Probing Conformational Changes of Human DNA Polymerase λ using Mass Spectrometry-Based Protein Footprinting

Journal of Molecular Biology

Volumn 390, Issue 3, 2009, Pages 368-379

  Fowler, Jason D ^a   Brown, Jessica A ^a   Kvaratskhelia, Mamuka ^a,b,c   Suo, Zucai ^a,b,c  

^a OHIO STATE UNIVERSITY   (United States)

^b Molecular   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

human DNA polymerase lambda; mass spectrometry based protein footprinting; nucleotide incorporation; pre steady state kinetics; protein conformational changes

Indexed keywords

ARGININE; DEOXYRIBONUCLEOTIDE; DNA DIRECTED DNA POLYMERASE LAMBDA; DNA POLYMERASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME SUBSTRATE; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN FOOTPRINTING; PROTEIN FUNCTION; SITE DIRECTED MUTAGENESIS;

EID: 67449084993     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.05.037     Document Type: Article

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