The influence of non-ionic surfactants on the rheological properties of drug/microcrystalline cellulose/water mixtures and their use in the preparation and drug release performance of pellets prepared by extrusion/spheronization

European Journal of Pharmaceutical Sciences

Volumn 37, Issue 3-4, 2009, Pages 334-340

  Podczeck, Fridrun ^a   Maghetti, Ana ^b   Newton, J Michael ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Extrusion spheronization; Ibuprofen; Non ionic surfactants; Paste rheology; Pellets; Solubility parameters

Indexed keywords

IBUPROFEN; MICROCRYSTALLINE CELLULOSE; SURFACTANT; WATER;

ARTICLE; CONCENTRATION RESPONSE; DRUG FORMULATION; DRUG RELEASE; DRUG SYNTHESIS; ELASTICITY; FLOW KINETICS; FLOW MEASUREMENT; IN VITRO STUDY; INTESTINE FLUID; PASTE; PERFORMANCE; PRIORITY JOURNAL; SPHERONIZATION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; ELASTICITY; EXCIPIENTS; HEXOSES; IBUPROFEN; INDICATORS AND REAGENTS; MICROSPHERES; PARTICLE SIZE; POLYSORBATES; RHEOLOGY; SOLUBILITY; SURFACE-ACTIVE AGENTS; WATER;

EID: 67349262102     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.03.003     Document Type: Article

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