The evaluation of the rheological properties of lactose/microcrystalline cellulose and water mixtures by controlled stress rheometry and the relationship to the production of spherical pellets by extrusion/spheronization

European Journal of Pharmaceutical Sciences

Volumn 17, Issue 1-2, 2002, Pages 43-50

  MacRitchie, K A ^a   Newton, J M ^a   Rowe, R C ^b  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Controlled stress rheometry; Extrusion spheronization; Lactose microcrystalline cellulose water mixtures; Loss modulus; Pellets; Storage modulus

Indexed keywords

EXTRUDERS; EXTRUSION; RHEOLOGY; RHEOMETERS; VISCOSITY;

SPHERONIZATION;

CELLULOSE;

ALPHA LACTOSE; MICROCRYSTALLINE CELLULOSE; WATER;

ARTICLE; CARBOHYDRATE ANALYSIS; FLOW KINETICS; FLOW MEASUREMENT; OSCILLATION; PELLET EXTRUSION; POWDER; PRIORITY JOURNAL; RELIABILITY; SHEAR RATE; SPHERONIZATION; STEADY STATE; STRESS; VISCOSITY; WATER CONTENT;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DRUG IMPLANTS; LACTOSE; RHEOLOGY; TECHNOLOGY, PHARMACEUTICAL; WATER;

EID: 0036803349     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(02)00130-6     Document Type: Article

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