-
1
-
-
0027308685
-
The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat
-
Williams, G. M., Iatropoulos, M.J., Djordjevic, M.V., and Kaltenberg, O.P., The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat, Carcinogenesis, 14:315, 1993.
-
(1993)
Carcinogenesis
, vol.14
, pp. 315
-
-
Williams, G.M.1
Iatropoulos, M.J.2
Djordjevic, M.V.3
Kaltenberg, O.P.4
-
2
-
-
0027428568
-
Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl:CD(BR) rats
-
Hard, G. C., Iatropoulos, M. J., Jordan, K., Radi, L., Kaltenberg, K. P., Imondi, A. R. and Williams, G. M., Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl:CD(BR) rats, Cancer Resarch, 53:4534, 1993.
-
(1993)
Cancer Resarch
, vol.53
, pp. 4534
-
-
Hard, G.C.1
Iatropoulos, M.J.2
Jordan, K.3
Radi, L.4
Kaltenberg, K.P.5
Imondi, A.R.6
Williams, G.M.7
-
3
-
-
0027397629
-
Tamoxifen induces hepatocellular carcinoma in rat liver: A 1-year study with two antiestrogens
-
Hirsimäki, P., Hirsimäki, Y., Nieminen, L., and Payne, B.J., Tamoxifen induces hepatocellular carcinoma in rat liver: a 1-year study with two antiestrogens, Archives of Toxicology, 67:49, 1993.
-
(1993)
Archives of Toxicology
, vol.67
, pp. 49
-
-
Hirsimäki, P.1
Hirsimäki, Y.2
Nieminen, L.3
Payne, B.J.4
-
4
-
-
0027201501
-
Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats
-
Greaves, P., Goonetilleke, R., Nunn, G., Topham, J. and Orton, T., Two-year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats, Cancer Research, 53:3919, 1993.
-
(1993)
Cancer Research
, vol.53
, pp. 3919
-
-
Greaves, P.1
Goonetilleke, R.2
Nunn, G.3
Topham, J.4
Orton, T.5
-
5
-
-
0031418379
-
Initiating activity of the antiestrogen tamoxifen but not toremifene in rat liver
-
Williams, G.M., Iatropoulos, M.J. and Karlsson, S., Initiating activity of the antiestrogen tamoxifen but not toremifene in rat liver, Carcinogenesis, 18:2247, 1997.
-
(1997)
Carcinogenesis
, vol.18
, pp. 2247
-
-
Williams, G.M.1
Iatropoulos, M.J.2
Karlsson, S.3
-
6
-
-
0026606580
-
Induction of covalent DNA adducts in rodents by tamoxifen
-
Han, X. L. and Liehr, J.G., Induction of covalent DNA adducts in rodents by tamoxifen, Cancer Research, 52:1360, 1992.
-
(1992)
Cancer Research
, vol.52
, pp. 1360
-
-
Han, X.L.1
Liehr, J.G.2
-
7
-
-
0027054733
-
Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells
-
White, A. N. H., Matteis, F., Davies, A., Smith, L.L., Crofton-Sleigh, C., Venitt, S., Hewer, A. and Phillips, D.H., Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells, Carcinogenesis, 13:2197, 1992.
-
(1992)
Carcinogenesis
, vol.13
, pp. 2197
-
-
White, A.N.H.1
Matteis, F.2
Davies, A.3
Smith, L.L.4
Crofton-Sleigh, C.5
Venitt, S.6
Hewer, A.7
Phillips, D.H.8
-
8
-
-
0028328274
-
Comparison of DNA reactivity of the polyphenylene hormonal agents diethylstilbestrol, tamoxifen, and toremifene in rat and hamster liver
-
Montandon, F. and Williams, G.M., Comparison of DNA reactivity of the polyphenylene hormonal agents diethylstilbestrol, tamoxifen, and toremifene in rat and hamster liver, Archives of Toxicology, 68:272, 1994.
-
(1994)
Archives of Toxicology
, vol.68
, pp. 272
-
-
Montandon, F.1
Williams, G.M.2
-
9
-
-
0028979277
-
DNA adducts caused by tamoxifen and toremifene in human microsomal system and lymphocytes in vitro
-
Hemminki, K., Widlak, P. and Hou, S-M., DNA adducts caused by tamoxifen and toremifene in human microsomal system and lymphocytes in vitro, Carcinogenesis, 16:1661, 1995.
-
(1995)
Carcinogenesis
, vol.16
, pp. 1661
-
-
Hemminki, K.1
Widlak, P.2
Hou, S.-M.3
-
10
-
-
0029985407
-
Activation of tamoxifen and its metabolite alpha-hydroxytamoxifen to DNA binding products: Comparison between human, rat and mouse hepatocytes
-
Phillips, D. H., Carmichael, P. L., Hewer, A., Cole K. J., Hardcastle, I. R., Poon, G. K., Keogh, A. and Strain, A. J. Activation of tamoxifen and its metabolite alpha-hydroxytamoxifen to DNA binding products: comparison between human, rat and mouse hepatocytes, Carcinogenesis, 17:89, 1996.
-
(1996)
Carcinogenesis
, vol.17
, pp. 89
-
-
Phillips, D.H.1
Carmichael, P.L.2
Hewer, A.3
Cole, K.J.4
Hardcastle, I.R.5
Poon, G.K.6
Keogh, A.7
Strain, A.J.8
-
11
-
-
0029978834
-
Lack of genotoxicity of tamoxifen in human endometrium
-
Carmichael, P. L., Ugwumadu, A. H. N., Neven, P., Hewer, A. J., Poon, G. K. and Phillips, D. H., Lack of genotoxicity of tamoxifen in human endometrium, Cancer Research, 56:1475, 1996.
-
(1996)
Cancer Research
, vol.56
, pp. 1475
-
-
Carmichael, P.L.1
Ugwumadu, A.H.N.2
Neven, P.3
Hewer, A.J.4
Poon, G.K.5
Phillips, D.H.6
-
12
-
-
0031409631
-
Tamoxifen-induced DNA adducts in leucocytes of breast cancer patients
-
Hemminki, K., Rajaniemi, H. J., Koskinen, M. and Hansson, J., Tamoxifen-induced DNA adducts in leucocytes of breast cancer patients, Carcinogenesis, 18:9, 1997.
-
(1997)
Carcinogenesis
, vol.18
, pp. 9
-
-
Hemminki, K.1
Rajaniemi, H.J.2
Koskinen, M.3
Hansson, J.4
-
14
-
-
0022453672
-
A new triphenylethylene compound, Fc-1157a. I. Hormonal effects
-
Kallio, S., Kangas, L., Blanco, G., Johansson, R., Karjalainen, A., Perilä, M., Piippo, I., Sundquist, H., Södervall, M., Toivola, R., A new triphenylethylene compound, Fc-1157a. I. Hormonal effects, Cancer Chemotherapy Pharmacology, 17:103, 1986.
-
(1986)
Cancer Chemotherapy Pharmacology
, vol.17
, pp. 103
-
-
Kallio, S.1
Kangas, L.2
Blanco, G.3
Johansson, R.4
Karjalainen, A.5
Perilä, M.6
Piippo, I.7
Sundquist, H.8
Södervall, M.9
Toivola, R.10
-
16
-
-
2642657654
-
Comparison of toremifene and tamoxifen in post-menopausal patients with advanced breast cancer: A randomized double-blind, the "nordic" phase III study
-
Pyrhönen, S., Valavaara, R., Modig, H., Pawlicki, M., Pienkowski, T., Gundersen, S., Bauer, J., Westman, G., Lundgren, S., Blanco, G., Mella, O., Nilsson, I., Hietanen, T., Hindy, I., Vuorinen, J. and Hajba, A., Comparison of toremifene and tamoxifen in post-menopausal patients with advanced breast cancer: a randomized double-blind, the "nordic" phase III study, British Journal Cancer, 78:270, 1997.
-
(1997)
British Journal Cancer
, vol.78
, pp. 270
-
-
Pyrhönen, S.1
Valavaara, R.2
Modig, H.3
Pawlicki, M.4
Pienkowski, T.5
Gundersen, S.6
Bauer, J.7
Westman, G.8
Lundgren, S.9
Blanco, G.10
Mella, O.11
Nilsson, I.12
Hietanen, T.13
Hindy, I.14
Vuorinen, J.15
Hajba, A.16
-
17
-
-
0029084658
-
Randomized comparison of tamoxifen and two separate doses of toremifene in postmenopausal patients withy metastatic breast cancer
-
Hayes, D. F., Van Zyl, J. A., Hacking, A., Goedhals, L., Bezwoda, W. R., Maillard, J. A. et al., Randomized comparison of tamoxifen and two separate doses of toremifene in postmenopausal patients withy metastatic breast cancer, Journal of Clinical Oncology, 13:2556, 1995.
-
(1995)
Journal of Clinical Oncology
, vol.13
, pp. 2556
-
-
Hayes, D.F.1
Van Zyl, J.A.2
Hacking, A.3
Goedhals, L.4
Bezwoda, W.R.5
Maillard, J.A.6
-
18
-
-
2442707437
-
-
Directorate General III, Brussels
-
European Commission, Fareston containing Toremifene, Directorate General III, Brussels, 1996.
-
(1996)
Fareston Containing Toremifene
-
-
-
19
-
-
12644313239
-
A two-year dietary carcinogenicity study of the antiestrogen toremifene in Sprague-Dawley rats
-
Karlsson, S., Hirsimäki, Y., Mäntylä, E., Nieminen, L., Kangas, L., Hirsimäki, P., Perry, C. J., Mulhern, M., Millar, P., Handa, J., and Williams, G. M., A two-year dietary carcinogenicity study of the antiestrogen toremifene in Sprague-Dawley rats, Drug and Chemical Toxicology, 19:245, 1996.
-
(1996)
Drug and Chemical Toxicology
, vol.19
, pp. 245
-
-
Karlsson, S.1
Hirsimäki, Y.2
Mäntylä, E.3
Nieminen, L.4
Kangas, L.5
Hirsimäki, P.6
Perry, C.J.7
Mulhern, M.8
Millar, P.9
Handa, J.10
Williams, G.M.11
-
21
-
-
15844385780
-
Induction of hepatic aneuploidy in vivo by tamoxifen, toremifene, and idoxifene in female Sprague-Dawley rats
-
Sargent, L. M., Dragan, Y. P., Sattler, C., Bahnub, N., Sattler, G., Martin, P., Cisneros, A., Mann, J., Thorgiersson, S., Jordan, V. C., and Pitot, H. C., Induction of hepatic aneuploidy in vivo by tamoxifen, toremifene, and idoxifene in female Sprague-Dawley rats, Carcinogenesis, 17:1051, 1996.
-
(1996)
Carcinogenesis
, vol.17
, pp. 1051
-
-
Sargent, L.M.1
Dragan, Y.P.2
Sattler, C.3
Bahnub, N.4
Sattler, G.5
Martin, P.6
Cisneros, A.7
Mann, J.8
Thorgiersson, S.9
Jordan, V.C.10
Pitot, H.C.11
-
22
-
-
0028035492
-
Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing cytochrome P450s
-
Styles, J. A., Davies, A., Lim, C. K., DeMatteis, F., Stanley, L. A., White, I. N. H., Yuan, Z-X. and Smith, L. L., Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing cytochrome P450s, Carcinogenesis, 15:5, 1994.
-
(1994)
Carcinogenesis
, vol.15
, pp. 5
-
-
Styles, J.A.1
Davies, A.2
Lim, C.K.3
DeMatteis, F.4
Stanley, L.A.5
White, I.N.H.6
Yuan, Z.-X.7
Smith, L.L.8
-
23
-
-
0030066508
-
A study of the structural basis of the carcinogenicity of tamoxifen, toremifene and their metabolites
-
Cunningham, A., Klopman, G. and Rosenkranz, H. S., A study of the structural basis of the carcinogenicity of tamoxifen, toremifene and their metabolites, Mutation Research, 349:85, 1996.
-
(1996)
Mutation Research
, vol.349
, pp. 85
-
-
Cunningham, A.1
Klopman, G.2
Rosenkranz, H.S.3
-
24
-
-
0024470842
-
Structure-activity relationships in the rat hepatocyte DNA-repair test for 300 chemicals
-
Williams, G. M., Mori, H., and McQueen, C. A., Structure-activity relationships in the rat hepatocyte DNA-repair test for 300 chemicals, Mutation Research, 221:263, 1989.
-
(1989)
Mutation Research
, vol.221
, pp. 263
-
-
Williams, G.M.1
Mori, H.2
McQueen, C.A.3
-
25
-
-
2242477458
-
The micronucleus assay, I in vivo
-
Eds. H.F. Stich and R.H.C. San, Springer-Verlag, NY
-
Heddle, J. A. and Salamone, M. F., The micronucleus assay, I In vivo In: Short-term tests for chemical carcinogens. Eds. H.F. Stich and R.H.C. San, Springer-Verlag, NY, pp. 249-251, 1979.
-
(1979)
Short-term Tests for Chemical Carcinogens
, pp. 249-251
-
-
Heddle, J.A.1
Salamone, M.F.2
-
26
-
-
0028229919
-
Bone Marrow Micronucleus Assay: A review of the mouse stocks used and their published mean spontaneous micronucleus frequencies
-
Salamone, M. F. and Mavournin, K. H., Bone Marrow Micronucleus Assay: A review of the mouse stocks used and their published mean spontaneous micronucleus frequencies, Environmental and Molecular Mutagenesis, 23:239, 1994.
-
(1994)
Environmental and Molecular Mutagenesis
, vol.23
, pp. 239
-
-
Salamone, M.F.1
Mavournin, K.H.2
-
27
-
-
0026724239
-
Phase I clinical and pharmacokinetic study of high-dose toremifene in postmenopausal patients with advanced breast cancer
-
Bishop, J., Murray, R., Webster, L., Pitt, P., Stokes, K., Fennessy, A., Oliver, I., and Leber, G., Phase I clinical and pharmacokinetic study of high-dose toremifene in postmenopausal patients with advanced breast cancer, Cancer Chemotherapy Pharmacology, 30:174, 1992.
-
(1992)
Cancer Chemotherapy Pharmacology
, vol.30
, pp. 174
-
-
Bishop, J.1
Murray, R.2
Webster, L.3
Pitt, P.4
Stokes, K.5
Fennessy, A.6
Oliver, I.7
Leber, G.8
-
28
-
-
0025354668
-
Pharmacokinetics of toremifene
-
Anttila, M., Valavaara, R., Kivinen, S., and Maënpää, J., Pharmacokinetics of toremifene. Journal Steroid Biochemistry, 36:249, 1990.
-
(1990)
Journal Steroid Biochemistry
, vol.36
, pp. 249
-
-
Anttila, M.1
Valavaara, R.2
Kivinen, S.3
Maënpää, J.4
-
29
-
-
0020533372
-
Revised methods for the Salmonella mutagenicity test
-
Maron, D. M. and Ames, B., Revised methods for the Salmonella mutagenicity test, Mutation Research, 113:173, 1983.
-
(1983)
Mutation Research
, vol.113
, pp. 173
-
-
Maron, D.M.1
Ames, B.2
-
31
-
-
0030345886
-
Mutational spectra of tamoxifen-induced mutations in the livers of loci transgenic rats
-
Davies, R., Oreffo, V. I. C., Bayliss, S., Dinh, P-A., Lilley, K. S., Whith, I. N. H, Smith, L. L., and Styles, J. A., Mutational spectra of tamoxifen-induced mutations in the livers of loci transgenic rats, Environmental and Molecular Mutagenicity, 28:430, 1996.
-
(1996)
Environmental and Molecular Mutagenicity
, vol.28
, pp. 430
-
-
Davies, R.1
Oreffo, V.I.C.2
Bayliss, S.3
Dinh, P.-A.4
Lilley, K.S.5
Whith, I.N.H.6
Smith, L.L.7
Styles, J.A.8
-
32
-
-
0028326053
-
A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism
-
Potter, G.A., McCague, R., and Jarman, M., A mechanistic hypothesis for DNA adduct formation by tamoxifen following hepatic oxidative metabolism, Carcinogenesis, 15:439, 1994.
-
(1994)
Carcinogenesis
, vol.15
, pp. 439
-
-
Potter, G.A.1
McCague, R.2
Jarman, M.3
-
33
-
-
0028232498
-
Involvement of cytochrome P450 3A enzyme family in the major metabolic pathway of toremifene in human liver microsomes
-
Berthou, F., Dreano, Y., Belloc, C., Kangas, L., Gautier, J-C., and Baune, P., Involvement of cytochrome P450 3A enzyme family in the major metabolic pathway of toremifene in human liver microsomes, Biochemical Pharmacology, 47:1883, 1994.
-
(1994)
Biochemical Pharmacology
, vol.47
, pp. 1883
-
-
Berthou, F.1
Dreano, Y.2
Belloc, C.3
Kangas, L.4
Gautier, J.-C.5
Baune, P.6
-
34
-
-
0030030676
-
Transfer of PCBs via lactation simultaneously induces the expression of P450 isozymes and the protooncogenes c-Ha-ras and c-raf in neonates
-
Borlak, J. T., Scott, A., Henderson, C. J., Jenke, H. J. and Wolf, C. R., Transfer of PCBs via lactation simultaneously induces the expression of P450 isozymes and the protooncogenes c-Ha-ras and c-raf in neonates, Biochemical Pharmacology, 51:517, 1996.
-
(1996)
Biochemical Pharmacology
, vol.51
, pp. 517
-
-
Borlak, J.T.1
Scott, A.2
Henderson, C.J.3
Jenke, H.J.4
Wolf, C.R.5
-
35
-
-
0029745072
-
Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients
-
Hemminki, K., Rajaniemi, H., Lindahl, B. and Moberger, B., Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients, Cancer Research, 56:4374, 1996.
-
(1996)
Cancer Research
, vol.56
, pp. 4374
-
-
Hemminki, K.1
Rajaniemi, H.2
Lindahl, B.3
Moberger, B.4
-
36
-
-
0028979270
-
32P-postlabelled DNA adducts in liver obtained from women treated with tamoxifen
-
32P-postlabelled DNA adducts in liver obtained from women treated with tamoxifen, Carcinogenesis, 16:1651, 1995.
-
(1995)
Carcinogenesis
, vol.16
, pp. 1651
-
-
Martin, E.A.1
Rich, K.J.2
White, I.N.H.3
Woods, K.L.4
Powles, T.J.5
Smith, L.L.6
-
37
-
-
0026720681
-
The effects of diethylstilbestrol, tamoxifen, and toremifene on estrogen-inducible hepatic proteins and estrogen receptor proteins in female rats
-
Kendall, M. E. and Rose, D. P., The effects of diethylstilbestrol, tamoxifen, and toremifene on estrogen-inducible hepatic proteins and estrogen receptor proteins in female rats, Toxicology and Applied Pharmacology, 114:127-131.
-
Toxicology and Applied Pharmacology
, vol.114
, pp. 127-131
-
-
Kendall, M.E.1
Rose, D.P.2
-
38
-
-
0028810502
-
Comparison of the effects of tamoxifen and toremifene on liver and kidney promotion in female rats
-
Dragan, V. P., Vaughan, J., Jordan, V. C. and Pitot, H. C., Comparison of the effects of tamoxifen and toremifene on liver and kidney promotion in female rats, Carcinogenesis, 16:2733, 1995.
-
(1995)
Carcinogenesis
, vol.16
, pp. 2733
-
-
Dragan, V.P.1
Vaughan, J.2
Jordan, V.C.3
Pitot, H.C.4
-
39
-
-
0030773262
-
Correspondence re: "K Hemminki et al. Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients,"
-
Orton, T. C. and Topham, J. C., Correspondence re: "K Hemminki et al. Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients," Cancer Research, 57:4148, 1997.
-
(1997)
Cancer Research
, vol.57
, pp. 4148
-
-
Orton, T.C.1
Topham, J.C.2
-
40
-
-
0028969780
-
Peroxidase activation of tamoxifen and toremifene resulting in DNA damage and covalently bound protein adducts
-
Davies, A.M., Martin, E. A., Jones, R. M., Lim, C. K., Smith, L. L. and White, I. N., Peroxidase activation of tamoxifen and toremifene resulting in DNA damage and covalently bound protein adducts, Carcinogenesis, 16:539, 1995.
-
(1995)
Carcinogenesis
, vol.16
, pp. 539
-
-
Davies, A.M.1
Martin, E.A.2
Jones, R.M.3
Lim, C.K.4
Smith, L.L.5
White, I.N.6
-
41
-
-
0019213140
-
Peroxidase activity in glands and stroma of human endometriu
-
Holinka, C. F. and Gurpide, E, Peroxidase activity in glands and stroma of human endometriu, American Journal Obstetrics Gynecology, 138:599, 1980.
-
(1980)
American Journal Obstetrics Gynecology
, vol.138
, pp. 599
-
-
Holinka, C.F.1
Gurpide, E.2
-
42
-
-
0016705606
-
Fine structural and cytochemical identification of microperoxisomes in developing human erythrocytic cells
-
Breton-Gorius, J. and Guichard, J., Fine structural and cytochemical identification of microperoxisomes in developing human erythrocytic cells, Amercan Journal of Pathology 79:523 1975.
-
(1975)
Amercan Journal of Pathology
, vol.79
, pp. 523
-
-
Breton-Gorius, J.1
Guichard, J.2
|