Fusion of antigen to chemokine CCL20 or CXCL13 strategy to enhance DNA vaccine potency

International Immunopharmacology

Volumn 9, Issue 7-8, 2009, Pages 925-930

  Guo, Ji Hua ^a   Fan, Ming Wen ^a   Sun, Jing Hua ^a   Jia, Rong ^a  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

CCL20; CXCL13; DNA vaccine

Indexed keywords

ANTIGEN; CXCL13 CHEMOKINE; DNA VACCINE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; DNA IMMUNIZATION; DRUG POTENCY; DRUG POTENTIATION; FEMALE; FUSION GENE; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNOGENICITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; ANTIGENS; CELL LINE; CHEMOKINE CCL20; CHEMOKINE CXCL13; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; GREEN FLUORESCENT PROTEINS; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNIZATION; IMMUNOGLOBULIN G; MICE; PROTEIN ENGINEERING; RECOMBINANT FUSION PROTEINS; TRANSFECTION; VACCINES, DNA;

EID: 67349244885     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.03.019     Document Type: Article

References (43)

1. Wolff J.A., Malone R.W., Williams P., Chong W., Acsadi G., et al. Direct gene transfer into mouse muscle in vivo. Science 247 (1990) 1465-1468
2. Tang D., Devit M., and Johnston S.A. Genetic immunization is a simple method for eliciting an immune response. Nature 356 (1992) 152-154
3. Ulmer J.B., Donnelly J.J., Parker S.E., Rhodes G.H., Felgner P.L., et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259 (1993) 1745-1749
4. Huygen K. Plasmid DNA vaccination. Microbes Infect 7 (2005) 932-938
5. Takashima A., and Morita A. Dendritic cells in genetic immunization. J Leukoc Biol 66 (1999) 350-356
6. Zanetti M., Castiglioni P., Rizzi M., Wheeler M., and Gerloni M. B lymphocytes as antigen-presenting cell-based genetic vaccines. Immunol Rev 199 (2004) 264-278
7. Christopherson II K., and Hromas R. Chemokine regulation of normal and pathologic immune responses. Stem Cells 19 (2001) 388-396
8. Rossi D., and Zlotnik A. The biology of chemokines and their receptors. Annu Rev Immunol 18 (2000) 217-242
9. Charo I.F., and Ransohoff R.M. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354 (2006) 610-621
10. Fujiwara H., and Hamaoka T. Coordination of chemokine and adhesion systems in intratumoral T cell migration responsible for the induction of tumor regression. Int Immunopharmacol 1 (2001) 613-623
11. Schluger N.W., and Rom W.N. Early responses to infection: chemokines as mediators of inflammation. Curr Opin Immunol 9 (1997) 504-508
12. Baggiolini M. Chemokines and leukocyte traffic. Nature 392 (1998) 565-568
13. Sallusto F., Mackay C.R., and Lanzavecchia A. The role of chemokine receptors in primary, effector, and memory immune responses. Annu Rev Immunol 18 (2000) 593-620
14. Scheerlinck J.Y. Genetic adjuvants for DNA vaccines. Vaccine 19 (2001) 2647-2656
15. Williams I.R. CCR6 and CCL20: partners in intestinal immunity and lymphorganogenesis. Ann NY Acad Sci 1072 (2006) 52-61
16. Gunn M.D., Ngo V.N., Ansel K.M., Ekland E.H., Cyster J.G., et al. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature 391 (1998) 799-803
17. Ansel K.M., McHeyzer-Williams L.J., Ngo V.N., McHeyzer-Williams M.G., and Cyster J.G. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J Exp Med 190 (1999) 1123-1134
18. Saeki H., Wu H.T., Olasz E., and Hwang S.T. A migratory population of skin-derived dendritic cells express CXCR5, responds to B lymphocyte chemoattractant in vitro, and co-localizes to B cell zones in lymph nodes in vivo. Eur J Immunol 30 (2000) 2808-2814
19. Bono M.R., Elgueta R., Sauma D., Pino K., Osorio F., et al. The essential role of chemokines in the selective regulation of lymphocyte homing. Cytokine Growth Factor Rev 18 (2007) 33-43
20. Kim C.H., and Broxmeyer H.E. Chemokines: signal lamps for trafficking of T and B cells for development and effector function. J Leukoc Biol 65 (1999) 6-15
21. Baggiolini M., Dewald B., and Moser B. Human chemokines: an update. Annu Rev Immunol 15 (1997) 675-705
22. Ohl L., Bernhardt G., Pabst O., and Förster R. Chemokines as organizers of primary and secondary lymphoid organs. Semin Immunol 15 (2003) 249-255
23. Von Andrian U.H. Introduction: chemokines - regulation of immune cell trafficking and lymphoid organ architecture. Semin Immunol 15 (2003) 239-241
24. Kutzler M.A., and Weiner D.B. Developing DNA vaccines that call to dendritic cells. J Clin Invest 114 (2004) 1241-1244
25. Dieu-Nosjean M.C., Massacrier C., Homey B., Vanbervliet B., Pin J.J., et al. Macrophage inflammatory protein 3α is expressed at inflamed epithelial surfaces and is the most potent chemokine known in attracting Langerhans cell precursors. J Exp Med 192 (2000) 705-718
26. Fujiie S., Hieshima K., Izawa D., Nakayama T., Fujisawa R., et al. Proinflammatory cytokines induce liver and activation-regulated chemokine/macrophage inflammatory protein-3alpha/CCL20 in mucosal epithelial cells through NF-kappaB. Int Immunol 13 (2001) 1255-1263
27. Schmuth M., Neyer S., Rainer C., Grassegger A., Fritsch P., et al. Expression of the C-C chemokine MIP-3 alpha/CCL20 in human epidermis with impaired permeability barrier function. Exp Dermatol 11 (2002) 135-142
28. Schutyser E., Struyf S., and Van Damme J. The CC chemokine CCL20 and its receptor CCR6. Cytokine Growth Factor Rev 14 (2003) 409-426
29. Yang D., Chen Q., Hoover D.M., Staley P., Tucker K.D., et al. Many chemokines including CCL20/MIP-3α display antimicrobial activity. J Leukoc Biol 74 (2003) 448-455
30. Coggin Jr. J.H., Barsoum A.L., and Rohrer J.W. 37 kiloDalton oncofetal antigen protein and immature laminin receptor protein are identical, universal T-cell inducing immunogens on primary rodent and human cancers. Anticancer Res 19 (1999) 5535-5542
31. Biragyn A., Schiavo R., Olkhanud P., Sumitomo K., King A., et al. Tumor-associated embryonic antigen-expressing vaccines that target CCR6 elicit potent CD8+ T cell-Mediated Protective and therapeutic antitumor immunity. J Immunol 179 (2007) 1381-1388
32. Song R., Liu S., and Leong K.W. Effects of MIP-1 alpha, MIP-3 alpha, and MIP-3 beta on the induction of HIV Gag-specific immune response with DNA vaccines. Molec Ther 15 (2007) 1007-1015
33. Chavan R., Marfatia K.A., An I.C., Garber D.A., and Feinberg M.B. Expression of CCL20 and granulocyte-macrophage colony-stimulating factor, but not Flt3-L, from modified vaccinia virus ankara enhances antiviral cellular and humoral immune responses. J Virol 80 (2006) 7676-7687
34. Biragyn A., Tani K., Grimm M.C., Weeks S., and Kwak L.W. Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity. Nat Biotechnol 17 (1999) 253-258
35. Biragyn A., Belyakov I.M., Chow Y.H., Dimitrov D.S., Berzofsky J.A., et al. DNA vaccines encoding human immunodeficiency virus-1 glycoprotein 120 fusions with proinflammatory chemoattractants induce systemic and mucosal immune responses. Blood 100 (2002) 1153-1159
36. Cyster J.G. Chemokines and cell migration in secondary lymphoid organs. Science 286 (1999) 2098-2102
37. Legler D.F., Loetscher M., Roos R.S., Clark-Lewis I., Baggiolini M., et al. B cell-attracting Chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med 187 (1998) 655-660
38. Rasheed A.U., Rahn H.P., Sallusto F., Lipp M., and Müller G. Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression. Eur J Immunol 36 (2006) 1892-1903
39. Forster R., Emrich T., Kremmer E., and Lipp M. Expression of the G-protein-coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells. Blood 84 (1994) 830-840
40. Forster R., Mattis A.E., Kremmer E., Wolf E., Brem G., et al. A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87 (1996) 1037-1047
41. Frauenschuh A., DeVico A.L., Lim S.P., Gallo R.C., and Garzino-Demo A. Differential polarization of immune responses by co-administration of antigens with chemokines. Vaccine 23 (2004) 546-554
42. Kaufmann S.H. The contribution of immunology to the rational design of novel antibacterial vaccines. Nat Rev Microbiol 5 (2007) 491-504
43. Blink E.J., Light A., Kallies A., Nutt S.L., Hodgkin P.D., et al. Early appearance of germinal center-derived memory B cells and plasma cells in blood after primary immunization. J Exp Med 201 (2005) 545-554