Many chemokines including CCL20/MIP-3α display antimicrobial activity

Journal of Leukocyte Biology

Volumn 74, Issue 3, 2003, Pages 448-455

  Yang, De ^a   Chen, Qian ^a   Hoover, David M ^a   Staley, Patricia ^a   Tucker, Kenneth D ^a   Lubkowski, Jacek ^a   Oppenheim, Joost J ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b CCR   (United States)

Author keywords

Colony forming assay; Defensin; Macrophage inflammatory protein

Indexed keywords

CHEMOKINE; DEFENSIN; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; BETA CHEMOKINE; BETA DEFENSIN; CCL20 PROTEIN, HUMAN; MACROPHAGE INFLAMMATORY PROTEIN; RECOMBINANT PROTEIN;

ANTIMICROBIAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; HUMAN; IN VITRO STUDY; MORAXELLA CATARRHALIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PSEUDOMONAS AERUGINOSA; SCREENING; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES; BACTERIAL COUNT; BACTERIUM; CHEMISTRY; COMPARATIVE STUDY; DRUG EFFECT; FUNGUS; METABOLISM;

CANDIDA; CANDIDA ALBICANS; ENTEROCOCCUS; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; MORAXELLA CATARRHALIS; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PYOGENES;

ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIFUNGAL AGENTS; BACTERIA; BETA-DEFENSINS; CHEMOKINES; CHEMOKINES, CC; COLONY COUNT, MICROBIAL; FUNGI; HUMANS; MACROPHAGE INFLAMMATORY PROTEINS; RECOMBINANT PROTEINS;

EID: 0142093059     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0103024     Document Type: Article

References (40)

1. Rollins, B. J. (1997) Chemokines. Blood 90, 909-928.
2. Baggiolini, M. (1998) Chemokines and leukocyte traffic. Nature 392, 565-568.
3. Zlotnik, A., Yoshie, O. (2000) Chemokines: a new classification system and their role in immunity. Immunity 12, 121-127.
4. Murphy, P. M., Baggiolini, M., Charo, I. F., Hebert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., Power, C. A. (2000) International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol. Rev. 52, 145-176.
5. Baba, M., Imai, T., Nishimura, M., Kakizaki, M., Takagi, S., Hieshima, K., Nomiyama, H., Yoshie, O. (1997) Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J. Biol. Chem. 272, 14893-14898.
6. Liao, F., Alderson, R., Su, J., Ullrich, S. J., Kreider, B. L., Farber, J. M. (1997) STRL22 is a receptor for the CC chemokine MIP-3α. Biochem. Biophys. Res. Commun. 236, 212-217.
7. Power, C. A., Church, D. J., Meyer, A., Alouani, S., Proudfoot, A. E. I., Clark-Lewis, I., Sozzani, S., Mantovani, A., Wells, T. N. C. (1997) Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3α from lung dendritic cells. J. Exp. Med. 186, 825-835.
8. Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schroder, J. M., Wang, J. M., Howard, O. M. Z., Oppenheim, J. J. (1999) β-Defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 286, 525-528.
9. Biragyn, A., Surenhu, M., Yang, D., Ruffini, P. A., Haines, B. A., Klyushnenkova, E., Oppenheim, J. J., Kwak, L. W. (2001) Mediators of innate immunity that target immature, but not mature, dendritic cells induce antitumor immunity when genetically fused with nonimmunogenic tumor antigens. J. Immunol. 167, 6644-6653.
10. Ganz, T., Lehrer, R. I. (1998) Antimicrobial peptides of vertebrates. Curr. Opin. Immunol. 10, 41-44.
11. Lehrer, R. I., Ganz, T. (2002) Defensins of vertebrate animals. Curr. Opin. Immunol. 14, 96-102.
12. Zasloff, M. (2002) Antimicrobial peptides of multicellular organisms. Nature 415, 389-395.
13. Territo, M. C., Ganz, T., Selsted, M. E., Lehrer, R. (1989) Monocyte-chemotactic activity of defensins from human neutrophils. J. Clin. Invest. 84, 2017-2020.
14. Chertov, O., Michiel, D. F., Xu, L., Wang, J. M., Tani, K., Murphy, W. J., Longo, D. L., Taub, D. D., Oppenheim, J. J. (1996) Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J. Biol. Chem. 271, 2935-2940.
15. Yang, D., Chen, Q., Chertov, O., Oppenheim, J. J. (2000) Human neutrophil defensins selectively chemoattract naïve T and immature dendritic cells. J. Leukoc. Biol. 68, 9-14.
16. Hoover, D. M., Rajashankar, K. R., Blumenthal, R., Puri, A., Oppenheim, J. J., Chertov, O., Lubkowski, J. (2000) The structure of human β-defensin-2 shows evidence of higher order oligomerization. J. Biol. Chem. 275, 32911-32918.
17. Sawai, M. V., Jia, H. P., Liu, L., Aseyev, V., Wiencek, J. M., McCray Jr., P. B., Ganz, T., Kearney, W. R., Tack, B. F. (2001) The NMR structure of human β-defensin-2 reveals a novel α-helical segment. Biochemistry 40, 3810-3816.
18. Pérez-Cañadillas, J. M., Zaballos, A., Gutiérrez, J., Varona, R., Roncal, F., Albar, J. P., Márquez, G., Bruix, M. (2001) NMR solution structure of murine CCL20/MIP-3α, a chemokine that specifically chemoattracts immature dendritic cells and lymphocytes through its highly specific interaction with the β-chemokine receptor CCR6. J. Biol. Chem. 276, 28372-28379.
19. Hoover, D. M., Boulegue, C., Yang, D., Oppenheim, J. J., Tucker, K. D., Lu, W., Lubkowski, J. (2002) The structure of human MIP-3α/CCL20: linking antimicrobial and CCR6 receptor binding activities with human β-defensins. J. Biol. Chem. 277, 37647-37654.
20. Yang, D., Biragyn, A., Kwak, L. W., Oppenheim, J. J. (2002) Mammalian defensins in immunity: more than just microbicidal. Trends Immunol. 23, 291-296.
21. - CXC chemokines display defensin-like antimicrobial activity. J. Immunol. 167, 623-627.
22. Harder, J., Bartels, J., Christophers, E., Schröder, J. M. (2001) Isolation and characterization of human β-defensin-3, a novel human inducible peptide antibiotics. J. Biol. Chem. 276, 5707-5713.
23. Kyte, J., Doolittle, R. F. (1982) A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 157, 105-132.
24. Nicholls, A., Sharp, K. A., Honig, B. (1991) Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 11, 281-296.
25. Harder, J., Bartels, J., Christophers, E., Schröder, J. M. (1997) A peptide antibiotic from human skin. Nature 387, 861.
26. Krögsveld, J., Zaat, S. A., Meeldijk, J., van-Veelen, P. A., Fang, G., Poolman, B., Brandt, E., Ehlert, J. E., Kuijpers, A. J., Engbers, G. H., Feijen, J., Dankert, J. (2000) Thrombocidins, microbicidal proteins from human blood platelets, are C-terminal deletion products of CXC chemokines. J. Biol. Chem. 275, 20374-20381.
27. Tang, Y-Q., Yeaman, M. R., Selsted, M. E. (2002) Antimicrobial peptides from human platelets. Infect. Immun. 70, 6524-6533.
28. Lauw, F. N., Simpson, A. J., Prins, J. M., Deventer, S. J., Chaowagul, W., White, N. J., van der Poll, T. (2000) The CXC chemokines gamma interferon (IFN-gamma)-inducible protein 10 and monokine induced by IFN-gamma are released during severe melioidosis. Infect.-Immun. 68, 3888-3893.
29. Fujiie, S., Hieshima, K., Izawa, D., Nakayama, T., Fujisawa, R., Ohyanagi, H., Yoshie, O. (2001) Proinflammatory cytokines induce liver and activation-regulated chemokine/macrophage inflammatory protein-3α/CCL20 in mucosal epithelial cells through NF-κB. Int. Immunol. 13, 1255-1263.
30. Nakayama, T., Fujisawa, R., Yamada, H., Horikawa, T., Kawasaki, H., Hieshima, K., Izawa, D., Fujiie, S., Tezuka, T., Yoshie, O. (2001) Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)/macrophage inflammatory protein (MIP)-3α/CCL20 by epidermal keratinocytes and its role in atopic dermatitis. Int. Immunol. 13, 95-103.
31. Qiu, B., Frait, K. A., Reich, F., Komuniecki, E., Chensue, S. W. (2001) Chemokine expression dynamics in mycobacterial (type-1) and schistosomal (type-2) antigen-elicited pulmonary granuloma formation. Am. J. Pathol. 158, 1503-1515.
32. Schön, M. P., Ruzicka, T. (2001) Psoriasis: the plot thickens. Nat. Immunol. 2, 91.
33. Schröder, J. M. (1999) Epithelial antimicrobial peptides: innate local host response elements. Cell. Mol. Life Sci. 56, 32-46.
34. Huh, W. K., Oono, T., Shirafuji, Y., Akiyama, H., Arata, J., Sakaguchi, M., Huh, N. H., Iwatsuki, K. (2002) Dynamic alteration of human beta-defensin 2 localization from cytoplasm to intercellular space in psoriatic skin. J. Mol. Med. 80, 678-684.
35. Bensch, K. W., Raida, M., Magert, H-J., Schulz-Knappe, P., Forssmann, W-G. (1995) hBD-1: a novel β-defensin from human plasma. FEBS Lett. 368, 331-335.
36. Bals, R., Wang, X., Wu, Z., Bafna, V., Zasloff, M., Wilson, J. M. (1998) Human β-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J. Clin. Invest. 102, 874-880.
37. Goldman, M. J., Anderson, G. M., Stolzenberg, E. D., Kari, U. P., Zasloff, M., Wilson, J. M. (1997) Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88, 553-560.
38. Schmuth, M., Neyer, S., Rainer, C., Grassegger, A., Fritsch, P., Romani, N., Heufler, C. (2002) Expression of the C-C chemokine MIP-3α/CCL20 in human epidermis with impaired permeability barrier function. Exp. Dermatol. 11, 135-142.
39. Tanaka, Y., Imai, T., Baba, M., Ishikawa, I., Uehira, M., Nomiyama, H., Yoshie, O. (1999) Selective expression of liver and activation-regulated chemokine (LARC) in intestinal epithelium in mice and humans. Eur. J. Immunol. 29, 633-642.
40. Schild, L., Kellenberger, S. (2001) Structure function relationships of ENaC and its role in sodium handling. Adv. Exp. Med. Biol. 502, 305-314.