The transcription factors Egr1 and Egr2 have opposing influences on adipocyte differentiation

Cell Death and Differentiation

Volumn 16, Issue 5, 2009, Pages 782-789

  Boyle, K B ^a   Hadaschik, D ^a   Virtue, S ^a   Cawthorn, W P ^a   Ridley, S H ^a   O'Rahilly, S ^a   Siddle, K ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; EARLY GROWTH RESPONSE FACTOR 1; EARLY GROWTH RESPONSE FACTOR 2; ISOBUTYLMETHYLXANTHINE; LUCIFERASE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; SHORT HAIRPIN RNA;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL LYSATE; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; MUTANT; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE; ZINC FINGER MOTIF;

1-METHYL-3-ISOBUTYLXANTHINE; 3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CCAAT-ENHANCER-BINDING PROTEIN-ALPHA; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL DIFFERENTIATION; CELL LINE; EARLY GROWTH RESPONSE PROTEIN 1; EARLY GROWTH RESPONSE PROTEIN 2; GENE KNOCKDOWN TECHNIQUES; MICE; PHOSPHORYLATION; PPAR GAMMA; RNA INTERFERENCE;

MURINAE;

EID: 67349265144     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2009.11     Document Type: Article

References (39)

1. Moitra J, Mason MM, Olive M, Krylov D, Gavrilova O, Marcus-Samuels B et al. Life without white fat: A transgenic mouse. Genes Dev 1998; 12: 3168-3181.
2. Petersen KF, Oral EA, Dufour S, Befroy D, Ariyan C, Yu C et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest 2002; 109: 1345-1350.
3. Farmer SR. Transcriptional control of adipocyte formation. Cell Metab 2006; 4: 263-273.
4. Rosen ED, MacDougald OA. Adipocyte differentiation from the inside out. Nat Rev Mol Cell Biol 2006; 7: 885-896.
5. El-Jack AK, Hamm JK, Pilch PF, Farmer SR. Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARgamma and C/EBPalpha. J Biol Chem 1999; 274: 7946-7951.
6. Wu Z, Rosen ED, Brun R, Hauser S, Adelmant G, Troy AE et al. Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol Cell 1999; 3: 151-158.
7. Fox KE, Fankell DM, Erickson PF, Majka SM, Crossno Jr JT, Klemm DJ. Depletion of cAMP-response element-binding protein/ATF1 inhibits adipogenic conversion of 3T3-L1 cells ectopically expressing CCAAT/ enhancer-binding protein (C/EBP) alpha, C/EBP beta, or PPAR gamma 2. J Biol Chem 2006; 281: 40341-40353.
8. Klemm DJ, Leitner JW, Watson P, Nesterova A, Reusch JE, Goalstone ML et al. Insulin-induced adipocyte differentiation. Activation of CREB rescues adipogenesis from the arrest caused by inhibition of prenylation. J Biol Chem 2001; 276: 28430-28435.
9. Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM et al. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature 2002; 417: 563-567.
10. Takahashi N, Kawada T, Yamamoto T, Goto T, Taimatsu A, Aoki N et al Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor gamma. J Biol Chem 2002; 277 16906-16912.
11. Yamauchi T, Oike Y, Kamon J, Waki H, Komeda K, Tsuchida A et al. Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous mice. Nat Genet 2002; 30: 221-226.
12. Rochford JJ, Semple RK, Laudes M, Boyle KB, Christodoulides C, Mulligan C et al. ETO/MTG8 is an inhibitor of C/EBPbeta activity and a regulator of early adipogenesis. Mol Cell Biol 2004; 24: 9863-9872.
13. Wiper-Bergeron N, Wu D, Pope L, Schild-Poulter C, Hache RJ. Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex. EMBO J 2003; 22: 2135-2145.
14. Chen Z, Torrens JI, Anand A, Spiegelman BM, Friedman JM. Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metab 2005; 1: 93-106.
15. Joseph LJ, Le Beau MM, Jamieson Jr GA, Acharya S, Shows TB, Rowley JD et al. Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with 'zinc-binding finger' structure. Proc Natl Acad Sci USA 1988; 85: 7164-7168.
16. Milbrandt J. A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science 1987; 238: 797-799.
17. Lau LF, Nathans D. Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: Coordinate regulation with c-fos or c-myc. Proc Natl Acad Sci USA 1987; 84: 1182-1186.
18. Dinkel A, Warnatz K, Ledermann B, Rolink A, Zipfel PF, Burki K et al The transcription factor early growth response 1 (Egr-1) advances differentiation of pre-B and immature B cells. J Exp Med 1998; 188: 2215-2224.
19. Nguyen HQ, Hoffman-Liebermann B, Liebermann DA. The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage. Cell 1993; 72: 197-209.
20. Pignatelli M, Cortes-Canteli M, Santos A, Perez-Castillo A. Involvement of the NGFI-A gene in the differentiation of neuroblastoma cells. FEBS Lett 1999; 461: 37-42.
21. Lucerna M, Pomyje J, Mechtcheriakova D, Kadl A, Gruber F, Bilban M et al. Sustained expression of early growth response protein-1 blocks angiogenesis and tumor growth. Cancer Res 2006; 66: 6708-6713.
22. Lawrence JT, Birnbaum MJ. ADP-ribosylation factor 6 delineates separate pathways used by endothelin 1 and insulin for stimulating glucose uptake in 3T3-L1 adipocytes. Mol Cell Biol 2001; 21: 5276-5285.
23. Peitz M, Pfannkuche K, Rajewsky K, Edenhofer F. Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: A tool for efficient genetic engineering of mammalian genomes. Proc Natl Acad Sci USA 2002; 99: 4489-4494.
24. Reusch JE, Colton LA, Klemm DJ. CREB activation induces adipogenesis in 3T3-L1 cells. Mol Cell Biol 2000; 20: 1008-1020.
25. Cao Z, Umek RM, McKnight SL. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev 1991; 5: 1538-1552.
26. Yeh WC, Cao Z, Classon M, McKnight SL. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev 1995; 9: 168-181.
27. Christy RJ, Kaestner KH, Geiman DE, Lane MD. CCAAT/enhancer binding protein gene promoter: Binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proc Natl Acad Sci USA 1991; 88: 2593-2597.
28. Clarke SL, Robinson CE, Gimble JM. CAAT/enhancer binding proteins directly modulate transcription from the peroxisome proliferator-activated receptor gamma 2 promoter. Biochem Biophys Res Commun 1997; 240: 99-103.
29. Birsoy K, Chen Z, Friedman J. Transcriptional regulation of adipogenesis by KLF4. Cell Metab 2008; 7: 339-347.
30. Swirnoff AH, Milbrandt J. DNA-binding specificity of NGFI-A and related zinc finger transcription factors. Mol Cell Biol 1995; 15: 2275-2287.
31. Decker EL, Nehmann N, Kampen E, Eibel H, Zipfel PF, Skerka C. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. Nucleic Acids Res 2003; 31: 911-921.
32. Dzialo-Hatton R, Milbrandt J, Hockett Jr RD, Weaver CT. Differential expression of Fas ligand in Th1 and Th2 cells is regulated by early growth response gene and NF-AT family members. J Immunol 2001; 166: 4534-4542.
33. Takemori H, Doi J, Katoh Y, Halder SK, Lin XZ, Horike N et al. Characterization of a proximal element in the rat preadipocyte factor-1 (Pref-1) gene promoter. Eur J Biochem 2001; 268: 205-217.
34. Liao H, Hyman MC, Lawrence DA, Pinsky DJ. Molecular regulation of the PAI-1 gene by hypoxia: Contributions of Egr-1, HIF-1{alpha}, and C/ EBP{alpha}. FASEB J 2007; 21: 935-949.
35. Topilko P, Levi G, Merlo G, Mantero S, Desmarquet C, Mancardi G et al Differential regulation of the zinc finger genes Krox-20 and Krox-24 (Egr-1) suggests antagonistic roles in Schwann cells. J Neurosci Res 1997; 50: 702-712.
36. Collins S, Lutz MA, Zarek PE, Anders RA, Kersh GJ, Powell JD. Opposing regulation of T cell function by Egr-1/NAB2 and Egr-2/Egr-3. Eur J Immunol 2008; 38: 528-536.
37. Laslo P, Spooner CJ, Warmflash A, Lancki DW, Lee HJ, Sciammas R et al Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell 2006; 126: 755-766.
38. Carter JH, Lefebvre JM, Wiest DL, Tourtellotte WG. Redundant role for early growth response transcriptional regulators in thymocyte differentiation and survival. J Immunol 2007; 178: 6796-6805.
39. Tang QQ, Jiang MS, Lane MD. Repression of transcription mediated by dual elements in the CCAAT/enhancer binding protein alpha gene. Proc Natl Acad Sci USA 1997; 94: 13571-13575.