메뉴 건너뛰기




Volumn 10, Issue SUPPL.1, 2009, Pages

Emerging data with antiangiogenic therapies in early and advanced non-small-cell lung cancer

Author keywords

Axitinib; Bevacizumab; BIBF 1120; Cediranib; Motesanib; Multikinase inhibitors; Pazopanib; Sorafenib; Sunitinib; Thalidomide; Vandetanib; Vascular endothelial growth factor; XL647

Indexed keywords

ANGIOGENESIS INHIBITOR; BENZENESULFONIC ACID DERIVATIVE; BEVACIZUMAB; INDOLE DERIVATIVE; MONOCLONAL ANTIBODY; N (4 BROMO 2 FLUOROPHENYL) 6 METHOXY 7 ((1 METHYLPIPERIDIN 4 YL)METHOXY)QUINAZOLIN 4 AMINE; N-(4-BROMO-2-FLUOROPHENYL)-6-METHOXY-7-((1-METHYLPIPERIDIN-4-YL)METHOXY)QUINAZOLIN-4-AMINE; PIPERIDINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIDINE DERIVATIVE; PYRROLE DERIVATIVE; QUINAZOLINE DERIVATIVE; SORAFENIB; SUNITINIB; THALIDOMIDE; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR;

EID: 67449107060     PISSN: 15257304     EISSN: 19380690     Source Type: Journal    
DOI: 10.3816/CLC.2009.s.002     Document Type: Review
Times cited : (16)

References (96)
  • 3
    • 49049109683 scopus 로고    scopus 로고
    • Lung adjuvant cisplatin evaluation: A pooled analysis by the lace collaborative group
    • Pignon J-P, Tribodet H, Scagliotti GV, et al. Lung Adjuvant Cisplatin Evaluation: a pooled analysis by the LACE collaborative group. J Clin Oncol 2008; 26:3552-9.
    • (2008) J Clin Oncol , vol.26 , pp. 3552-3559
    • Pignon, J.-P.1    Tribodet, H.2    Scagliotti, G.V.3
  • 5
    • 0034282780 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis
    • Yano S, Shinohara H, Herbst RS, et al. Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis. Cancer Res 2000; 60:4959-67.
    • (2000) Cancer Res , vol.60 , pp. 4959-4967
    • Yano, S.1    Shinohara, H.2    Herbst, R.S.3
  • 6
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971; 285:1182-6.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 7
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • DOI 10.1016/S0092-8674(00)80108-7
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86:353-64. (Pubitemid 26272076)
    • (1996) Cell , vol.86 , Issue.3 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 8
    • 33744466541 scopus 로고    scopus 로고
    • Antiangiogenic therapy: A universal chemosensitization strategy for cancer?
    • DOI 10.1126/science.1125950
    • Kerbel RS. Antiangiogenic therapy: a universal chemosensitization strategy for cancer? Science 2006; 312:1171-5. (Pubitemid 43801134)
    • (2006) Science , vol.312 , Issue.5777 , pp. 1171-1175
    • Kerbel, R.S.1
  • 9
    • 12344312042 scopus 로고    scopus 로고
    • Cellular abnormalities of blood vessels as targets in cancer
    • DOI 10.1016/j.gde.2004.12.005, PII S0959437X04001911, Oncogenes and Cell Proliferation
    • Baluk P, Hashizume H, McDonald DM. Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev 2005; 15:102-11. (Pubitemid 40127638)
    • (2005) Current Opinion in Genetics and Development , vol.15 , Issue.1 , pp. 102-111
    • Baluk, P.1    Hashizume, H.2    McDonald, D.M.3
  • 11
    • 0028951043 scopus 로고
    • Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppression
    • Holmgren L, O'Reilly MS, Folkman J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1995; 1:149-53.
    • (1995) Nat Med , vol.1 , pp. 149-153
    • Holmgren, L.1    O'Reilly, M.S.2    Folkman, J.3
  • 12
    • 0029100451 scopus 로고
    • Microvessel count predicts metastatic disease and survival in non-small cell lung cancer
    • Fontanini G, Bigini D, Vignati S, et al. Microvessel count predicts metastatic disease and survival in non-small cell lung cancer. J Pathol 1995; 177:57-63.
    • (1995) J Pathol , vol.177 , pp. 57-63
    • Fontanini, G.1    Bigini, D.2    Vignati, S.3
  • 16
    • 35548962413 scopus 로고    scopus 로고
    • Randomised, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naive patients with advanced or recurrent non-squamous nonsmall cell lung cancer (NSCLC): BO17704
    • (Abstract LBA7514)
    • Manegold C, von Pawel J, Zatloukal P, et al. Randomised, double-blind multicentre phase III study of bevacizumab in combination with cisplatin and gemcitabine in chemotherapy-naive patients with advanced or recurrent non-squamous nonsmall cell lung cancer (NSCLC): BO17704. J Clin Oncol 2007; 25(18 suppl):388s (Abstract LBA7514).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Manegold, C.1    Von Pawel, J.2    Zatloukal, P.3
  • 17
    • 34547427567 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin and gemcitabine with bevacizumab in first-line advanced non-small cell lung cancer (NSCLC)
    • (Abstract 17009)
    • Davila E, Lilenbaum R, Raez L, et al. Phase II trial of oxaliplatin and gemcitabine with bevacizumab in first-line advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2006; 24(18 suppl):667s (Abstract 17009).
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Davila, E.1    Lilenbaum, R.2    Raez, L.3
  • 18
    • 70350299392 scopus 로고    scopus 로고
    • A phase II study of oxaliplatin and pemetrexed plus bevacizumab in advanced non-squamous non-small cell lung cancer (An International Oncology Network study, #I-04-015)
    • (Abstract 19018)
    • Waples JM, Auerbach M, Steis R, et al. A phase II study of oxaliplatin and pemetrexed plus bevacizumab in advanced non-squamous non-small cell lung cancer (An International Oncology Network study, #I-04-015). J Clin Oncol 2008; 26(15 suppl):707s (Abstract 19018).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Waples, J.M.1    Auerbach, M.2    Steis, R.3
  • 19
    • 70350271869 scopus 로고    scopus 로고
    • A phase II second-line study of pemetrexed (pem) in combination with bevacizumab (bev) in patients with advanced nonsmall cell lung cancer (NSCLC): An NCCTG and SWOG study
    • (Abstract 8080)
    • Adjei AA, Mandrekar SJ, Dy GK, et al. A phase II second-line study of pemetrexed (pem) in combination with bevacizumab (bev) in patients with advanced nonsmall cell lung cancer (NSCLC): an NCCTG and SWOG study. J Clin Oncol 2008; 26(15 suppl)443s (Abstract 8080).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Adjei, A.A.1    Mandrekar, S.J.2    Dy, G.K.3
  • 20
    • 36048982143 scopus 로고    scopus 로고
    • Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non-small-cell lung cancer
    • DOI 10.1200/JCO.2007.12.3026
    • Herbst RS, O'Neill VJ, Fehrenbacher L, et al. Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. J Clin Oncol 2007; 25:4743-50. (Pubitemid 350086476)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.30 , pp. 4743-4750
    • Herbst, R.S.1    O'Neill, V.J.2    Fehrenbacher, L.3    Belani, C.P.4    Bonomi, P.D.5    Hart, L.6    Melnyk, O.7    Ramies, D.8    Lin, M.9    Sandler, A.10
  • 21
    • 65349185527 scopus 로고    scopus 로고
    • A phase II study of multikinase inhibitor sorafenib in patients with relapse non-small cell lung cancer (NSCLC)
    • (Abstract 19084)
    • Gutierrez M, Kummar S, Allen D, et al. A phase II study of multikinase inhibitor sorafenib in patients with relapse non-small cell lung cancer (NSCLC). J Clin Oncol 2008; 26(15 suppl)712s (Abstract 19084).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Gutierrez, M.1    Kummar, S.2    Allen, D.3
  • 22
    • 33748913369 scopus 로고    scopus 로고
    • Phase II trial of single-agent sorafenib in patients with advanced non-small cell lung carcinoma
    • (Abstract 7002)
    • Gatzemeier U, Blumenschein G, Fosella F, et al. Phase II trial of single-agent sorafenib in patients with advanced non-small cell lung carcinoma. J Clin Oncol 2006; 24(18 suppl):364s (Abstract 7002).
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Gatzemeier, U.1    Blumenschein, G.2    Fosella, F.3
  • 23
    • 35548976756 scopus 로고    scopus 로고
    • A front-line window of opportunity phase ii study of sorafenib in patients with advanced non-small cell lung cancer: A north central cancer treatment group study
    • (Abstract 7547)
    • Adjei AA, Molina JR, Hillman SL, et al. A front-line window of opportunity phase II study of sorafenib in patients with advanced non-small cell lung cancer: a North Central Cancer Treatment Group study. J Clin Oncol 2007; 25(18 suppl):396s (Abstract 7547).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Adjei, A.A.1    Molina, J.R.2    Hillman, S.L.3
  • 25
    • 33748901860 scopus 로고    scopus 로고
    • Sorafenib combined with carboplatin/ paclitaxel for advanced non-small cell lung cancer: A phase i subset analysis
    • (Abstract 7194)
    • Schiller JH, Flaherty KT, Redlinger M, et al. Sorafenib combined with carboplatin/ paclitaxel for advanced non-small cell lung cancer: a phase I subset analysis. J Clin Oncol 2006; 24(18 suppl):412s (Abstract 7194).
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Schiller, J.H.1    Flaherty, K.T.2    Redlinger, M.3
  • 26
    • 45849149177 scopus 로고    scopus 로고
    • Phase III Trial comparing carboplatin and paclitaxel with or without sorafenib in chemonaive patients with stage IIIB (with effusion) or IV non-small cell lung cancer
    • Geneva, Switzerland; April 23-26, 2008
    • Scagliotti G, Von Pawel J, Reck M, et al. Phase III Trial comparing carboplatin and paclitaxel with or without sorafenib in chemonaive patients with stage IIIB (with effusion) or IV non-small cell lung cancer. Paper presented at: The 1st IASLC-ESMO European Lung Cancer Conference 2008; Geneva, Switzerland; April 23-26, 2008.
    • (2008) The 1st IASLC-ESMO European Lung Cancer Conference
    • Scagliotti, G.1    Von Pawel, J.2    Reck, M.3
  • 28
    • 33750087886 scopus 로고    scopus 로고
    • ZD6474 versus gefitinib in patients with advanced NSCLC: Final results from a two-part, double-blind, randomized phase II trial
    • (Abstract 7000)
    • Natale RB, Bodkin D, Govindan R, et al. ZD6474 versus gefitinib in patients with advanced NSCLC: final results from a two-part, double-blind, randomized phase II trial. J Clin Oncol 2006; 24(18 suppl):364s (Abstract 7000).
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Natale, R.B.1    Bodkin, D.2    Govindan, R.3
  • 30
    • 35948978403 scopus 로고    scopus 로고
    • Randomized phase II study of vandetanib (VAN) alone or in combination with carboplatin and paclitaxel (CP) as first-line treatment for advanced non-small cell lung cancer (NSCLC)
    • (Abstract 7544)
    • Heymach J, Paz-Ares L, De Braud F, et al. Randomized phase II study of vandetanib (VAN) alone or in combination with carboplatin and paclitaxel (CP) as first-line treatment for advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2007; 25(18 suppl):395s (Abstract 7544).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Heymach, J.1    Paz-Ares, L.2    De Braud, F.3
  • 32
    • 36749052079 scopus 로고    scopus 로고
    • Efficacy and safety of continuous daily sunitinib dosing in previously treated advanced non-small cell lung cancer (NSCLC): Results from a phase II study
    • (Abstract 7542)
    • Brahmer JR, Govindan R, Novello S, et al. Efficacy and safety of continuous daily sunitinib dosing in previously treated advanced non-small cell lung cancer (NSCLC): results from a phase II study. J Clin Oncol 2007; 25(18 suppl):395s (Abstract 7542).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Brahmer, J.R.1    Govindan, R.2    Novello, S.3
  • 33
    • 65349099972 scopus 로고    scopus 로고
    • A phase i dose escalation study of sunitinib in combination with gemcitabine + cisplatin for advanced non-small cell lung cancer (NSCLC)
    • (Abstract 18057)
    • Reck M, Frickhofen N, Gatzemeier U, et al. A phase I dose escalation study of sunitinib in combination with gemcitabine + cisplatin for advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2007; 25(18 suppl):688s (Abstract 18057).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Reck, M.1    Frickhofen, N.2    Gatzemeier, U.3
  • 34
    • 33746316839 scopus 로고    scopus 로고
    • Phase II study of carboplatin, irinotecan, and thalidomide in patients with advanced non-small cell lung cancer (NSCLC)
    • (Abstract 7132)
    • Miller AA, Case D, Atkins J, et al. Phase II study of carboplatin, irinotecan, and thalidomide in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2004; 22:646 (Abstract 7132).
    • (2004) J Clin Oncol , vol.22 , pp. 646
    • Miller, A.A.1    Case, D.2    Atkins, J.3
  • 35
    • 58849164550 scopus 로고    scopus 로고
    • Two randomised phase III, double-blind, placebo controlled trials of thalidomide in patients with advanced non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC)
    • (Abstract 8045)
    • Lee S, Rudd RM, Woll PJ, et al. Two randomised phase III, double-blind, placebo controlled trials of thalidomide in patients with advanced non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). J Clin Oncol 2008; 26(15 suppl):435s (Abstract 8045).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Lee, S.1    Rudd, R.M.2    Woll, P.J.3
  • 36
    • 84860596909 scopus 로고    scopus 로고
    • A phase II trial of thalidomide (T), irinotecan (I) and gemcitabine (G) in chemonaive patients (pts) with advanced nonsmall cell lung cancer (NSCLC)
    • (Abstract 7258)
    • Flora DB, Kleykamp B, Knapp M, et al. A phase II trial of thalidomide (T), irinotecan (I) and gemcitabine (G) in chemonaive patients (pts) with advanced nonsmall cell lung cancer (NSCLC). J Clin Oncol 2004; 22:670 (Abstract 7258).
    • (2004) J Clin Oncol , vol.22 , pp. 670
    • Flora, D.B.1    Kleykamp, B.2    Knapp, M.3
  • 37
    • 84860560449 scopus 로고    scopus 로고
    • Phase I-II trial of daily thalidomide in combination with docetaxel in patients with relapsed non-small cell lung cancer: A final analysis
    • (Abstract 17060)
    • Seidler CW, Scepansky E, Khanani S, et al. Phase I-II trial of daily thalidomide in combination with docetaxel in patients with relapsed non-small cell lung cancer: A final analysis. J Clin Oncol 2006; 24(18 suppl):671s (Abstract 17060).
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Seidler, C.W.1    Scepansky, E.2    Khanani, S.3
  • 38
    • 42949105645 scopus 로고    scopus 로고
    • Phase i and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: The National Cancer Institute of Canada clinical trials group
    • Laurie SA, Gauthier I, Arnold A, et al. Phase I and pharmacokinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: the National Cancer Institute of Canada clinical trials group. J Clin Oncol 2008; 26:1871-8.
    • (2008) J Clin Oncol , vol.26 , pp. 1871-1878
    • Laurie, S.A.1    Gauthier, I.2    Arnold, A.3
  • 39
    • 36349033172 scopus 로고    scopus 로고
    • Efficacy and safety of axitinib (AG-013736; AG) in patients (pts) with advanced non-small cell lung cancer (NSCLC): A phase II trial
    • (Abstract 7507)
    • Schiller JH, Larson T, Ou SI, et al. Efficacy and safety of axitinib (AG-013736; AG) in patients (pts) with advanced non-small cell lung cancer (NSCLC): a phase II trial. J Clin Oncol 2007; 25(18 suppl):386s (Abstract 7507).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Schiller, J.H.1    Larson, T.2    Ou, S.I.3
  • 40
    • 56349121456 scopus 로고    scopus 로고
    • Activity and tolerance of XL647 in NSCLC patients with acquired resistance to EGFR-TKIs: Preliminary results of a phase II trial
    • (Abstract 8028)
    • Miller VA, Wakelee HA, Lara PN, et al. Activity and tolerance of XL647 in NSCLC patients with acquired resistance to EGFR-TKIs: preliminary results of a phase II trial. J Clin Oncol 2008; 26(15 suppl):430s (Abstract 8028).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Miller, V.A.1    Wakelee, H.A.2    Lara, P.N.3
  • 41
    • 56349165038 scopus 로고    scopus 로고
    • Activity of XL647 in clinically selected NSCLC patients (pts) enriched for the presence of EGFR mutations. Result from phase 2
    • (Abstract 8053)
    • Rizvi NA, Kris MG, Miller VA, et al. Activity of XL647 in clinically selected NSCLC patients (pts) enriched for the presence of EGFR mutations. Result from phase 2. J Clin Oncol 2008; 26 (Abstract 8053).
    • (2008) J Clin Oncol , vol.26
    • Rizvi, N.A.1    Kris, M.G.2    Miller, V.A.3
  • 42
    • 0031966682 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression in non-small-cell lung cancer: Prognostic significance in squamous cell carcinoma
    • DOI 10.1016/S0022-5223(98)70398-8
    • Imoto H, Osaki T, Taga S, et al. Vascular endothelial growth factor expression in non-small-cell lung cancer: prognostic significance in squamous cell carcinoma. J Thorac Cardiovasc Surg 1998; 115:1007-14. (Pubitemid 28224393)
    • (1998) Journal of Thoracic and Cardiovascular Surgery , vol.115 , Issue.5 , pp. 1007-1014
    • Imoto, H.1    Osaki, T.2    Taga, S.3    Ohgami, A.4    Ichiyoshi, Y.5    Yasumoto, K.6
  • 43
    • 1842328560 scopus 로고    scopus 로고
    • Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer
    • DOI 10.1002/(SICI)1097-0215(199702 20)74:1<64::AID-IJ C11>3.0.CO;2-I
    • Volm M, Koomagi R, Mattern J. Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer. Int J Cancer 1997; 74:64-8. (Pubitemid 27157857)
    • (1997) International Journal of Cancer , vol.74 , Issue.1 , pp. 64-68
    • Volm, M.1    Koomagi, R.2    Mattern, J.3
  • 46
    • 2442621619 scopus 로고    scopus 로고
    • Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
    • Ferrara N, Hillan KJ, Gerber HP, et al. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004; 3:391-400. (Pubitemid 38618122)
    • (2004) Nature Reviews Drug Discovery , vol.3 , Issue.5 , pp. 391-400
    • Ferrara, N.1    Hillan, K.J.2    Gerber, H.-P.3    Novotny, W.4
  • 47
  • 48
    • 37849052774 scopus 로고    scopus 로고
    • Outcomes for elderly, advancedstage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: Analysis of eastern cooperative oncology group trial 4599
    • Ramalingam SS, Dahlberg SE, Langer CJ, et al. Outcomes for elderly, advancedstage non small-cell lung cancer patients treated with bevacizumab in combination with carboplatin and paclitaxel: analysis of Eastern Cooperative Oncology Group Trial 4599. J Clin Oncol 2008; 26:60-5.
    • (2008) J Clin Oncol , vol.26 , pp. 60-65
    • Ramalingam, S.S.1    Dahlberg, S.E.2    Langer, C.J.3
  • 50
    • 42649143421 scopus 로고    scopus 로고
    • An open-label, phase II trial of nanoparticle albumin bound paclitaxel (nab-paclitaxel), carboplatin, and bevacizumab in firstline patients with advanced non-squamous non-small cell lung cancer (NSCLC)
    • (Abstract 7610)
    • Reynolds C, Barrera D, Vu DQ, et al. An open-label, phase II trial of nanoparticle albumin bound paclitaxel (nab-paclitaxel), carboplatin, and bevacizumab in firstline patients with advanced non-squamous non-small cell lung cancer (NSCLC). J Clin Oncol 2007; 25(18 suppl):411s (Abstract 7610).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Reynolds, C.1    Barrera, D.2    Vu, D.Q.3
  • 51
    • 35948954665 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in combination with docetaxel and carboplatin in patients with metastatic non-small cell lung cancer (NSCLC)
    • (Abstract 18098)
    • William WN Jr, Kies MS, Fossella FV, et al. Phase II study of bevacizumab in combination with docetaxel and carboplatin in patients with metastatic non-small cell lung cancer (NSCLC). J Clin Oncol 2007; 25(18 suppl):691s (Abstract 18098).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • William Jr., W.N.1    Kies, M.S.2    Fossella, F.V.3
  • 52
    • 35948932525 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab plus pemetrexed and carboplatin in previously untreated advanced nonsquamous nonsmall cell lung cancer
    • (Abstract 18163)
    • Dalsania CJ, Hageboutros A, Harris E, et al. Phase II trial of bevacizumab plus pemetrexed and carboplatin in previously untreated advanced nonsquamous nonsmall cell lung cancer. J Clin Oncol 2007; 25(18 suppl):691s (Abstract 18163).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Dalsania, C.J.1    Hageboutros, A.2    Harris, E.3
  • 53
    • 35948938878 scopus 로고    scopus 로고
    • Pemetrexed and carboplatin plus bevacizumab for advanced non-squamous non-small cell lung cancer (NSCLC): Preliminary results
    • (Abstract 7601)
    • Patel JD, Hensing TA, Villafor V, et al. Pemetrexed and carboplatin plus bevacizumab for advanced non-squamous non-small cell lung cancer (NSCLC): preliminary results. J Clin Oncol 2007; 25(18 suppl):409s (Abstract 7601).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Patel, J.D.1    Hensing, T.A.2    Villafor, V.3
  • 54
    • 35948995260 scopus 로고    scopus 로고
    • Single agent bevacizumab and bevacizumab in combination with docetaxel and cisplatin as induction therapy for resectable IB-IIIA non-small cell lung cancer
    • (Abstract 18045)
    • Rizvi NA, Rusch V, Zhao B, et al. Single agent bevacizumab and bevacizumab in combination with docetaxel and cisplatin as induction therapy for resectable IB-IIIA non-small cell lung cancer. J Clin Oncol 2007; 25(18 suppl):687s (Abstract 18045).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Rizvi, N.A.1    Rusch, V.2    Zhao, B.3
  • 56
    • 49749127690 scopus 로고    scopus 로고
    • Acceptable safety of bevacizumab therapy in patients with brain metastases due to non-small cell lung cancer
    • (Abstract 8043)
    • Akerley WL, Langer CJ, Oh Y, et al. Acceptable safety of bevacizumab therapy in patients with brain metastases due to non-small cell lung cancer. J Clin Oncol 2008; 26(15 suppl):434s (Abstract 8043).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Akerley, W.L.1    Langer, C.J.2    Oh, Y.3
  • 57
    • 49749096080 scopus 로고    scopus 로고
    • Safety of bevacizumab-based therapy as first-line treatment of patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): MO19390 (SAiL)
    • (Abstract 8085)
    • Dansin E, Mezger J, Isla D, et al. Safety of bevacizumab-based therapy as first-line treatment of patients with advanced or recurrent non-squamous non-small cell lung cancer (NSCLC): MO19390 (SAiL). J Clin Oncol 2008; 26(15 suppl):445s (Abstract 8085).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Dansin, E.1    Mezger, J.2    Isla, D.3
  • 58
    • 49749113288 scopus 로고    scopus 로고
    • Safety of first-line bevacizumab-based therapy with concomitant cardiovascular or anticoagulation medication in advanced or recurrent non-squamous non-small cell lung cancer (NSCLC) in MO19390 (SAiL)
    • (Abstract 8049)
    • Griesinger F, Laskin JJ, Pavlakis N, et al. Safety of first-line bevacizumab-based therapy with concomitant cardiovascular or anticoagulation medication in advanced or recurrent non-squamous non-small cell lung cancer (NSCLC) in MO19390 (SAiL). J Clin Oncol 2008; 26(15 suppl):436s (Abstract 8049).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Griesinger, F.1    Laskin, J.J.2    Pavlakis, N.3
  • 59
    • 65349154564 scopus 로고    scopus 로고
    • Preliminary treatment patterns and safety outcomes for non-small cell lung cancer (NSCLC) from ARIES, a bevacizumab treatment observational cohort study (OCS)
    • (Abstract 8077)
    • Lynch TJ, Brahmer J, Fischbach N, et al. Preliminary treatment patterns and safety outcomes for non-small cell lung cancer (NSCLC) from ARIES, a bevacizumab treatment observational cohort study (OCS). J Clin Oncol 2008; 26(15 suppl):443s (Abstract 8077).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Lynch, T.J.1    Brahmer, J.2    Fischbach, N.3
  • 61
    • 0036401105 scopus 로고    scopus 로고
    • BAY 43-9006: Preclinical data
    • DOI 10.2174/1381612023393026
    • Wilhelm S, Chien DS. BAY 43-9006: preclinical data. Curr Pharm Des 2002; 8:2255-7. (Pubitemid 35189898)
    • (2002) Current Pharmaceutical Design , vol.8 , Issue.25 , pp. 2255-2257
    • Wilhelm, S.1    Chien, D.-S.2
  • 64
    • 34147161209 scopus 로고    scopus 로고
    • Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006)
    • Murphy DA, Makonnen S, Lassoued W, et al. Inhibition of tumor endothelial ERK activation, angiogenesis, and tumor growth by sorafenib (BAY43-9006). Am J Pathol 2006; 169:1875-85.
    • (2006) Am J Pathol , vol.169 , pp. 1875-18785
    • Murphy, D.A.1    Makonnen, S.2    Lassoued, W.3
  • 65
    • 33845321649 scopus 로고    scopus 로고
    • A phase II study of BAY 43-9006 (Sorafenib) in patients with relapsed non-small cell lung cancer (NSCLC)
    • (Abstract 17119)
    • Liu B, Barrett T, Choyke P, et al. A phase II study of BAY 43-9006 (Sorafenib) in patients with relapsed non-small cell lung cancer (NSCLC). J Clin Oncol 2006; 24(18 suppl)676s (Abstract 17119).
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Liu, B.1    Barrett, T.2    Choyke, P.3
  • 66
    • 65349161533 scopus 로고    scopus 로고
    • A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501
    • (Abstract 8014)
    • Schiller JH, Lee JW, Hanna NH, et al. A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501. J Clin Oncol 2008; 26(15 suppl):427s (Abstract 8014).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Schiller, J.H.1    Lee, J.W.2    Hanna, N.H.3
  • 67
    • 34250026980 scopus 로고    scopus 로고
    • Effects of sorafenib on symptoms and quality of life: Results from a large randomized placebo-controlled study in renal cancer
    • DOI 10.1097/01.coc.0000258732.80710.05, PII 0000042120070600000002
    • Bukowski R, Cella D, Gondek K, et al. Effects of sorafenib on symptoms and quality of life: results from a large randomized placebo-controlled study in renal cancer. Am J Clin Oncol 2007; 30:220-7. (Pubitemid 46884139)
    • (2007) American Journal of Clinical Oncology: Cancer Clinical Trials , vol.30 , Issue.3 , pp. 220-227
    • Bukowski, R.1    Cella, D.2    Gondek, K.3    Escudier, B.4
  • 68
    • 21244501441 scopus 로고    scopus 로고
    • Preliminary phase II safety evaluation of ZD6474, in combination with carboplatin and paclitaxel, as 1st-line treatment in patients with NSCLC
    • (Abstract 7102)
    • Johnson BE, Ma P, West H, et al. Preliminary phase II safety evaluation of ZD6474, in combination with carboplatin and paclitaxel, as 1st-line treatment in patients with NSCLC. J Clin Oncol 2005; 23(16 suppl):645s (Abstract 7102).
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL.
    • Johnson, B.E.1    Ma, P.2    West, H.3
  • 71
    • 5044236157 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in tumor angiogenesis
    • DOI 10.1016/j.hoc.2004.06.002, PII S0889858804000504, Elbow Injuries in Athletes
    • Ellis LM. Epidermal growth factor receptor in tumor angiogenesis. Hematol Oncol Clin North Am 2004; 18:1007-21 viii. (Pubitemid 39335756)
    • (2004) Hematology/Oncology Clinics of North America , vol.18 , Issue.5 , pp. 1007-1021
    • Ellis, L.M.1
  • 72
    • 20644447818 scopus 로고    scopus 로고
    • Molecular determinants of cetuximab efficacy
    • Vallbohmer D, Zhang W, Gordon M, et al. Molecular determinants of cetuximab efficacy. J Clin Oncol 2005; 23:3536-44.
    • (2005) J Clin Oncol , vol.23 , pp. 3536-3544
    • Vallbohmer, D.1    Zhang, W.2    Gordon, M.3
  • 73
    • 34147130694 scopus 로고    scopus 로고
    • The role of VEGF and EGFR inhibition: Implications for combining Anti-VEGF and Anti-EGFR Agents
    • DOI 10.1158/1541-7786.MCR-06-0404
    • Tabernero J. The role of VEGF and EGFR inhibition: implications for combining anti-VEGF and anti-EGFR agents. Mol Cancer Res 2007; 5:203-20. (Pubitemid 46569773)
    • (2007) Molecular Cancer Research , vol.5 , Issue.3 , pp. 203-220
    • Tabernero, J.1
  • 74
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
    • Abrams TJ, Lee LB, Murray LJ, et al. SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther 2003; 2:471-8.
    • (2003) Mol Cancer Ther , vol.2 , pp. 471-478
    • Abrams, T.J.1    Lee, L.B.2    Murray, L.J.3
  • 75
    • 35548988774 scopus 로고    scopus 로고
    • A phase i dose-escalation and pharmacokinetic (PK) study of sunitinib (SU) plus docetaxel (D) in patients (pts) with advanced solid tumors (STs)
    • (Abstract 3543)
    • Robert F, Sandler A, Schiller JH, et al. A phase I dose-escalation and pharmacokinetic (PK) study of sunitinib (SU) plus docetaxel (D) in patients (pts) with advanced solid tumors (STs). J Clin Oncol 2007; 25(18 suppl):148s (Abstract 3543).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Robert, F.1    Sandler, A.2    Schiller, J.H.3
  • 76
    • 2542593141 scopus 로고    scopus 로고
    • Thalidomide
    • DOI 10.1016/S0140-6736(04)16308-3, PII S0140673604163083
    • Franks ME, Macpherson GR, Figg WD. Thalidomide. Lancet 2004; 363:1802-11. (Pubitemid 38698386)
    • (2004) Lancet , vol.363 , Issue.9423 , pp. 1802-1811
    • Franks, M.E.1    Macpherson, G.R.2    Figg, W.D.3
  • 77
    • 33750359418 scopus 로고    scopus 로고
    • Phase i evaluation of AZD2171, a highly potent and selective inhibitor of VEGFR signaling, in combination with selected chemotherapy regimens in patients with advanced solid tumors
    • (Abstract 3034)
    • Lorusso PM, Heath E, Valdivieso M, et al. Phase I evaluation of AZD2171, a highly potent and selective inhibitor of VEGFR signaling, in combination with selected chemotherapy regimens in patients with advanced solid tumors. J Clin Oncol 2006; 24(18 suppl):129s (Abstract 3034).
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Lorusso, P.M.1    Heath, E.2    Valdivieso, M.3
  • 78
    • 32044459807 scopus 로고    scopus 로고
    • Phase i clinical evaluation of AZD2171 in combination with gefitinib, in patients with advanced tumors
    • (Abstract 3030)
    • van Cruijsen H, Voest EE, van Herpen CML, et al. Phase I clinical evaluation of AZD2171 in combination with gefitinib, in patients with advanced tumors. J Clin Oncol 2005; 23(16 suppl):199s (Abstract 3030).
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL.
    • Van Cruijsen, H.1    Voest, E.E.2    Van Herpen Cml3
  • 79
    • 35948990764 scopus 로고    scopus 로고
    • Ind.175: Phase i study of daily oral azd2171, a vascular endothelial growth factor receptor inhibitor (vegfri), in combination with gemcitabine and cisplatin (g/c) in patients with advanced nonsmall cell lung cancer (ansclc): A study of the ncic clinical trials group
    • (Abstract 7649)
    • Goss GD, Laurie S, Shepherd F, et al. IND.175: Phase I study of daily oral AZD2171, a vascular endothelial growth factor receptor inhibitor (VEGFRI), in combination with gemcitabine and cisplatin (G/C) in patients with advanced nonsmall cell lung cancer (ANSCLC): A study of the NCIC Clinical Trials Group. J Clin Oncol 2007; 25(18 suppl):421s (Abstract 7649).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Goss, G.D.1    Laurie, S.2    Shepherd, F.3
  • 80
    • 31644448755 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of AMG 706 in patients with advanced solid tumors
    • (Abstract 3013)
    • Rosen L, Kurzrock R, Jackson E, et al. Safety and pharmacokinetics of AMG 706 in patients with advanced solid tumors. J Clin Oncol 2005; 23(16 suppl):195s (Abstract 3013).
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL.
    • Rosen, L.1    Kurzrock, R.2    Jackson, E.3
  • 81
    • 50249102996 scopus 로고    scopus 로고
    • Safety and pharmacokinetics (PK) of AMG 706 in combination with gemcitabine for the treatment of patients (pts) with solid tumors
    • (Abstract 14005)
    • Price TJ, Lipton L, Williams J, et al. Safety and pharmacokinetics (PK) of AMG 706 in combination with gemcitabine for the treatment of patients (pts) with solid tumors. J Clin Oncol 2007; 25(18 suppl):612s (Abstract 14005).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Price, T.J.1    Lipton, L.2    Williams, J.3
  • 82
    • 33750940321 scopus 로고    scopus 로고
    • Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and carboplatin/paclitaxel (CP) for the treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC)
    • (Abstract 7119)
    • Blumenschein G, Jr, Sandler A, O'Rourke T, et al. Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and carboplatin/paclitaxel (CP) for the treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2006; 24(18 suppl):393s (Abstract 7119).
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Blumenschein, G.1    Sandler Jr., A.2    O'Rourke, T.3
  • 83
    • 55849108694 scopus 로고    scopus 로고
    • Safety and pharmacokinetics (PK) of AMG 706 in combination with panitumumab and gemcitabine-cisplatin in patients (pts) with advanced cancer
    • (Abstract 14057)
    • Crawford J, Burris H, Stephenson J, Jr, et al. Safety and pharmacokinetics (PK) of AMG 706 in combination with panitumumab and gemcitabine-cisplatin in patients (pts) with advanced cancer. J Clin Oncol 2007; 25(18 suppl):616s (Abstract 14057).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Crawford, J.1    Burris, H.2    Stephenson Jr., J.3
  • 84
    • 24944453855 scopus 로고    scopus 로고
    • Phase i trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: Pharmacokinetic and clinical results
    • Rugo HS, Herbst RS, Liu G, et al. Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J Clin Oncol 2005; 23:5474-83.
    • (2005) J Clin Oncol , vol.23 , pp. 5474-5483
    • Rugo, H.S.1    Herbst, R.S.2    Liu, G.3
  • 85
    • 33646258383 scopus 로고    scopus 로고
    • Safety, tolerability and pharmacokinetics of oral administration of GW786034 in pts with solid tumors
    • (Abstract 3012)
    • Hurwitz H, Dowlati A, Savage S, et al. Safety, tolerability and pharmacokinetics of oral administration of GW786034 in pts with solid tumors. J Clin Oncol 2005; 23(16 suppl):195s (Abstract 3012).
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL.
    • Hurwitz, H.1    Dowlati, A.2    Savage, S.3
  • 86
    • 65349122441 scopus 로고    scopus 로고
    • Analyses of plasma cytokine/angiogenic factors (C/AFs) profile during preoperative treatment with pazopanib (GW786034) in early-stage non-small cell lung cancer
    • (Abstract 7568)
    • Nikolinakos P, Altorki N, Guarino M, et al. Analyses of plasma cytokine/angiogenic factors (C/AFs) profile during preoperative treatment with pazopanib (GW786034) in early-stage non-small cell lung cancer. J Clin Oncol 2008; 26(15 suppl):414s (Abstract 7568).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Nikolinakos, P.1    Altorki, N.2    Guarino, M.3
  • 87
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg F, Roth GJ, Krssak M, et al. BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 2008; 68:4774-82.
    • (2008) Cancer Res , vol.68 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3
  • 88
    • 33845333277 scopus 로고    scopus 로고
    • A clinical phase I, pharmacokinetic (PK), and pharmacodynamic study of twice daily BIBF 1120 in advanced cancer patients
    • (Abstract 3031)
    • Mross KB, Gmehling D, Frost A, et al. A clinical phase I, pharmacokinetic (PK), and pharmacodynamic study of twice daily BIBF 1120 in advanced cancer patients. J Clin Oncol 2005; 23(16 suppl):199s (Abstract 3031).
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL.
    • Mross, K.B.1    Gmehling, D.2    Frost, A.3
  • 89
    • 37549024347 scopus 로고    scopus 로고
    • A double-blind phase II study of BIBF 1,120 in patients suffering from relapsed advanced non-small cell lung cancer (NSCLC)
    • (Abstract 7635)
    • Von Pawel J, Kaiser R, Eschbach C, et al. A double-blind phase II study of BIBF 1,120 in patients suffering from relapsed advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2007; 25(18 suppl):418s (Abstract 7635).
    • (2007) J Clin Oncol , vol.25 , Issue.18 SUPPL.
    • Von Pawel, J.1    Kaiser, R.2    Eschbach, C.3
  • 90
    • 69349105666 scopus 로고    scopus 로고
    • A phase i study of continuous oral treatment with the triple angiokinase inhibitor BIBF 1120 together with pemetrexed in previously treated patients with non-small cell lung cancer: P3-091
    • Hanna N, Ellis P, Stopfer P, et al. A phase I study of continuous oral treatment with the triple angiokinase inhibitor BIBF 1120 together with pemetrexed in previously treated patients with non-small cell lung cancer: P3-091. J Thorac Oncol 2007; 2:S717-8.
    • (2007) J Thorac Oncol , vol.2
    • Hanna, N.1    Ellis, P.2    Stopfer, P.3
  • 91
    • 44649125425 scopus 로고    scopus 로고
    • A phase i dose-escalation and pharmacokinetic (PK) study of a novel spectrum selective kinase inhibitor, XL647, in patients with advanced solid malignancies (ASM)
    • (Abstract 3044)
    • Wakelee HA, Adjei AA, Halsey J, et al. A phase I dose-escalation and pharmacokinetic (PK) study of a novel spectrum selective kinase inhibitor, XL647, in patients with advanced solid malignancies (ASM). J Clin Oncol 2006; 24(18 suppl):131s (Abstract 3044).
    • (2006) J Clin Oncol , vol.24 , Issue.18 SUPPL.
    • Wakelee, H.A.1    Adjei, A.A.2    Halsey, J.3
  • 92
    • 84860562516 scopus 로고    scopus 로고
    • A phase i dose-escalation and pharmacokinetic (PK) study of a novel multiple-targeted receptor tyrosine kinase (RTK) inhibitor, XL647, in patients with advanced solid malignancies
    • (Abstract 3142)
    • Wakelee H, Adjei AA, Keer H, et al. A phase I dose-escalation and pharmacokinetic (PK) study of a novel multiple-targeted receptor tyrosine kinase (RTK) inhibitor, XL647, in patients with advanced solid malignancies. J Clin Oncol 2005; 23(16 suppl):227s (Abstract 3142).
    • (2005) J Clin Oncol , vol.23 , Issue.16 SUPPL.
    • Wakelee, H.1    Adjei, A.A.2    Keer, H.3
  • 93
    • 59349102359 scopus 로고    scopus 로고
    • A phase i study of XL647, an EGFR, HER2, VEGFR2 inhibitor, administered orally daily to patients (pts) with advanced solid malignancies (ASM)
    • (Abstract 3528)
    • Wakelee HA, Fehling JM, Molina JR, et al. A phase I study of XL647, an EGFR, HER2, VEGFR2 inhibitor, administered orally daily to patients (pts) with advanced solid malignancies (ASM). J Clin Oncol 2008; 26(15 suppl):160s (Abstract 3528).
    • (2008) J Clin Oncol , vol.26 , Issue.15 SUPPL.
    • Wakelee, H.A.1    Fehling, J.M.2    Molina, J.R.3
  • 95
    • 0036692153 scopus 로고    scopus 로고
    • The antiangiogenic agent Neovastat (AE-941) induces endothelial cell apoptosis
    • Boivin D, Gendron S, Beaulieu E, et al. The antiangiogenic agent Neovastat (AE-941) induces endothelial cell apoptosis. Mol Cancer Ther 2002; 1:795-802.
    • (2002) Mol Cancer Ther , vol.1 , pp. 795-802
    • Boivin, D.1    Gendron, S.2    Beaulieu, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.