CD27 expression on CD4+ T cells differentiates effector from regulatory T cell subsets in the lung

Journal of Immunology

Volumn 182, Issue 11, 2009, Pages 7317-7324

  Mack, Douglas G ^a   Lanham, Allison M ^a   Palmer, Brent E ^a   Maier, Lisa A ^a,c   Fontenot, Andrew P ^a,b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF COLORADO   (United States)

^c DEPARTMENT OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BERYLLIUM; CD27 ANTIGEN; INTERLEUKIN 2 RECEPTOR ALPHA; TRANSCRIPTION FACTOR FOXP3;

ADAPTIVE IMMUNITY; ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; BERYLLIOSIS; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; EFFECTOR CELL; FEMALE; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; LUNG LAVAGE; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE FUNCTION; MALE; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; CASE CONTROL STUDY; FIBROSIS; IMMUNOLOGY; LUNG; LUNG DISEASE; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; ANTIGENS, CD27; BERYLLIUM; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; FIBROSIS; HUMANS; IMMUNOPHENOTYPING; LUNG; LUNG DISEASES; MALE; MIDDLE AGED; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 67449113503     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0804305     Document Type: Article

References (40)

1. Newman, L. S., and L. A. Maier. 2003. Beryllium disease. In Interstitial Lung Disease, 3rd Ed. M. I. Schwarz, and T. E. King, Jr., eds. BC Decker, Hamilton, Ontario, pp. 435-451.
2. Maier, L. A., D. S. McGrath, H. Sato, P. Lympany, K. Welsh, R. Du Bois, L. Silveira, A. P. Fontenot, R. T. Sawyer, E. Wilcox, and L. S. Newman. 2003. Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease. J. Immunol. 171: 6910-6918.
3. Richeldi, L., R. Sorrentino, and C. Saltini. 1993. HLA-DPB1 glutamate 69: a genetic marker of beryllium disease. Science 262: 242-244. (Pubitemid 23344468)
4. Rossman, M. D., J. Stubbs, C. W. Lee, E. Argyris, E. Magira, and D. Monos. 2002. Human leukocyte antigen class II amino acid epitopes: susceptibility and progression markers for beryllium hypersensitivity. Am. J. Respir. Crit. Care Med. 165: 788-794.
5. Wang, Z., P. S. White, M. Petrovic, O. L. Tatum, L. S. Newman, L. A. Maier, and B. L. Marrone. 1999. Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA-DPB1 and -DPA1 alleles. J. Immunol. 163: 1647-1653. (Pubitemid 29352790)
6. + T cells in patients with chronic beryllium disease. J. Clin. Invest. 110: 1473-1482.
7. + T cells in blood determines proliferative response. J. Clin. Invest. 115: 2886-2893.
8. Tinkle, S. S., L. A. Kittle, B. A. Schumacher, and L. S. Newman. 1997. Beryllium induces IL-2 and IFN-γ in berylliosis. J. Immunol. 158: 518-526. (Pubitemid 127483896)
9. + T cells. J. Clin. Invest. 112: 776-784.
10. Mack, D. G., A. K. Lanham, B. E. Palmer, L. A. Maier, T. H. Watts, and A. P. Fontenot. 2008. 4-1BB enhances proliferation of beryllium-specific T cells in the lung of subjects with chronic beryllium disease. J. Immunol. 181: 4381-4388.
11. + T cells in chronic beryllium disease. J. Immunol. 180: 2704-2712.
12. Watts, T. H. 2005. TNF/TNFR family members in costimulation of T cell responses. Annu. Rev. Immunol. 23: 23-68.
13. Hintzen, R. Q., R. de Jong, S. M. Lens, M. Brouwer, P. Baars, and R. A. van Lier. 1993. Regulation of CD27 expression on subsets of mature T-lymphocytes. J. Immunol. 151: 2426-2435. (Pubitemid 23264495)
14. + T cells. J. Exp. Med. 186: 1407-1418.
15. van Lier, R. A., J. Borst, T. M. Vroom, H. Klein, P. Van Mourik, W. P. Zeijlemaker, and C. J. Melief. 1987. Tissue distribution and biochemical and functional properties of Tp55 (CD27), a novel T cell differentiation antigen. J. Immunol. 139: 1589-1596.
16. Hendriks, J., Y. Xiao, and J. Borst. 2003. CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool. J. Exp. Med. 198: 1369-1380.
17. Hendriks, J., L. A. Gravestein, K. Tesselaar, R. A. van Lier, T. N. Schumacher, and J. Borst. 2000. CD27 is required for generation and long-term maintenance of T cell immunity. Nat. Immunol. 1: 433-440.
18. Newman, L. S., K. Kreiss, T. E. King, Jr., S. Seay, and P. A. Campbell. 1989. Pathologic and immunologic alterations in early stages of beryllium disease: re-examination of disease definition and natural history. Am. Rev. Respir. Dis. 139: 1479-1486.
19. Rossman, M. D., J. A. Kern, J. A. Elias, M. R. Cullen, P. E. Epstein, O. P. Preuss, T. N. Markham, and R. P. Daniele. 1988. Proliferative response of bronchoalveolar lymphocytes to beryllium. Ann. Intern. Med. 108: 687-693.
20. Newman, L. S. 1996. Significance of the blood beryllium lymphocyte proliferation test. Environ. Health Perspect. 104: 953-956.
21. Mroz, M. M., K. Kreiss, D. C. Lezotte, P. A. Campbell, and L. S. Newman. 1991. Reexamination of the blood lymphocyte transformation test in the diagnosis of chronic beryllium disease. J. Allergy Clin. Immunol. 88: 54-60.
22. Fontenot, A. P., B. L. Kotzin, C. E. Comment, and L. S. Newman. 1998. Expansions of T-cell subsets expressing particular T cell receptor variable regions in chronic beryllium disease. Am. J. Respir. Cell Mol. Biol. 18: 581-589.
23. Fontenot, A. P., M. T. Falta, B. M. Freed, L. S. Newman, and B. L. Kotzin. 1999. Identification of pathogenic T cells in patients with beryllium-induced lung disease. J. Immunol 163: 1019-1026.
24. + T cells specific for respiratory viruses in the human lung. J. Exp. Med. 202: 1433-1442.
25. Campbell, J. J., K. E. Murphy, E. J. Kunkel, C. E. Brightling, D. Soler, Z. Shen, J. Boisvert, H. B. Greenberg, M. A. Vierra, S. B. Goodman, et al. 2001. CCR7 expression and memory T cell diversity in humans. J. Immunol. 166: 877-884.
26. Fritsch, R. D., X. Shen, G. P. Sims, K. S. Hathcock, R. J. Hodes, and P. E. Lipsky. 2005. Stepwise differentiation of CD4 memory T cells defined by expression of CCR7 and CD27. J. Immunol. 175: 6489-6497.
27. + regulatory T cells in inflamed synovia. J. Exp. Med. 201: 1793-1803.
28. high regulatory cells in human peripheral blood. J. Immunol. 167: 1245-1253.
29. Sakaguchi, S., K. Fukuma, K. Kuribayashi, and T. Masuda. 1985. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease. J. Exp. Med. 161: 72-87.
30. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25): breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155: 1151-1164.
31. Sakaguchi, S. 2000. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 101: 455-458.
32. Shevach, E. M. 2000. Regulatory T cells in autoimmmunity. Annu. Rev. Immunol. 18: 423-449.
33. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296.
34. Brunkow, M. E., E. W. Jeffery, K. A. Hjerrild, B. Paeper, L. B. Clark, S. A. Yasayko, J. E. Wilkinson, D. Galas, S. F. Ziegler, and F. Ramsdell. 2001. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27: 68-73.
35. + regulatory T cells. Nat. Immunol. 4: 330-336.
36. + regulatory T cells. J. Exp. Med. 201: 1061-1067.
37. + Treg cells. J. Exp. Med. 203: 1701-1711.
38. + cells. Immunology 121: 129-139.
39. Hintzen, R. Q., S. M. Lens, K. Lammers, H. Kuiper, M. P. Beckmann, and R. A. van Lier. 1995. Engagement of CD27 with its ligand CD70 provides a second signal for T cell activation. J. Immunol 154: 2612-2623.
40. + regulatory T cells in immunological tolerance to self and non-self. Nat. Immunol. 6: 345-352.