The preparation of pellets containing a surfactant or a mixture of mono- and di-gylcerides by extrusion/spheronization

European Journal of Pharmaceutical Sciences

Volumn 30, Issue 3-4, 2007, Pages 333-342

  Newton, John Michael ^a   Pinto, Mariana Reis ^a   Podczeck, Fridrun ^b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF SUNDERLAND   (United Kingdom)

Author keywords

Extrusion spheronization; Mixture of mono and di glycerides; Pellets and their properties; Polysorbate 80; Statistical analysis

Indexed keywords

DECANOIC ACID; DIACYLGLYCEROL; EMULSIFYING AGENT; GRANULAC 70; LACTOSE; MICROCRYSTALLINE CELLULOSE; MONOACYLGLYCEROL; OCTANOIC ACID; POLYSORBATE 80; SURFACTANT; UNCLASSIFIED DRUG; WATER;

ANALYSIS OF VARIANCE; AQUEOUS SOLUTION; ARTICLE; DRUG FORMULATION; DRUG MIXTURE; DRUG SOLUBILITY; LIQUID; PELLET EXTRUSION; POROSITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SPHERONIZATION; SYSTEM ANALYSIS; TENSILE STRENGTH;

BIOPHARMACEUTICS; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; DIGLYCERIDES; DOSAGE FORMS; DRUG COMPOUNDING; DRUG DESIGN; EXCIPIENTS; GLYCERIDES; HARDNESS; MICROSCOPY, ELECTRON, SCANNING; MODELS, STATISTICAL; MOLECULAR WEIGHT; PARTICLE SIZE; POLYSORBATES; REGRESSION ANALYSIS; SURFACE-ACTIVE AGENTS; TENSILE STRENGTH;

EID: 33847148114     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2006.11.020     Document Type: Article

References (9)

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6. Pouton C.W. Self-emulsifying drug delivery systems: assessment of the efficacy of emulsification. Int. J. Pharm. 17 (1985) 15-23
7. Serratoni M., Newton J.M., Booth S., and Clarke A. Controlled drug release from pellets containing water-insoluble drugs dissolved in a self-emulsifying system. Eur. J. Pharm. Biopharm. 65 (2007) 94-98
8. Tenenhaus M., and Young F.W. An analysis and synthesis of multiple correspondence analysis, optimal scaling, dual scaling and other methods for quantifying categorical multivariate data. Psychometrica 50 (1985) 90-104
9. Tuleu C., Newton J.M., Rose J., Euller D., Saklatvala R., Clarke A., and Booth S. Comparative bioavailability study in dogs of a self-emulsified formulation of progesterone presented in a pellet and a liquid form compared with an aqueous suspension of progesterone. J. Pharm. Sci. 93 (2004) 1495-1502