronic oxazolone-induced mouse dermatitis. Biol. Pharm. Bull. 28: 1079-1082. doi:10.1248/bpb.28.1079. PMID:15930749.
27. Wilms, H., Zecca, L., Rosenstiel, P., Sievers, J., Deuschl, G., and Lucius, R. 2007. Inflammation in Parkinson's diseases and other neurodegenerative diseases: cause and therapeutic implications. Curr. Pharm. Des. 13: 1925-1928. doi:10.2174/138161207780858429. PMID:17584117.
28. Wood, P.L. 1995. Microglia as a unique cellular target in the treatment of stroke: potential neurotoxic mediators produced by activated microglia. Neurol. Res. 17: 242-248. PMID:7477737.
29. Yun, S.P., Jung, W.S., Park, S.U., Moon, S.K., Ko, C.N., Cho, K.H., et al. 2005. Anti-hypertensive effect of chunghyul-dan (qingxue-dan) on stroke patients with essential hypertension. Am. J. Chin. Med. 33: 357-364. doi:10.1142/S0192415X05002977. PMID:16047554.
30. Zhu, F., and Qian, C. 2006. Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1beta and inducible nitric oxide synthase in the rat model of Alzheimer's disease. BMC Neurosci. 7: 78. doi:10.1186/1471-2202-7-78. PMID:17137520. (Pubitemid 44942821)