Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate β1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis

Molecular and Cellular Biochemistry

Volumn 304, Issue 1-2, 2007, Pages 361-367

  Shen, Jialin ^a   Jiang, Jianhai ^a   Wei, Yuanyan ^a   Zhou, Lei ^a   Liu, Dan ^a   Zhou, Jin ^a   Gu, Jianxin ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

1,4 galactosyltransferase I; Apoptosis; Cycloheximide; LY294002; SMMC 7721 hepatocarcinoma cells; Wortmannin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BETA1,4 GALACTOSYLTRANSFERASE 1; CYCLOHEXIMIDE; GALACTOSE; GALACTOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; UNCLASSIFIED DRUG; WORTMANNIN;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL SURFACE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PROTEIN EXPRESSION; SENSITIZATION; UPREGULATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CHROMONES; CYCLOHEXIMIDE; DRUG EVALUATION, PRECLINICAL; DRUG SYNERGISM; GALACTOSYLTRANSFERASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LIVER NEOPLASMS; MORPHOLINES; SUBSTRATE SPECIFICITY; UP-REGULATION;

EID: 34648846495     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-007-9519-1     Document Type: Article

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