Redundant mole for early growth response transcriptional regulators in thymocyte differentiation and survival

Journal of Immunology

Volumn 178, Issue 11, 2007, Pages 6796-6805

  Carter, John H ^a   Lefebvre, Juliet M ^c   Wiest, David L ^c   Tourtellotte, Warren G ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c FOX CHASE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; EARLY GROWTH RESPONSE FACTOR 2; EARLY GROWTH RESPONSE FACTOR 3; T LYMPHOCYTE RECEPTOR; EGR1 PROTEIN, MOUSE; EGR3 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL METABOLISM; CELL SURVIVAL; CELL TYPE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; THYMOCYTE; TRANSCRIPTION REGULATION; ANIMAL; ATROPHY; BIOSYNTHESIS; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DOWN REGULATION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION; THYMUS; UPREGULATION;

ANIMALS; APOPTOSIS; ATROPHY; CELL DIFFERENTIATION; CELL SURVIVAL; CELLS, CULTURED; DOWN-REGULATION; EARLY GROWTH RESPONSE PROTEIN 1; EARLY GROWTH RESPONSE PROTEIN 3; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; UP-REGULATION;

EID: 34249814911     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.11.6796     Document Type: Article

References (45)

1. Godfrey, D. I., and A. Zlotnik. 1993. Control points in early T-cell development. Immunol. Today 14: 547-553.
2. Kruisbeek, A. M., M. C. Haks, M. Carleton, A. M. Michie, J. C. Zuniga-Pflucker, and D. L. Wiest. 2000. Branching out to gain control: how the pre-TCR is linked to multiple functions. Immunol. Today 21: 637-644.
3. 2+ mobilization and activation of NF-κB and NFAT. Nat. Immunol. 2: 403-409.
4. Engel, I., C. Johns, G. Bain, R. R. Rivera, and C. Murre. 2001. Early thymocyte development is regulated by modulation of E2A protein activity. J. Exp. Med. 194: 733-745.
5. Engel, I., and C. Murre. 2004. E2A proteins enforce a proliferation checkpoint in developing thymocytes. EMBO J. 23: 202-211.
6. Goux, D., J. D. Coudert, D. Maurice, L. Scarpellino, G. Jeannet, S. Piccolo, K. Weston, J. Huelsken, and W. Held. 2005. Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival. Blood 106: 1726-1733.
7. Voll, R. E., E. Jimi, R. J. Phillips, D. F. Barber, M. Rincon, A. C. Hayday, R. A. Flavell, and S. Ghosh. 2000. NF-κB activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity 13: 677-689.
8. Michie, A. M., and J. C. Zuniga-Pflucker. 2002. Regulation of thymocyte differentiation: pre-TCR signals and β-selection. Semin. Immunol. 14: 311-323.
9. Aifantis, I., M. Mandal, K. Sawai, A. Ferrando, and T. Vilimas. 2006. Regulation of T-cell progenitor survival and cell-cycle entry by the pre-T-cell receptor. Immunol. Rev. 209: 159-169.
10. Mandal, M., C. Borowski, T. Palomero, A. A. Ferrando, P. Oberdoerffer, F. Meng, A. Ruiz-Vela, M. Ciofani, J. C. Zuniga-Pflucker, I. Screpanti, et al. 2005. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival. J. Exp. Med. 201: 603-614.
11. Sicinska, E., 1. Aifantis, L. Le Cam, W. Swat, C. Borowski, Q. Yu, A. A. Ferrando, S. D. Levin, Y. Geng, H. von Boehmer, and P. Sicinski. 2003. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 4: 451-461.
12. Swirnoff, A. H., and J. Milbrandt. 1995. DNA-binding specificity of NGFI-A and related zinc finger transcription factors. Mol. Cell. Biol. 15: 2275-2287.
13. + stage. J. Immunol. 168: 1649-1658.
14. Shao, H., D. H. Kono, L. Y. Chen, E. M. Rubin, and J. Kaye. 1997. Induction of the early growth response (Egr) family of transcription factors during thymic selection. J. Exp. Med. 185: 731-744.
15. Bettini, M., H. Xi, J. Milbrandt, and G. J. Kersh. 2002. Thymocyte development in early growth response gene 1-deficient mice. J. Immunol. 169: 1713-1720.
16. +. J. Immunol. 172: 964-971.
17. Xi, H., and G. J. Kersh. 2004. Sustained early growth response gene 3 expression inhibits the survival of CD4/CD8 double-positive thymocytes. J. Immunol. 173: 340-348.
18. Xi, H., R. Schwartz, I. Engel, C. Murre, and G. J. Kersh. 2006. Interplay between ROR-γt, Egr3, and E proteins controls proliferation in response to pre-TCR signals. Immunity 24: 813-826.
19. Lee, S. L., L. C. Tourtellotte, R. L. Wesselschmidt, and J. Milbrandt. 1995. Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A. J. Biol. Chem. 270: 9971-9977.
20. Tourtellotte, W. G., and J. Milbrandt. 1998. Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3. Nat. Genet. 20: 87-91.
21. Tourtellotte, W. G., R. Nagarajan, A. Bartke, and J. Milbrandt. 2000. Functional compensation by Egr4 in Egr1-dependent luteinizing hormone regulation and Leydig cell steroidogenesis. Mol. Cell. Biol. 20: 5261-5268.
22. Whitehead, J., C. Keller-Peck, J. Kucera, and W. G. Tourtellotte. 2005. Glial cell-line derived neurotrophic factor-dependent fusimotor neuron survival during development. Mech. Dev. 122: 27-41.
23. Gavrieli, Y., Y. Sherman, and S. A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493-501.
24. Allman, D., A. Sambandam, S. Kim, J. P. Miller, A. Pagan, D. Well, A. Meraz, and A. Bhandoola. 2003. Thymopoiesis independent of common lymphoid progenitors. Nat. Immunol. 4: 168-174.
25. Schmitt, T. M., R. F. de Pooter, M. A. Gronski, S. K. Cho, P. S. Ohashi, and J. C. Zuniga-Pflucker. 2004. Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro. Nat. Immunol. 5: 410-417.
26. Albert, Y., J. Whitehead, L. Eldredge, J. Carter, X. Gao, and W. G. Tourtellotte. 2005. Transcriptional regulation of myotube fate specification and intrafusal muscle fiber morphogenesis. J. Cell Biol. 169: 257-268.
27. Li, L., J. Carter, X. Gao, J. Whitehead, and W. G. Tourtellotte. 2005. The neuroplasticity-associated arc gene is a direct transcriptional target of early growth response (Egr) transcription factors. Mol. Cell. Biol. 25: 10286-10300.
28. Surh, C. D., and J. Sprent. 1994. T-cell apoptosis detected in situ during positive and negative selection in the thymus. Nature 372: 100-103.
29. Shamir, R., A. Maron-Katz, A. Tanay, C. Linhart, I. Steinfeld, R. Sharan, Y. Shiloh, and R. Elkon. 2005. EXPANDER - an integrative program suite for microarray data analysis. BMC Bioinformatics 6: 232.
30. + distinguished in the early growth response (Egr)-1 transgenic mice with a recombinase- activating gene-deficient background. J. Exp. Med. 186: 877-885.
31. Abe, N., K. Kohu, H. Ohmori, K. Hayashi, T. Watanabe, K. Hozumi, T. Sato, S. Habu, and M. Satake. 2005. Reduction of Runx1 transcription factor activity up-regulates Fas and Bim expression and enhances the apoptotic sensitivity of double positive thymocytes. J. Immunol. 175: 4475-4482.
32. Lorsbach, R. B., J. Moore, S. O. Ang, W. Sun, N. Lenny, and J. R. Downing. 2004. Role of RUNX1 in adult hematopoiesis: analysis of RUNX1-IRES-GFP knock-in mice reveals differential lineage expression. Blood 103: 2522-2529.
33. Ciofani, M., and J. C. Zuniga-Pflucker. 2005. Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism. Nat. Immunol. 6: 881-888.
34. Rathmell, J. C., M. G. Vander Heiden, M. H. Harris, K. A. Frauwirth, and C. B. Thompson. 2000. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol. Cell 6: 683-692.
35. Schipper, R. G., L. C. Penning, and A. A. Verhofstad. 2000. Involvement of polyamines in apoptosis: facts and controversies: effectors or protectors? Semin. Cancer Biol. 10: 55-68.
36. Brune, B., P. Hartzell, P. Nicotera, and S. Orrenius. 1991. Spermine prevents endonuclease activation and apoptosis in thymocytes. Exp. Cell Res. 195: 323-329.
37. Hegardt, C., G. Andersson, and S. M. Oredsson. 2001. Different roles of spermine in glucocorticoid- and Fas-induced apoptosis. Exp. Cell Res. 266: 333-341.
38. Hegardt, C., G. Andersson, and S. M. Oredsson. 2003. Spermine prevents cytochrome c release in glucocorticoid-induced apoptosis in mouse thymocytes. Cell Biol. Int. 27: 115-121.
39. Dang, C. V., K. A. O'Donnell, K., K. I. Zeller, T. Nguyen, R. C. Osthus, and F. Li. 2006. The c-Myc target gene network. Semin. Cancer Biol. 16: 253-264.
40. Cam, H., E. Balciunaite, A. Blais, A. Spektor, R. C. Scarpulla, R. Young, Y. Kluger, and B. D. Dynlacht. 2004. A common set of gene regulatory networks links metabolism and growth inhibition. Mol. Cell 16: 399-411.
41. Fernandez, P. C., S. R, Frank, L. Wang, M. Schroeder, S. Liu, J. Greene, A. Cocito, and B. Amati. 2003. Genomic targets of the human c-Myc protein. Genes Dev. 17: 1115-1129.
42. Leone, G., J. DeGregori, R. Sears, L. Jakoi, and J. R. Nevins. 1997. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature 387: 422-426.
43. Polager, S., Y. Kalma, E. Berkovich, and D. Ginsberg. 2002. E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis. Oncogene 21: 437-446.
44. 2-M checkpoints. Genes Dev. 16: 245-256.
45. Bain, G., C. B. Cravatt, C. Loomans, J. Alberola-Ila, S. M. Hedrick, and C. Murre. 2001. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras- ERK MAPK cascade. Nat. Immunol. 2: 165-171.