Mechanism of the antiviral effect of hydroxytyrosol on influenza virus appears to involve morphological change of the virus

Antiviral Research

Volumn 83, Issue 1, 2009, Pages 35-44

  Yamada, Kentaro ^a   Ogawa, Haruko ^a   Hara, Ayako ^a   Yoshida, Yukio ^a   Yonezawa, Yutaka ^a   Karibe, Kazuji ^a   Nghia, Vuong Bui ^a   Yoshimura, Hiroyuki ^b   Yamamoto, Yu ^c   Yamada, Manabu ^c   Nakamura, Kuniyasu ^c   Imai, Kunitoshi ^a  

^a OBIHIRO UNIVERSITY OF AGRICULTURE AND VETERINARY MEDICINE   (Japan)

^b EISAI CO LTD   (Japan)

^c NATIONAL INSTITUTE OF ANIMAL HEALTH   (Japan)

Author keywords

Antiviral effect; Envelope; Hydroxytyrosol; Influenza A virus; Morphology

Indexed keywords

HYDROXYTYROSOL;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CHICK EMBRYO LETHAL ORPHAN VIRUS; CONTROLLED STUDY; DOG; DRUG CYTOTOXICITY; DRUG MECHANISM; INFLUENZA VIRUS A; KIDNEY CELL; NEWCASTLE DISEASE PARAMYXOVIRUS; NONHUMAN; PRIORITY JOURNAL; ROTAVIRUS; VIRUS ENVELOPE; VIRUS INHIBITION; VIRUS MORPHOLOGY;

ADENOVIRIDAE; ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CYTOPLASM; DOGS; INFLUENZA A VIRUS; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; INFLUENZA A VIRUS, H5N1 SUBTYPE; NEWCASTLE DISEASE VIRUS; PHENYLETHYL ALCOHOL; RNA, VIRAL; ROTAVIRUS; VIRAL PROTEINS; VIRION; VIRUS ASSEMBLY; VIRUS ATTACHMENT; VIRUS REPLICATION;

ADENOVIRIDAE; BOVINE ROTAVIRUS; INFLUENZA A VIRUS; NEWCASTLE DISEASE VIRUS; ORTHOMYXOVIRIDAE;

EID: 67349256139     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2009.03.002     Document Type: Article

References (26)

1. Aziz N.H., Farag S.E., Mousa L.A., and Abo-Zaid M.A. Comparative antibacterial and antifungal effects of some phenolic compounds. Microbios 93 (1998) 43-54
2. Bao J., Zhang D.W., Zhang J.Z., Huang P.L., Huang P.L., and Lee-Huang S. Computational study of bindings of olive leaf extract (OLE) to HIV-1 fusion protein gp41. FEBS Lett. 581 (2007) 2737-2742
3. Beauchamp G.K., Keast R.S., Morel D., Lin J., Pika J., Han Q., Lee C.H., Smith A.B., and Breslin P.A. Phytochemistry: ibuprofen-like activity in extra-virgin olive oil. Nature 437 (2005) 45-46
4. Bisignano G., Tomaino A., Lo Cascio R., Crisafi G., Uccella N., and Saija A. On the in vitro antimicrobial activity of oleuropein and hydroxytyrosol. J. Pharm. Pharmacol. 51 (1999) 971-974
5. Bitler C.M., Viale T.M., Damaj B., and Crea R. Hydrolyzed olive vegetation water in mice has anti-inflammatory activity. J. Nutr. 135 (2005) 1475-1479
6. Capasso R., Evidente A., Avolio S., and Solla F. A highly convenient synthesis of hydroxytyrosol and its recovery from agricultural waste waters. J. Agric. Food Chem. 47 (1999) 1745-1748
7. Caruso D., Visioli F., Patelli R., Galli C., and Galli G. Urinary excretion of olive oil phenols and their metabolites in humans. Metabolism 50 (2001) 1426-1428
8. Ciafardini G., Marsilio V., Lanza B., and Pozzi N. Hydrolysis of oleuropein by Lactobacillus plantarum strains associated with olive fermentation. Appl. Environ. Microbiol. 60 (1994) 4142-4147
9. Coni E., Di Benedetto R., Di Pasquale M., Masella R., Modesti D., Mattei R., and Carlini E.A. Protective effect of oleuropein, an olive oil biophenol, on low density lipoprotein oxidizability in rabbits. Lipids 35 (2000) 45-54
10. Covas M.I. Olive oil and the cardiovascular system. Pharmacol. Res. 55 (2007) 175-186
11. Ehrhardt C., Hrincius E.R., Korte V., Mazur I., Droebner K., Poetter A., Dreschers S., Schmolke M., Planz O., and Ludwig S. A polyphenol rich plant extract, CYSTUS052, exerts anti influenza virus activity in cell culture without toxic side effects or the tendency to induce viral resistance. Antiviral Res. 76 (2007) 38-47
12. Espín J.C., Soler-Rivas C., Cantos E., Tomás-Barberán F.A., and Wichers H.J. Synthesis of the antioxidant hydroxytyrosol using tyrosinase as biocatalyst. J. Agric. Food Chem. 49 (2001) 1187-1193
13. Eto M., and Mase M. Isolation of the Newcastle disease virus and the H9N2 influenza A virus from chicken imported from China. J. Jpn. Vet. Med. Assoc. 56 (2003) 333-339
14. Furneri P.M., Marino A., Saija A., Uccella N., and Bisignano G. In vitro antimycoplasmal activity of oleuropein. Int. J. Antimicrob. Agents 20 (2002) 293-296
15. Lee-Huang S., Zhang L., Huang P.L., Chang Y.T., and Huang P.L. Anti-HIV activity of olive leaf extract (OLE) and modulation of host cell gene expression by HIV-1 infection and OLE treatment. Biochem. Biophys. Res. Commun. 307 (2003) 1029-1037
16. Lee-Huang S., Huang P.L., Zhang D., Lee J.W., Bao J., Sun Y., Chang Y.T., Zhang J., and Huang P.L. Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol: Part I. Fusion inhibition. Biochem. Biophys. Res. Commun. 354 (2007) 872-878
17. Lee-Huang S., Huang P.L., Zhang D., Lee J.W., Bao J., Sun Y., Chang Y.T., Zhang J., and Huang P.L. Discovery of small-molecule HIV-1 fusion and integrase inhibitors oleuropein and hydroxytyrosol. Part II. Integrase inhibition. Biochem. Biophys. Res. Commun. 354 (2007) 879-884
18. Ma S.C., He Z.D., Deng X.L., But P.P., Ooi V.E., Xu H.X., Lee S.H., and Lee S.F. In vitro evaluation of secoiridoid glucosides from the fruits of Ligustrum lucidum as antiviral agents. Chem. Pharm. Bull. 49 (2001) 1471-1473
19. Micol V., Caturla N., Pérez-Fons L., Más V., Pérez L., and Estepa A. The olive leaf extract exhibits antiviral activity against viral haemorrhagic septicaemia rhabdovirus (VHSV). Antiviral Res. 66 (2005) 129-136
20. Miró-Casas E., Farré Albaladejo M., Covas M.I., Rodriguez J.O., Menoyo Colomer E., Lamuela Raventós R.M., and de la Torre R. Capillary gas chromatography-mass spectrometry quantitative determination of hydroxytyrosol and tyrosol in human urine after olive oil intake. Anal. Biochem. 294 (2001) 63-72
21. Pacheco Y.M., Bermúdez B., López S., Abia R., Villar J., and Muriana F.J. Minor compounds of olive oil have postprandial anti-inflammatory effects. Br. J. Nutr. 29 (2007) 1-4
22. Tuck K.L., Tan H.W., and Hayball P.J. Synthesis of tritium-labeled hydroxytyrosol, a phenolic compound found in olive oil. J. Agric. Food Chem. 48 (2000) 4087-4090
23. Visioli F., Bellomo G., Montedoro G., and Galli C. Low density lipoprotein oxidation is inhibited in vitro by olive oil constituents. Atherosclerosis 117 (1995) 25-32
24. Visioli F., Bellomo G., and Galli C. Free radical-scavenging properties of olive oil polyphenols. Biochem. Biophys. Res. Commun. 247 (1998) 60-64
25. Visioli F., Bellosta S., and Galli C. Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages. Life Sci. 62 (1998) 541-546
26. Visioli F., Caruso D., Plasmati E., Patelli R., Mulinacci N., Romani A., Galli G., and Galli C. Hydroxytyrosol, as a component of olive mill waste water, is dose-dependently absorbed and increases the antioxidant capacity of rat plasma. Free Radic. Res. 34 (2001) 301-305