Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway

Journal of Virology

Volumn 83, Issue 13, 2009, Pages 6739-6747

  Lee, Hye Ra ^a,b   Toth, Zsolt ^a   Shin, Young C ^b   Lee, Jong Soo ^a,b   Chang, Heesoon ^a,b   Gu, Wei ^c   Oh, Tae Kwang ^d   Myung, Hee Kim ^d   Jung, Jae U ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYCLOHEXIMIDE; DOXYCYCLINE; ETOPOSIDE; FLUOROURACIL; INTERFERON REGULATORY FACTOR 4; PROTEIN MDM2; PROTEIN P53; UBIQUITIN PROTEIN LIGASE E3; INTERFERON REGULATORY FACTOR; MDM2 PROTEIN, HUMAN; REPRESSOR PROTEIN; VIRAL INTERFERON REGULATORY FACTORS; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; CELL GROWTH; CELL STRAIN HCT116; CONTROLLED STUDY; GENE OVEREXPRESSION; GROWTH REGULATION; HERPES VIRUS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; KAPOSI SARCOMA; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE; VIRUS CELL INTERACTION; VIRUS INFECTION; VIRUS REPLICATION; CELL LINE; DOWN REGULATION; GENE EXPRESSION REGULATION; GENETICS; HUMAN HERPESVIRUS 8; METABOLISM; UBIQUITINATION;

HUMAN HERPESVIRUS 8; MURINAE;

APOPTOSIS; CELL LINE; DOWN-REGULATION; GENE EXPRESSION REGULATION; HERPESVIRUS 8, HUMAN; HUMANS; INTERFERON REGULATORY FACTORS; PROTO-ONCOGENE PROTEINS C-MDM2; REPRESSOR PROTEINS; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITINATION; VIRAL PROTEINS;

EID: 67449097025     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02353-08     Document Type: Article

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