Non-Ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 2, 2003, Pages 692-698

  Luo, Jiing C ^a   Shin, Vivian Y ^b   Liu, Edgar S L ^b   So, Wallace H L ^b   Ye, Yi N ^b   Chang, Full Y ^a   Cho, Chi H ^b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; CORTICOSTEROID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DEXAMETHASONE; PHOSPHOLIPASE A2; PROSTAGLANDIN E2;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG MECHANISM; EPITHELIUM CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH MUCOSA LESION; STOMACH MUCUS; STOMACH ULCER; ULCER HEALING; ULCEROGENESIS; WESTERN BLOTTING; WOUND HEALING IMPAIRMENT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CELL DIVISION; CYCLOOXYGENASE 1; DEXAMETHASONE; DINOPROSTONE; GASTRIC MUCOSA; GENE EXPRESSION; ISOENZYMES; MALE; MEMBRANE PROTEINS; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHOLIPASES A; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, SPRAGUE-DAWLEY; STOMACH ULCER; WOUND HEALING;

EID: 0142210125     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.055202     Document Type: Article

References (40)

1. Akiba Y, Nakamura M, Mori M, Suzuki H, Oda M, Kimura H, Miura S, Tsuchiya M, and Ishii H (1998) Inhibition of inducible nitric oxide synthase delays gastric ulcer healing in the rat. J Clin Gastroenterol 27 (Suppl 1):S64-S73.
2. Augustin HG, Braun K, Telemenakis I, Modlich U, and Kuhn W (1995) Ovarian angiogenesis. Phenotypic characterization of endothelial cells in a physiological model of blood vessel growth and regression. Am J Pathol 147:339-351.
3. Bandyopadhyay U, Biswas K, Bandyopadhyay D, Ganguly CK, and Banerjee RK (1999) Dexamethasone makes the gastric mucosa susceptible to ulceration by inhibiting prostaglandin synthetase and peroxidase-two important gastroprotective enzymes. Mol Cell Biochem 202:31-36.
4. Carpani de Kaski M, Rentsch R, Levi S, and Hodgson HJ (1995) Corticosteroids reduce regenerative repair of epithelium in experimental gastric ulcers. Gut 37:613-616.
5. Chatham WW and Kimberly RP (2001) Treatment of lupus with corticosteroids. Lupus 10:140-147.
6. Cho CH, Chen BW, Hui WM, Luk CT, and Lam SK (1990) Endogenous prostaglandins: its role in gastric mucosal blood flow and ethanol ulceration in rats. Prostaglandins 40:397-403.
7. Conn HO and Blitzer BL (1976) Nonassociation of adrenocorticosteroid therapy and peptic ulcer. N Engl J Med 294:473-479.
8. Delaney JP, Michel HM, Bonsack ME, Eisenberg MM, and Dunn DH (1979) Adrenal corticosteroids cause gastrin cell hyperplasia. Gastroenterology 76:913-916.
9. Fernandez-Morata JC, Mullol J, Fuentes M, Pujols L, Roca-Ferrer J, Perez M, Xaubet A, and Picado C (2000) Regulation of cyclooxygenase-1 and -2 expression in human nasal mucosa. Effects of cytokines and dexamethasone. Clin Exp Allergy 30:1275-1284.
10. Filep JG, Herman F, Foldes-Filep E, Schneider F, and Braquet P (1992) Dexamethasone-induced gastric mucosal damage in the rat: possible role of platelet-activating factor. Br J Pharmacol 105:912-918.
11. Flower RJ (1988) Eleventh Gaddum memorial lecture. Lipocortin and the mechanism of action of the glucocorticoids. Br J Pharmacol 94:987-1015.
12. Gavrieli Y, Sherman Y, and Ben-Sasson SA (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Cell Biol 119:493-501.
13. Ghosh AK, Hirasawa N, Niki H, and Ohuchi K (2000) Cyclooxygenase-2-mediated angiogenesis in carrageenin-induced granulation tissue in rats. J Pharmacol Exp Ther 295:802-809.
14. Goppelt-Struebe M, Wolter D, and Resch K (1989) Glucocorticoids inhibit prostaglandin synthesis not only at the level of phospholipase A2 but also at the level of cyclo-oxygenase/PGE isomerase. Br J Pharmacol 98:1287-1295.
15. Gretzer B, Maricic N, Respondek M, Schuligoi R, and Peskar BM (2001) Effects of specific inhibition of cyclo-oxygenase-1 and cyclo-oxygenase-2 in the rat stomach with normal mucosa and after acid challenge. Br J Pharmacol 132:1565-1573.
16. Izhar M, Pasmanik M, Marcus S, and Shemesh M (1992) Dexamethasone inhibition of cyclooxygenase expression in bovine term placenta. Prostaglandins 43:239-254.
17. Kuwayama H, Matsuo Y, and Eastwood GL (1991) Effects of prostaglandins on hydrocortisone-induced delayed healing of chronic gastric ulcers in the rat. J Clin Gastroenterol 13 (Suppl 1):S54-S57.
18. Lacy ER, Kuwayama H, Cowart KS, King JS, Deutz AH, and Sistrunk S (1991) A rapid, accurate, immunohistochemical method to label proliferating cells in the digestive tract. A comparison with tritiated thymidine. Gastroenterology 100:259-262.
19. Li Y, Wang HY, and Cho CH (1999) Association of heparin with basic fibroblast growth factor, epidermal growth factor, and constitutive nitric oxide synthase on healing of gastric ulcer in rats. J Pharmacol Exp Ther 290:789-796.
20. Ma L, Wang WP, Chow JY, Lam SK, and Cho CH (2000) The role of polyamines in gastric mucus synthesis inhibited by cigarette smoke or its extract. Gut 47:170-177.
21. Menguy R and Masters YF (1963) Effect of cortisol on mucoprotein secretion by gastric antrum of dogs: pathogenesis of steroid ulcers. Surgery 54:19-28.
22. Messer J, Reitman D, Sacks HS, Smith H Jr, and Chalmers TC (1983) Association of adrenocorticosteroid therapy and peptic-ulcer disease. N Engl J Med 309:21-24.
23. Mizuno H, Sakamoto C, Matsuda K, Wada K, Uchida T, Noguchi H, Akamatsu T, and Kasuga M (1997) Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 112:387-397.
24. Nobuhara Y, Ueki S, and Takeuchi K (1985) Influence of prednisolone on gastric alkaline response in rat stomach. A possible explanation for steroid-induced gastric lesion. Dig Dis Sci 30:1166-1173.
25. Okazaki K, Chiba T, and Hajiro K (1998) Downregulation of gastric mucin gene expression and its biosynthesis by dexamethasone in the human. J Clin Gastroenterol 27 (Suppl 1):S91-S96.
26. Pai R, Soreghan B, Szabo IL, Pavelka M, Baatar D, and Tarnawski AS (2002) Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy. Nat Med 8:289-293.
27. Pai R, Szabo IL, Soreghan BA, Atay S, Kawanaka H, and Tarnawski AS (2001) PGE(2) stimulates VEGF expression in endothelial cells via ERK2/JNK1 signaling pathways. Biochem Biophys Res Commun 286:923-928.
28. Singh JM, Palda VA, Stanbrook MB, and Chapman KR (2002) Corticosteroid therapy for patients with acute exacerbations of chronic obstructive pulmonary disease: a systematic review. Arch Intern Med 162:2527-2536.
29. Szabo S, Khomenko T, Gombos Z, Deng XM, Jadus MR, and Yoshida M (2000) Review article: transcription factors and growth factors in ulcer healing. Aliment Pharmacol Ther 14 (Suppl 1):33-43.
30. Takahashi M, Ota S, Hata Y, Mikami Y, Azuma N, Nakamura T, Terano A, and Omata M (1996) Hepatocyte growth factor as a key to modulate anti-ulcer action of prostaglandins in stomach. J Clin Investig 98:2604-2611.
31. Tarnawski AS, Jones MK, Baatar D, and Pai R (2002) Role of angiogenesis and angiogenic growth factors in mucosal repair and ulcer healing, in Gastrointestinal Mucosal Repair and Experimental Therapeutics (Cho CH and Wang JY eds) pp 101-116, Karger, Basel, Switzerland.
32. Tsukimi Y and Okabe S (1994) Validity of kissing gastric ulcers induced in rats for screening of antiulcer drugs. J Gastroenterol Hepatol 9 (Suppl 1):S60-S65.
33. Vecht CJ (1998) Clinical management of brain metastasis. J Neurol 245:127-131.
34. Wallace JL (1987) Glucocorticoid-induced gastric mucosal damage: inhibition of leukotriene, but not prostaglandin biosynthesis. Prostaglandins 34:311-323.
35. Wallace JL, McKnight W, Reuter BK, and Vergnolle N (2000) NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology 119:706-714.
36. Wang H, Ma L, Li Y, and Cho CH (2000) Exposure to cigarette smoke increases apoptosis in the rat gastric mucosa through a reactive oxygen species-mediated and p53-independent pathway. Free Radic Biol Med 28:1125-1131.
37. Wang JY (2002) Expression of early primary response genes in healing of gastrointestinal mucosal injury, in Gastrointestinal Mucosal Repair and Experimental Therapeutics (Cho CH and Wang JY eds) pp 82-100, Karger, Basel, Switzerland.
38. Whittle BJ, Lopez-Belmonte J, and Moncada S (1990) Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 99:607-611.
39. Wolfe MM, Lichtenstein DR, and Singh G (1999) Gastrointestinal toxicity of nonsteroidal antiinflammatory drugs. N Engl J Med 340:1888-1899.
40. Yang YX and Lichtenstein GR (2002) Corticosteroids in Crohn's disease. Am J Gastroenterol 97:803-830.