Adrenocorticotropic hormone directly stimulates testosterone production by the fetal and neonatal mouse testis

Endocrinology

Volumn 144, Issue 8, 2003, Pages 3279-3284

  O'Shaughnessy, P J ^a   Fleming, L M ^a   Jackson, G ^a   Hochgeschwender, U ^b   Reed, P ^b   Baker, P J ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERMEDIN; CORTICOTROPIN; GAMMA INTERMEDIN; MELANOCORTIN RECEPTOR; RNA; TESTOSTERONE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FETUS; FETUS CELL; HORMONAL REGULATION; LEYDIG CELL; MALE; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTOSTERONE SYNTHESIS;

ADRENOCORTICOTROPIC HORMONE; ALPHA-MSH; ANIMALS; ANIMALS, NEWBORN; CHORIONIC GONADOTROPIN; GAMMA-MSH; LEYDIG CELLS; LUTEINIZING HORMONE; MALE; MICE; MICE, INBRED C3H; MICE, KNOCKOUT; POLYMERASE CHAIN REACTION; PRO-OPIOMELANOCORTIN; RECEPTOR, MELANOCORTIN, TYPE 2; RECEPTORS, CORTICOTROPIN; TESTIS; TESTOSTERONE;

EID: 0041758465     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-0277     Document Type: Article

References (43)

1. Baker PJ, Sha JA, McBride MW, Peng L, Payne AH, O'Shaughnessy PJ 1999 Expression of 3β-hydroxysteriod dehydrogenase type I and VI isoforms in the mouse testis during development. Eur J Biochem 260:911-916
2. Nef S, Shipman T, Parada LF 2000 A molecular basis for estrogen-induced cryptorchidism. Dev Biol 224:354-361
3. Vergouwen RPFA, Jacobs SGPM, Huiskamp R, Davids JAG, Derooij 1991 Proliferative activity of gonocytes, sertoli cells and interstitial cells during testicular development in mice. J Reprod Fertil 93:233-243
4. Zhang F-P, Poutanen M, Wilbertz J, Huhtaniemi I 2001 Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice. Mol Endocrinol 15:172-183
5. Lei ZM, Mishra S, Zou W, Xu B, Foltz M, Li X, Rao CV 2001 Targeted disruption of luteinizing hormone/human chorionic gonadotrophin receptor gene. Mol Endocrinol 15:184-200
6. O'Shaughnessy PJ, Baker P, Sohnius U, Haavisto A-M, Charlton HM, Huhtaniemi I 1998 Fetal development of Leydig cell activity in the mouse is independent of pituitary gonadotroph function. Endocrinology 139:1141-1146
7. Baker PJ, O'Shaughnessy PJ 2001 Role of gonadotrophins in regulating numbers of Leydig and Sertoli cells during fetal and postnatal development in mice. Reproduction 122:227-234
8. Kendall SK, Samuelson LC, Saunders TL, Wood RI, Camper SA 1995 Targeted disruption of the pituitary glycoprotein hormone α-subunit produces hypogonadal and hypothyroid mice. Genes Dev 9:2007-2019
9. Cattanach BM, Iddon CA, Charlton HM, Chiappa SA, Fink G 1977 Gonadtrophin releasing hormone deficiency in a mutant mouse with hypogonadism. Nature 269:338-340
10. Pakarinen P, Kimura S, El Gehani F, Pelliniemi LJ, Huhtaniemi I 2002 Pituitary hormones are not required for sexual differentiation of male mice: phenotype of the T/ebp/Nkx2.1 null mutant mice. Endocrinology 143:4477-4482
11. Yaswen L, Diehl N, Brennan MB, Hochgeschwender U 1999 Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin. Nat Med 5:1066-1070
12. Stalvey JR, Payne AH 1983 Luteinizing hormone receptors and testosterone production in whole testes and purified Leydig cells from the mouse: differences among inbred strains. Endocrinology 112:1696-1701
13. O'Shaughnessy PJ, Wong KL, Payne AH 1981 Differential steroidogenic enzyme-activities in different populations of rat leydig-cells. Endocrinology 109:1061-1066
14. O'Shaughnessy PJ, Murphy L 1993 Cytochrome P-450 17α-hydroxylase protein and mRNA in the testis of the testicular feminized (Tfm) mouse. J Mol Endocrinol 11:77-82
15. O'Shaughnessy PJ, Marsh P, Dudley K 1994 Follicle-stimulating hormone receptor mRNA in the mouse ovary during post-natal development in the normal mouse and in the adult hypogonadal (hpg) mouse: structure of alternate transcripts. Mol Cell Endocrinol 101:197-201
16. Bustin SA 2000 Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 25:169-193
17. O'Shaughnessy PJ, Willerton L, Baker PJ 2002 Changes in Leydig cell gene expression during development in the mouse. Biol Reprod 66:966-975
18. Baker PJ, O'Shaughnessy PJ 2001 Expression of prostaglandin D synthetase during development in the mouse testis. Reproduction 122:553-559
19. O'Shaughnessy PJ, Sheffield JW 1990 Effect of testosterone on testicular steroidogenesis in the hypogonadal (hpg) mouse. J Steroid Biochem 35:729-734
20. Pointis G, Mahoudeau JA, Courrier R 1975 The effect of gonadotropic hormones and the fetal hypophysis on testosterone production by the testis of 18 day mouse fetuses in organ culture. C R Acad Sci Hebd Seances Acad Sci Ser D 280:2361-2364
21. Pointis G, Mahoudeau JA 1977 Responsiveness of foetal mouse testis to gonadotrophins at various times during sexual differentiation. J Endocrinol 74:149-150
22. Chatelain A, Dupouy JP, Allaume P 1980 Fetal-maternal adrenocorticotropin and corticosterone relationships in the rat: effects of maternal adrenalectomy. Endocrinology 106:1297-1303
23. Boudouresque F, Guillaume V, Grino M, Strbak V, Chautard T, Conte-Devolx B, Oliver C 1988 Maturation of the pituitary-adrenal function in rat fetuses. Neuroendocrinology 48:417-422
24. Erisman S, Carnes M, Takahashi LK, Lent SJ 1990 The effects of stress on plasma ACTH and corticosterone in young and aging pregnant rats and their fetuses. Life Sci 47:1527-1533
25. Abdel-Malek ZA 2001 Melanocortin receptors: their functions and regulation by physiological agonists and antagonists. Cell Mol Life Sci 58:434-441
26. Mountjoy KG, Robbins LS, Mortrud MT, Cone RD 1992 The cloning of a family of genes that encode the melanocortin receptors. Science 257:1248-1251
27. Boston BA, Cone RD 1996 Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line. Endocrinology 137:2043-2050
28. Slominski A, Ermak G, Mihm M 1996 ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin. J Clin Endocrinol Metab 81:2746-2749
29. Kojima I, Kojima K, Rasmussen H 1985 Role of calcium and cAMP in the action of adrenocorticotropin on aldosterone secretion. J Biol Chem 260:4248-4256
30. Tait JF, Tait SA, Gould RP, Mee MS 1974 The properties of adrenal zona glomerulosa cells after purification by gravitational sedimentation. Proc R Soc Lond B Biol Sci 185:375-407
31. Roselli-Rehfuss L, Mountjoy KG, Robbins LS, Mortrud MT, Low MJ, Tatro JB, Entwistle ML, Simerly RB, Cone RD 1993 Identification of a receptor for γ melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc Natl Acad Sci USA 90:8856-8860
32. Gantz I, Miwa H, Konda Y, Shimoto Y, Tashiro T, Watson SJ, DelValle J, Yamada T 1993 Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J Biol Chem 268:15174-15179
33. Hatano O, Takakusu A, Nomura M, Morohashi K 1996 Identical origin of adrenal cortex and gonad revealed by expression profiles of Ad4BP/SF-1. Genes Cells 1:663-671
34. Wang GM, Ge RS, Latif SA, Morris DJ, Hardy MP 2002 Expression of 11beta-hydroxylase in rat Leydig cells. Endocrinology 143:621-626
35. Hu MC, Hsu NC, El Hadj NB, Pai CI, Chu HP, Wang CK, Chung BC 2002 Steroid deficiency syndromes in mice with targeted disruption of CYP11A1. Mol Endocrinol 16:1943-1950
36. Kero J, Poutanen M, Zhang FP, Rahman N, McNicol AM, Nilson JH, Keri RA, Huhtaniemi IT 2000 Elevated luteinizing hormone induces expression of its receptor and promotes steroidogenesis in the adrenal cortex. J Clin Invest 105:633-641
37. Clark AM, Garland KK, Russell LD 2000 Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type Leydig cells and normal development of peritubular cells and seminiferous tubules. Biol Reprod 63:1825-1838
38. Kerr JB, Knell CM 1988 The fate of fetal leydig-cells during the development of the fetal and postnatal rat testis. Development 103:535-544
39. O'Shaughnessy PJ, Baker PJ, Heikkila M, Vainio S, McMahon AP 2000 Localization of 17β-hydroxysteroid dehydrogenase/17-ketosteroid reductase isoform expression in the developing mouse testis - androstenedione is the major androgen secreted by fetal/neonatal Leydig cells. Endocrinology 141:2631-2637
40. Kremer H, Kraaij R, Toledo SPA, Pos M, Fridman JB, Hayashida CY, van Reen M, Milgrom E, Ropers HH, Mariman E, Themmen APN, Brunner HG 1995 Male pseudohermaphroditism due to a homozygous missense mutation of the luteinizing hormone receptor gene. Nat Genet 9:160-164
41. Srikanth MS, West BR, Ishitani M, Isaacs Jr H, Applebaum H, Costin G 1992 Benign testicular tumors in children with congenital adrenal hyperplasia. J Pediatr Surg 27:639-641
42. Domenice S, Latronico AC, Brito VN, Arnhold IJ, Kok F, Mendonca BB 2001 Adrenocorticotropin-dependent precocious puberty of testicular origin in a boy with X-linked adrenal hypoplasia congenita due to a novel mutation in the DAX1 gene. J Clin Endocrinol Metab 86:4068-4071
43. Merke DP, Bornstein SR, Avila NA, Chrousos GP 2002 NIH Conference: future directions in the study and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Ann Intern Med 136:320-334