LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion

Atherosclerosis

Volumn 204, Issue 1, 2009, Pages 171-177

  Feitosa, Mary F ^a   Myers, Richard H ^b   Pankow, James S ^c   Province, Michael A ^a   Borecki, Ingrid B ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

BMI; Cardiovascular disease; Diabetes; Hepatic lipase; Lipids; Polymorphism

Indexed keywords

HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ARTICLE; CHOLESTEROL BLOOD LEVEL; DIABETES MELLITUS; DYSLIPIDEMIA; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC TRAIT; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INTRON; LIPID METABOLISM; MALE; PHENOTYPE; POPULATION RESEARCH; PRIORITY JOURNAL; PROGENY; PROMOTER REGION; QUANTITATIVE TRAIT; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; CHOLESTEROL, HDL; DYSLIPIDEMIAS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; HAPLOTYPES; HUMANS; INTRONS; LINKAGE DISEQUILIBRIUM; LIPASE; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; SEX FACTORS; UNITED STATES;

EID: 67349208491     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.09.007     Document Type: Article

References (36)

1. Lewington S., Whitlock G., Clarke R., et al., Prospective Studies Collaboration. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet 370 (2007) 1829-1839
2. Aguilera C.M., Gil-Campos M., Cañete R., and Gil A. Alterations in plasma and tissue lipids associated with obesity and metabolic syndrome. Clin Sci (Lond) 114 (2008) 183-193
3. Grundy S.M., Cleeman J.I., Merz C.N., et al., National Heart, Lung, and Blood Institute; American College of Cardiology Foundation; American Heart Association. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 110 (2004) 227-239
4. Rollins J., Chen Y., Paigen B., and Wang X. In search of new targets for plasma high-density lipoprotein cholesterol levels: promise of human-mouse comparative genomics. Trends Cardiovasc Med 16 (2006) 220-234
5. Feitosa M.F., Province M.A., Heiss G., et al. Evidence of QTL on 15q21 for high-density lipoprotein cholesterol: the National Heart, Lung, and Blood Institute Family Heart Study (NHLBI FHS). Atherosclerosis 190 (2007) 232-237
6. Carr M.C., Brunzell J.D., and Deeb S.S. Ethnic differences in hepatic lipase and HDL in Japanese, black, and white Americans: role of central obesity and LIPC polymorphisms. J Lipid Res 45 (2004) 466-473
7. Grarup N., and Andersen G. Gene-environment interactions in the pathogenesis of type 2 diabetes and metabolism. Curr Opin Clin Nutr Metab Care 10 (2007) 420-426
8. Guerra R., Wang J., Grundy S.M., and Cohen J.C. A hepatic lipase (LIPC) allele associated with high plasma concentrations of high density lipoprotein cholesterol. Proc Natl Acad Sci USA 94 (1997) 4532-4537
9. Zambon A., Deeb S.S., Hokanson J.E., Brown B.G., and Brunzell J.D. Common variants in the promoter of the hepatic lipase gene are associated with lower levels of hepatic lipase activity, buoyant LDL, and higher HDL2 cholesterol. Arterioscler Thromb Vasc Biol 18 (1998) 1723-1729
10. Isaacs A., Sayed-Tabatabaei F.A., Njajou O.T., Witteman J.C., and van Duijn CM. The -514 C->T hepatic lipase promoter region polymorphism and plasma lipids: a meta-analysis. J Clin Endocrinol Metab 89 (2004) 3858-3863
11. Kathiresan S., Melander O., Guiducci C., et al. Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet 40 (2008) 189-197
12. Willer CJ, Sanna S, Jackson AU, Scuteri A, Bonnycastle LL, Clarke R, Heath SC, Timpson NJ, Najjar SS, Stringham HM, Strait J, Duren WL, Maschio A, Busonero F, Mulas A, Albai G, Swift AJ, Morken MA, Narisu N, Bennett D, Parish S, Shen H, Galan P, Meneton P, Hercberg S, Zelenika D, Chen WM, Li Y, Scott LJ, Scheet PA, Sundvall J, Watanabe RM, Nagaraja R, Ebrahim S, Lawlor DA, Ben-Shlomo Y, Davey-Smith G, Shuldiner AR, Collins R, Bergman RN, Uda M, Tuomilehto J, Cao A, Collins FS, Lakatta E, Lathrop GM, Boehnke M, Schlessinger D, Mohlke KL, Abecasis GR. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 2008 January 13 [Epub ahead of print].
13. Cohen J.C., Wang Z., Grundy S.M., Stoesz M.R., and Guerra R. Variation at the hepatic lipase and apolipoprotein AI/CIII/AIV loci is a major cause of genetically determined variation in plasma HDL cholesterol levels. J Clin Invest 94 (1994) 2377-2384
14. Couture P., Otvos J.D., Cupples L.A., et al. Association of the C-514T polymorphism in the hepatic lipase gene with variations in lipoprotein subclass profiles: The Framingham Offspring Study. Arterioscler Thromb Vasc Biol 20 (2000) 815-822
15. Carr M.C., Hokanson J.E., Zambon A., et al. The contribution of intraabdominal fat to gender differences in hepatic lipase activity and low/high density lipoprotein heterogeneity. J Clin Endocrinol Metab 86 (2001) 2831-2837
16. Park K.W., Choi J.H., Chae I.H., et al. Hepatic lipase C514T polymorphism and its relationship with plasma HDL-C levels and coronary artery disease in Koreans. J Biochem Mol Biol 36 (2003) 237-242
17. Ko Y.L., Hsu L.A., Hsu K.H., Ko Y.H., and Lee Y.S. The interactive effects of hepatic lipase gene promoter polymorphisms with sex and obesity on high-density-lipoprotein cholesterol levels in Taiwanese-Chinese. Atherosclerosis 172 (2004) 135-142
18. Zhang C., Lopez-Ridaura R., Rimm E.B., et al. Interactions between the -514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men. Am J Clin Nutr 81 (2005) 1429-1435
19. Berg A., Frey I., Baumstark M.W., Halle M., and Keul J. Physical activity and lipoprotein lipid disorders. Sports Med 17 (1994) 6-21
20. Teran-Garcia M., Santoro N., Rankinen T., et al. Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study. Diabetes 54 (2005) 2251-2255
21. Ordovas J.M., Corella D., Demissie S., et al., HERITAGE Family Study. Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene-nutrient interaction in the Framingham Study. Circulation 106 (2002) 2315-2321
22. Nettleton J.A., Steffen L.M., Ballantyne C.M., Boerwinkle E., and Folsom A.R. Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults. Atherosclerosis 194 (2007) e131-e140
23. Higgins M., Province M., Heiss G., et al. NHLBI Family Heart Study: objectives and design. Am J Epidemiol 143 (1996) 1219-1228
24. Feitosa M.F., Borecki I.B., Rich S.S., et al. Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: the National Heart, Lung, and Blood Institute Family Heart Study. Am J Hum Genet 70 (2002) 72-82
25. Jiang Y., Wilk J.B., Borecki I., et al. Common variants in the 5′ region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study. Am J Hum Genet 75 (2004) 220-230
26. Wilk J.B., DeStefano A.L., Arnett D.K., et al. A genome-wide scan of pulmonary function measures in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Respir Crit Care Med 167 (2003) 1528-1533
27. 2+ precipitation procedure for quantitation of high-density-lipoprotein cholesterol. Clin Chem 28 (1982) 1379-1388
28. Clayton D. A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet 65 (1999) 1170-1177
29. Yu K., Zhang S., Borecki I., et al. A haplotype similarity based transmission/disequilibrium test under founder heterogeneity. Ann Hum Genet 69 (2005) 455-467
30. Benjamini Y., and Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc 85 (1995) 289-300
31. Barrett J.C., Fry B., Maller J., and Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21 (2005) 263-265
32. Jansen H., Verhoeven A.J., and Sijbrands E.J. Hepatic lipase: a pro- or anti-atherogenic protein?. J Lipid Res 43 (2002) 1352-1362
33. Perret B., Mabile L., Martinez L., et al. Hepatic lipase: structure/function relationship, synthesis, and regulation. J Lipid Res 43 (2002) 1163-1169
34. Botma G.J., Verhoeven A.J., and Jansen H. Hepatic lipase promoter activity is reduced by the C-480T and G-216A substitutions present in the common LIPC gene variant, and is increased by Upstream Stimulatory Factor. Atherosclerosis 154 (2001) 625-632
35. Fan Y.M., Lehtimäki T., Rontu R., et al. Age-dependent association between hepatic lipase gene C-480T polymorphism and the risk of pre-hospital sudden cardiac death: the Helsinki Sudden Death Study. Atherosclerosis 192 (2007) 421-427
36. Mattsson C., and Olsson T. Estrogens and glucocorticoid hormones in adipose tissue metabolism. Curr Med Chem 14 (2007) 2918-2924