The rheological properties of modified microcrystalline cellulose containing high levels of model drugs

Journal of Pharmaceutical Sciences

Volumn 98, Issue 6, 2009, Pages 2160-2169

  Knight, Paul E ^a   Podczeck, Fridrun ^b   Newton, J Michael ^b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Extrusion; Formulation; Polymers; Spheronization; Viscosity

Indexed keywords

ASCORBIC ACID; CARBOXYMETHYLCELLULOSE; IBUPROFEN; LACTOSE; MICROCRYSTALLINE CELLULOSE; WATER;

ARTICLE; CAPILLARY; FLOW KINETICS; FLOW MEASUREMENT; FRICTION; PARAMETER; SHEAR RATE; SHEAR STRESS; STEREOCHEMISTRY; VELOCITY; VISCOSITY;

EID: 67049136372     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21587     Document Type: Article

References (18)

1. Goskonda SR, Hileman GA, Upadrashta SM. 1994. Controlled release pellets by extrusion-spheronization. Int J Pharm 111:89-97. (Pubitemid 24277382)
2. Fitzpatrick S, Taylor S, Booth SW, Newton JM. 2006. The development of a stable coated pellet formulation of a water-sensitive drug, a case study: Development of a stable core formulation. Pharm Dev Technol 11:521-528. (Pubitemid 44852434)
3. Jover I, Podczeck F, Newton JM. 1996. Evaluation, by statistically designed experiment, of an experimental grade of microcrystalline cellulose, Avicel 955, as a technology to aid the production of pellets of high drug loading. J Pharm Sci 85:700-705. (Pubitemid 26234673)
4. Podczeck F, Knight PE, Newton JM. 2008. The evaluation of modified microcrystalline cellulose for the preparation of pellets with high drug loading by extrusion/spheronization. Int J Pharm 350:145-154. (Pubitemid 351146681)
5. Harrison PJ, Newton JM, Rowe RC. 1986. The application of capillary rheometry to the extrusion of wet powder masses. Int J Pharm 37:81-83.
6. Raines CL, Newton JM, Rowe RC. 1990. Extrusion of microcrystalline cellulose formulations. In: Rheology of food, pharmaceuticals, and biological materials with general rheology. Carter RE, editor. London: Elsevier Applied Science. pp. 248-257.
7. Anderson AH, Newton JM. 1990. Influence of moisture content and particle size of barium sulphate on the extrusion properties of mixtures with microcrystalline cellulose. In: Carter RE, editor. Rheology of food, pharmaceuticals and biological materials with general rheology. London: Elsevier Applied Science. p 258-267.
8. Chohan RK, Newton JM. 1996. Analysis of extrusion of some wet powder masses used in extrusion/ spheronization. Int J Pharm 131:201-217. (Pubitemid 26144954)
9. Luukkonen P, Newton JM, Podczeck F, Yliruusi J. 2001. Use of a capillary rheometer to evaluate the rheological properties of microcrystalline cellulose and silicified microcrystalline cellulose. Int J Pharm 216:147-157. (Pubitemid 32232104)
10. MacRitchie KA, Newton JM, Rowe RC. 2002. The evaluation of the rheological properties of lactose/ microcrystalline cellulose and water mixtures by controlled stress rheometry and the relationship to the production of spherical pellets by the process of extrusion/spheronization. Eur J Pharm Sci 17:43-50. (Pubitemid 35287170)
11. Newton JM, Bazzigialuppi M, Podczeck F, Booth S, Clarke A. 2005. The rheological properties of self-emulsifying systems, water and microcrystalline cellulose. Eur J Pharm Sci 26:176-183. (Pubitemid 41169800)
12. Benbow JJ, Oxley EW, Bridgwater J. 1987. The extrusion mechanics of pastes-the influence of paste formulation. Chem Eng Sci 42:2151-2162.
13. Benbow JJ, Bridgwater J. 1993. Paste flow and extrusion. Oxford series on advanced manufacturing. Oxford, UK: Clarendon Press.
14. Bagley EB. 1957. End correction in the capillary flow of polyethylene. J Appl Phys 28:624-627.
15. Barnes HA, Hutton JF, Walters K. 1989. An introduction to rheology. Amsterdam, Netherlands: Elsevier.
16. Podczeck F, Knight PE. 2006. Evaluation of formulations for the preparation of pellets with high drug loading by extrusion/spheronization. Pharm Dev Technol 11:263-274. (Pubitemid 44221680)
17. Raines CL. 1990. The extrusion of various formulations of microcrystalline cellulose. PhD Thesis. UK: University of London.
18. Wight JF Jr, Reed JS. 2002. Nonaqueous aluminium nitride extrusion. II. Die-land flow and tribology. J Am Ceram Soc 85:1689-1694. (Pubitemid 34813584)