Human plasma leptin in obese subjects and diabetics

Endocrine Journal

Volumn 44, Issue 5, 1997, Pages 671-676

  Tasaka, Yoshimasa ^a   Yanagisawa, Keiko ^a   Iwamoto, Yasuhiko ^a  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

Diabetes mellitus; Gender; Obesity; Plasma leptin

Indexed keywords

LEPTIN;

ADULT; ARTICLE; BLOOD LEVEL; BODY WEIGHT; CORRELATION FUNCTION; DISEASE SEVERITY; FEMALE; GENDER; GLUCOSE TOLERANCE; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY;

EID: 0031449491     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.44.671     Document Type: Article

References (24)

1. Zhang Y, Droenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432.
2. Halaas JL, Gajiwala KS, Maffei M, Cohen SC, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546.
3. Weigle DS, Bukowski TR, Foster DC, Holderman S, Kramer JM, Lasser G, Lofton-Day CE, Prunkard DE, Raymond C, Kuijper JL (1995) Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J Clin Invest 96: 2065-2070.
4. Considine RV, Sinha MK, Heiman ML, Kriaciunas A, Stephens TW, Nyce MR, Ohannesin JP, Marco CC, McKee LJ, Bauer TL, Caro JF (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334: 292-295.
5. Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H,Kim H, Lallone R, Ranganathan S, Kern PA, Friedman JM (1995) Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nature Medicine 1: 1155-1161.
6. Segal KR, Landt M, Klein S (1996) Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes 45: 988-991.
7. Zhongmin MA, Gingerich RL, Santiago JV, Klein S, Smith CH, Landt M (1996) Radioimmunoassay of leptin in human plasma. Clinical Chemistry 42: 942-946.
8. Zimmet P, Hodge A, Nicolson M, Staten M, de Courten M, Moore J, Morawiecki A, Lubina J, Collier G, Alberti J, Dowse G (1996) Serum leptin concentration, obesity, and insulin resistance in Western Samoans: Cross sectioal study. BMJ 313: 965-969.
9. Ogawa Y, Masuzaki H, Isse N, Okazaki T, Mori K, Shigemoto M, Satoh N, Tamura N, Hosoda K, Yoshimasa Y, Jingami H, Kawada T, Nakao K (1995) Molecular cloning of rat obese cDNA and augmented gene expression in genetically obese Zucker fatty (fa/fa) rats. J Clin Invest 96: 1647-1652.
10. Murakami T, Shima K (1995) Cloning of rat obese cDNA and its expression in obese rats. Biochem Biophys Res Commun 209: 944-952.
11. Masuzaki H, Ogawa Y, Isse N, Satoh N, Okazaki T, Shigemoto M, Morio K, Tamura N, Hosoda K, Yoshimasa Y, Jingami H, Kawada T, Nakao K (1995) Human obese gene expression: Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 44: 855-858.
12. Maffei M, Fei H, Lee G-H, Dani C, Leroy P, Zhang Y, Proenca R, Negrel R, Ailhaud G, Friedman JM (1995) Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA 92: 6957-6960.
13. Funahashi T, Shimomura I, Hiraoka H, Arai T, Takahashi M, Nakamura T, Nozaki S, Yamashita S, Takemura K, Tokunaga K, Matsuzawa Y (1995) Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats. Bioch Bioph Res Comm 211: 469-475.
14. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG (1996) Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98: 1101-1106.
15. Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F, Leibel RL (1996) Effect of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 1: 3424-3427.
16. Morgan CR, Lazarow A (1963) Immunoassay of insulin: Two antibody system plasma insulin levels of normal, subdiabatic and diabatic rats. Diabetes 12: 115-126.
17. Utriainen T, Malmstrom R, Mkimattila S, Yki-Jarvinen H (1996) Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects. Diabetes 45: 1364-1366.
18. Lonnqvist F, Arner P, Nordfors L, Schalling M (1995) Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nature Medicine 1: 950-955.
19. Sinha MK, Ohannesian JP, Heiman ML, Kriaciunas A, Stephenns TW, Magosin SA, Marco C, Caro JF (1996) Nocturnal rise of leptin in lean, obese and non-diabetes mellitus subject. J Clin Invest 97: 1344-1347.
20. Saladin R, Vos PD, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J (1995) Transient increase in obese gene expression after food intake or insulin administration. Nature 377: 527-529.
21. Malmstrom R, Taskinen M-R, Karonen S-L, Yki-Jarvinen H (1996) Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia 39: 993-996.
22. Muscelli E, Camastra A, Masoni A, Baldi S, Sironi AM, Natali A, Ferrannini E (1996) Acute administration does not affect plasma leptin levels in lean or obese subjects. Eur J Clin Invst 26: 940-943.
23. Boden G, Chen X, Mozzoli M, Ryan I (1996) Effect of fasting serum leptin in normal human subjects. J Clin Endocrinol Metab 81: 3419-3423.
24. Vos PD, Saladin R, Auwerx J, Staels B (1995) Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 270: 15958-15961.