Synthesis and biological activity of tricyclic analogues of 9-{[cis-1′,2′-bis(hydroxymethyl)cycloprop-1′-yl]methyl}guanine

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 10, 2006, Pages 3535-3542

  Ostrowski, Tomasz ^a   Golankiewicz, Bozenna ^a   Clercq, Erik De ^b   Balzarini, Jan ^b  

^a INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

A 5021; Anti HSV 1; Anti VZV activity; Cytostatic activity; Fluorescence; HSV 2 activity; Synthesis; Tricyclic analogues

Indexed keywords

3 [[1',2' BIS(HYDROXYMETHYL)CYCLOPROP 1' YL]METHYL] 3,9 DIHYDRO 6 (4 METHOXYPHENYL) 9 OXO 5H IMIDAZO[1,2 A]PURINE; 3 [[1',2' BIS(HYDROXYMETHYL)CYCLOPROP 1' YL]METHYL] 3,9 DIHYDRO 6 ETHYL 9 OXO 5H IMIDAZO[1,2 A]PURINE; 3 [[1',2' BIS(HYDROXYMETHYL)CYCLOPROP 1' YL]METHYL] 3,9 DIHYDRO 6 METHYL 9 OXO 5H IMIDAZO[1,2 A]PURINE; 3 [[1',2' BIS(HYDROXYMETHYL)CYCLOPROP 1' YL]METHYL] 3,9 DIHYDRO 9 OXO 6 PHENYL 5H IMIDAZO[1,2 A]PURINE; 6 (4 METHOXYPHENYL)TRICYCLIC ACYCLOVIR; 6 (4 METHOXYPHENYL)TRICYCLIC GANCICLOVIR; 9 [1,2 BIS(HYDROXYMETHYL)CYCLOPROPYLMETHYL]GUANINE; ACICLOVIR; ANTIVIRUS AGENT; FUNCTIONAL GROUP; GANCICLOVIR; GUANINE DERIVATIVE; PURINE DERIVATIVE; SUGAR; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; COMPARATIVE STUDY; CYTOSTASIS; DRUG ACTIVITY; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; EMBRYO; FLUORESCENCE; GENETIC TRANSDUCTION; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HERPES VIRUS; HUMAN; HUMAN CELL; LIPOPHILICITY; NONHUMAN; OSTEOSARCOMA; TUMOR CELL; VARICELLA ZOSTER VIRUS; VIRUS STRAIN;

ANTIVIRAL AGENTS; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; GUANINE; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; VIRUS REPLICATION;

HERPESVIRIDAE; HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2; HUMAN HERPESVIRUS 3;

EID: 33645843357     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.014     Document Type: Article

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