Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine analogues

European Journal of Medicinal Chemistry

Volumn 44, Issue 8, 2009, Pages 3313-3317

  Ostrowski, Tomasz ^a   Golankiewicz, Bozenna ^a   De Clercq, Erik ^b   Andrei, Graciela ^b   Snoeck, Robert ^b  

^a INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

6 Heteroaryl tricyclic analogues; A 5021; Acyclovir; Anti VZV activity; Synthesis

Indexed keywords

3 [[1',2' BIS(HYDROXYMETHYL)CYCLOPROP 1' YL]METHYL] 3,9 DIHYDRO 6 (FURAN 2 YL) 9 OXO 5H IMIDAZO[1,2 A]PURINE; 3 [[1',2' BIS(HYDROXYMETHYL)CYCLOPROP 10 YL]METHYL] 3,9 DIHYDRO 9 OXO 6 (THIEN 2 YL) 5H IMIDAZO[1,2 A]PURINE; 3 [[1',2' BIS(HYDROXYMETHYL)CYCLOPROP 10 YL]METHYL] 6 (5 BROMOTHIEN 2 YL) 3,9 DIHYDRO 9 OXO 5H IMIDAZO[1,2 A]PURINE; 3,9 DIHYDRO 3 [(2 HYDROXYETHOXY)METHYL] 6 (FURAN 2 YL) 9 OXO 5H IMIDAZO[1,2 A]PURINE; 3,9 DIHYDRO 3 [(2 HYDROXYETHOXY)METHYL] 9 OXO 6 (THIEN 2 YL) 5H IMIDAZO[1,2 A]PURINE; 5 (2 BROMOVINYL) 2' DEOXYURIDINE; 6 (5 BROMOTHIEN 2 YL) 3,9 DIHYDRO 3 [(2 HYDROXYETHOXY)METHYL] 9 OXO 5H IMIDAZO[1,2 A]PURINE; 9 [1,2 BIS(HYDROXYMETHYL)CYCLOPROPYLMETHYL]GUANINE; ACICLOVIR; CIDOFOVIR; GANCICLOVIR; NUCLEOSIDE ANALOG; RA 5021; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOPATHOGENIC EFFECT; DRUG CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; VARICELLA ZOSTER VIRUS; VIRUS INHIBITION;

ACYCLOVIR; ANTIVIRAL AGENTS; CELL LINE; GUANINE; HERPESVIRUS 3, HUMAN; HUMANS;

EID: 67349255270     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.03.005     Document Type: Article

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